UA75053C2 - Substituted pyridines and pyridazines able to inhibit angiogenesis - Google Patents

Substituted pyridines and pyridazines able to inhibit angiogenesis Download PDF

Info

Publication number: UA75053C2
Authority: UA; Ukraine
Prior art keywords: amino; alkyl; methyl; substituted; optionally substituted
Prior art date: 1999-09-28

Application number

UA2002043504A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Bayer Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2000-09-26

Publication date

2006-03-15

2000-09-26 Application filed by Bayer Corp filed Critical Bayer Corp

2006-03-15 Publication of UA75053C2 publication Critical patent/UA75053C2/uk

Links

230000033115 angiogenesis Effects 0.000 title claims abstract description 25
150000003222 pyridines Chemical class 0.000 title abstract description 7
150000004892 pyridazines Chemical class 0.000 title abstract description 5
238000000034 method Methods 0.000 claims abstract description 131
125000001424 substituent group Chemical group 0.000 claims abstract description 72
125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 27
125000003118 aryl group Chemical group 0.000 claims abstract description 22
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 22
241000124008 Mammalia Species 0.000 claims abstract description 9
230000002159 abnormal effect Effects 0.000 claims abstract description 8
230000008569 process Effects 0.000 claims abstract description 8
125000004076 pyridyl group Chemical group 0.000 claims abstract description 8
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
125000000217 alkyl group Chemical group 0.000 claims description 192
150000001875 compounds Chemical class 0.000 claims description 136
125000003277 amino group Chemical group 0.000 claims description 103
239000012634 fragment Substances 0.000 claims description 103
125000004429 atom Chemical group 0.000 claims description 87
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 77
-1 amino- Chemical class 0.000 claims description 68
125000004446 heteroarylalkyl group Chemical group 0.000 claims description 63
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 53
125000004432 carbon atom Chemical group C* 0.000 claims description 52
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 49
125000000623 heterocyclic group Chemical group 0.000 claims description 48
125000001072 heteroaryl group Chemical group 0.000 claims description 40
125000001589 carboacyl group Chemical group 0.000 claims description 33
229910052736 halogen Inorganic materials 0.000 claims description 33
150000002367 halogens Chemical class 0.000 claims description 31
125000003107 substituted aryl group Chemical group 0.000 claims description 28
229910052799 carbon Inorganic materials 0.000 claims description 27
229910052760 oxygen Inorganic materials 0.000 claims description 25
230000015572 biosynthetic process Effects 0.000 claims description 24
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 23
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 19
150000001409 amidines Chemical class 0.000 claims description 18
150000001412 amines Chemical class 0.000 claims description 18
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 17
125000003342 alkenyl group Chemical group 0.000 claims description 16
125000003282 alkyl amino group Chemical class 0.000 claims description 15
125000000392 cycloalkenyl group Chemical group 0.000 claims description 15
125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 14
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 12
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 11
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 11
125000005842 heteroatom Chemical group 0.000 claims description 11
125000003545 alkoxy group Chemical group 0.000 claims description 10
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125000002619 bicyclic group Chemical group 0.000 claims description 10
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QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 9
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201000010099 disease Diseases 0.000 claims description 8
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 7
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206010038923 Retinopathy Diseases 0.000 claims description 4
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125000006413 ring segment Chemical group 0.000 claims description 2
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229910002651 NO3 Inorganic materials 0.000 claims 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

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UA2002043504A 1999-09-28 2000-09-26 Substituted pyridines and pyridazines able to inhibit angiogenesis UA75053C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40760099A	1999-09-28	1999-09-28
PCT/US2000/026500 WO2001023375A2 (fr)	1999-09-28	2000-09-26	Pyridines et pyridazines substituees a activite inhibitrice de l'angiogenese

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Publication Number	Publication Date
UA75053C2 true UA75053C2 (en)	2006-03-15

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ID=23612752

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Application Number	Title	Priority Date	Filing Date
UA2002043504A UA75053C2 (en)	1999-09-28	2000-09-26	Substituted pyridines and pyridazines able to inhibit angiogenesis

