MA26337A1 - Melanges d'analogues de la cyclosporine et leur usage comme immunomodulateurs. - Google Patents

Melanges d'analogues de la cyclosporine et leur usage comme immunomodulateurs.

Info

Publication number: MA26337A1
Authority: MA; Morocco
Prior art keywords: immunomodulators; mixtures; cyclosporin analogs; cyclosporin; analogs
Prior art date: 2001-10-19

Application number

MA27598A

Other languages

English (en)

Inventor

Selvaraj Naicker

Randall W Yatscoff

Robert T Foster

Original Assignee

Isotechnika Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-19

Filing date

2004-03-26

Publication date

2004-10-01

2004-03-26 Application filed by Isotechnika Inc filed Critical Isotechnika Inc

2004-10-01 Publication of MA26337A1 publication Critical patent/MA26337A1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Rheumatology (AREA)
Neurology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dispersion Chemistry (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Transplantation (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Oncology (AREA)

MA27598A 2001-10-19 2004-03-26 Melanges d'analogues de la cyclosporine et leur usage comme immunomodulateurs. MA26337A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34620101P	2001-10-19	2001-10-19

Publications (1)

Publication Number	Publication Date
MA26337A1 true MA26337A1 (fr)	2004-10-01

Family

ID=23358378

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA27598A MA26337A1 (fr)	2001-10-19	2004-03-26	Melanges d'analogues de la cyclosporine et leur usage comme immunomodulateurs.

Country Status (38)

Country	Link
US (2)	US20110092669A1 (fr)
EP (2)	EP1436322B1 (fr)
JP (4)	JP2005511538A (fr)
KR (1)	KR100992850B1 (fr)
CN (1)	CN100344648C (fr)
AR (1)	AR036853A1 (fr)
AT (1)	ATE401339T1 (fr)
AU (1)	AU2002331510B2 (fr)
BE (1)	BE2022C547I2 (fr)
BR (1)	BR0213659A (fr)
CA (2)	CA2727642C (fr)
CO (1)	CO5570682A2 (fr)
CY (2)	CY1108410T1 (fr)
DE (1)	DE60227686D1 (fr)
DK (1)	DK1436322T3 (fr)
EC (3)	ECSP045059A (fr)
ES (1)	ES2310604T3 (fr)
FI (1)	FIC20220041I1 (fr)
FR (1)	FR22C1051I2 (fr)
HR (1)	HRP20040353B1 (fr)
IL (2)	IL160762A0 (fr)
LT (1)	LTC1436322I2 (fr)
MA (1)	MA26337A1 (fr)
ME (1)	ME00487B (fr)
MX (1)	MXPA04003624A (fr)
MY (1)	MY187182A (fr)
NL (1)	NL301200I2 (fr)
NO (2)	NO331745B1 (fr)
NZ (1)	NZ531945A (fr)
PL (1)	PL210697B1 (fr)
PT (1)	PT1436322E (fr)
PY (2)	PY0225477A (fr)
RU (1)	RU2337106C2 (fr)
SI (1)	SI1436322T1 (fr)
TN (1)	TNSN04069A1 (fr)
UY (1)	UY27502A1 (fr)
WO (1)	WO2003033527A2 (fr)
ZA (1)	ZA200402270B (fr)

Families Citing this family (32)

