LV10265B - Derivatives of pyridine and pyrimidine, their preparation, pharmaceutical composition and treating method - Google Patents

Derivatives of pyridine and pyrimidine, their preparation, pharmaceutical composition and treating method Download PDF

Info

Publication number: LV10265B
Authority: LV; Latvia
Prior art keywords: hydrogen; lower alkyl; halogen; hjih; cyano
Prior art date: 1988-09-28

Application number

LVP-93-577A

Other languages

English (en)

Latvian (lv)

Other versions

LV10265A (lv

Inventor

Olsson Knut Gunnar

Abramo Aina Lisbeth

Torbjoern Lundstedt Erik

Harry Nordvi Curt

Original Assignee

Kabi Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-28

Filing date

1993-06-15

Publication date

1995-08-20

1993-06-15 Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab

1994-10-20 Publication of LV10265A publication Critical patent/LV10265A/xx

1995-08-20 Publication of LV10265B publication Critical patent/LV10265B/lv

Links

238000000034 method Methods 0.000 title claims 4
239000008194 pharmaceutical composition Substances 0.000 title claims 3
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
150000003222 pyridines Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 claims abstract 22
125000003545 alkoxy group Chemical group 0.000 claims abstract 6
-1 2-pyrimidyl Chemical group 0.000 claims abstract 3
125000000753 cycloalkyl group Chemical group 0.000 claims abstract 3
150000003839 salts Chemical class 0.000 claims abstract 3
229910052739 hydrogen Inorganic materials 0.000 claims description 25
150000001875 compounds Chemical class 0.000 claims description 22
239000001257 hydrogen Substances 0.000 claims 24
150000002431 hydrogen Chemical class 0.000 claims 15
229910052736 halogen Inorganic materials 0.000 claims 11
150000002367 halogens Chemical class 0.000 claims 11
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
125000004093 cyano group Chemical group *C#N 0.000 claims 7
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
150000001408 amides Chemical group 0.000 claims 5
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
229910052760 oxygen Inorganic materials 0.000 claims 3
239000001301 oxygen Substances 0.000 claims 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
125000004076 pyridyl group Chemical group 0.000 claims 2
WGNUNYPERJMVRM-UHFFFAOYSA-N 3-pyridylacetic acid Chemical compound OC(=O)CC1=CC=CN=C1 WGNUNYPERJMVRM-UHFFFAOYSA-N 0.000 claims 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
239000004480 active ingredient Substances 0.000 claims 1
239000013543 active substance Substances 0.000 claims 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
239000000975 dye Substances 0.000 claims 1
229910052731 fluorine Inorganic materials 0.000 claims 1
239000011737 fluorine Substances 0.000 claims 1
230000003993 interaction Effects 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
208000020016 psychiatric disease Diseases 0.000 claims 1
125000000714 pyrimidinyl group Chemical group 0.000 claims 1
229910052717 sulfur Chemical group 0.000 claims 1
239000011593 sulfur Chemical group 0.000 claims 1
125000001475 halogen functional group Chemical group 0.000 abstract 4
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
BGEBZHIAGXMEMV-UHFFFAOYSA-N 5-methoxypsoralen Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC BGEBZHIAGXMEMV-UHFFFAOYSA-N 0.000 description 1
235000017399 Caesalpinia tinctoria Nutrition 0.000 description 1
101100366940 Mus musculus Stom gene Proteins 0.000 description 1
241000388430 Tara Species 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
101150067113 prxl2a gene Proteins 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

LVP-93-577A 1988-09-28 1993-06-15 Derivatives of pyridine and pyrimidine, their preparation, pharmaceutical composition and treating method LV10265B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8803429A SE8803429D0 (sv)	1988-09-28	1988-09-28	Novel pyridyl- and pyrimidyl derivatives
HU895103A HU203232B (en)	1988-09-28	1989-09-28	Process for producing new pyridyl and pyrimidinyl derivatives

Publications (2)

