ATE266013T1 - 1-phenyl-4-benzylpiperazine: spezifische liganden für den dopamin rezeptor (d4) - Google Patents

1-phenyl-4-benzylpiperazine: spezifische liganden für den dopamin rezeptor (d4)

Info

Publication number: ATE266013T1
Authority: AT; Austria
Prior art keywords: sub; phenyl; benzylpiperazine; dopamine receptor; specific ligands
Prior art date: 1997-01-30

Application number

AT98903796T

Other languages

English (en)

Inventor

Andrew Thurkauf

Xi Chen

Original Assignee

Neurogen Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-30

Filing date

1998-01-29

Publication date

2004-05-15

1998-01-29 Application filed by Neurogen Corp filed Critical Neurogen Corp

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE266013T1 publication Critical patent/ATE266013T1/de

Links

VEJWDLHOLWGRLH-UHFFFAOYSA-N 1-benzyl-4-phenylpiperazine Chemical compound C=1C=CC=CC=1CN(CC1)CCN1C1=CC=CC=C1 VEJWDLHOLWGRLH-UHFFFAOYSA-N 0.000 title 1
102000015554 Dopamine receptor Human genes 0.000 title 1
108050004812 Dopamine receptor Proteins 0.000 title 1
239000003446 ligand Substances 0.000 title 1
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
206010026749 Mania Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
-1 hydroxy, amino Chemical group 0.000 abstract 1
208000024714 major depressive disease Diseases 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/08—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing three- or four-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Hydrogenated Pyridines (AREA)

AT98903796T 1997-01-30 1998-01-29 1-phenyl-4-benzylpiperazine: spezifische liganden für den dopamin rezeptor (d4) ATE266013T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/791,673 US5859246A (en)	1997-01-30	1997-01-30	1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
PCT/US1998/001628 WO1998033784A1 (en)	1997-01-30	1998-01-29	1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands (d4)

Publications (1)

Publication Number	Publication Date
ATE266013T1 true ATE266013T1 (de)	2004-05-15

Family

ID=25154442

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98903796T ATE266013T1 (de)	1997-01-30	1998-01-29	1-phenyl-4-benzylpiperazine: spezifische liganden für den dopamin rezeptor (d4)

Country Status (14)