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DK1436322T3 (da) *	2001-10-19	2008-11-03	Isotechnika Inc	Blandinger af cyclosporinanaloger og deres anvendelse som immunmodulerende midler
HRP20070058B1 (hr)	2001-10-19	2014-05-23	Isotechnika Inc.	Sinteza ciklosporinskih analoga
CA2518265A1 (fr)	2003-03-17	2004-09-30	Albany Molecular Research, Inc.	Nouvelles cyclosporines
TW200505946A (en) *	2003-04-08	2005-02-16	Hoffmann La Roche	Process for preparation of cyclosporin a analog
US7378391B2 (en)	2004-09-29	2008-05-27	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008514702A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
WO2006041631A2 (fr)	2004-10-06	2006-04-20	Amr Technology, Inc.	Alcynes de cyclosporine, et leur utilite comme agents pharmaceutiques
TW200635954A (en) *	2004-12-17	2006-10-16	Isotechnika Inc	Metabolites of cyclosporin analogs
KR101273681B1 (ko) *	2005-10-26	2013-06-25	아스텔라스세이야쿠 가부시키가이샤	신규 시클릭 펩티드 화합물
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
EP2150269B1 (fr) *	2007-05-02	2012-11-21	Astellas Pharma Inc.	Nouveaux composés peptidiques cycliques
JP5668476B2 (ja)	2007-10-08	2015-02-12	オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃ．	カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物
RU2361604C1 (ru) *	2007-10-29	2009-07-20	Федеральное агентство по высокотехнологичной медицинской помощи Федеральное государственное учреждение "Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии" (ФГУ УрНИИДВиИ Росмедтехнологий)	Способ лечения атопического дерматита
EP2440185B1 (fr)	2009-06-09	2015-04-08	Aurinia Pharmaceuticals Inc.	Systemes d'administration de medicament topique pour une utilisation ophtalmique
GB0912584D0 (en) *	2009-07-20	2009-08-26	Ucl Business Plc	Cyclosporin conjugates
AU2011342284C1 (en)	2010-12-15	2017-07-13	Contravir Pharmaceuticals, Inc.	Cyclosporine analogue molecules modified at amino acid 1 and 3
GB201222455D0 (en) *	2012-12-13	2013-01-30	Perioc Ltd	Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
EP3549051A4 (fr) *	2016-11-30	2020-04-29	Schrodinger, Inc.	Interface graphique d'utilisateur pour calculs d'états de transition chimique
CA3045944A1 (fr)	2016-12-07	2018-06-14	Progenity, Inc.	Procedes, dispositifs et systemes de detection du tractus gastro-intestinal
WO2018106928A1 (fr)	2016-12-08	2018-06-14	Contravir Pharmaceuticals, Inc.	Traitement et prévention de maladies du vhb par des molécules analogues de cyclosporine modifiées au niveau des acides aminés 1 et 3
US11523772B2 (en)	2016-12-14	2022-12-13	Biora Therapeutics, Inc.	Treatment of a disease of the gastrointestinal tract with an immunosuppressant
US10286036B2 (en) *	2017-05-12	2019-05-14	Aurinia Pharmaceuticals Inc.	Protocol for treatment of lupus nephritis
US20190224275A1 (en)	2017-05-12	2019-07-25	Aurinia Pharmaceuticals Inc.	Protocol for treatment of lupus nephritis
US20230041197A1 (en)	2018-06-20	2023-02-09	Progenity, Inc.	Treatment of a disease of the gastrointestinal tract with an immunomodulator
CA3172535A1 (fr) *	2020-03-26	2021-09-30	Ching-Pong Mak	Inhibiteurs de cyclophiline et leurs utilisations
EP4201952A1 (fr)	2021-12-21	2023-06-28	Curia Spain, S.A.U.	Procédé de synthèse contrôlée de voclosporine
WO2024052941A1 (fr) *	2022-09-09	2024-03-14	Dr. Reddy's Laboratories Limited	Procédé amélioré pour la préparation de voclosporine
IT202300001056A1 (it) *	2023-01-25	2024-07-25	Procos Spa	Nuovo processo per la preparazione di voclosporina amorfa
IT202300001116A1 (it) *	2023-01-25	2024-07-25	Indena Spa	Processo per la preparazione di un intermedio utile per la sintesi di voclosporina
WO2025119925A1 (fr)	2023-12-05	2025-06-12	Medichem, S.A.	Procédé de préparation de voclosporine
IT202300028041A1 (it) *	2023-12-27	2025-06-27	Indena Spa	Processo per la preparazione di voclosporina

Family Cites Families (13)

