ATE341632T1 - Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen - Google Patents

Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen

Info

Publication number
ATE341632T1
ATE341632T1 AT00944154T AT00944154T ATE341632T1 AT E341632 T1 ATE341632 T1 AT E341632T1 AT 00944154 T AT00944154 T AT 00944154T AT 00944154 T AT00944154 T AT 00944154T AT E341632 T1 ATE341632 T1 AT E341632T1
Authority
AT
Austria
Prior art keywords
avermectins
ratio
streptomyces avermitilis
gene regulating
avermitilis gene
Prior art date
Application number
AT00944154T
Other languages
English (en)
Inventor
Yan Chen
Claes Gustafsson
Anke Krebber
Jeremy Stephen Minshull
Sun Ai Raillard
Kim Jonelle Stutzman-Engwall
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE341632T1 publication Critical patent/ATE341632T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00944154T 1999-08-12 2000-07-24 Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen ATE341632T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14864599P 1999-08-12 1999-08-12

Publications (1)

Publication Number Publication Date
ATE341632T1 true ATE341632T1 (de) 2006-10-15

Family

ID=22526696

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00944154T ATE341632T1 (de) 1999-08-12 2000-07-24 Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen

Country Status (39)

Country Link
US (3) US6632673B1 (de)
EP (1) EP1200606B1 (de)
JP (1) JP3884651B2 (de)
KR (1) KR100489856B1 (de)
CN (1) CN1186446C (de)
AP (1) AP2002002418A0 (de)
AR (1) AR022646A1 (de)
AT (1) ATE341632T1 (de)
AU (1) AU778837B2 (de)
BG (1) BG65902B1 (de)
BR (1) BRPI0013119B8 (de)
CA (1) CA2380872C (de)
CO (1) CO5290295A1 (de)
CY (1) CY1105778T1 (de)
CZ (1) CZ304402B6 (de)
DE (1) DE60031126T2 (de)
DK (1) DK1200606T3 (de)
EA (1) EA200200056A1 (de)
ES (1) ES2272299T3 (de)
GT (1) GT200000136A (de)
HK (1) HK1046710B (de)
HR (1) HRP20020130A2 (de)
HU (1) HU230600B1 (de)
IL (2) IL147563A0 (de)
IS (1) IS6250A (de)
MA (1) MA26813A1 (de)
MX (1) MXPA02001513A (de)
NO (1) NO20020664D0 (de)
NZ (1) NZ516517A (de)
OA (1) OA11998A (de)
PA (1) PA8499501A1 (de)
PE (1) PE20010690A1 (de)
PL (1) PL203818B1 (de)
PT (1) PT1200606E (de)
SK (1) SK288086B6 (de)
TN (1) TNSN00171A1 (de)
UY (1) UY26286A1 (de)
WO (1) WO2001012821A1 (de)
ZA (1) ZA200201072B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012821A1 (en) * 1999-08-12 2001-02-22 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
RS50813B (sr) * 2002-02-12 2010-08-31 Pfizer Products Inc. Streptomyces avermitilis gen koji određuje odnos b2:b1 avermektina
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
US9493744B2 (en) * 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents
KR102657859B1 (ko) 2021-04-07 2024-04-16 윤재식 일체형 내화 소켓

