LUC00133I2 - - Google Patents

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Publication number
LUC00133I2
LUC00133I2 LU00133C LUC00133C LUC00133I2 LU C00133 I2 LUC00133 I2 LU C00133I2 LU 00133 C LU00133 C LU 00133C LU C00133 C LUC00133 C LU C00133C LU C00133 I2 LUC00133 I2 LU C00133I2
Authority
LU
Luxembourg
Application number
LU00133C
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39868905&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LUC00133(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of LUC00133I1 publication Critical patent/LUC00133I1/fr
Publication of LUC00133I2 publication Critical patent/LUC00133I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
LU00133C 2007-05-25 2019-10-14 LUC00133I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/807,227 US7534595B2 (en) 2006-06-12 2007-05-25 Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
LU2008006661 2008-05-23

Publications (2)

Publication Number Publication Date
LUC00133I1 LUC00133I1 (fr) 2019-10-16
LUC00133I2 true LUC00133I2 (fr) 2020-07-16

Family

ID=39868905

Family Applications (1)

Application Number Title Priority Date Filing Date
LU00133C LUC00133I2 (fr) 2007-05-25 2019-10-14

Country Status (29)

Country Link
US (1) US7534595B2 (fr)
EP (2) EP2657335A1 (fr)
JP (1) JP5670183B2 (fr)
KR (2) KR20150038753A (fr)
CN (1) CN101842482B (fr)
AR (2) AR066716A1 (fr)
AU (1) AU2008263190B2 (fr)
BR (1) BRPI0811267B8 (fr)
CA (1) CA2687450C (fr)
CL (1) CL2008001497A1 (fr)
CY (2) CY1116894T1 (fr)
DK (1) DK2152868T3 (fr)
EA (1) EA018443B1 (fr)
ES (1) ES2551315T3 (fr)
HR (1) HRP20151268T1 (fr)
HU (2) HUE025784T2 (fr)
IL (1) IL202132A (fr)
LT (1) LTC2152868I2 (fr)
LU (1) LUC00133I2 (fr)
MX (1) MX2009012453A (fr)
MY (1) MY151413A (fr)
NL (1) NL301011I2 (fr)
NO (1) NO2019037I1 (fr)
PE (1) PE20090315A1 (fr)
PL (1) PL2152868T3 (fr)
PT (1) PT2152868E (fr)
SI (1) SI2152868T1 (fr)
TW (1) TWI418633B (fr)
WO (1) WO2008153776A1 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534595B2 (en) 2006-06-12 2009-05-19 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7531341B1 (en) 2006-06-12 2009-05-12 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7560263B2 (en) 2007-08-17 2009-07-14 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
WO2010014225A2 (fr) * 2008-07-30 2010-02-04 Biomarin Pharmaceutical Inc. Dosages permettant la détection de la phénylalanine ammoniac-lyase et des anticorps contre la phénylalanine ammoniac-lyase
ES2690542T3 (es) 2010-02-04 2018-11-21 Biomarin Pharmaceutical Inc. Método para purificar variantes de fenilalanina amoníaco-liasa procariotas
US20150246083A1 (en) * 2012-07-27 2015-09-03 University Of North Texas Genetically modified probiotic for the treatment of phenylketonuria (pku) disease
SMT201900315T1 (it) 2013-04-18 2019-07-11 Codexis Inc Polipeptidi di fenilalanina ammoniaca liasi ingegnerizzati
EP3071515A2 (fr) 2013-11-18 2016-09-28 Rubius Therapeutics, Inc. Complexes membrane synthétique- récepteur
HUE054471T2 (hu) 2014-04-01 2021-09-28 Rubius Therapeutics Inc Immunmodulációs módszerek és készítmények
EP3928787A1 (fr) 2014-04-16 2021-12-29 Codexis, Inc. Tyrosine ammoniac-lyase génétiquement modifiée
FI3237621T3 (fi) 2014-12-22 2023-06-01 Codexis Inc Ihmisen alfa-galaktosidaasivariantteja
TWI899515B (zh) * 2015-08-04 2025-10-01 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
IL263801B2 (en) 2016-07-26 2024-01-01 Biomarin Pharm Inc Novel adeno-associated virus capsid proteins
WO2018043546A1 (fr) * 2016-08-30 2018-03-08 三菱ケミカル株式会社 Procédé de production d'une enzyme mutante, et alcool acyltransférase mutante
CN106497905A (zh) * 2016-12-14 2017-03-15 江南大学 一株鱼腥藻来源的苯丙氨酸脱氨酶的突变体
CA3051262A1 (fr) 2017-02-13 2018-08-16 Codexis, Inc. Polypeptides de phenylalanine ammonia-lyase modifies
CN107653275A (zh) * 2017-10-30 2018-02-02 安徽工程大学 D‑苯丙氨酸的制备方法
CN108004225B (zh) * 2017-12-19 2020-05-08 江南大学 一种成团泛菌来源的苯丙氨酸氨基变位酶的突变体
JP2021522811A (ja) 2018-05-09 2021-09-02 ビオマリン プハルマセウトイカル インコーポレイテッド フェニルケトン尿症の治療方法
TW202005978A (zh) 2018-05-14 2020-02-01 美商拜奧馬林製藥公司 新穎肝靶向腺相關病毒載體
WO2019241132A1 (fr) * 2018-06-12 2019-12-19 Codexis, Inc. Tyrosine ammonia-lyase modifiée
US11198861B2 (en) * 2018-07-12 2021-12-14 Codexis, Inc. Engineered phenylalanine ammonia lyase polypeptides
AU2019397401A1 (en) 2018-12-14 2021-06-17 Codexis, Inc. Engineered tyrosine ammonia lyase
EP3898960A4 (fr) 2018-12-20 2022-11-30 Codexis, Inc. Variants d'alpha-galactosidase humaine
CN110456056A (zh) * 2019-07-22 2019-11-15 浙江大学 一种新生儿苯丙酮尿症无创筛查试纸的制备方法
MX2022002473A (es) 2019-08-30 2022-08-02 Codexis Inc Variantes de lipasa modificadas geneticamente.
WO2021127457A1 (fr) 2019-12-20 2021-06-24 Codexis, Inc. Variants d'alpha-glucosidase acide modifiés
CN116113691A (zh) 2020-02-04 2023-05-12 科德克希思公司 工程化亮氨酸脱羧酶
WO2021168060A1 (fr) * 2020-02-19 2021-08-26 Trustees Of Tufts College Procédés d'ingénierie d'enzymes amino acide ammonia lyase et enzymes ainsi obtenues
AR122409A1 (es) 2020-04-03 2022-09-07 Biomarin Pharm Inc Tratamiento de la fenilcetonuria con aav y formulaciones terapéuticas
AU2021331493A1 (en) 2020-08-28 2023-03-09 Codexis, Inc. Engineered amylase variants
EP4204554A4 (fr) 2020-08-28 2024-08-21 Codexis, Inc. Variants de protéase modifiés
WO2022245924A1 (fr) * 2021-05-19 2022-11-24 Biomarin Pharmaceutical Inc. Compositions de phénylalanine ammonia-lyase procaryotique et méthodes de traitement de sujets adolescents
TW202313969A (zh) 2021-05-21 2023-04-01 美商克迪科思股份有限公司 經工程化的甲硫胺酸γ解離酶變異體
US20250000957A1 (en) * 2021-09-16 2025-01-02 Arcturus Therapeutics, Inc. Compositions and methods for treating phenylketonuria
WO2023077169A2 (fr) 2021-11-01 2023-05-04 Codexis, Inc. Leucine décarboxylases modifiées
CN117417925A (zh) * 2022-07-18 2024-01-19 浙江泽科塔生物医药有限公司 Pal变体、包含该pal变体的药物组合物以及用于制备该pal变体的方法
CN118931888A (zh) * 2023-05-09 2024-11-12 重庆派金生物科技有限公司 苯丙氨酸裂解酶突变体及其偶联物或其药学上可接受的盐
GB202307239D0 (en) 2023-05-15 2023-06-28 Evox Therapeutics Ltd Gene therapies for Phenylketonuria
CN116478975B (zh) * 2023-06-16 2023-09-01 苏州优信合生技术有限公司 高活性苯丙氨酸解氨酶突变体及其表达菌株
TW202521161A (zh) 2023-11-17 2025-06-01 美商拜奧馬林製藥公司 苯丙胺酸解氨酶與ｐｏｅｇｍａ之結合物及其使用方法

