MA23899A1 - Procede pour la preparation de derives de pyrimidinedione et -trione, triazinedione et quinazolinedione, procede de preparation de compositions pharmaceutiques les contenant et leur utilisation - Google Patents

Procede pour la preparation de derives de pyrimidinedione et -trione, triazinedione et quinazolinedione, procede de preparation de compositions pharmaceutiques les contenant et leur utilisation

Info

Publication number: MA23899A1
Authority: MA; Morocco
Prior art keywords: preparation; triazinedione; pyrimidinedione; trione; pharmaceutical compositions
Prior art date: 1995-06-09

Application number

MA24270A

Other languages

English (en)

Inventor

W Bante Gary

J L Tapia F

Guzman Angol

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-09

Filing date

1996-06-06

Publication date

1996-12-31

1996-06-06 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1996-12-31 Publication of MA23899A1 publication Critical patent/MA23899A1/fr

Links

238000000034 method Methods 0.000 title 2
238000002360 preparation method Methods 0.000 title 2
230000008569 process Effects 0.000 title 2
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000008515 quinazolinediones Chemical class 0.000 title 1
BFGQTWYXWNCTSX-UHFFFAOYSA-N triazine-4,5-dione Chemical compound O=C1C=NN=NC1=O BFGQTWYXWNCTSX-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

MA24270A 1995-06-09 1996-06-06 Procede pour la preparation de derives de pyrimidinedione et -trione, triazinedione et quinazolinedione, procede de preparation de compositions pharmaceutiques les contenant et leur utilisation MA23899A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48918395A	1995-06-09	1995-06-09

Publications (1)

Publication Number	Publication Date
MA23899A1 true MA23899A1 (fr)	1996-12-31

Family

ID=23942748

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA24270A MA23899A1 (fr)	1995-06-09	1996-06-06	Procede pour la preparation de derives de pyrimidinedione et -trione, triazinedione et quinazolinedione, procede de preparation de compositions pharmaceutiques les contenant et leur utilisation

Country Status (31)

Country	Link
EP (1)	EP0748800B1 (fr)
JP (1)	JP2721147B2 (fr)
KR (1)	KR100446877B1 (fr)
CN (1)	CN1118459C (fr)
AR (1)	AR003428A1 (fr)
AT (1)	ATE201016T1 (fr)
AU (1)	AU710754B2 (fr)
BR (1)	BR9602705A (fr)
CA (1)	CA2178548A1 (fr)
CO (1)	CO4700472A1 (fr)
CZ (1)	CZ290004B6 (fr)
DE (1)	DE69612698T2 (fr)
DK (1)	DK0748800T3 (fr)
ES (1)	ES2157366T3 (fr)
GR (1)	GR3036307T3 (fr)
HU (1)	HU223594B1 (fr)
IL (1)	IL118519A (fr)
MA (1)	MA23899A1 (fr)
MY (1)	MY113499A (fr)
NO (1)	NO309424B1 (fr)
NZ (1)	NZ286720A (fr)
PE (1)	PE46497A1 (fr)
PL (1)	PL188061B1 (fr)
PT (1)	PT748800E (fr)
RU (1)	RU2175322C2 (fr)
SA (1)	SA96170263B1 (fr)
SG (1)	SG45486A1 (fr)
TR (1)	TR970073A2 (fr)
TW (1)	TW340846B (fr)
UY (1)	UY24257A1 (fr)
ZA (1)	ZA964561B (fr)