Country	Link
US (6)	US5859246A (de)
EP (1)	EP0960106B1 (de)
JP (1)	JP2001521492A (de)
KR (1)	KR100588391B1 (de)
CN (1)	CN1083448C (de)
AT (1)	ATE266013T1 (de)
AU (1)	AU6047298A (de)
CA (1)	CA2279620C (de)
DE (1)	DE69823648T2 (de)
ES (1)	ES2216266T3 (de)
HU (1)	HUP0001309A3 (de)
IL (1)	IL131172A (de)
NZ (1)	NZ336953A (de)
WO (1)	WO1998033784A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5859246A (en) *	1997-01-30	1999-01-12	Neurogen Corporation	1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
US6040448A (en)	1997-10-24	2000-03-21	Neurogen Corporation	Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
DE69829989T2 (de) *	1997-10-24	2006-02-23	Neurogen Corp., Branford	1-(2-naphthyl) und 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazine als dopamin d4 subtype liganden
US6177566B1 (en)	1998-06-30	2001-01-23	Neurogen Corporation	6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands
CA2336089A1 (en) *	1998-06-30	2000-01-06	Neurogen Corporation	6-(4-arylalkylpiperazin-1-yl)benzodioxane and 6-(4-arylalkylpiperazin-1-yl)chromane derivatives: dopamine receptor subtype specific ligands
US6284761B1 (en)	1999-01-08	2001-09-04	Neurogen Corporation	1-phenyl-4-(1-[2-aryl]cyclopropyl)methylpiperazines: dopamine receptor ligands
NZ512772A (en) *	1999-01-08	2003-11-28	Neurogen Corp	1-Phenyl-4-(1-[2-aryl]cyclopropyl) methylpiperazines useful as dopamine receptor ligands
US6569861B2 (en)	2000-07-06	2003-05-27	Neurogen Corporation	Melanin concentrating hormone receptor ligands
KR100394083B1 (ko) *	2000-12-04	2003-08-06	학교법인 성신학원	도파민 ｄ3 및 ｄ4 수용체의 선택적 활성을 지닌 신규4,5-디히드로이소옥사졸릴알킬피페라진 유도체와, 이의제조방법
WO2002069973A1 (en) *	2001-03-02	2002-09-12	Sepracor, Inc.	Piperidine-piperazine ligand for neurotransmitter receptors
IL158941A0 (en) *	2001-05-22	2004-05-12	Neurogen Corp	Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
US7183410B2 (en)	2001-08-02	2007-02-27	Bidachem S.P.A.	Stable polymorph of flibanserin
UA78974C2 (en)	2001-10-20	2007-05-10	Boehringer Ingelheim Pharma	Use of flibanserin for treating disorders of sexual desire
US10675280B2 (en)	2001-10-20	2020-06-09	Sprout Pharmaceuticals, Inc.	Treating sexual desire disorders with flibanserin
WO2005110989A1 (en) *	2004-04-07	2005-11-24	Neurogen Corporation	Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
WO2005110982A2 (en) *	2004-04-07	2005-11-24	Neurogen Corporation	Substituted 1-benzyl-4-substituted piperazine analogues
TW200609219A (en) *	2004-06-17	2006-03-16	Neurogen Corp	Aryl-substituted piperazine derivatives
DE102005061657A1 (de) *	2005-06-16	2006-12-28	Merck Patent Gmbh	Verwendung von substituierten Piperazin- und Morpholinderivaten
ES2646326T3 (es)	2005-08-03	2017-12-13	Sprout Pharmaceuticals, Inc.	Uso de flibanserina en el tratamiento de la obesidad
WO2007048803A1 (en)	2005-10-29	2007-05-03	Boehringer Ingelheim International Gmbh	Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
WO2008000760A1 (en)	2006-06-30	2008-01-03	Boehringer Ingelheim International Gmbh	Flibanserin for the treatment of urinary incontinence and related diseases
BRPI0716439B8 (pt)	2006-08-14	2021-05-25	Boehringer Ingelheim Int	sistemas de liberação farmacêutico compreendendo flibanserina, processo para preparação e uso dos mesmos
CL2007002214A1 (es)	2006-08-14	2008-03-07	Boehringer Ingelheim Int	Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp
BRPI0716436B8 (pt)	2006-08-25	2021-05-25	Boehringer Ingelheim Int	sistema de liberação controlada e método para fabricação do mesmo
CN101835750B (zh)	2007-08-22	2013-07-17	阿斯利康(瑞典)有限公司	环丙基酰胺衍生物
CL2008002693A1 (es)	2007-09-12	2009-10-16	Boehringer Ingelheim Int	Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad
EP2149373A1 (de) *	2008-08-01	2010-02-03	Laboratorios Del. Dr. Esteve, S.A.	5HT7-Rezeptorliganden und Zusammensetzungen damit
JP2012501344A (ja) *	2008-08-29	2012-01-19	トレヴェンティスコーポレイション	アミロイド症を治療する組成物及び方法
TW201039825A (en)	2009-02-20	2010-11-16	Astrazeneca Ab	Cyclopropyl amide derivatives 983
US20110201623A1 (en)	2010-02-18	2011-08-18	Uczynski Michael A	Crystalline Form Of A Cyclopropyl Benzamide Derivative

