MA26644A1 - Derives de 1,7, diaza-spiro (3,5) nonane, procede de preparation et medicament les contenant - Google Patents

Derives de 1,7, diaza-spiro (3,5) nonane, procede de preparation et medicament les contenant

Info

Publication number: MA26644A1
Authority: MA; Morocco
Prior art keywords: diaza; nonane; spiro; derivatives; preparation
Prior art date: 1998-06-12

Application number

MA25616A

Other languages

English (en)

Inventor

Juergen Wichmann

Stephan Roever

Geo Adam

Andrea Cesura

Sabine Kolczewski

Francois Jenck

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-12

Filing date

1999-06-10

Publication date

2004-12-20

1999-06-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-20 Publication of MA26644A1 publication Critical patent/MA26644A1/fr

Links

YKXOWLUZZIFXMJ-UHFFFAOYSA-N 1,2-diazaspiro[3.5]nonane Chemical compound C1NNC11CCCCC1 YKXOWLUZZIFXMJ-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Addiction (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

MA25616A 1998-06-12 1999-06-10 Derives de 1,7, diaza-spiro (3,5) nonane, procede de preparation et medicament les contenant MA26644A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP98110804		1998-06-12

Publications (1)

Publication Number	Publication Date
MA26644A1 true MA26644A1 (fr)	2004-12-20

Family

ID=8232114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA25616A MA26644A1 (fr)	1998-06-12	1999-06-10	Derives de 1,7, diaza-spiro (3,5) nonane, procede de preparation et medicament les contenant

Country Status (28)

Country	Link
US (1)	US6113527A (fr)
EP (1)	EP0970957B1 (fr)
JP (1)	JP3286268B2 (fr)
KR (1)	KR100344732B1 (fr)
CN (1)	CN1107066C (fr)
AR (1)	AR019859A1 (fr)
AT (1)	ATE204279T1 (fr)
AU (1)	AU743983B2 (fr)
BR (1)	BR9902651A (fr)
CA (1)	CA2274202A1 (fr)
DE (1)	DE69900220T2 (fr)
DK (1)	DK0970957T3 (fr)
ES (1)	ES2162503T3 (fr)
HR (1)	HRP990188A2 (fr)
HU (1)	HU220894B1 (fr)
ID (1)	ID23304A (fr)
IL (1)	IL130377A0 (fr)
MA (1)	MA26644A1 (fr)
NO (1)	NO312590B1 (fr)
NZ (1)	NZ336189A (fr)
PE (1)	PE20000548A1 (fr)
PL (1)	PL333695A1 (fr)
PT (1)	PT970957E (fr)
SG (1)	SG79259A1 (fr)
SI (1)	SI0970957T1 (fr)
TR (1)	TR199901381A2 (fr)
YU (1)	YU26499A (fr)
ZA (1)	ZA993852B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030040479A1 (en) *	2001-07-02	2003-02-27	Omeros Corporation	Rotational intrathecal analgesia method and device
WO2003004034A1 (fr) *	2001-07-02	2003-01-16	Omeros Corporation	Procede visant a induire une analgesie, qui comprend l'administration alternee d'un agoniste de recepteur d'opioides et d'un agoniste de recepteur 1 du type recepteur d'opioides, et pompe a perfusion implantable
US7566728B2 (en)	2002-03-29	2009-07-28	Mitsubishi Tanabe Pharma Corporation	Remedy for sleep disturbance
JP2005289816A (ja)	2002-05-14	2005-10-20	Banyu Pharmaceut Co Ltd	ベンズイミダゾール誘導体
PT1519939E (pt) *	2002-07-05	2010-02-10	Targacept Inc	Compostos n-arildiazaspirocíclicos e métodos para a sua preparação e utilização
AU2003268512A1 (en) *	2002-09-09	2004-03-29	Janssen Pharmaceutica N.V.	Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
GB0323204D0 (en) *	2003-10-03	2003-11-05	Novartis Ag	Organic compounds
WO2005060947A2 (fr) *	2003-12-19	2005-07-07	Sri International	Ligands agonistes et antagonistes du recepteur de la nociceptine
US20060178390A1 (en) *	2004-08-02	2006-08-10	Alfonzo Jordan	1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
JP2008510711A (ja) *	2004-08-20	2008-04-10	ターガセプト，インコーポレイテッド	嗜癖治療におけるｎ−アリールジアザスピラ環状化合物の使用
US20080247964A1 (en) *	2006-05-08	2008-10-09	Yuelian Xu	Substituted azaspiro derivatives
CN103202840B (zh) *	2006-11-28	2015-02-11	詹森药业有限公司	3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
EP2150552B1 (fr) *	2007-04-09	2013-01-02	Janssen Pharmaceutica NV	Dérivés de 1,3,8-trisubstitué-1,3,8-triaza-spiro[4.5]décan-4-one utilisés comme ligands du récepteur orl-i dans le traitement de l'anxiété et de la dépression
KR101704226B1 (ko)	2015-06-30	2017-02-07	현대자동차주식회사	자동차의 쿼터글라스 어셈블리
AU2022421224A1 (en) *	2021-12-22	2024-06-20	The Regents Of The University Of California	Covalently binding inhibitors of g12s, g12d and/or g12e mutants of k-ras gtpase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5756743A (en) *	1996-04-10	1998-05-26	Hoechst Marion Roussel Inc.	Spiro cyclopent b!indole-piperidines!

