MA25563A1 - Pyridines et pyridazines substitues avec une activite inhibitrice angiogenese. - Google Patents

Pyridines et pyridazines substitues avec une activite inhibitrice angiogenese.

Info

Publication number: MA25563A1
Authority: MA; Morocco
Prior art keywords: angiogenically; pyridines; inhibiting activity; substituted pyridazines; pyridazines
Prior art date: 1999-09-28

Application number

MA26619A

Other languages

English (en)

Inventor

Lee Wendy

Nagarathnam Dhanapalan

Su Ning

P Dumas Jacques

A Dixon Julie

Kite Joe Teddy

C E Kluender Harold

N Sibley Robert

J Boyer Stephen

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2002-04-26

Publication date

2002-10-01

2002-04-26 Application filed by Bayer Ag filed Critical Bayer Ag

2002-10-01 Publication of MA25563A1 publication Critical patent/MA25563A1/fr

Links

RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
150000004892 pyridazines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Rheumatology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

MA26619A 1999-09-28 2002-04-26 Pyridines et pyridazines substitues avec une activite inhibitrice angiogenese. MA25563A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US40760099A	1999-09-28	1999-09-28

Publications (1)

Publication Number	Publication Date
MA25563A1 true MA25563A1 (fr)	2002-10-01

Family

ID=23612752

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA26619A MA25563A1 (fr)	1999-09-28	2002-04-26	Pyridines et pyridazines substitues avec une activite inhibitrice angiogenese.

Country Status (35)

