LV10105A - Insulina attirisanas panemiens - Google Patents

Insulina attirisanas panemiens

Info

Publication number: LV10105A
Authority: LV; Latvia
Prior art keywords: insulin; removal control; zwitterions; aqueous buffered; solvents
Prior art date: 1990-09-05

Application number

LV930285A

Other languages

English (en)

Other versions

LV10105B (en

Inventor

Rainer Dickhardt

Bernhard Unger

Leonhard Haefner

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-05

Filing date

1993-05-04

Publication date

1994-05-10

1993-05-04 Application filed by Hoechst Ag filed Critical Hoechst Ag

1994-05-10 Publication of LV10105A publication Critical patent/LV10105A/lv

1995-04-20 Publication of LV10105B publication Critical patent/LV10105B/lv

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
102000004877 Insulin Human genes 0.000 title abstract 3
108090001061 Insulin Proteins 0.000 title abstract 3
229940125396 insulin Drugs 0.000 title abstract 2
239000004026 insulin derivative Substances 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000011877 solvent mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)

LVP-93-285A 1990-09-05 1993-05-04 Method of purification of insulin LV10105B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4028120A DE4028120C2 (de)	1990-09-05	1990-09-05	Verfahren zur Reinigung von Insulin und/oder Insulinderivaten

Publications (2)

Publication Number	Publication Date
LV10105A true LV10105A (lv)	1994-05-10
LV10105B LV10105B (en)	1995-04-20

Family

ID=6413631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-93-285A LV10105B (en)	1990-09-05	1993-05-04	Method of purification of insulin

Country Status (28)

Country	Link
US (1)	US5245008A (lv)
EP (1)	EP0474213B1 (lv)
JP (1)	JP3161770B2 (lv)
KR (1)	KR100191699B1 (lv)
AT (1)	ATE128145T1 (lv)
AU (1)	AU637255B2 (lv)
CA (1)	CA2050644C (lv)
CZ (1)	CZ283356B6 (lv)
DE (2)	DE4028120C2 (lv)
DK (1)	DK0474213T3 (lv)
ES (1)	ES2078405T3 (lv)
FI (1)	FI98216C (lv)
GR (1)	GR3017750T3 (lv)
HR (1)	HRP940716B1 (lv)
HU (1)	HU207100B (lv)
IE (1)	IE68956B1 (lv)
IL (1)	IL99384A (lv)
LT (1)	LT3329B (lv)
LV (1)	LV10105B (lv)
NO (1)	NO180681C (lv)
NZ (1)	NZ239650A (lv)
PL (1)	PL168114B1 (lv)
PT (1)	PT98864B (lv)
RU (1)	RU2037500C1 (lv)
SK (1)	SK278099B6 (lv)
UA (1)	UA26375A1 (lv)
YU (1)	YU147591A (lv)
ZA (1)	ZA917006B (lv)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0547544T3 (da) *	1991-12-18	1997-09-08	Hoechst Ag	Fremgangsmåde til fremstilling af insulinholdige opløsninger.
JP3279362B2 (ja) *	1992-10-05	2002-04-30	井上聰一	糖尿病判定方法及び糖尿病判定装置
JP3319812B2 (ja) *	1993-04-05	2002-09-03	井上聰一	リウマチ判定方法及びリウマチ判定装置
US6869930B1 (en) *	1993-09-17	2005-03-22	Novo Nordisk A/S	Acylated insulin
DE4405179A1 (de) *	1994-02-18	1995-08-24	Hoechst Ag	Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
DE19652713C2 (de) *	1996-12-18	2001-11-22	Aventis Pharma Gmbh	Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
RU2122549C1 (ru) *	1997-12-29	1998-11-27	Закрытое акционерное общество "Фосфосорб"	Способ хроматографического выделения и очистки белков, пептидов и их комплексов
DE19838097A1 (de) *	1998-08-24	2000-03-02	Hoechst Marion Roussel De Gmbh	Verfahren zur chromatographischen Reinigung von Insulinen
US6248683B1 (en) *	1999-04-07	2001-06-19	Silicycle Inc.	Process for the regeneration of used silica gel
US7309581B2 (en) *	2000-11-01	2007-12-18	Sysmex Corporation	Method of staining, detection and counting bacteria, and a diluent for bacterial stain
UA46668C2 (en) *	2001-12-29	2006-01-16	Omakooe Ltd Liability Company	Method for preparing combined dosage form of human insulin
UA46666C2 (en) *	2001-12-29	2006-01-16	Omakooe Ltd Liability Company	Method for preparing dosage form of short-term acting insulin
UA46669C2 (uk) *	2001-12-29	2005-12-15	Товариство З Обмеженою Відповідальністю "Мако"	Спосіб приготування готової лікарської форми інсуліну пролонгованої дії
BRPI0408978B8 (pt) *	2003-04-08	2021-07-27	Novo Nordisk As	processos para regenerar uma fase estacionária cromatográfica
AU2004228890B2 (en) *	2003-04-08	2010-04-01	Novo Nordisk A/S	Regeneration of chromatographic stationary phases
RU2251426C1 (ru) *	2003-09-18	2005-05-10	Цыганков Владимир Владимирович	Способ получения инсулина из природного источника и инсулин
KR101002296B1 (ko) *	2005-07-06	2010-12-20	주식회사 코오롱	전방향족 폴리아미드 필라멘트의 제조방법
GB0524782D0 (en) *	2005-12-05	2006-01-11	Chiron Srl	Analysis of samples
WO2009104199A1 (en) *	2008-02-19	2009-08-27	Biocon Limited	A method of obtaining purified heterologous insulins expressed in yeast
US20120123089A1 (en) *	2009-07-09	2012-05-17	Biocon Limited	Preparative non-linear gradient based chromatographic method and purified products thereof
EP2464655B1 (en) *	2009-08-11	2017-02-15	Biocon Limited	Chromatographic processes
JP5992836B2 (ja) *	2010-03-01	2016-09-14	ノヴォノルディスクアー／エス	ペプチドを精製するための分取ｒｐ−ｈｐｌｃ法
EP2570183A1 (en)	2011-09-15	2013-03-20	InstrAction GmbH	Sorbent comprising on its surface an aliphatic unit for the purification of organic molecules
EP3171888B1 (en)	2014-07-21	2022-12-28	Merck Sharp & Dohme LLC	Chromatography process for purification of inlsulin and insulin analogs
CN115505035B (zh) *	2022-08-22	2023-09-05	南京汉欣医药科技有限公司	一种司美格鲁肽中间体多肽的纯化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2629568C3 (de) *	1976-07-01	1981-09-10	Hoechst Ag, 6000 Frankfurt	Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
DE3101382A1 (de) *	1981-01-17	1982-09-02	Hoechst Ag, 6000 Frankfurt	"verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
DE3147842A1 (de) *	1981-12-03	1983-06-23	Hoechst Ag, 6230 Frankfurt	"verfahren zur trennung von gemischen aus insulin, insulinderivaten und gegebenenfalls verunreinigungen"
GB2119248A (en) *	1982-04-28	1983-11-16	John Kenneth Mcmullen	Insulin formulations and method of producing them
WO1989001485A1 (fr) *	1987-08-14	1989-02-23	Gebro Broschek Kg	Purification de peptides bruts par chromatographie liquide de preparation sous une pression moyenne