1999
- 1999-06-07 ES ES99110943T patent/ES2162503T3/es not_active Expired - Lifetime
- 1999-06-07 DK DK99110943T patent/DK0970957T3/da active
- 1999-06-07 AT AT99110943T patent/ATE204279T1/de not_active IP Right Cessation
- 1999-06-07 EP EP99110943A patent/EP0970957B1/fr not_active Expired - Lifetime
- 1999-06-07 SI SI9930008T patent/SI0970957T1/xx unknown
- 1999-06-07 DE DE69900220T patent/DE69900220T2/de not_active Expired - Lifetime
- 1999-06-07 PT PT99110943T patent/PT970957E/pt unknown
- 1999-06-08 ID IDP990543D patent/ID23304A/id unknown
- 1999-06-08 PE PE1999000487A patent/PE20000548A1/es not_active Application Discontinuation
- 1999-06-08 ZA ZA9903852A patent/ZA993852B/xx unknown
- 1999-06-09 SG SG9903066A patent/SG79259A1/en unknown
- 1999-06-09 IL IL13037799A patent/IL130377A0/xx unknown
- 1999-06-09 NZ NZ336189A patent/NZ336189A/xx unknown
- 1999-06-09 CA CA002274202A patent/CA2274202A1/fr not_active Abandoned
- 1999-06-09 HU HU9901911A patent/HU220894B1/hu not_active IP Right Cessation
- 1999-06-10 AR ARP990102763A patent/AR019859A1/es active IP Right Grant
- 1999-06-10 AU AU34987/99A patent/AU743983B2/en not_active Ceased
- 1999-06-10 YU YU26499A patent/YU26499A/sh unknown
- 1999-06-10 MA MA25616A patent/MA26644A1/fr unknown
- 1999-06-10 KR KR1019990021485A patent/KR100344732B1/ko not_active Expired - Fee Related
- 1999-06-10 JP JP16357099A patent/JP3286268B2/ja not_active Expired - Fee Related
- 1999-06-11 CN CN99108373A patent/CN1107066C/zh not_active Expired - Fee Related
- 1999-06-11 PL PL99333695A patent/PL333695A1/xx unknown
- 1999-06-11 BR BR9902651-1A patent/BR9902651A/pt not_active Application Discontinuation
- 1999-06-11 TR TR1999/01381A patent/TR199901381A2/xx unknown
- 1999-06-11 HR HR98110804.6A patent/HRP990188A2/hr not_active Application Discontinuation
- 1999-06-11 US US09/330,851 patent/US6113527A/en not_active Expired - Fee Related
- 1999-06-11 NO NO19992873A patent/NO312590B1/no unknown

Also Published As

Publication number	Publication date
NO992873L (no)	1999-12-13
HU220894B1 (en)	2002-06-29
HU9901911D0 (en)	1999-08-30
EP0970957A1 (fr)	2000-01-12
SI0970957T1 (fr)	2001-12-31
HUP9901911A1 (hu)	2000-05-28
YU26499A (sh)	2002-09-19
CA2274202A1 (fr)	1999-12-12
TR199901381A3 (tr)	2000-01-21
DK0970957T3 (da)	2001-12-03
EP0970957B1 (fr)	2001-08-16
IL130377A0 (en)	2000-06-01
NZ336189A (en)	2000-10-27
AU3498799A (en)	1999-12-23
HRP990188A2 (en)	2000-02-29
PT970957E (pt)	2002-02-28
BR9902651A (pt)	2000-05-16
CN1242366A (zh)	2000-01-26
ZA993852B (en)	1999-12-13
CN1107066C (zh)	2003-04-30
JP3286268B2 (ja)	2002-05-27
US6113527A (en)	2000-09-05
AU743983B2 (en)	2002-02-14
ATE204279T1 (de)	2001-09-15
DE69900220T2 (de)	2002-05-08
TR199901381A2 (xx)	2000-01-21
JP2000053679A (ja)	2000-02-22
KR20000006060A (ko)	2000-01-25
AR019859A1 (es)	2002-03-20
PE20000548A1 (es)	2000-07-15
NO312590B1 (no)	2002-06-03
ES2162503T3 (es)	2001-12-16
NO992873D0 (no)	1999-06-11
KR100344732B1 (ko)	2002-07-19
DE69900220D1 (de)	2001-09-20
PL333695A1 (en)	1999-12-20
ID23304A (id)	2000-04-05
SG79259A1 (en)	2001-03-20

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