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN167980B (de) * 1987-01-23 1991-01-19 Pfizer
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
ATE89604T1 (de) 1987-10-23 1993-06-15 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
DE69023036T2 (de) 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
KR100221385B1 (ko) 1993-07-30 1999-10-01 디. 제이. 우드 스트렙토마이세스 아베르미틸리스로 부터의 측쇄 알파-케토산 데하이드로게나제 복합체를 암호화하는 유전자
FI942725A7 (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
CA2266423A1 (en) 1996-09-27 1998-04-02 Maxygen, Inc. Methods for optimization of gene therapy by recursive sequence shuffling and selection
EP1717322B1 (de) 1997-01-17 2012-07-18 Codexis Mayflower Holdings, LLC Evolution ganzer Zellen durch rekursive Sequenzrekombination
AU1449499A (en) 1997-10-31 1999-05-24 Maxygen, Incorporated Modification of virus tropism and host range by viral genome shuffling
PL194270B1 (pl) * 1998-02-13 2007-05-31 Pfizer Prod Inc Wyizolowana cząsteczka polinukleotydowa, cząsteczka oligonukleotydowa, zrekombinowany wektor, komórka gospodarza, wyizolowany produkt genu AveC S. avermitilis, wyizolowany produkt homologu genu AveC S. hygroscopicus, sposób wytwarzania zrekombinowanego produktu genu AveC, sposób wytwarzania zrekombinowanego produktu homologu genu AveC, cząsteczka polinukleotydowa, wektor do zastępowania genu, sposób identyfikowania mutacji otwartej ramki odczytuAveC, sposób wytwarzania nowych szczepów S. avermitilis, szczep S. avermitilis i sposób wytwarzaniaawermektyn
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
WO2001012821A1 (en) * 1999-08-12 2001-02-22 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Also Published As

Publication number Publication date
US20030232415A1 (en) 2003-12-18
SK288086B6 (sk) 2013-06-03
PL203818B1 (pl) 2009-11-30
KR20020029379A (ko) 2002-04-18
CN1186446C (zh) 2005-01-26
ES2272299T3 (es) 2007-05-01
MA26813A1 (fr) 2004-12-20
CA2380872C (en) 2007-11-27
OA11998A (en) 2006-04-18
CA2380872A1 (en) 2001-02-22
BG65902B1 (bg) 2010-04-30
EP1200606B1 (de) 2006-10-04
CY1105778T1 (el) 2011-02-02
US6632673B1 (en) 2003-10-14
CZ2002296A3 (cs) 2002-08-14
JP3884651B2 (ja) 2007-02-21
KR100489856B1 (ko) 2005-05-17
BRPI0013119B8 (pt) 2021-05-25
IL147563A (en) 2009-06-15
DK1200606T3 (da) 2007-01-08
IS6250A (is) 2002-01-25
HRP20020130A2 (en) 2003-06-30
UY26286A1 (es) 2001-03-16
EA200200056A1 (ru) 2002-06-27
WO2001012821A1 (en) 2001-02-22
HU230600B1 (hu) 2017-02-28
HUP0202487A3 (en) 2004-07-28
PT1200606E (pt) 2006-12-29
HUP0202487A2 (en) 2002-10-28
BR0013119B1 (pt) 2014-02-25
PA8499501A1 (es) 2001-12-14
EP1200606A1 (de) 2002-05-02
HK1046710A1 (en) 2003-01-24
PL353874A1 (en) 2003-12-01
CO5290295A1 (es) 2003-06-27
NZ516517A (en) 2003-10-31
SK1392002A3 (en) 2002-12-03
ZA200201072B (en) 2003-04-30
HK1046710B (zh) 2005-05-13
MXPA02001513A (es) 2002-07-02
NO20020664L (no) 2002-02-11
PE20010690A1 (es) 2001-07-06
DE60031126T2 (de) 2007-02-08
AP2002002418A0 (en) 2002-03-31
AU778837B2 (en) 2004-12-23
BR0013119A (pt) 2002-04-23
US7858340B2 (en) 2010-12-28
BG106479A (bg) 2002-10-31
CZ304402B6 (cs) 2014-04-16
DE60031126D1 (de) 2006-11-16
JP2003507017A (ja) 2003-02-25
IL147563A0 (en) 2002-08-14
GT200000136A (es) 2002-02-01
NO20020664D0 (no) 2002-02-11
AU5838600A (en) 2001-03-13
TNSN00171A1 (fr) 2005-11-10
US20040009560A1 (en) 2004-01-15
AR022646A1 (es) 2002-09-04
CN1373809A (zh) 2002-10-09

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