MA24573A1 - Derives de l'acide barbiturique avec une activite anti-metastasique et anti-tumorale - Google Patents

Derives de l'acide barbiturique avec une activite anti-metastasique et anti-tumorale

Info

Publication number: MA24573A1
Authority: MA; Morocco
Prior art keywords: metastasic; acid derivatives; tumor activity; barbituric acid; barbituric
Prior art date: 1997-06-21

Application number

MA25126A

Other languages

English (en)

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-21

Filing date

1998-06-19

Publication date

1998-12-31

1998-06-19 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1998-12-31 Publication of MA24573A1 publication Critical patent/MA24573A1/fr

Links

230000000259 anti-tumor effect Effects 0.000 title 1
150000007656 barbituric acids Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

MA25126A 1997-06-21 1998-06-19 Derives de l'acide barbiturique avec une activite anti-metastasique et anti-tumorale MA24573A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97110200		1997-06-21

Publications (1)

Publication Number	Publication Date
MA24573A1 true MA24573A1 (fr)	1998-12-31

Family

ID=8226939

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA25126A MA24573A1 (fr)	1997-06-21	1998-06-19	Derives de l'acide barbiturique avec une activite anti-metastasique et anti-tumorale

Country Status (18)

Country	Link
US (1)	US6335332B1 (fr)
EP (1)	EP0989982B1 (fr)
JP (1)	JP2002504916A (fr)
KR (1)	KR20010014020A (fr)
CN (1)	CN1295227C (fr)
AR (1)	AR018997A1 (fr)
AT (1)	ATE302200T1 (fr)
AU (1)	AU746853B2 (fr)
BR (1)	BR9810450A (fr)
CA (1)	CA2294259A1 (fr)
CO (1)	CO4940451A1 (fr)
DE (1)	DE69831233T2 (fr)
ES (1)	ES2247707T3 (fr)
HR (1)	HRP980340A2 (fr)
MA (1)	MA24573A1 (fr)
TR (1)	TR199903148T2 (fr)
WO (1)	WO1998058925A1 (fr)
ZA (1)	ZA985352B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AUPO190596A0 (en)	1996-08-26	1996-09-19	Alchemia Pty Ltd	Oligosaccharide synthesis
AUPO937597A0 (en) *	1997-09-24	1997-10-16	Alchemia Pty Ltd	Protecting and linking groups for organic synthesis
US6265578B1 (en)	1999-02-12	2001-07-24	Hoffmann-La Roche Inc.	Pyrimidine-2,4,6-triones
PA8498701A1 (es) *	1999-08-12	2002-08-26	Pfizer Prod Inc	Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas
AU5723001A (en)	2000-04-24	2001-11-07	Aryx Therapeutics	Ultrashort acting hypnotic barbiturates
US6841671B2 (en)	2000-10-26	2005-01-11	Pfizer Inc.	Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
EP1332146A2 (fr) *	2000-10-26	2003-08-06	Pfizer Products Inc.	Inhibiteurs de metalloproteinase spiro-pyrimidine-2,4,6-trione
EE200300195A (et) *	2000-10-26	2003-10-15	Pfizer Products Inc.	Pürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid
SE0100902D0 (sv)	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
ATE344041T1 (de) *	2001-05-03	2006-11-15	Hoffmann La Roche	Kombination eines gelatinasehemmers und eines anti-tumor-agent, und deren verwendung
DE60302150D1 (en)	2002-04-26	2005-12-08	Pfizer Prod Inc	N-substituiete heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trion metalloproteinase inhibitoren
JP2005529889A (ja)	2002-04-26	2005-10-06	ファイザー・プロダクツ・インク	ピリミジン−２，４，６−トリオンメタロ−プロテイナーゼ阻害剤
ES2247527T3 (es)	2002-04-26	2006-03-01	Pfizer Prod Inc	Inhibidores de metaloproteinasa de triaril-oxi-aril-espiro-pirimidina-2,4,6-triona.
NI200300045A (es)	2002-04-26	2005-07-08	Pfizer Prod Inc	Inhibidores de triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa.
US20070225253A1 (en) *	2004-04-01	2007-09-27	Didier Cataldo	Use of a trioxopyrimidine for the treatment and prevention of bronchial inflammatory diseases
KR100837137B1 (ko) *	2004-04-01	2008-06-11	에프. 호프만-라 로슈 아게	기관지 염증성 질환의 치료 및 예방을 위한트리옥소피리미딘의 용도
NZ596889A (en)	2006-04-07	2013-06-28	Vertex Pharma	Use of amide indole derivatives as modulators of ATP-binding cassette transporters
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
KR100862969B1 (ko)	2007-03-05	2008-10-13	바이오스펙트럼 주식회사	바르비투르산을 유효성분으로 포함하는 피부 미백제
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
RU2745977C2 (ru)	2010-04-22	2021-04-05	Вертекс Фармасьютикалз Инкорпорейтед	Способ получения циклоалкилкарбоксамидо-индольных соединений
AU2013290444B2 (en)	2012-07-16	2018-04-26	Vertex Pharmaceuticals Incorporated	Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
WO2015123003A1 (fr)	2014-02-14	2015-08-20	Warrell Raymond P	Composés bifonctionnels et leur utilisation pour réduire les taux d'acide urique
SG10201913575VA (en)	2014-04-15	2020-02-27	Vertex Pharma	Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
WO2016118611A1 (fr)	2015-01-22	2016-07-28	Warrell Raymond P Jr	Composés bifonctionnels et leur utilisation pour la réduction des niveaux de l'acide urique
TWI771303B (zh)	2016-06-30	2022-07-21	美商艾克奎斯特有限責任公司	化合物及其於降低尿酸位準之用途(一)
TWI749024B (zh)	2016-07-06	2021-12-11	美商艾克奎斯特有限責任公司	化合物及其於降低尿酸位準之用途
LV15384B (lv)	2017-07-24	2019-05-20	Latvijas Organiskās Sintēzes Institūts	1-Acetil-5-nitro-4-fenil-3-pirolin-2-ons pielietošanai vēža ārstēšanā

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU643248B2 (en) *	1989-11-14	1993-11-11	Sloan-Kettering Institute For Cancer Research	Novel potent inducers of terminal differentiation and method of use thereof
EP0457213B1 (fr) *	1990-05-16	1997-07-23	Abbott Laboratories	Essai pour barbiturates, traceurs, immunogènes, anticorps et trousse
DE19548624A1 (de)	1995-12-23	1997-06-26	Boehringer Mannheim Gmbh	Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

1998
- 1998-06-18 ES ES98936361T patent/ES2247707T3/es not_active Expired - Lifetime
- 1998-06-18 TR TR1999/03148T patent/TR199903148T2/xx unknown
- 1998-06-18 CA CA002294259A patent/CA2294259A1/fr not_active Abandoned
- 1998-06-18 AU AU85391/98A patent/AU746853B2/en not_active Ceased
- 1998-06-18 JP JP50374899A patent/JP2002504916A/ja not_active Ceased
- 1998-06-18 KR KR19997012049A patent/KR20010014020A/ko not_active Ceased
- 1998-06-18 EP EP98936361A patent/EP0989982B1/fr not_active Expired - Lifetime
- 1998-06-18 WO PCT/EP1998/003677 patent/WO1998058925A1/fr not_active Ceased
- 1998-06-18 BR BR9810450-0A patent/BR9810450A/pt not_active IP Right Cessation
- 1998-06-18 AT AT98936361T patent/ATE302200T1/de not_active IP Right Cessation
- 1998-06-18 CN CNB988083558A patent/CN1295227C/zh not_active Expired - Fee Related
- 1998-06-18 DE DE69831233T patent/DE69831233T2/de not_active Expired - Fee Related
- 1998-06-18 US US09/445,461 patent/US6335332B1/en not_active Expired - Fee Related
- 1998-06-19 AR ARP980102928A patent/AR018997A1/es not_active Application Discontinuation
- 1998-06-19 ZA ZA9805352A patent/ZA985352B/xx unknown
- 1998-06-19 MA MA25126A patent/MA24573A1/fr unknown
- 1998-06-19 HR HR97110200.9A patent/HRP980340A2/hr not_active Application Discontinuation
- 1998-06-23 CO CO98035555A patent/CO4940451A1/es unknown

Also Published As

Publication number	Publication date
JP2002504916A (ja)	2002-02-12
AU746853B2 (en)	2002-05-02
TR199903148T2 (xx)	2000-04-21
CN1295227C (zh)	2007-01-17
CA2294259A1 (fr)	1998-12-30
WO1998058925A1 (fr)	1998-12-30
ZA985352B (en)	1999-12-20
HRP980340A2 (en)	1999-02-28
CO4940451A1 (es)	2000-07-24
BR9810450A (pt)	2000-09-05
AU8539198A (en)	1999-01-04
EP0989982B1 (fr)	2005-08-17
DE69831233D1 (de)	2005-09-22
EP0989982A1 (fr)	2000-04-05
US6335332B1 (en)	2002-01-01
CN1267296A (zh)	2000-09-20
DE69831233T2 (de)	2006-06-01
ATE302200T1 (de)	2005-09-15
KR20010014020A (ko)	2001-02-26
ES2247707T3 (es)	2006-03-01
AR018997A1 (es)	2001-12-26

Publication	Publication Date	Title
MA24573A1 (fr)	1998-12-31	Derives de l'acide barbiturique avec une activite anti-metastasique et anti-tumorale
MA26634A1 (fr)	2004-12-20	Nouveaux derives de l'acide 3-aryl propionique et analogues
MA24488A1 (fr)	1998-10-01	Derives d'acide hexanoique nouveaux .
MA24307A1 (fr)	1998-04-01	Derives d'acides d'arylsulfonylamino-hydroxamiques.
ATE237580T1 (de)	2003-05-15	5-alkyl-2-arylaminophenylessigsäure und derivative
ITMI940018A0 (it)	1994-01-11	Eterobicicli ad attivita' fungicida
FI963148L (fi)	1996-08-12	3'-substituoidut nukleosidijohdannaiset
FR2763953B1 (fr)	2005-01-07	Derives de 5'-desoxy-cytidine
MA26616A1 (fr)	2004-12-20	Derives de l'acide phenoxyacetique et du phenoxymethyltetrazole ayant une activite antitumorale
IT1291366B1 (it)	1999-01-07	Composizione farmaceutica antivirale comprendente acido glicirrizico ed almeno una proteina dotata di attivita' antivirale
TR199701051A3 (tr)	1999-03-22	2' -Fluoro-5-metil- -l-arabino-furanosilüridin hazirlanma prosesi
ITMI941469A0 (it)	1994-07-14	Proteine ad attivita' antitumorale
FR2543552B1 (fr)	1986-07-25	Derives de 3-isoxazolyl-2-imidazolidinone doues d'une activite herbicide
EP1011701A4 (fr)	2004-01-07	Extraits d'especes de sauge dotees d'une activite antivirale
FR2761577B1 (fr)	1999-05-14	Composition fongicide synergique a base de propacarbe et de derives de l'acide phosphoreux
EP1046648A4 (fr)	2002-09-11	Derives de 3'-desoxyribonucleotide
MA23843A1 (fr)	1996-12-31	Nouveaux derives de l'acide hydroximique
MA23133A1 (fr)	1994-10-01	Derives d'acide d'acyloxyhexanoique .
DE69608696D1 (de)	2000-07-06	N-sulfonyl-und n-sulfinylaminosäurederivate als mikrobiozide
IT1293525B1 (it)	1999-03-01	Bis-acridincarbossiammidi aventi attivita' antitumorale
KR960022267U (ko)	1996-07-20	후론트사이드멤버와 거셋트의 결합구조
BR9505557A (pt)	1997-11-04	Colpo hístero tracionador
KR950024133U (ko)	1995-09-13	트랙터용 쟁기
KR960017319U (ko)	1996-06-17	후론트사이드멤버와 라디에터서포트로워멤버의 결합구조
KR960031066U (ko)	1996-10-22	자동차용 인사이드 밀러의 체결구조