Country	Link
EP (1)	EP1228063B1 (fr)
JP (1)	JP4919567B2 (fr)
KR (3)	KR100890473B1 (fr)
CN (3)	CN100374435C (fr)
AR (3)	AR025752A1 (fr)
AT (1)	ATE422494T1 (fr)
AU (1)	AU782820B2 (fr)
BG (1)	BG65860B1 (fr)
BR (1)	BRPI0014382B8 (fr)
CA (1)	CA2385817C (fr)
CO (1)	CO5200835A1 (fr)
CZ (1)	CZ304767B6 (fr)
DE (1)	DE60041548D1 (fr)
DO (1)	DOP2000000070A (fr)
EE (1)	EE05258B1 (fr)
ES (1)	ES2320525T3 (fr)
GT (1)	GT200000158A (fr)
HR (1)	HRP20020308A2 (fr)
HU (1)	HU230223B1 (fr)
IL (3)	IL148880A0 (fr)
MA (1)	MA25563A1 (fr)
MX (1)	MXPA02003156A (fr)
MY (3)	MY143580A (fr)
NO (1)	NO20021520L (fr)
NZ (1)	NZ518589A (fr)
PA (1)	PA8503201A1 (fr)
PE (1)	PE20010607A1 (fr)
PL (1)	PL205957B1 (fr)
RS (1)	RS50369B (fr)
RU (1)	RU2260008C2 (fr)
SK (1)	SK287417B6 (fr)
TW (1)	TW593315B (fr)
UA (1)	UA75053C2 (fr)
WO (1)	WO2001023375A2 (fr)
ZA (1)	ZA200202760B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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US20030207878A1 (en) *	2000-08-09	2003-11-06	Hennequin Lawrent Francois Andre	Chemical compounds
KR100600550B1 (ko)	2000-10-20	2006-07-13	에자이 가부시키가이샤	질소 함유 방향환 유도체
CA2471314A1 (fr) *	2001-12-21	2003-07-24	Bayer Pharmaceuticals Corporation	Polytherapies antiangiogeneses a base de derives de pyridazine ou pyridine
TWI299664B (en)	2003-01-06	2008-08-11	Osi Pharm Inc	(2-carboxamido)(3-amino)thiophene compounds
KR20050108383A (ko) *	2003-03-11	2005-11-16	노파르티스 아게	이소퀴놀린 유도체의 암 및 ｍａｐ 키나제 관련 질병의치료를 위한 용도
EP1616576A4 (fr) *	2003-04-08	2010-02-10	Mitsubishi Tanabe Pharma Corp	Inhibiteur d'oxydase nad(p)h specifique
JP4303726B2 (ja)	2003-11-11	2009-07-29	エーザイ・アール・アンド・ディー・マネジメント株式会社	ウレア誘導体およびその製造方法
KR100553398B1 (ko) *	2004-03-12	2006-02-16	한미약품 주식회사	티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
WO2006030941A1 (fr)	2004-09-13	2006-03-23	Eisai R & D Management Co., Ltd.	Utilisation concomitante d'un compose contenant du sulfonamide et d'un inhibiteur d'angiogenese
US8772269B2 (en)	2004-09-13	2014-07-08	Eisai R&D Management Co., Ltd.	Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
US8969379B2 (en)	2004-09-17	2015-03-03	Eisai R&D Management Co., Ltd.	Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
JP4989476B2 (ja)	2005-08-02	2012-08-01	エーザイ・アール・アンド・ディー・マネジメント株式会社	血管新生阻害物質の効果を検定する方法
CA2648957A1 (fr) *	2006-04-15	2007-10-25	Bayer Healthcare Ag	Composes pour traiter une hypertension pulmonaire
CN104706637A (zh)	2006-05-18	2015-06-17	卫材R&D管理有限公司	针对甲状腺癌的抗肿瘤剂
JP5368096B2 (ja)	2006-08-28	2013-12-18	エーザイ・アール・アンド・ディー・マネジメント株式会社	未分化型胃癌に対する抗腫瘍剤
WO2008093855A1 (fr)	2007-01-29	2008-08-07	Eisai R & D Management Co., Ltd.	Composition destinée au traitement d'un cancer de l'estomac de type indifférencié
CA2704000C (fr)	2007-11-09	2016-12-13	Eisai R&D Management Co., Ltd.	Combinaison d'une substance antiangiogenique et d'un complexe de platine antitumoral
CN101481380B (zh) *	2008-01-08	2012-10-17	浙江医药股份有限公司新昌制药厂	噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
CA2771403C (fr)	2009-08-19	2015-02-24	Eisai R&D Management Co. Ltd.	Composition pharmaceutique contenant un derive de quinoleine
CN102958523B (zh)	2010-06-25	2014-11-19	卫材R&D管理有限公司	使用具有激酶抑制作用的组合的抗肿瘤剂
AU2012246490B2 (en)	2011-04-18	2016-08-04	Eisai R&D Management Co., Ltd.	Therapeutic agent for tumor
JP6038128B2 (ja)	2011-06-03	2016-12-07	エーザイ・アール・アンド・ディー・マネジメント株式会社	レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
JPWO2014098176A1 (ja)	2012-12-21	2017-01-12	エーザイ・アール・アンド・ディー・マネジメント株式会社	キノリン誘導体のアモルファス及びその製造方法
CA2912219C (fr)	2013-05-14	2021-11-16	Eisai R&D Management Co., Ltd.	Biomarqueurs pour predire et evaluer la reponse de sujets atteints de cancer de l'endometre a des composes a base de lenvatinib
CN103396361B (zh) *	2013-07-24	2016-05-04	中国人民解放军第二军医大学	3,4-二氢异喹啉类抗肿瘤化合物及其制备方法与应用
EP3187491A4 (fr)	2014-08-28	2018-08-01	Eisai R&D Management Co., Ltd.	Dérivé de quinoline de pureté élevée et son procédé de fabrication
US20180028662A1 (en)	2015-02-25	2018-02-01	Eisai R&D Management Co., Ltd.	Method for Suppressing Bitterness of Quinoline Derivative
KR20240064733A (ko)	2015-03-04	2024-05-13	머크 샤프 앤드 돔 코포레이션	암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN104804008B (zh) *	2015-03-27	2016-03-23	亿腾药业（泰州）有限公司	一种工业化生产甲磺酸特拉替尼的方法
CA2988707C (fr)	2015-06-16	2023-10-10	Eisai R&D Management Co., Ltd.	Combinaison de proteine se liant au cre/inhibiteur de catenine et d'un inhibiteur de point de controle immunitaire servant au traitement du cancer
CN108135894B (zh)	2015-08-20	2021-02-19	卫材R&D管理有限公司	肿瘤治疗剂
CN110072528B (zh)	2017-02-08	2022-04-26	卫材R&D管理有限公司	治疗肿瘤的药物组合物
CN107129502B (zh) *	2017-04-13	2022-08-05	泰州亿腾景昂药业股份有限公司	EOC315 Mod.I晶型化合物及其制备方法
WO2018212202A1 (fr)	2017-05-16	2018-11-22	Eisai R&D Management Co., Ltd.	Traitement du carcinome hépatocellulaire
US12421228B2 (en) *	2019-04-22	2025-09-23	Mirati Therapeutics, Inc.	Naphthyridine derivatives as PRC2 inhibitors
CN112830932B (zh) *	2020-12-25	2022-04-08	泰州亿腾景昂药业股份有限公司	特拉替尼的游离碱晶型及其制备方法与用途
US20250129067A1 (en)	2021-11-08	2025-04-24	Progentos Therapeutics, Inc.	Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof

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FR1453897A (fr) *	1965-06-16	1966-07-22		Dérivés du thiophène et de thiéno pyridazines
GB1094044A (en) *	1965-07-12	1967-12-06	Vantorex Ltd	Phthalazine derivatives
FR1516777A (fr) *	1966-08-02	1968-02-05	Innothera Lab Sa	Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation
GB1293565A (en) *	1969-05-03	1972-10-18	Aspro Nicholas Ltd	Aminophthalazines and pharmaceutical compositions thereof
JPH03106875A (ja) *	1989-09-20	1991-05-07	Morishita Pharmaceut Co Ltd	１―（３―ピリジルメチル）フタラジン誘導体
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IL118631A (en) *	1995-06-27	2002-05-23	Tanabe Seiyaku Co	History of pyridazinone and processes for their preparation
CO4950519A1 (es) *	1997-02-13	2000-09-01	Novartis Ag	Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
ES2342240T3 (es) *	1998-08-11	2010-07-02	Novartis Ag	Derivados de isoquinolina con actividad que inhibe la angiogenia.
ATE329596T1 (de) *	1999-03-30	2006-07-15	Novartis Pharma Gmbh	Phthalazinderivate zur behandlung von entzündlicher erkrankungen
AR025068A1 (es) *	1999-08-10	2002-11-06	Bayer Corp	Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis
WO2001058899A1 (fr) *	2000-02-09	2001-08-16	Novartis Ag	Derives de pyridine inhibant l'angiogenese et/ou la tyrosine-kinase du recepteur de vegf

2000
- 2000-09-22 AR ARP000104981A patent/AR025752A1/es not_active Application Discontinuation
- 2000-09-22 CO CO00072226A patent/CO5200835A1/es active IP Right Grant
- 2000-09-22 GT GT200000158A patent/GT200000158A/es unknown
- 2000-09-22 DO DO2000000070A patent/DOP2000000070A/es unknown
- 2000-09-25 MY MYPI20051063A patent/MY143580A/en unknown
- 2000-09-25 TW TW089119700A patent/TW593315B/zh not_active IP Right Cessation
- 2000-09-25 MY MYPI20051064A patent/MY143377A/en unknown
- 2000-09-25 PA PA20008503201A patent/PA8503201A1/es unknown
- 2000-09-25 PE PE2000001004A patent/PE20010607A1/es not_active Application Discontinuation
- 2000-09-25 MY MYPI20004467A patent/MY135058A/en unknown
- 2000-09-26 RU RU2002111414/04A patent/RU2260008C2/ru active
- 2000-09-26 BR BRPI0014382A patent/BRPI0014382B8/pt not_active IP Right Cessation
- 2000-09-26 UA UA2002043504A patent/UA75053C2/uk unknown
- 2000-09-26 IL IL14888000A patent/IL148880A0/xx active IP Right Grant
- 2000-09-26 SK SK591-2002A patent/SK287417B6/sk not_active IP Right Cessation
- 2000-09-26 KR KR1020027003972A patent/KR100890473B1/ko not_active Expired - Lifetime
- 2000-09-26 HU HU0202704A patent/HU230223B1/hu not_active IP Right Cessation
- 2000-09-26 EE EEP200200161A patent/EE05258B1/xx not_active IP Right Cessation
- 2000-09-26 KR KR1020087021380A patent/KR100895572B1/ko not_active Expired - Lifetime
- 2000-09-26 DE DE60041548T patent/DE60041548D1/de not_active Expired - Lifetime
- 2000-09-26 MX MXPA02003156A patent/MXPA02003156A/es active IP Right Grant
- 2000-09-26 RS YUP-229/02A patent/RS50369B/sr unknown
- 2000-09-26 EP EP00978215A patent/EP1228063B1/fr not_active Expired - Lifetime
- 2000-09-26 NZ NZ518589A patent/NZ518589A/en not_active IP Right Cessation
- 2000-09-26 PL PL366342A patent/PL205957B1/pl unknown
- 2000-09-26 ES ES00978215T patent/ES2320525T3/es not_active Expired - Lifetime
- 2000-09-26 JP JP2001526527A patent/JP4919567B2/ja not_active Expired - Lifetime
- 2000-09-26 WO PCT/US2000/026500 patent/WO2001023375A2/fr not_active Ceased
- 2000-09-26 CA CA2385817A patent/CA2385817C/fr not_active Expired - Lifetime
- 2000-09-26 KR KR1020087021379A patent/KR100895571B1/ko not_active Expired - Lifetime
- 2000-09-26 AT AT00978215T patent/ATE422494T1/de not_active IP Right Cessation
- 2000-09-26 CN CNB008163693A patent/CN100374435C/zh not_active Expired - Lifetime
- 2000-09-26 AU AU15696/01A patent/AU782820B2/en not_active Expired
- 2000-09-26 CN CNB2005101271092A patent/CN100422172C/zh not_active Expired - Lifetime
- 2000-09-26 CZ CZ2002-1444A patent/CZ304767B6/cs not_active IP Right Cessation
- 2000-09-26 HR HR20020308A patent/HRP20020308A2/xx not_active IP Right Cessation
- 2000-09-26 CN CNB2005101271105A patent/CN100422173C/zh not_active Expired - Lifetime
2002
- 2002-03-26 NO NO20021520A patent/NO20021520L/no unknown
- 2002-04-09 ZA ZA200202760A patent/ZA200202760B/xx unknown
- 2002-04-23 BG BG106637A patent/BG65860B1/bg unknown
- 2002-04-26 MA MA26619A patent/MA25563A1/fr unknown
2008
- 2008-08-11 IL IL193367A patent/IL193367A/en active IP Right Grant
- 2008-08-11 IL IL193368A patent/IL193368A/en active IP Right Grant
2011
- 2011-07-15 AR ARP110102559A patent/AR082232A2/es unknown
- 2011-07-15 AR ARP110102558A patent/AR082231A2/es unknown

