MA24182A1 - Procede pour la preparation de 2,4-diaminopyrimidines substituees - Google Patents

Procede pour la preparation de 2,4-diaminopyrimidines substituees

Info

Publication number
MA24182A1
MA24182A1 MA24620A MA24620A MA24182A1 MA 24182 A1 MA24182 A1 MA 24182A1 MA 24620 A MA24620 A MA 24620A MA 24620 A MA24620 A MA 24620A MA 24182 A1 MA24182 A1 MA 24182A1
Authority
MA
Morocco
Prior art keywords
diaminopyrimidines
substituted
preparation
Prior art date
Application number
MA24620A
Other languages
English (en)
Inventor
Guerry Philippe
Wyss Pierre-Charles
Stalder Henri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA24182A1 publication Critical patent/MA24182A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA24620A 1996-05-15 1997-05-15 Procede pour la preparation de 2,4-diaminopyrimidines substituees MA24182A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96107739 1996-05-15

Publications (1)

Publication Number Publication Date
MA24182A1 true MA24182A1 (fr) 1997-12-31

Family

ID=8222784

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24620A MA24182A1 (fr) 1996-05-15 1997-05-15 Procede pour la preparation de 2,4-diaminopyrimidines substituees

Country Status (29)

Country Link
US (1) US5866583A (fr)
EP (1) EP0901488B1 (fr)
JP (1) JP3098259B2 (fr)
KR (1) KR100295509B1 (fr)
CN (1) CN1098260C (fr)
AR (1) AR007088A1 (fr)
AT (1) ATE227282T1 (fr)
AU (1) AU726416B2 (fr)
BR (1) BR9709251A (fr)
CA (1) CA2254117C (fr)
CO (1) CO4840509A1 (fr)
CY (1) CY2425B1 (fr)
CZ (1) CZ364698A3 (fr)
DE (1) DE69716901T2 (fr)
DK (1) DK0901488T3 (fr)
ES (1) ES2184089T3 (fr)
HR (1) HRP970260A2 (fr)
IL (1) IL126702A0 (fr)
MA (1) MA24182A1 (fr)
NO (1) NO985335L (fr)
NZ (1) NZ332481A (fr)
PE (1) PE78898A1 (fr)
PL (1) PL330277A1 (fr)
PT (1) PT901488E (fr)
TR (1) TR199802331T2 (fr)
TW (1) TW438796B (fr)
WO (1) WO1997043277A1 (fr)
YU (1) YU51498A (fr)
ZA (1) ZA973984B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9808135A (pt) * 1997-03-03 2000-03-28 Hoffmann La Roche 2 4 diamnopirimidas substituìdas
EP0966464B1 (fr) * 1997-03-03 2003-05-28 Basilea Pharmaceutica AG 2,4,-diaminopyrimidines substitues
US6277860B1 (en) * 1999-10-29 2001-08-21 Pfizer Inc Furopyridine antibacterials
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
AU2004260636A1 (en) * 2003-06-13 2005-02-10 Arena Pharmaceuticals, Inc. 5-substituted 2H-pyrazole-3-carboxylic acid derivatives as agonists for the nicotinic acid receptor RUP25 for the treatment of dyslipidemia and related diseases
WO2005016877A2 (fr) * 2003-08-07 2005-02-24 Merck & Co., Inc. Carboxamides de pyrazole utilises comme inhibiteurs de la dehydrogenase-1 11-beta-hydroxysteroide
WO2005016278A2 (fr) 2003-08-12 2005-02-24 Advancis Pharmaceuticals Corporation Antibiotique, utilisation et formulation associees
DE102005062987A1 (de) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
BRPI0814758A2 (pt) * 2007-08-03 2015-03-03 Hoffmann La Roche Piridinacarboxamida e derivados de benzamida como ligantes taar1
BRPI0921097B8 (pt) * 2008-11-21 2021-05-25 Raqualia Pharma Inc composto ou seu sal farmaceuticamente aceitável, intermediário do composto, composição farmacêutica e uso do composto
US8716280B2 (en) * 2009-01-21 2014-05-06 Basilea Pharmaceutica Ag Bicyclic antibiotics
CN102753531B (zh) * 2009-12-15 2015-07-01 拜尔农作物科学股份公司 制备1-烷基-/1-芳基-5-吡唑羧酸衍生物的方法
PE20141050A1 (es) 2011-04-05 2014-08-30 Pfizer Ltd Inhibidores de quinasa relacionados con pirrolo (2,3-d) pirimidina tropomiosina
DE102013208484B4 (de) 2013-05-08 2018-04-26 Wirtgen Gmbh Vorrichtung zum Bearbeiten von Straßen- oder Bodenoberflächen, sowie Verfahren zum Lenken einer Straßenfräsmaschine
US12043601B2 (en) * 2018-08-22 2024-07-23 The Regents Of The University Of Colorado N-substituted-1H-1,2,4-triazole-3-carboxamides, analogues thereof, and methods of treatment using same
AR117169A1 (es) * 2018-11-28 2021-07-14 Bayer Ag (tio)amidas de piridazina como compuestos fungicidas
US20230192617A1 (en) * 2020-05-19 2023-06-22 Bayer Cropscience Aktiengesellschaft Azabicyclic(thio)amides as fungicidal compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
US4013644A (en) * 1976-03-15 1977-03-22 G. D. Searle & Co. [8 α(E), 13aβ]-5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-8-(2-phenylethenyl)-6H-dibenzo[a,g]quinolizines and intermediates thereto
US4444770A (en) * 1980-05-29 1984-04-24 Bayer Aktiengesellschaft New imidazoazole-alkenoic acid amide compounds, intermediate products for their production, their production, and their medicinal use
US4594199A (en) * 1983-09-19 1986-06-10 E. R. Squibb & Sons, Inc. Method for making phosphinic acid intermediates
EP0639075A1 (fr) * 1990-11-14 1995-02-22 Chiron Corporation Inhibition specifique de la dihydrofolate reductase et composes prevus a cet effet
CA2205406C (fr) * 1994-11-24 2008-02-05 F. Hoffmann-La Roche Ag Nouvelles benzylpyrimidines
EP0832069B1 (fr) * 1995-06-07 2003-03-05 Pfizer Inc. DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B)
EP1149834A1 (fr) * 1995-12-04 2001-10-31 F. Hoffmann-La Roche Ag Diaminopyrimidines, compositions pharmaceutiques les contenant et utilisation de celles-ci en tant qu' agents antibactériens