Publication Number	Publication Date
LV10265A LV10265A (lv)	1994-10-20
LV10265B true LV10265B (en)	1995-08-20

Family

ID=26317811

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-93-577A LV10265B (en)	1988-09-28	1993-06-15	Derivatives of pyridine and pyrimidine, their preparation, pharmaceutical composition and treating method

Country Status (25)

Country	Link
US (1)	US5034390A (da)
EP (1)	EP0361271B1 (da)
JP (1)	JP2857693B2 (da)
KR (1)	KR930007413B1 (da)
CN (1)	CN1028756C (da)
AT (1)	ATE97665T1 (da)
AU (1)	AU616307B2 (da)
CA (1)	CA1337417C (da)
DD (1)	DD290884A5 (da)
DE (1)	DE68910922T2 (da)
DK (1)	DK171133B1 (da)
ES (1)	ES2060709T3 (da)
FI (1)	FI94629C (da)
HU (1)	HU203232B (da)
IE (1)	IE62790B1 (da)
IL (1)	IL91701A (da)
LT (1)	LT3549B (da)
LV (1)	LV10265B (da)
NO (1)	NO174667C (da)
NZ (1)	NZ230743A (da)
PH (1)	PH27039A (da)
PT (1)	PT91826B (da)
RU (1)	RU2021269C1 (da)
SE (1)	SE8803429D0 (da)
ZA (1)	ZA897404B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5219855A (en) *	1988-01-29	1993-06-15	Mitsubishi Kasei Corporation	Anxiolytic drug
IE911774A1 (en) *	1990-06-11	1991-12-18	Akzo Nv	Pyridinylpiperazine derivatives
US5166148A (en) *	1990-07-09	1992-11-24	The Du Pont Merck Pharmaceutical Company	2-amino-1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
US5270312A (en) *	1990-11-05	1993-12-14	Warner-Lambert Company	Substituted piperazines as central nervous system agents
SE9201956D0 (sv) *	1992-06-25	1992-06-25	Kabi Pharmacia Ab	Novel nicotinicacid esters
PL180899B1 (pl) *	1994-09-30	2001-04-30	Pfizer	Nowe pochodne 2,7-podstawionej oktahydro-1H-pirydo[1,2-a]pirazyny i środek farmaceutyczny je zawierający
GB9517381D0 (en) *	1995-08-24	1995-10-25	Pharmacia Spa	Aryl and heteroaryl piperazine derivatives
DE19600934A1 (de) *	1996-01-12	1997-07-17	Basf Ag	Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
SE9601708D0 (sv) *	1996-05-06	1996-05-06	Pharmacia Ab	Pyridyl- and pyrimidyl-piperazines in the treatment of substance abuse disorders
DE19728996A1 (de)	1997-07-07	1999-01-14	Basf Ag	Triazolverbindungen und deren Verwendung
AU744539B2 (en)	1997-10-27	2002-02-28	Neurosearch A/S	Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
TR200103214T2 (tr) *	1999-05-04	2002-03-21	Schering Corporation	CCR5 antagonistleri olarak yararlì piperazin trevleri.
GB0224917D0 (en) *	2002-10-25	2002-12-04	Novartis Ag	Organic compounds
AU2004221812B2 (en) *	2003-03-19	2010-02-18	Exelixis Inc.	Tie-2 modulators and methods of use
RU2436772C2 (ru) *	2010-01-28	2011-12-20	Закрытое акционерное общество "НПК ЭХО"	4[(4'-никотиноиламино)бутироиламино]бутановая кислота, проявляющая ноотропную активность, и способ ее получения
WO2018148529A1 (en) *	2017-02-10	2018-08-16	Florida A&M University	Identification of agents displaying functional activation of dopamine d2 and d4 receptors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2979508A (en) *	1959-10-12	1961-04-11	Paul A J Janssen	Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
GB966493A (en) *	1961-11-13	1964-08-12	Soc Ind Fab Antibiotiques Sifa	Novel n,n-disubstituted piperazine compounds and their preparation
US4191765A (en) *	1976-05-25	1980-03-04	Hoechst Aktiengesellschaft	1-Aryloxy-2-hydroxy-3-aminopropanes
US4339580A (en) *	1979-06-26	1982-07-13	Mitsubishi Chemical Industries, Limited	Piperazinylalkoxyindanes and acid addition salts thereof
CH659069A5 (en) *	1983-11-02	1986-12-31	Sandoz Ag	2-Piperazino- or -homopiperazino-quinazoline derivatives, process for their preparation and pharmaceuticals containing them
US4701456A (en) *	1984-09-19	1987-10-20	Warner-Lambert Company	Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents
US4892943A (en) *	1985-10-16	1990-01-09	American Home Products Corporation	Fused bicyclic imides with psychotropic activity
GB8603120D0 (en) *	1986-02-07	1986-03-12	Pfizer Ltd	Anti-dysrhythmia agents
US4704390A (en) *	1986-02-13	1987-11-03	Warner-Lambert Company	Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
AR242678A1 (es) *	1986-03-05	1993-04-30	Gonzalez Jorge Alberto	Mejoras en instrumentos musicales de cuerda de arco.
MX174210B (es) *	1987-02-17	1994-04-28	Pfizer	Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
US4748240A (en) *	1987-04-03	1988-05-31	American Home Products Corporation	Psychotropic bicyclic imides
HU206109B (en) *	1987-10-26	1992-08-28	Pfizer	Process for producing heterocyclic carbonylpropyl pyrimidinyl piperazine derivatives and pharmaceutical compositions comprising same
JP2712222B2 (ja) *	1988-01-29	1998-02-10	三菱化学株式会社	抗不安薬
US4873331A (en) *	1988-12-09	1989-10-10	American Home Products Corporation	Noradamantyl-carboxylic acid piperazinoalkyl esters