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Publication number	Publication date
AR082231A2 (es)	2012-11-21
DOP2000000070A (es)	2002-02-28
IL193367A (en)	2011-03-31
HUP0202704A2 (hu)	2002-12-28
YU22902A (sh)	2004-12-31
IL193368A0 (en)	2009-02-11
HRP20020308A2 (en)	2004-06-30
KR100895571B1 (ko)	2009-04-29
RU2260008C2 (ru)	2005-09-10
CN100422172C (zh)	2008-10-01
NO20021520D0 (no)	2002-03-26
HUP0202704A3 (en)	2003-12-29
CA2385817A1 (fr)	2001-04-05
EP1228063B1 (fr)	2009-02-11
CA2385817C (fr)	2010-05-04
BR0014382B1 (pt)	2014-04-01
HU230223B1 (en)	2015-10-28
CN1420879A (zh)	2003-05-28
IL148880A0 (en)	2002-09-12
PL205957B1 (pl)	2010-06-30
KR20080091505A (ko)	2008-10-13
EE200200161A (et)	2003-08-15
CZ304767B6 (cs)	2014-10-08
ATE422494T1 (de)	2009-02-15
KR100890473B1 (ko)	2009-03-26
GT200000158A (es)	2002-03-16
MY143377A (en)	2011-05-13
BR0014382A (pt)	2003-06-24
CZ20021444A3 (cs)	2002-08-14
MY143580A (en)	2011-05-31
KR20080086547A (ko)	2008-09-25
AR082232A2 (es)	2012-11-21
CN1769282A (zh)	2006-05-10
EP1228063A2 (fr)	2002-08-07
CN1769283A (zh)	2006-05-10
SK287417B6 (sk)	2010-09-07
NZ518589A (en)	2005-03-24
MY135058A (en)	2008-01-31
KR20020038775A (ko)	2002-05-23
JP4919567B2 (ja)	2012-04-18
HK1091819A1 (zh)	2007-01-26
JP2003526632A (ja)	2003-09-09
PA8503201A1 (es)	2002-08-26
MXPA02003156A (es)	2002-09-30
BRPI0014382B8 (pt)	2021-05-25
PE20010607A1 (es)	2001-07-12
IL193367A0 (en)	2009-02-11
TW593315B (en)	2004-06-21
UA75053C2 (en)	2006-03-15
AR025752A1 (es)	2002-12-11
NO20021520L (no)	2002-05-23
WO2001023375A2 (fr)	2001-04-05
CN100374435C (zh)	2008-03-12
DE60041548D1 (de)	2009-03-26
BG65860B1 (bg)	2010-03-31
KR100895572B1 (ko)	2009-04-29
IL193368A (en)	2011-05-31
HK1091818A1 (zh)	2007-01-26
RS50369B (sr)	2009-11-10
PL366342A1 (en)	2005-01-24
AU782820B2 (en)	2005-09-01
HRP20020308B1 (fr)	2013-01-31
CN100422173C (zh)	2008-10-01
SK5912002A3 (en)	2003-01-09
ZA200202760B (en)	2003-10-29
WO2001023375A3 (fr)	2002-05-02
AU1569601A (en)	2001-04-30
CO5200835A1 (es)	2002-09-27
BG106637A (bg)	2003-02-28
EE05258B1 (et)	2010-02-15
ES2320525T3 (es)	2009-05-25

Publication	Publication Date	Title
ZA200202760B (en)	2003-10-29	Substituted pyridines and pyridazines with angiogenesis inhibiting activity.
TR199902372A3 (tr)	2000-04-21	Sulfanilsilanlar.
TR200000520A3 (tr)	2001-06-21	4-Fenil-piridin türevleri.
PT1164870E (pt)	2004-08-31	Barra de cereais
MA25391A1 (fr)	2002-04-01	Inhibiteurs d'alcenyl et alcynyl metalloproteases.
NL1016477A1 (nl)	2001-04-26	Gemodificeerd oxymethyleenpolymeer.
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