Also Published As

Publication number Publication date
ATE227282T1 (de) 2002-11-15
PL330277A1 (en) 1999-05-10
BR9709251A (pt) 1999-08-10
EP0901488B1 (fr) 2002-11-06
US5866583A (en) 1999-02-02
CA2254117C (fr) 2003-03-11
CA2254117A1 (fr) 1997-11-20
PE78898A1 (es) 1998-11-13
ZA973984B (en) 1997-11-17
IL126702A0 (en) 1999-08-17
CO4840509A1 (es) 1999-09-27
DK0901488T3 (da) 2003-03-03
DE69716901T2 (de) 2003-09-18
AU2894297A (en) 1997-12-05
CN1098260C (zh) 2003-01-08
PT901488E (pt) 2003-03-31
JPH11511749A (ja) 1999-10-12
NO985335D0 (no) 1998-11-16
CY2425B1 (en) 2004-11-12
EP0901488A1 (fr) 1999-03-17
CZ364698A3 (cs) 1999-02-17
HRP970260A2 (en) 1998-04-30
WO1997043277A1 (fr) 1997-11-20
AU726416B2 (en) 2000-11-09
DE69716901D1 (de) 2002-12-12
CN1218465A (zh) 1999-06-02
YU51498A (en) 1999-11-22
JP3098259B2 (ja) 2000-10-16
NO985335L (no) 1999-01-15
NZ332481A (en) 2000-04-28
ES2184089T3 (es) 2003-04-01
TW438796B (en) 2001-06-07
KR100295509B1 (ko) 2001-09-17
TR199802331T2 (xx) 1999-04-21
AR007088A1 (es) 1999-10-13
KR20000011053A (ko) 2000-02-25

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