1990
- 1990-09-05 DE DE4028120A patent/DE4028120C2/de not_active Expired - Lifetime
1991
- 1991-09-03 UA UA5001389A patent/UA26375A1/uk unknown
- 1991-09-03 US US07/754,003 patent/US5245008A/en not_active Expired - Lifetime
- 1991-09-03 NZ NZ239650A patent/NZ239650A/en not_active IP Right Cessation
- 1991-09-03 IL IL9938491A patent/IL99384A/en not_active IP Right Cessation
- 1991-09-03 RU SU915001389A patent/RU2037500C1/ru active
- 1991-09-03 FI FI914150A patent/FI98216C/fi not_active IP Right Cessation
- 1991-09-04 ZA ZA917006A patent/ZA917006B/xx unknown
- 1991-09-04 JP JP22324291A patent/JP3161770B2/ja not_active Expired - Lifetime
- 1991-09-04 ES ES91114936T patent/ES2078405T3/es not_active Expired - Lifetime
- 1991-09-04 SK SK2717-91A patent/SK278099B6/sk not_active IP Right Cessation
- 1991-09-04 YU YU147591A patent/YU147591A/sh unknown
- 1991-09-04 EP EP91114936A patent/EP0474213B1/de not_active Expired - Lifetime
- 1991-09-04 PL PL91291616A patent/PL168114B1/pl unknown
- 1991-09-04 NO NO913476A patent/NO180681C/no not_active IP Right Cessation
- 1991-09-04 PT PT98864A patent/PT98864B/pt not_active IP Right Cessation
- 1991-09-04 CZ CS912717A patent/CZ283356B6/cs not_active IP Right Cessation
- 1991-09-04 AU AU83568/91A patent/AU637255B2/en not_active Expired
- 1991-09-04 DK DK91114936.7T patent/DK0474213T3/da active
- 1991-09-04 KR KR1019910015402A patent/KR100191699B1/ko not_active Expired - Lifetime
- 1991-09-04 AT AT91114936T patent/ATE128145T1/de not_active IP Right Cessation
- 1991-09-04 CA CA002050644A patent/CA2050644C/en not_active Expired - Lifetime
- 1991-09-04 IE IE311591A patent/IE68956B1/en not_active IP Right Cessation
- 1991-09-04 DE DE59106519T patent/DE59106519D1/de not_active Expired - Lifetime
- 1991-09-05 HU HU912874A patent/HU207100B/hu unknown
1993
- 1993-05-04 LV LVP-93-285A patent/LV10105B/lv unknown
- 1993-06-25 LT LTIP713A patent/LT3329B/lt not_active IP Right Cessation
1994
- 1994-10-20 HR HRP-1475/91A patent/HRP940716B1/xx not_active IP Right Cessation
1995
- 1995-10-16 GR GR950402850T patent/GR3017750T3/el unknown