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EP (1)	EP1228063B1 (fr)
JP (1)	JP4919567B2 (fr)
KR (3)	KR100895571B1 (fr)
CN (3)	CN100422173C (fr)
AR (3)	AR025752A1 (fr)
AT (1)	ATE422494T1 (fr)
AU (1)	AU782820B2 (fr)
BG (1)	BG65860B1 (fr)
BR (1)	BRPI0014382B8 (fr)
CA (1)	CA2385817C (fr)
CO (1)	CO5200835A1 (fr)
CZ (1)	CZ304767B6 (fr)
DE (1)	DE60041548D1 (fr)
DO (1)	DOP2000000070A (fr)
EE (1)	EE05258B1 (fr)
ES (1)	ES2320525T3 (fr)
GT (1)	GT200000158A (fr)
HR (1)	HRP20020308A2 (fr)
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IL (3)	IL148880A0 (fr)
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MX (1)	MXPA02003156A (fr)
MY (3)	MY135058A (fr)
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NZ (1)	NZ518589A (fr)
PA (1)	PA8503201A1 (fr)
PE (1)	PE20010607A1 (fr)
PL (1)	PL205957B1 (fr)
RS (1)	RS50369B (fr)
RU (1)	RU2260008C2 (fr)
SK (1)	SK287417B6 (fr)
TW (1)	TW593315B (fr)
UA (1)	UA75053C2 (fr)
WO (1)	WO2001023375A2 (fr)
ZA (1)	ZA200202760B (fr)

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CN103402519B (zh)	2011-04-18	2015-11-25	卫材R&D管理有限公司	肿瘤治疗剂
JP6038128B2 (ja)	2011-06-03	2016-12-07	エーザイ・アール・アンド・ディー・マネジメント株式会社	レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
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EP2997377B1 (fr)	2013-05-14	2018-07-18	Eisai R&D Management Co., Ltd.	Biomarqueurs pour la prédiction et l'estimation de la sensibilité de sujets atteints d'un cancer de l' endometre vis-à-vis de composés lenvatinib
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PT3524595T (pt)	2014-08-28	2022-09-19	Eisai R&D Man Co Ltd	Derivado de quinolina altamente puro e método para produção do mesmo
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- 2000-09-22 GT GT200000158A patent/GT200000158A/es unknown
- 2000-09-22 CO CO00072226A patent/CO5200835A1/es active IP Right Grant
- 2000-09-22 DO DO2000000070A patent/DOP2000000070A/es unknown
- 2000-09-22 AR ARP000104981A patent/AR025752A1/es not_active Application Discontinuation
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- 2000-09-25 PE PE2000001004A patent/PE20010607A1/es not_active Application Discontinuation
- 2000-09-25 MY MYPI20051064A patent/MY143377A/en unknown
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- 2000-09-26 CN CNB2005101271105A patent/CN100422173C/zh not_active Expired - Lifetime
- 2000-09-26 UA UA2002043504A patent/UA75053C2/uk unknown
- 2000-09-26 IL IL14888000A patent/IL148880A0/xx active IP Right Grant
- 2000-09-26 WO PCT/US2000/026500 patent/WO2001023375A2/fr not_active Ceased
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- 2000-09-26 HU HU0202704A patent/HU230223B1/hu not_active IP Right Cessation
- 2000-09-26 RU RU2002111414/04A patent/RU2260008C2/ru active
- 2000-09-26 EP EP00978215A patent/EP1228063B1/fr not_active Expired - Lifetime
- 2000-09-26 DE DE60041548T patent/DE60041548D1/de not_active Expired - Lifetime
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- 2000-09-26 AT AT00978215T patent/ATE422494T1/de not_active IP Right Cessation
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- 2000-09-26 KR KR1020027003972A patent/KR100890473B1/ko not_active Expired - Lifetime
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2002
- 2002-03-26 NO NO20021520A patent/NO20021520L/no unknown
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- 2002-04-23 BG BG106637A patent/BG65860B1/bg unknown
- 2002-04-26 MA MA26619A patent/MA25563A1/fr unknown
2008
- 2008-08-11 IL IL193367A patent/IL193367A/en active IP Right Grant
- 2008-08-11 IL IL193368A patent/IL193368A/en active IP Right Grant
2011
- 2011-07-15 AR ARP110102558A patent/AR082231A2/es unknown
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Also Published As

