MA26813A1 - Gene de streptomyces avermitilis commandant le rapport des avermectines b2 :b1 - Google Patents

Gene de streptomyces avermitilis commandant le rapport des avermectines b2 :b1

Info

Publication number
MA26813A1
MA26813A1 MA26513A MA26513A MA26813A1 MA 26813 A1 MA26813 A1 MA 26813A1 MA 26513 A MA26513 A MA 26513A MA 26513 A MA26513 A MA 26513A MA 26813 A1 MA26813 A1 MA 26813A1
Authority
MA
Morocco
Prior art keywords
avermitilated
avermectins
streptomyces
ordering
gene
Prior art date
Application number
MA26513A
Other languages
English (en)
Inventor
Yan Chen
Claes Gustafsson
Anke Krebber
Jeremy Stephen Minshull
Sun Ai Raillard
Kim Jonelle Stutzman-Engwall
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA26813A1 publication Critical patent/MA26813A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MA26513A 1999-08-12 2002-02-07 Gene de streptomyces avermitilis commandant le rapport des avermectines b2 :b1 MA26813A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14864599P 1999-08-12 1999-08-12

Publications (1)

Publication Number Publication Date
MA26813A1 true MA26813A1 (fr) 2004-12-20

Family

ID=22526696

Family Applications (1)

Application Number Title Priority Date Filing Date
MA26513A MA26813A1 (fr) 1999-08-12 2002-02-07 Gene de streptomyces avermitilis commandant le rapport des avermectines b2 :b1

Country Status (39)

Country Link
US (3) US6632673B1 (fr)
EP (1) EP1200606B1 (fr)
JP (1) JP3884651B2 (fr)
KR (1) KR100489856B1 (fr)
CN (1) CN1186446C (fr)
AP (1) AP2002002418A0 (fr)
AR (1) AR022646A1 (fr)
AT (1) ATE341632T1 (fr)
AU (1) AU778837B2 (fr)
BG (1) BG65902B1 (fr)
BR (1) BRPI0013119B8 (fr)
CA (1) CA2380872C (fr)
CO (1) CO5290295A1 (fr)
CY (1) CY1105778T1 (fr)
CZ (1) CZ304402B6 (fr)
DE (1) DE60031126T2 (fr)
DK (1) DK1200606T3 (fr)
EA (1) EA200200056A1 (fr)
ES (1) ES2272299T3 (fr)
GT (1) GT200000136A (fr)
HK (1) HK1046710B (fr)
HR (1) HRP20020130A2 (fr)
HU (1) HU230600B1 (fr)
IL (2) IL147563A0 (fr)
IS (1) IS6250A (fr)
MA (1) MA26813A1 (fr)
MX (1) MXPA02001513A (fr)
NO (1) NO20020664D0 (fr)
NZ (1) NZ516517A (fr)
OA (1) OA11998A (fr)
PA (1) PA8499501A1 (fr)
PE (1) PE20010690A1 (fr)
PL (1) PL203818B1 (fr)
PT (1) PT1200606E (fr)
SK (1) SK288086B6 (fr)
TN (1) TNSN00171A1 (fr)
UY (1) UY26286A1 (fr)
WO (1) WO2001012821A1 (fr)
ZA (1) ZA200201072B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ516517A (en) * 1999-08-12 2003-10-31 Pfizer Prod Inc Mutations in the aveC allele of Streptomyces avermitilis gene that reduce the ratio of cyclohexyl B2:cyclohexyl B1 avermectins
SI1476539T1 (sl) * 2002-02-12 2009-06-30 Pfizer Prod Inc Gen streptomyces avermitilis, ki uravnava razmerje B2:B1 avermektinov
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
US9493744B2 (en) * 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents
KR102657859B1 (ko) 2021-04-07 2024-04-16 윤재식 일체형 내화 소켓