Also Published As

Publication number	Publication date
US5245008A (en)	1993-09-14
YU147591A (sh)	1995-10-24
NO180681B (no)	1997-02-17
PL168114B1 (pl)	1996-01-31
PL291616A1 (en)	1992-03-09
FI98216B (fi)	1997-01-31
CS271791A3 (en)	1992-03-18
GR3017750T3 (en)	1996-01-31
HRP940716B1 (en)	1999-12-31
ZA917006B (en)	1992-04-29
EP0474213B1 (de)	1995-09-20
HU207100B (en)	1993-03-01
DK0474213T3 (da)	1996-01-15
PT98864A (pt)	1992-07-31
IE913115A1 (en)	1992-03-11
NO913476D0 (no)	1991-09-04
KR920006372A (ko)	1992-04-27
FI98216C (fi)	1997-05-12
ATE128145T1 (de)	1995-10-15
KR100191699B1 (ko)	1999-06-15
IL99384A (en)	1995-05-26
AU8356891A (en)	1992-03-12
CZ283356B6 (cs)	1998-03-18
IE68956B1 (en)	1996-07-24
LV10105B (en)	1995-04-20
IL99384A0 (en)	1992-08-18
CA2050644A1 (en)	1992-03-06
DE59106519D1 (de)	1995-10-26
DE4028120A1 (de)	1992-03-12
DE4028120C2 (de)	1996-09-19
FI914150L (fi)	1992-03-06
NZ239650A (en)	1992-09-25
NO913476L (no)	1992-03-06
UA26375A1 (uk)	1999-08-30
SK278099B6 (en)	1996-01-10
CA2050644C (en)	2001-11-27
PT98864B (pt)	1999-02-26
HRP940716A2 (en)	1997-06-30
JP3161770B2 (ja)	2001-04-25
AU637255B2 (en)	1993-05-20
EP0474213A1 (de)	1992-03-11
LTIP713A (en)	1995-01-31
ES2078405T3 (es)	1995-12-16
FI914150A0 (fi)	1991-09-03
RU2037500C1 (ru)	1995-06-19
HUT59418A (en)	1992-05-28
JPH04230699A (ja)	1992-08-19
NO180681C (no)	1997-05-28
LT3329B (en)	1995-07-25

Publication	Publication Date	Title
LV10105A (lv)	1994-05-10	Insulina attirisanas panemiens
ATE74137T1 (de)	1992-04-15	Verfahren zur reinigung von toxinconjugaten unter verwendung von hydrophober chromatographie.
DK394786A (da)	1987-02-20	Fremgangsmaade til rensning og aktivering af proteiner fra uoploeselige inklusionslegemer
DK575184A (da)	1985-06-06	Fremgangsmaade til oprensning af factor viii.c samt farmaceutisk praeparat indeholdende denne
ATE113960T1 (de)	1994-11-15	Proteingewinnung.
KR830008995A (ko)	1983-12-16	인체 인슐린 및 그의 유도체의 제조방법
ATE4116T1 (de)	1983-07-15	Reinigung von menschlichem wachstumshormon.
GB1534812A (en)	1978-12-06	Method for the purification of interferon
ATE150032T1 (de)	1997-03-15	Verfahren zur gewinnung von insulinhaltigen lösungen
AU583388B2 (en)	1989-04-27	High performance liquid chromatography mobile phase
DE59304941D1 (de)	1997-02-13	Verfahren zum Abtrennen von Aminosäuren aus wässrigen Lösungen