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Publication number	Priority date	Publication date	Assignee	Title
US4278545A (en) *	1979-09-12	1981-07-14	The Bendix Corporation	Apparatus for separating solids and liquid components
CH670644A5 (fr) *	1986-12-18	1989-06-30	Lonza Ag
US5162540A (en) *	1986-12-18	1992-11-10	Lonza Ltd.	Process for the production of (+) biotin
ATE95193T1 (de) *	1987-06-17	1993-10-15	Sandoz Ag	Cyclosporine und deren benutzung als arzneimittel.
US5972630A (en) *	1991-08-19	1999-10-26	Dade Behring Marburg Gmbh	Homogeneous immunoassays using enzyme inhibitors
GB9204466D0 (en) *	1992-03-02	1992-04-15	Sandoz Ltd	Improvements in or relating to organic compounds
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5750510A (en) *	1997-04-04	1998-05-12	Abbott Laboratories	3-descladinose-2,3-anhydroerythromycin derivatives
DK0869810T3 (da) *	1996-06-19	2005-02-07	Novartis Ag	Cyclosporinholdige blöde kapselpræparater
US5939406A (en) *	1997-07-21	1999-08-17	Wisconsin Alumni Research Foundation	18-substituted-19-nor-vitamin D compounds
DE69832984T2 (de) *	1997-10-08	2006-09-21	Isotechnika, Inc., Edmonton	DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN
HRP20070058B1 (hr) *	2001-10-19	2014-05-23	Isotechnika Inc.	Sinteza ciklosporinskih analoga
DK1436322T3 (da) *	2001-10-19	2008-11-03	Isotechnika Inc	Blandinger af cyclosporinanaloger og deres anvendelse som immunmodulerende midler

2002
- 2002-10-17 DK DK02767028T patent/DK1436322T3/da active
- 2002-10-17 ES ES02767028T patent/ES2310604T3/es not_active Expired - Lifetime
- 2002-10-17 AU AU2002331510A patent/AU2002331510B2/en not_active Expired
- 2002-10-17 RU RU2004110941/04A patent/RU2337106C2/ru active
- 2002-10-17 SI SI200230742T patent/SI1436322T1/sl unknown
- 2002-10-17 EP EP02767028A patent/EP1436322B1/fr not_active Expired - Lifetime
- 2002-10-17 CA CA2727642A patent/CA2727642C/fr not_active Expired - Lifetime
- 2002-10-17 MY MYPI20023885A patent/MY187182A/en unknown
- 2002-10-17 HR HRP20040353AA patent/HRP20040353B1/hr not_active IP Right Cessation
- 2002-10-17 BR BR0213659-7A patent/BR0213659A/pt not_active IP Right Cessation
- 2002-10-17 AR ARP020103918A patent/AR036853A1/es not_active Application Discontinuation
- 2002-10-17 PY PY200200225477A patent/PY0225477A/es unknown
- 2002-10-17 JP JP2003536265A patent/JP2005511538A/ja not_active Withdrawn
- 2002-10-17 CN CNB02820798XA patent/CN100344648C/zh not_active Expired - Lifetime
- 2002-10-17 PT PT02767028T patent/PT1436322E/pt unknown
- 2002-10-17 PL PL370501A patent/PL210697B1/pl unknown
- 2002-10-17 AT AT02767028T patent/ATE401339T1/de active
- 2002-10-17 PY PY200200225478A patent/PY0225478A/es unknown
- 2002-10-17 IL IL16076202A patent/IL160762A0/xx unknown
- 2002-10-17 NZ NZ531945A patent/NZ531945A/en not_active IP Right Cessation
- 2002-10-17 ME MEP-2008-780A patent/ME00487B/fr unknown
- 2002-10-17 EP EP07106871A patent/EP1816138A1/fr not_active Withdrawn
- 2002-10-17 DE DE60227686T patent/DE60227686D1/de not_active Expired - Lifetime
- 2002-10-17 KR KR1020047005721A patent/KR100992850B1/ko not_active Expired - Lifetime
- 2002-10-17 WO PCT/CA2002/001560 patent/WO2003033527A2/fr not_active Ceased
- 2002-10-17 MX MXPA04003624A patent/MXPA04003624A/es active IP Right Grant
- 2002-10-17 UY UY27502A patent/UY27502A1/es not_active Application Discontinuation
- 2002-10-17 CA CA2460685A patent/CA2460685C/fr not_active Expired - Lifetime
2004
- 2004-03-05 IL IL160762A patent/IL160762A/en active IP Right Grant
- 2004-03-23 ZA ZA2004/02270A patent/ZA200402270B/en unknown
- 2004-03-26 MA MA27598A patent/MA26337A1/fr unknown
- 2004-04-14 EC EC2004005059A patent/ECSP045059A/es unknown
- 2004-04-14 EC EC2004005061A patent/ECSP045061A/es unknown
- 2004-04-14 EC EC2004005060A patent/ECSP045060A/es unknown
- 2004-04-16 TN TNP2004000069A patent/TNSN04069A1/en unknown
- 2004-04-19 CO CO04035672A patent/CO5570682A2/es not_active Application Discontinuation
- 2004-05-14 NO NO20042029A patent/NO331745B1/no not_active IP Right Cessation
2008
- 2008-10-13 CY CY20081101130T patent/CY1108410T1/el unknown
2009
- 2009-06-11 JP JP2009140608A patent/JP5272140B2/ja not_active Expired - Lifetime
2010
- 2010-07-02 JP JP2010151859A patent/JP2011006417A/ja active Pending
- 2010-12-23 US US12/977,602 patent/US20110092669A1/en not_active Abandoned
2013
- 2013-01-31 JP JP2013017448A patent/JP2013136597A/ja active Pending
2014
- 2014-03-18 US US14/217,827 patent/US20140288266A1/en not_active Abandoned
2022
- 2022-10-14 BE BE2022C547C patent/BE2022C547I2/nl unknown
- 2022-10-14 LT LTPA2022521C patent/LTC1436322I2/lt unknown
- 2022-10-14 CY CY2022030C patent/CY2022030I2/el unknown
- 2022-10-14 NO NO2022042C patent/NO2022042I1/no unknown
- 2022-10-14 NL NL301200C patent/NL301200I2/nl unknown
- 2022-10-14 FI FIC20220041C patent/FIC20220041I1/fi unknown
- 2022-10-14 FR FR22C1051C patent/FR22C1051I2/fr active Active