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GB2355456A (en)	1999-09-30	2001-04-25	Merck & Co Inc	Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists
GB2355457A (en)	1999-09-30	2001-04-25	Merck & Co Inc	Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
GB2355263A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
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DE10311065A1 (de)	2003-03-13	2004-09-23	Abbott Gmbh & Co. Kg	Pyrimidin-2-on-Verbindungen und ihre therapeutische Verwendung
CA2518465A1 (fr)	2003-03-25	2004-10-14	Takeda San Diego, Inc.	Inhibiteurs de dipeptidyle peptidase
KR20060041309A (ko)	2003-08-13	2006-05-11	다케다 야쿠힌 고교 가부시키가이샤	４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
JP2007505121A (ja)	2003-09-08	2007-03-08	武田薬品工業株式会社	ジペプチジルぺプチダーゼ阻害剤
MY140489A (en) *	2003-12-26	2009-12-31	Eisai R&D Man Co Ltd	1,2-di (cyclic) substituted benzene compounds
GB0400290D0 (en)	2004-01-08	2004-02-11	Medivir Ab	dUTPase inhibitors
EA013427B1 (ru)	2004-03-15	2010-04-30	Такеда Фармасьютикал Компани Лимитед	Ингибиторы дипептидилпептидазы
EP1655288A1 (fr) *	2004-11-05	2006-05-10	Institut Pasteur	Composés aryle-pyrimidyle, compositions pharmaceutiques les contenant et leur utilisation comme agents antimicrobiens
EP1832580A4 (fr)	2004-12-20	2009-03-11	Eisai R&D Man Co Ltd	Cristal et sel de 1-cyclopropylmethyl-4-ý2-(3,3,5,5)-tetramethylcyclohexyl)phenyl¨piperazine
EP1828192B1 (fr)	2004-12-21	2014-12-03	Takeda Pharmaceutical Company Limited	Inhibiteurs de dipeptidyle peptidase
CA2609255A1 (fr) *	2005-05-25	2006-11-30	Eisai R&D Management Co., Ltd.	Intermediaire dans la production d'un compose de [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine
AU2006290205B2 (en)	2005-09-14	2012-12-13	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors for treating diabetes
CA2622642C (fr) *	2005-09-16	2013-12-31	Takeda Pharmaceutical Company Limited	Inhibiteurs de dipeptidylpeptidase
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en)	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
DE102008030091B4 (de)	2008-06-25	2011-03-03	Resprotect Gmbh	Uracilderivate und deren Verwendung
US9452980B2 (en) *	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
RU2449994C1 (ru) *	2011-03-10	2012-05-10	Светлана Алексеевна Мещерякова	6-(4-бензилпиперазино)-1,3-диметилурацила дигидрохлорид, проявляющий биологическую активность
KR101925955B1 (ko) *	2011-03-18	2018-12-06	코어셉트 쎄라퓨틱스, 잉크.	피리미딘 사이클로헥실 글루코코르티코이드 수용체 조절제
GB201318886D0 (en) *	2013-10-25	2013-12-11	Givaudan Sa	Improvements i or relating to organic compounds
MY195528A (en)	2016-03-17	2023-01-30	Hoffmann La Roche	5-Ethyl-4-Methyl-Pyrazole-3-Carboxamide Derivative Having Activity as Agonist of Taar
KR102945882B1 (ko) *	2019-10-28	2026-03-30	닛뽕소다 가부시키가이샤	2,6-디옥소-3,6-디하이드로피리미딘 화합물 그리고 농원예용 살균제, 살선충제, 및 의료용·동물용 항진균제
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JPH02184667A (ja) *	1989-01-11	1990-07-19	Meiji Seika Kaisha Ltd	Ｎ，ｎ’―ジ置換ピペラジル誘導体及びそれを有効成分とする排尿障害改善剤
JPH0344379A (ja) *	1989-07-13	1991-02-26	Yamasa Shoyu Co Ltd	Ｎ↑３―ピペラジノウラシル誘導体
JP2814600B2 (ja) *	1989-08-31	1998-10-22	正幸石川	排尿障害治療剤
FR2673628B1 (fr) *	1991-03-07	1993-07-09	Esteve Labor Dr	Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
SG65570A1 (en) *	1992-02-25	1999-06-22	Recordati Chem Pharm	Heterobicyclic compounds
GB9305623D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
IL111730A (en) *	1993-11-29	1998-12-06	Fujisawa Pharmaceutical Co	Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
FR2727682A1 (fr) *	1994-12-02	1996-06-07	Pf Medicament	Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament

1996
- 1996-05-28 AT AT96108493T patent/ATE201016T1/de not_active IP Right Cessation
- 1996-05-28 PT PT96108493T patent/PT748800E/pt unknown
- 1996-05-28 DK DK96108493T patent/DK0748800T3/da active
- 1996-05-28 EP EP96108493A patent/EP0748800B1/fr not_active Expired - Lifetime
- 1996-05-28 DE DE69612698T patent/DE69612698T2/de not_active Expired - Fee Related
- 1996-05-28 ES ES96108493T patent/ES2157366T3/es not_active Expired - Lifetime
- 1996-05-31 IL IL11851996A patent/IL118519A/xx not_active IP Right Cessation
- 1996-06-03 ZA ZA964561A patent/ZA964561B/xx unknown
- 1996-06-03 AU AU54690/96A patent/AU710754B2/en not_active Ceased
- 1996-06-04 NZ NZ286720A patent/NZ286720A/en unknown
- 1996-06-05 HU HU9601529A patent/HU223594B1/hu not_active IP Right Cessation
- 1996-06-05 PL PL96314635A patent/PL188061B1/pl not_active IP Right Cessation
- 1996-06-06 MA MA24270A patent/MA23899A1/fr unknown
- 1996-06-06 TR TR96/00475A patent/TR970073A2/xx unknown
- 1996-06-06 AR ARP960103000A patent/AR003428A1/es active IP Right Grant
- 1996-06-06 PE PE1996000428A patent/PE46497A1/es not_active Application Discontinuation
- 1996-06-07 MY MYPI96002314A patent/MY113499A/en unknown
- 1996-06-07 JP JP8145236A patent/JP2721147B2/ja not_active Expired - Fee Related
- 1996-06-07 RU RU96111418/04A patent/RU2175322C2/ru not_active IP Right Cessation
- 1996-06-07 CA CA002178548A patent/CA2178548A1/fr not_active Abandoned
- 1996-06-07 CN CN96110490A patent/CN1118459C/zh not_active Expired - Fee Related
- 1996-06-07 SG SG1996010018A patent/SG45486A1/en unknown
- 1996-06-07 UY UY24257A patent/UY24257A1/es not_active IP Right Cessation
- 1996-06-07 BR BR9602705A patent/BR9602705A/pt not_active IP Right Cessation
- 1996-06-07 NO NO962412A patent/NO309424B1/no unknown
- 1996-06-07 CO CO96029677A patent/CO4700472A1/es unknown
- 1996-06-08 KR KR1019960020447A patent/KR100446877B1/ko not_active Expired - Fee Related
- 1996-06-10 CZ CZ19961696A patent/CZ290004B6/cs not_active IP Right Cessation
- 1996-07-11 TW TW085108416A patent/TW340846B/zh active
- 1996-08-26 SA SA96170263A patent/SA96170263B1/ar unknown
2001
- 2001-07-31 GR GR20010401157T patent/GR3036307T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1149051A (zh)	1997-05-07
NO962412D0 (no)	1996-06-07
CN1118459C (zh)	2003-08-20
NO962412L (no)	1996-12-10
AR003428A1 (es)	1998-08-05
DE69612698D1 (de)	2001-06-13
NZ286720A (en)	1998-08-26
EP0748800A2 (fr)	1996-12-18
HU9601529D0 (en)	1996-07-29
TR970073A2 (tr)	1997-02-21
GR3036307T3 (en)	2001-10-31
PL188061B1 (pl)	2004-12-31
EP0748800A3 (fr)	1996-12-27
UY24257A1 (es)	2000-12-29
CZ169696A3 (en)	1997-01-15
HUP9601529A3 (en)	2000-02-28
MY113499A (en)	2002-03-30
KR100446877B1 (ko)	2004-11-06
TW340846B (en)	1998-09-21
ZA964561B (en)	1996-12-09
PT748800E (pt)	2001-10-30
EP0748800B1 (fr)	2001-05-09
AU710754B2 (en)	1999-09-30
ATE201016T1 (de)	2001-05-15
JP2721147B2 (ja)	1998-03-04
HUP9601529A2 (hu)	1998-09-28
HK1013065A1 (en)	1999-08-13
NO309424B1 (no)	2001-01-29
HU223594B1 (hu)	2004-09-28
SA96170263B1 (ar)	2006-05-23
CA2178548A1 (fr)	1996-12-10
AU5469096A (en)	1996-12-19
CO4700472A1 (es)	1998-12-29
DE69612698T2 (de)	2001-12-06
BR9602705A (pt)	1998-09-08
ES2157366T3 (es)	2001-08-16
DK0748800T3 (da)	2001-08-27
CZ290004B6 (cs)	2002-05-15
SG45486A1 (en)	1998-01-16
IL118519A0 (en)	1996-09-12
KR970001344A (ko)	1997-01-24
IL118519A (en)	1999-12-22
RU2175322C2 (ru)	2001-10-27
PL314635A1 (en)	1996-12-23
PE46497A1 (es)	1997-12-04
JPH09100269A (ja)	1997-04-15

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DE69622183D1 (de)	2002-08-08	Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
MA24484A1 (fr)	1998-10-01	Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenant .