TR199903148T2 - Antimetastatik ve antit�m�r etkinli�i olan barbit�rik asit t�revleri. - Google Patents

Antimetastatik ve antit�m�r etkinli�i olan barbit�rik asit t�revleri.

Info

Publication number: TR199903148T2
Authority: TR; Turkey
Prior art keywords: acid derivatives; antimetastatic; barbituric acid; antitumor activity; antitumor
Prior art date: 1997-06-21

Application number

TR1999/03148T

Other languages

English (en)

Turkish (tr)

Inventor

Oliva Ambrogio

De Cillis Gianpiero

Grams Frank

Livi Valeria

Zimmermann Gerd

Menta Ernesto

Krell Hans-Willi

Original Assignee

Roche Diagnostics Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-21

Filing date

1998-06-18

Publication date

2000-04-21

1998-06-18 Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh

2000-04-21 Publication of TR199903148T2 publication Critical patent/TR199903148T2/xx

Links

230000000259 anti-tumor effect Effects 0.000 title abstract 2
150000007656 barbituric acids Chemical class 0.000 title abstract 2
230000002001 anti-metastasis Effects 0.000 title 1
239000002257 antimetastatic agent Substances 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Diabetes (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

TR1999/03148T 1997-06-21 1998-06-18 Antimetastatik ve antit�m�r etkinli�i olan barbit�rik asit t�revleri. TR199903148T2 (xx)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97110200		1997-06-21

Publications (1)

Publication Number	Publication Date
TR199903148T2 true TR199903148T2 (xx)	2000-04-21

Family

ID=8226939

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR1999/03148T TR199903148T2 (xx)	1997-06-21	1998-06-18	Antimetastatik ve antit�m�r etkinli�i olan barbit�rik asit t�revleri.

Country Status (18)

Country	Link
US (1)	US6335332B1 (fr)
EP (1)	EP0989982B1 (fr)
JP (1)	JP2002504916A (fr)
KR (1)	KR20010014020A (fr)
CN (1)	CN1295227C (fr)
AR (1)	AR018997A1 (fr)
AT (1)	ATE302200T1 (fr)
AU (1)	AU746853B2 (fr)
BR (1)	BR9810450A (fr)
CA (1)	CA2294259A1 (fr)
CO (1)	CO4940451A1 (fr)
DE (1)	DE69831233T2 (fr)
ES (1)	ES2247707T3 (fr)
HR (1)	HRP980340A2 (fr)
MA (1)	MA24573A1 (fr)
TR (1)	TR199903148T2 (fr)
WO (1)	WO1998058925A1 (fr)
ZA (1)	ZA985352B (fr)

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AUPO190596A0 (en)	1996-08-26	1996-09-19	Alchemia Pty Ltd	Oligosaccharide synthesis
AUPO937597A0 (en) *	1997-09-24	1997-10-16	Alchemia Pty Ltd	Protecting and linking groups for organic synthesis
US6265578B1 (en) *	1999-02-12	2001-07-24	Hoffmann-La Roche Inc.	Pyrimidine-2,4,6-triones
HN2000000137A (es) *	1999-08-12	2001-02-02	Pfizer Prod Inc	Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas
AU2001257230B2 (en) *	2000-04-24	2006-09-14	Aryx Therapeutics	Ultrashort acting hypnotic barbiturates
HUP0302337A3 (en)	2000-10-26	2004-01-28	Pfizer Prod Inc	Pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use
CN1501937A (zh) *	2000-10-26	2004-06-02	�Ʒ�	螺-嘧啶-2,4,6-三酮金属蛋白酶抑制剂
US6841671B2 (en)	2000-10-26	2005-01-11	Pfizer Inc.	Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
SE0100902D0 (sv)	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
ES2274043T3 (es) *	2001-05-03	2007-05-16	F. Hoffmann-La Roche Ag	Combinacion de un inhibidor de gelatina con un agente antitumoral y usos de la misma.
WO2003091258A1 (fr)	2002-04-26	2003-11-06	Pfizer Products Inc.	Inhibiteurs de la metalloproteinase n-substitues-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione
EP1501834B1 (fr)	2002-04-26	2005-09-07	Pfizer Products Inc.	Inhibiteurs de la triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase
WO2003090751A1 (fr)	2002-04-26	2003-11-06	Pfizer Products Inc.	Inhibiteurs de metalloproteinase a base de pyrimidine-2, 4, 6-trione
NI200300045A (es)	2002-04-26	2005-07-08	Pfizer Prod Inc	Inhibidores de triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa.
KR100837137B1 (ko) *	2004-04-01	2008-06-11	에프. 호프만-라 로슈 아게	기관지 염증성 질환의 치료 및 예방을 위한트리옥소피리미딘의 용도
AU2005230379B2 (en) *	2004-04-01	2010-07-22	Universite De Liege	Use of a trioxopyrimidine for the treatment and prevention of bronchial inflammatory diseases
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
EP2674428B1 (fr)	2006-04-07	2016-04-06	Vertex Pharmaceuticals Incorporated	Modulateurs des transporteurs de cassettes de liaison de l'ATP
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
KR100862969B1 (ko)	2007-03-05	2008-10-13	바이오스펙트럼 주식회사	바르비투르산을 유효성분으로 포함하는 피부 미백제
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
MX353408B (es) *	2010-04-22	2018-01-11	Vertex Pharma	Proceso para producir compuestos de cicloalquilcarboxamido-indol.
AR092857A1 (es)	2012-07-16	2015-05-06	Vertex Pharma	Composiciones farmaceuticas de (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropancarboxamida y administracion de las mismas
US10093631B2 (en)	2014-02-14	2018-10-09	Acquist Llc	Bifunctional compounds and use for reducing uric acid levels
RU2744460C2 (ru)	2014-04-15	2021-03-09	Вертекс Фармасьютикалз Инкорпорейтед	Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости
JP2018502896A (ja)	2015-01-22	2018-02-01	ピー．，ジュニアワーレル，レイモンド	二機能性化合物および尿酸レベルを低下させるための使用
TWI772309B (zh)	2016-06-30	2022-08-01	美商艾克奎斯特有限責任公司	化合物及其於降低尿酸位準之用途(二)
ES2925186T3 (es)	2016-07-06	2022-10-14	Acquist Llc	Compuestos y su uso para reducir los niveles de ácido úrico
LV15384B (lv)	2017-07-24	2019-05-20	Latvijas Organiskās Sintēzes Institūts	1-Acetil-5-nitro-4-fenil-3-pirolin-2-ons pielietošanai vēža ārstēšanā

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69032871T2 (de) *	1989-11-14	1999-09-09	Sloan-Kettering Institute For Cancer Research	Neue potente induktoren terminaler differenzierung und verfahren zu ihrer verwendung
DE69126915T2 (de)	1990-05-16	1998-02-19	Abbott Lab	Test für Barbiturate, Tracer, Immunogene, Antikörper und Testsatz dafür
DE19548624A1 (de)	1995-12-23	1997-06-26	Boehringer Mannheim Gmbh	Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

1998
- 1998-06-18 TR TR1999/03148T patent/TR199903148T2/xx unknown
- 1998-06-18 WO PCT/EP1998/003677 patent/WO1998058925A1/fr not_active Ceased
- 1998-06-18 AT AT98936361T patent/ATE302200T1/de not_active IP Right Cessation
- 1998-06-18 US US09/445,461 patent/US6335332B1/en not_active Expired - Fee Related
- 1998-06-18 DE DE69831233T patent/DE69831233T2/de not_active Expired - Fee Related
- 1998-06-18 ES ES98936361T patent/ES2247707T3/es not_active Expired - Lifetime
- 1998-06-18 EP EP98936361A patent/EP0989982B1/fr not_active Expired - Lifetime
- 1998-06-18 CN CNB988083558A patent/CN1295227C/zh not_active Expired - Fee Related
- 1998-06-18 KR KR19997012049A patent/KR20010014020A/ko not_active Ceased
- 1998-06-18 BR BR9810450-0A patent/BR9810450A/pt not_active IP Right Cessation
- 1998-06-18 JP JP50374899A patent/JP2002504916A/ja not_active Ceased
- 1998-06-18 CA CA002294259A patent/CA2294259A1/fr not_active Abandoned
- 1998-06-18 AU AU85391/98A patent/AU746853B2/en not_active Ceased
- 1998-06-19 MA MA25126A patent/MA24573A1/fr unknown
- 1998-06-19 ZA ZA9805352A patent/ZA985352B/xx unknown
- 1998-06-19 HR HR97110200.9A patent/HRP980340A2/hr not_active Application Discontinuation
- 1998-06-19 AR ARP980102928A patent/AR018997A1/es not_active Application Discontinuation
- 1998-06-23 CO CO98035555A patent/CO4940451A1/es unknown

Also Published As

Publication number	Publication date
HRP980340A2 (en)	1999-02-28
AR018997A1 (es)	2001-12-26
CN1267296A (zh)	2000-09-20
EP0989982A1 (fr)	2000-04-05
DE69831233T2 (de)	2006-06-01
ATE302200T1 (de)	2005-09-15
AU8539198A (en)	1999-01-04
CA2294259A1 (fr)	1998-12-30
KR20010014020A (ko)	2001-02-26
US6335332B1 (en)	2002-01-01
WO1998058925A1 (fr)	1998-12-30
JP2002504916A (ja)	2002-02-12
MA24573A1 (fr)	1998-12-31
BR9810450A (pt)	2000-09-05
ZA985352B (en)	1999-12-20
DE69831233D1 (de)	2005-09-22
CN1295227C (zh)	2007-01-17
AU746853B2 (en)	2002-05-02
ES2247707T3 (es)	2006-03-01
EP0989982B1 (fr)	2005-08-17
CO4940451A1 (es)	2000-07-24

Publication	Publication Date	Title
TR199903148T2 (xx)	2000-04-21	Antimetastatik ve antit�m�r etkinli�i olan barbit�rik asit t�revleri.
ATE248175T1 (de)	2003-09-15	Epothilonderivate und ihre verwendung als antitumormittel
EE200000033A (et)	2000-10-16	Uudsed tetrasoolderivaadid
EE04189B1 (et)	2003-12-15	Asendatud 6-fenüülfenantridiinid
DK1140993T3 (da)	2003-10-06	Glycopeptidderivater og farmaceutiske præparater indeholdende dem
TR199802282T2 (xx)	1999-03-22	Karbolin t�revleri.
TR200002445T2 (tr)	2000-12-21	Fosfolipaz inhibitörleri.
BR0007527A (pt)	2001-12-04	Fenilfenantridinas com atividade inibitória depde-iv
TR200103186T2 (tr)	2002-04-22	MEK enzimlerinin inhibitörleri olarak kinolin türevleri
ATE375334T1 (de)	2007-10-15	Harnstoff derivate als entzündungshemmende mittel
TR199900636T2 (xx)	1999-10-21	Anti-t�m�r ajanlar� olarak ikameli/katk�l� heterosayk�llar.
DK1042319T3 (da)	2004-06-01	Dihydrobenzofuraner
DE59909760D1 (de)	2004-07-22	Benzonaphthyridin-n-oxide mit pde3 und pde4 inhibierender aktivität
TR199902257T2 (xx)	1999-12-21	Tetrahidropirido bile�ikleri
TR200201128T2 (tr)	2002-08-21	PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
AP2000001761A0 (en)	2000-03-31	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
TR200000637T2 (tr)	2000-07-21	Benzoksazin ve benzotiazin türevleri ve bunların ilaçlarda kullanımı.
DE60036558D1 (de)	2007-11-08	Phthalazinon-derivate als pde 4 hemmer
TR199901380A2 (xx)	2001-01-22	Di-ya da triazo-spiro$4,5] dekan t�revleri
TR200000444T2 (tr)	2000-07-21	3-Aril-süksinamido-hidroksamik asitler, üretim yöntemleri ve bu maddeleri içeren farmasötik terkipler.
PT1244614E (pt)	2004-10-29	Inibidores de triptase
DK1144423T3 (da)	2004-03-01	Bis-terpyridin-platin(II)-komplekser
ATE243698T1 (de)	2003-07-15	1,2-dihydro-1-oxo-pyrazino(1,2-)indolederivate
ATE148105T1 (de)	1997-02-15	Succinoylaminohydroxyäthylaminosulfamidsäureder vate und ihre verwendung als retrovirale proteasehemmer
BR9808210A (pt)	2000-05-16	Befeniloxazolinas dissubstituìdas