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2830056A (en) *		1958-04-08		Chj oh
NL127996C (de) *	1963-11-19
US3845058A (en) *	1970-07-20	1974-10-29	R Viterbo	N-(3,4-dihydro naphthyl)-n'phenyl piperazines
OA06083A (fr) *	1977-11-09	1981-06-30	Science Union & Cie Ste Franca	Nouvelles pipérazines disubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant.
CH643549A5 (de) *	1979-08-25	1984-06-15	Merz & Co	N-(trimethoxybenzyl)-n'-phenylpiperazine.
FR2573075B1 (fr) *	1984-09-14	1987-03-20	Innothera Lab Sa	Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique
JP2664238B2 (ja) *	1989-03-01	1997-10-15	日清製粉株式会社	ニコチン酸またはそのエステル誘導体
JPH0686438B2 (ja) *	1989-03-27	1994-11-02	三菱化成株式会社	アミノベンゼンスルホン酸誘導体
NZ240863A (en) *	1991-09-11	1995-04-27	Mcneilab Inc	Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
US5332743A (en) *	1992-06-12	1994-07-26	Mcneilab, Inc.	Benzyl and benzhydryl alcohols
US5314885A (en) *	1992-09-11	1994-05-24	Mcneilab, Inc.	Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents
US5607946A (en) *	1993-03-05	1997-03-04	Merck Sharp & Dohme Ltd.	Quinolone derivatives as dopamine D4 ligands
US5681954A (en) *	1993-05-14	1997-10-28	Daiichi Pharmaceutical Co., Ltd.	Piperazine derivatives
RU2124511C1 (ru) *	1993-05-14	1999-01-10	Фармасьютикал Ко., Лтд	Производные пиперазина
US6048876A (en) *	1995-01-23	2000-04-11	Suntory Limited	Medicament for the alleviation or treatment of symptom derived from ischemic disease and compound useful therefor
HU211523A9 (hu)	1995-06-22	1995-11-28	Pfizer	Neuroleptikus hatású aril-piperazinil-etil-(vagy butil)- alkilén heterociklusos vegyűletek Az átmeneti oltalom az 1-8. igénypontra vonatkozik.
AU2446297A (en) *	1996-04-30	1997-11-19	Warner-Lambert Company	Substituted piperazines and piperidines as central nervous system agents
HUP9601331A3 (en) *	1996-05-17	2000-06-28	Egyt Gyogyszervegyeszeti Gyar	Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them
US5859246A (en) *	1997-01-30	1999-01-12	Neurogen Corporation	1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands

1997
- 1997-01-30 US US08/791,673 patent/US5859246A/en not_active Expired - Fee Related
1998
- 1998-01-29 CN CN98803364A patent/CN1083448C/zh not_active Expired - Fee Related
- 1998-01-29 CA CA002279620A patent/CA2279620C/en not_active Expired - Fee Related
- 1998-01-29 AU AU60472/98A patent/AU6047298A/en not_active Abandoned
- 1998-01-29 JP JP53303098A patent/JP2001521492A/ja not_active Ceased
- 1998-01-29 NZ NZ336953A patent/NZ336953A/en unknown
- 1998-01-29 WO PCT/US1998/001628 patent/WO1998033784A1/en not_active Ceased
- 1998-01-29 EP EP98903796A patent/EP0960106B1/de not_active Expired - Lifetime
- 1998-01-29 IL IL13117298A patent/IL131172A/xx not_active IP Right Cessation
- 1998-01-29 AT AT98903796T patent/ATE266013T1/de not_active IP Right Cessation
- 1998-01-29 KR KR1019997006894A patent/KR100588391B1/ko not_active Expired - Fee Related
- 1998-01-29 HU HU0001309A patent/HUP0001309A3/hu unknown
- 1998-01-29 ES ES98903796T patent/ES2216266T3/es not_active Expired - Lifetime
- 1998-01-29 DE DE69823648T patent/DE69823648T2/de not_active Expired - Fee Related
1999
- 1999-01-11 US US09/228,106 patent/US6172229B1/en not_active Expired - Fee Related
2000
- 2000-12-13 US US09/736,566 patent/US6426347B2/en not_active Expired - Fee Related
2002
- 2002-06-28 US US10/186,235 patent/US6656943B2/en not_active Expired - Fee Related
2003
- 2003-09-22 US US10/667,821 patent/US20040083447A1/en not_active Abandoned
2005
- 2005-06-27 US US11/167,735 patent/US7101887B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL131172A (en)	2005-09-25
US5859246A (en)	1999-01-12
HUP0001309A3 (en)	2000-12-28
DE69823648T2 (de)	2005-04-28
EP0960106A1 (de)	1999-12-01
CA2279620C (en)	2008-07-15
US20050239799A1 (en)	2005-10-27
KR20000070645A (ko)	2000-11-25
CN1083448C (zh)	2002-04-24
US20020007064A1 (en)	2002-01-17
CN1250444A (zh)	2000-04-12
ES2216266T3 (es)	2004-10-16
US20040083447A1 (en)	2004-04-29
WO1998033784A1 (en)	1998-08-06
KR100588391B1 (ko)	2006-06-13
JP2001521492A (ja)	2001-11-06
US6656943B2 (en)	2003-12-02
US6172229B1 (en)	2001-01-09
NZ336953A (en)	2001-04-27
EP0960106B1 (de)	2004-05-06
DE69823648D1 (de)	2004-06-09
HUP0001309A2 (hu)	2000-10-28
CA2279620A1 (en)	1998-08-06
US20030119851A1 (en)	2003-06-26
AU6047298A (en)	1998-08-25
US7101887B2 (en)	2006-09-05
US6426347B2 (en)	2002-07-30
IL131172A0 (en)	2001-01-28