1988
- 1988-09-28 SE SE8803429A patent/SE8803429D0/xx unknown
1989
- 1989-09-19 IE IE299489A patent/IE62790B1/en not_active IP Right Cessation
- 1989-09-19 DE DE89117262T patent/DE68910922T2/de not_active Expired - Fee Related
- 1989-09-19 ES ES89117262T patent/ES2060709T3/es not_active Expired - Lifetime
- 1989-09-19 AT AT89117262T patent/ATE97665T1/de not_active IP Right Cessation
- 1989-09-19 EP EP89117262A patent/EP0361271B1/en not_active Expired - Lifetime
- 1989-09-20 IL IL91701A patent/IL91701A/xx not_active IP Right Cessation
- 1989-09-22 NZ NZ230743A patent/NZ230743A/xx unknown
- 1989-09-25 CA CA000612932A patent/CA1337417C/en not_active Expired - Fee Related
- 1989-09-25 AU AU41737/89A patent/AU616307B2/en not_active Ceased
- 1989-09-26 DD DD89332978A patent/DD290884A5/de not_active IP Right Cessation
- 1989-09-27 PT PT91826A patent/PT91826B/pt not_active IP Right Cessation
- 1989-09-27 PH PH39294A patent/PH27039A/en unknown
- 1989-09-27 NO NO893853A patent/NO174667C/no unknown
- 1989-09-27 DK DK477189A patent/DK171133B1/da not_active IP Right Cessation
- 1989-09-27 RU SU894742280A patent/RU2021269C1/ru not_active IP Right Cessation
- 1989-09-28 JP JP1250834A patent/JP2857693B2/ja not_active Expired - Fee Related
- 1989-09-28 US US07/414,114 patent/US5034390A/en not_active Expired - Lifetime
- 1989-09-28 KR KR1019890013966A patent/KR930007413B1/ko not_active Expired - Fee Related
- 1989-09-28 HU HU895103A patent/HU203232B/hu not_active IP Right Cessation
- 1989-09-28 FI FI894604A patent/FI94629C/fi active IP Right Grant
- 1989-09-28 CN CN89107600A patent/CN1028756C/zh not_active Expired - Fee Related
- 1989-09-28 ZA ZA897404A patent/ZA897404B/xx unknown
1993
- 1993-06-02 LT LTIP604A patent/LT3549B/lt not_active IP Right Cessation
- 1993-06-15 LV LVP-93-577A patent/LV10265B/lv unknown