Publication number	Publication date
MY143580A (en)	2011-05-31
GT200000158A (es)	2002-03-16
HK1091818A1 (zh)	2007-01-26
IL193367A (en)	2011-03-31
KR100890473B1 (ko)	2009-03-26
AU1569601A (en)	2001-04-30
KR20080086547A (ko)	2008-09-25
KR20080091505A (ko)	2008-10-13
ES2320525T3 (es)	2009-05-25
KR100895571B1 (ko)	2009-04-29
PE20010607A1 (es)	2001-07-12
EE05258B1 (et)	2010-02-15
BRPI0014382B8 (pt)	2021-05-25
DOP2000000070A (es)	2002-02-28
CA2385817A1 (fr)	2001-04-05
CA2385817C (fr)	2010-05-04
EE200200161A (et)	2003-08-15
HRP20020308B1 (fr)	2013-01-31
KR20020038775A (ko)	2002-05-23
CN1769283A (zh)	2006-05-10
RU2260008C2 (ru)	2005-09-10
WO2001023375A3 (fr)	2002-05-02
HRP20020308A2 (en)	2004-06-30
KR100895572B1 (ko)	2009-04-29
BR0014382B1 (pt)	2014-04-01
ATE422494T1 (de)	2009-02-15
AR025752A1 (es)	2002-12-11
YU22902A (sh)	2004-12-31
BG106637A (bg)	2003-02-28
WO2001023375A2 (fr)	2001-04-05
NO20021520L (no)	2002-05-23
AU782820B2 (en)	2005-09-01
CN1769282A (zh)	2006-05-10
EP1228063A2 (fr)	2002-08-07
HUP0202704A3 (en)	2003-12-29
SK5912002A3 (en)	2003-01-09
MY143377A (en)	2011-05-13
DE60041548D1 (de)	2009-03-26
HK1091819A1 (zh)	2007-01-26
PA8503201A1 (es)	2002-08-26
CN100422172C (zh)	2008-10-01
AR082231A2 (es)	2012-11-21
MXPA02003156A (es)	2002-09-30
CN100422173C (zh)	2008-10-01
RS50369B (sr)	2009-11-10
IL148880A0 (en)	2002-09-12
BG65860B1 (bg)	2010-03-31
EP1228063B1 (fr)	2009-02-11
CZ20021444A3 (cs)	2002-08-14
CN1420879A (zh)	2003-05-28
CO5200835A1 (es)	2002-09-27
HUP0202704A2 (hu)	2002-12-28
IL193368A0 (en)	2009-02-11
MA25563A1 (fr)	2002-10-01
HU230223B1 (en)	2015-10-28
PL205957B1 (pl)	2010-06-30
AR082232A2 (es)	2012-11-21
TW593315B (en)	2004-06-21
ZA200202760B (en)	2003-10-29
JP2003526632A (ja)	2003-09-09
BR0014382A (pt)	2003-06-24
NZ518589A (en)	2005-03-24
IL193367A0 (en)	2009-02-11
PL366342A1 (en)	2005-01-24
NO20021520D0 (no)	2002-03-26
CZ304767B6 (cs)	2014-10-08
MY135058A (en)	2008-01-31
SK287417B6 (sk)	2010-09-07
CN100374435C (zh)	2008-03-12
IL193368A (en)	2011-05-31
JP4919567B2 (ja)	2012-04-18

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UA75053C2 (en)	2006-03-15	Substituted pyridines and pyridazines able to inhibit angiogenesis
ES2968810T3 (es)	2024-05-14	Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística
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JP2016514719A (ja)	2016-05-23	ヘテロアリール置換インダゾール
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JP2015520143A (ja)	2015-07-16	癌を治療するためのｂｕｂ１阻害薬としての置換されているシクロアルケノピラゾール類
JP2016525075A (ja)	2016-08-22	ヘテロアリール置換ピラゾール類
WO2007037534A1 (fr)	2007-04-05	Derive indole substitue en position 2 par un groupe heteroaryle
JP2003522773A (ja)	2003-07-29	血管形成および／またはｖｅｇｆ受容体チロシンキナーゼを阻害するピリジン誘導体
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