Legal Events

Date	Code	Title	Description
2004-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69823648D1 (de)	2004-06-09	1-phenyl-4-benzylpiperazine: spezifische liganden für den dopamin rezeptor (d4)
BE2018C008I2 (de)	2021-02-04
HUP9802937A2 (hu)	1999-10-28	Benzo[g]kinolin-származékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk
CO5271691A1 (es)	2003-04-30	Nuevos compuestos
AP2000001803A0 (en)	2000-06-30	Chemical compounds
DE60102815D1 (de)	2004-05-19	7-substituierte kondensierte ring-tetrazyclin- verbindungen
DE69505542D1 (de)	1998-11-26	3-benzoylbenzofuran-derivate als thyroidhormonantagonisten
PT1159279E (pt)	2003-02-28	4-oxo-4,7-di-hidrotieno¬2,3-b\|piridino-5-carboxamidas como agentes antivirais
AU7517400A (en)	2001-04-24	N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
PT918776E (pt)	2004-07-30	Sintese total de acilfulvenos antitumorais
WO2001014330A3 (en)	2001-08-02	Phenylpiperazines as serotonin reuptake inhibitors
HRP20000406B1 (en)	2006-05-31	Arylpiperazines having activity at the serotonin 1a receptor
AU1367497A (en)	1997-08-01	Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of prostatic carcinoma
AU3853697A (en)	1998-02-10	N-benzenesulphonyl-l-proline derivatives as bradykinin b2 agonists
MX9600816A (es)	1997-02-28	Nuevos derivados triciclicos, su preparacion, su aplicacion a la preparacion de la colquicina y de la tiocolquicina, opticamente activas o racemicas, y de compuestos analogos o derivados e intermedios.
MX9804828A (es)	1998-09-30	Benzotiazolona etanaminas biologicamente activas.
MXPA04005077A (es)	2004-08-19	Derivados de benzotiazol.
MA27137A1 (fr)	2005-01-03	Derives substitues d'alkylaminopyridazinone, procedes de preparation et composition pharmaceutique les contenant
SE9704770D0 (sv)	1997-12-19	New use
ATE238300T1 (de)	2003-05-15	(3,4-dihydro-2h-benzo(1,4)oxazinyl-methyl)-3-(1 - indol-3-yl)-alkylamine
HUP9801951A2 (hu)	2000-02-28	Új diszubsztituált transz-3,4,4,4a,5,6,10b-hexahidro-2H-naft-[1,2-b] [1,4]-oxazin-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények
MY133207A (en)	2007-10-31	Substituted benzolactam compaunds
PT923576E (pt)	2003-02-28	Derivados de 4-amino-etoxi-indolona como agonistas de dopamina d2
MXPA04000139A (es)	2004-06-03	Uso de compuestos biciclo para tratar enfermedad de alzheimer.
EA200001157A2 (ru)	2001-06-25	Новые замещенные производные (дигидро)бензоксазина и (дигидро)бензотиазина, способ их получения и содержащие их фармацевтические композиции