Also Published As

Publication number	Publication date
DK477189D0 (da)	1989-09-27
KR900004720A (ko)	1990-04-14
LT3549B (en)	1995-11-27
CN1041360A (zh)	1990-04-18
JPH02134368A (ja)	1990-05-23
JP2857693B2 (ja)	1999-02-17
EP0361271B1 (en)	1993-11-24
SE8803429D0 (sv)	1988-09-28
NO893853L (no)	1990-03-29
NZ230743A (en)	1991-08-27
FI94629B (fi)	1995-06-30
RU2021269C1 (ru)	1994-10-15
ATE97665T1 (de)	1993-12-15
NO174667C (no)	1994-06-15
ES2060709T3 (es)	1994-12-01
DK477189A (da)	1990-03-29
DE68910922D1 (de)	1994-01-05
FI94629C (fi)	1995-10-10
NO893853D0 (no)	1989-09-27
HU203232B (en)	1991-06-28
IE892994L (en)	1990-03-28
IL91701A0 (en)	1990-06-10
PT91826B (pt)	1995-05-31
AU616307B2 (en)	1991-10-24
AU4173789A (en)	1990-04-05
DK171133B1 (da)	1996-06-24
LV10265A (lv)	1994-10-20
CN1028756C (zh)	1995-06-07
IE62790B1 (en)	1995-03-08
CA1337417C (en)	1995-10-24
US5034390A (en)	1991-07-23
PT91826A (pt)	1990-03-30
FI894604L (fi)	1990-03-29
LTIP604A (en)	1995-01-31
IL91701A (en)	1993-05-13
FI894604A0 (fi)	1989-09-28
EP0361271A1 (en)	1990-04-04
KR930007413B1 (ko)	1993-08-10
ZA897404B (en)	1990-07-25
DE68910922T2 (de)	1994-03-17
PH27039A (en)	1993-02-01
HUT51611A (en)	1990-05-28
DD290884A5 (de)	1991-06-13
NO174667B (no)	1994-03-07

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AU658567B2 (en)	1995-04-27	Styryl-substituted indole and pyridyl compounds
US4723011A (en)	1988-02-02	Preparation of substituted and disubstituted-pyridine-2,3-dicarboxylate esters
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MXPA04012845A (es)	2005-02-24	Derivado de amida.
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US5677329A (en)	1997-10-14	Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase
US4465686A (en)	1984-08-14	5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation
EP0067511A3 (en)	1983-04-06	Method of inducing tillering using pyridine derivatives, and some of the pyridines themselves, process for preparing them and agricultural compositions containing them
JP2512656B2 (ja)	1996-07-03	トロポロン誘導体ならびに虚血性疾患を予防および治療するためのその薬剤組成物
CZ282880B6 (cs)	1997-11-12	Způsob přípravy substituovaných a nesubstituovaných 2,3-pyridinkarboxylátů
IL91701A (en)	1993-05-13	Novel pyridyl- and pyrimidyl derivatives, process for their preparation and pharmaceutical compositions containing them
ATE282595T1 (de)	2004-12-15	Pyridin- und piperidinderivate zur behandlung von neurodegenerativen erkrankungen
US4599423A (en)	1986-07-08	Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones
NO943738L (no)	1994-10-05	Nye perhydroisoindolderivater og deres fremstilling
Ishmetova et al.	2014	Synthesis and tuberculostatic activity of amine-substituted 1, 2, 4, 5-tetrazines and pyridazines
EP0773214A1 (en)	1997-05-14	Trifluoromethylquinolinecarboxylic acid derivative
KR970701177A (ko)	1997-03-17	아세트산 아미드 유도체 및 그것의 제조 방법(amide derivatives and process for the preparation thereof)