Also Published As

Publication number	Publication date
PY0225478A (es)	2004-05-03
RU2004110941A (ru)	2005-08-10
ZA200402270B (en)	2005-05-25
FR22C1051I1 (fr)	2022-12-16
ES2310604T3 (es)	2009-01-16
KR20050037421A (ko)	2005-04-21
IL160762A0 (en)	2004-08-31
ECSP045059A (es)	2004-07-23
PL370501A1 (en)	2005-05-30
JP2009197036A (ja)	2009-09-03
ATE401339T1 (de)	2008-08-15
ECSP045060A (es)	2004-07-23
JP5272140B2 (ja)	2013-08-28
US20110092669A1 (en)	2011-04-21
NL301200I2 (nl)	2024-07-25
ME00487B (fr)	2011-10-10
CA2727642A1 (fr)	2003-04-24
HRP20040353B1 (hr)	2012-10-31
FR22C1051I2 (fr)	2023-11-17
AU2002331510B2 (en)	2008-05-01
EP1436322A2 (fr)	2004-07-14
ECSP045061A (es)	2004-08-27
AR036853A1 (es)	2004-10-06
US20140288266A1 (en)	2014-09-25
DK1436322T3 (da)	2008-11-03
NZ531945A (en)	2006-01-27
CY2022030I1 (el)	2023-01-27
PT1436322E (pt)	2008-10-23
IL160762A (en)	2010-11-30
KR100992850B1 (ko)	2010-11-09
LTC1436322I2 (fr)	2023-06-26
EP1816138A1 (fr)	2007-08-08
CN100344648C (zh)	2007-10-24
DE60227686D1 (de)	2008-08-28
PY0225477A (es)	2004-05-03
RU2337106C2 (ru)	2008-10-27
CY2022030I2 (el)	2023-06-09
CA2460685C (fr)	2014-05-27
HK1062567A1 (en)	2004-11-12
WO2003033527A3 (fr)	2003-10-16
CA2727642C (fr)	2014-02-04
BR0213659A (pt)	2004-10-26
HRP20040353A2 (en)	2005-04-30
BE2022C547I2 (fr)	2022-10-19
CN1571794A (zh)	2005-01-26
CY1108410T1 (el)	2012-05-23
LTPA2022521I1 (fr)	2022-11-10
CO5570682A2 (es)	2005-10-31
NO20042029L (no)	2004-05-14
PL210697B1 (pl)	2012-02-29
CA2460685A1 (fr)	2003-04-24
JP2005511538A (ja)	2005-04-28
TNSN04069A1 (en)	2006-06-01
JP2013136597A (ja)	2013-07-11
MY187182A (en)	2021-09-08
EP1436322B1 (fr)	2008-07-16
NO2022042I1 (no)	2022-10-14
SI1436322T1 (sl)	2008-12-31
WO2003033527A2 (fr)	2003-04-24
JP2011006417A (ja)	2011-01-13
UY27502A1 (es)	2003-04-30
FIC20220041I1 (fi)	2022-10-14
NO331745B1 (no)	2012-03-19
MXPA04003624A (es)	2004-12-06

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