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Also Published As

Publication number Publication date
EP2152868A1 (fr) 2010-02-17
CN101842482B (zh) 2014-10-22
ES2551315T3 (es) 2015-11-18
IL202132A0 (en) 2010-06-16
CA2687450A1 (fr) 2008-12-18
CA2687450C (fr) 2019-03-26
TWI418633B (zh) 2013-12-11
IL202132A (en) 2017-06-29
LUC00133I1 (fr) 2019-10-16
KR20150038753A (ko) 2015-04-08
HK1135141A1 (zh) 2010-05-28
AR110834A2 (es) 2019-05-08
HUE025784T2 (en) 2016-05-30
EA018443B1 (ru) 2013-08-30
CN101842482A (zh) 2010-09-22
LTPA2019517I1 (lt) 2019-10-25
JP5670183B2 (ja) 2015-02-18
EP2152868B1 (fr) 2015-09-02
AR066716A1 (es) 2009-09-09
WO2008153776A8 (fr) 2009-07-30
PE20090315A1 (es) 2009-03-19
MY151413A (en) 2014-05-30
CY2019039I2 (el) 2020-05-29
AU2008263190B2 (en) 2014-04-17
AU2008263190A1 (en) 2008-12-18
BRPI0811267A2 (pt) 2014-10-07
US7534595B2 (en) 2009-05-19
CY1116894T1 (el) 2017-04-05
MX2009012453A (es) 2010-01-25
BRPI0811267B8 (pt) 2021-05-25
NL301011I2 (nl) 2020-05-13
EP2657335A1 (fr) 2013-10-30
EA200970980A1 (ru) 2010-04-30
US20080008695A1 (en) 2008-01-10
HUS1900049I1 (hu) 2019-11-28
LTC2152868I2 (lt) 2020-09-25
NL301011I1 (nl) 2019-10-16
CY2019039I1 (el) 2020-05-29
CL2008001497A1 (es) 2009-01-09
TW200902052A (en) 2009-01-16
BRPI0811267B1 (pt) 2020-11-10
DK2152868T3 (en) 2015-11-16
HRP20151268T1 (hr) 2015-12-18
NO2019037I1 (no) 2019-10-16
PT2152868E (pt) 2015-11-13
WO2008153776A1 (fr) 2008-12-18
KR20100024437A (ko) 2010-03-05
KR101603796B1 (ko) 2016-03-17
JP2010529835A (ja) 2010-09-02
SI2152868T1 (sl) 2015-12-31
PL2152868T3 (pl) 2016-01-29

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