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
IN167980B (fr) * 1987-01-23 1991-01-19 Pfizer
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
EP0313297B1 (fr) 1987-10-23 1993-05-19 Pfizer Inc. Procédé de production d'aglycones d'avermectine et des cultures les contenant
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
ES2079436T3 (es) 1989-03-31 1996-01-16 Merck & Co Inc Clonacion de genes de streptomyces avermitilis para biosintesis de avermectinas y procedimientos para su uso.
DK0711349T3 (da) 1993-07-30 2003-11-24 Pfizer Gener, der koder for forgrenet alfaketosyredehydrogenasekompleks fra Streptomyces avermitilis
FI942725A7 (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
EP0964922A4 (fr) 1996-09-27 2000-10-25 Maxygen Inc Procedes permettant l'optimisation d'une therapie genique grace a un rearrangement et une selection recursifs de sequences
KR100568008B1 (ko) 1997-01-17 2006-04-07 맥시겐, 인크. 반복적 서열 재조합에 의한 전세포 및 유기체의 개량 방법
EP1690868A1 (fr) 1997-10-31 2006-08-16 Maxygen, Inc. Modification du tropisme viral et de la diversité d'espèces hôte par recombinaison du génome viral
CA2320031A1 (fr) * 1998-02-13 1999-08-19 Pfizer Products Inc. Gene de streptomyces avermitilis commandant le rapport d'avermectines b2/b1
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
NZ516517A (en) * 1999-08-12 2003-10-31 Pfizer Prod Inc Mutations in the aveC allele of Streptomyces avermitilis gene that reduce the ratio of cyclohexyl B2:cyclohexyl B1 avermectins

Also Published As

Publication number Publication date
CO5290295A1 (es) 2003-06-27
HK1046710B (zh) 2005-05-13
US20030232415A1 (en) 2003-12-18
EA200200056A1 (ru) 2002-06-27
MXPA02001513A (es) 2002-07-02
OA11998A (en) 2006-04-18
US20040009560A1 (en) 2004-01-15
HU230600B1 (hu) 2017-02-28
CN1186446C (zh) 2005-01-26
ATE341632T1 (de) 2006-10-15
AR022646A1 (es) 2002-09-04
NO20020664L (no) 2002-02-11
CY1105778T1 (el) 2011-02-02
JP2003507017A (ja) 2003-02-25
KR100489856B1 (ko) 2005-05-17
BRPI0013119B8 (pt) 2021-05-25
UY26286A1 (es) 2001-03-16
BG106479A (bg) 2002-10-31
NO20020664D0 (no) 2002-02-11
CN1373809A (zh) 2002-10-09
CZ304402B6 (cs) 2014-04-16
AU778837B2 (en) 2004-12-23
BR0013119A (pt) 2002-04-23
BG65902B1 (bg) 2010-04-30
CA2380872C (fr) 2007-11-27
DK1200606T3 (da) 2007-01-08
DE60031126T2 (de) 2007-02-08
HUP0202487A2 (en) 2002-10-28
GT200000136A (es) 2002-02-01
KR20020029379A (ko) 2002-04-18
SK1392002A3 (en) 2002-12-03
US6632673B1 (en) 2003-10-14
HUP0202487A3 (en) 2004-07-28
PA8499501A1 (es) 2001-12-14
CZ2002296A3 (cs) 2002-08-14
PT1200606E (pt) 2006-12-29
AP2002002418A0 (en) 2002-03-31
JP3884651B2 (ja) 2007-02-21
US7858340B2 (en) 2010-12-28
WO2001012821A1 (fr) 2001-02-22
BR0013119B1 (pt) 2014-02-25
PL203818B1 (pl) 2009-11-30
IL147563A (en) 2009-06-15
AU5838600A (en) 2001-03-13
ZA200201072B (en) 2003-04-30
EP1200606A1 (fr) 2002-05-02
ES2272299T3 (es) 2007-05-01
IS6250A (is) 2002-01-25
TNSN00171A1 (fr) 2005-11-10
NZ516517A (en) 2003-10-31
EP1200606B1 (fr) 2006-10-04
PE20010690A1 (es) 2001-07-06
IL147563A0 (en) 2002-08-14
DE60031126D1 (de) 2006-11-16
HRP20020130A2 (en) 2003-06-30
SK288086B6 (sk) 2013-06-03
PL353874A1 (en) 2003-12-01
CA2380872A1 (fr) 2001-02-22
HK1046710A1 (en) 2003-01-24

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