MA27137A1 - Derives substitues d'alkylaminopyridazinone, procedes de preparation et composition pharmaceutique les contenant - Google Patents

Derives substitues d'alkylaminopyridazinone, procedes de preparation et composition pharmaceutique les contenant

Info

Publication number: MA27137A1
Authority: MA; Morocco
Prior art keywords: sub; hydrogen; stands; alkyl; carbon atoms
Prior art date: 2001-09-27

Application number

MA27588A

Other languages

English (en)

Inventor

Jozsef Barkoczy

Gyula Simig

Nagy Peter Kotay

Gyorgy Levay

Istvan Gacsalyi

Marko Bernadett Martonne

Eva Schmidt

Andras Egyed

Hajnalka Kompagne

Csilla Leveleki

Kovacs Aniko Miklosne

Gabor Szenasi

Janos Wellmann

Laszlo Gabor Harsing

Original Assignee

Egyt Gyogyszervegyeszeti Gyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-27

Filing date

2004-03-24

Publication date

2005-01-03

2004-03-24 Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar

2005-01-03 Publication of MA27137A1 publication Critical patent/MA27137A1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

MA27588A 2001-09-27 2004-03-24 Derives substitues d'alkylaminopyridazinone, procedes de preparation et composition pharmaceutique les contenant MA27137A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU0103912A HU227237B1 (en)	2001-09-27	2001-09-27	Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
MA27137A1 true MA27137A1 (fr)	2005-01-03

Family

ID=89979721

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
MA27589A MA27068A1 (fr)	2001-09-27	2004-03-24	Derives d'alkylaminopyridazinone substitues, leur procede de preparation et composition pharmaceutique les contenant.
MA27588A MA27137A1 (fr)	2001-09-27	2004-03-24	Derives substitues d'alkylaminopyridazinone, procedes de preparation et composition pharmaceutique les contenant

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
MA27589A MA27068A1 (fr)	2001-09-27	2004-03-24	Derives d'alkylaminopyridazinone substitues, leur procede de preparation et composition pharmaceutique les contenant.

Country Status (25)

Country	Link
US (2)	US20050043314A1 (fr)
EP (2)	EP1430034B1 (fr)
JP (2)	JP2005508914A (fr)
KR (2)	KR100890667B1 (fr)
CN (3)	CN1325489C (fr)
AT (2)	ATE288910T1 (fr)
AU (2)	AU2002330656B9 (fr)
BR (2)	BR0212932A (fr)
CA (2)	CA2461510C (fr)
CZ (2)	CZ2004532A3 (fr)
DE (2)	DE60202970T2 (fr)
DK (2)	DK1430034T3 (fr)
EA (2)	EA006942B1 (fr)
ES (2)	ES2237696T3 (fr)
HU (1)	HU227237B1 (fr)
MA (2)	MA27068A1 (fr)
MX (2)	MXPA04002838A (fr)
NO (2)	NO326370B1 (fr)
NZ (2)	NZ532103A (fr)
PL (2)	PL369107A1 (fr)
PT (2)	PT1430047E (fr)
SI (2)	SI1430047T1 (fr)
SK (2)	SK1902004A3 (fr)
WO (2)	WO2003027078A1 (fr)
ZA (2)	ZA200402545B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7504395B2 (en) *	2001-07-20	2009-03-17	Psychogenics, Inc.	Treatment for attention-deficit hyperactivity disorder
HU227592B1 (en) *	2002-11-13	2011-09-28	Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag	Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
CL2008000725A1 (es) *	2007-03-15	2008-11-14	Schering Corp	Compuestos derivados de heterociclos aromaticos; composicion farmaceutica; kit farmceuticos; uso de la composicion y de los compuestos como inhibidores de glucano sintasa para el tratamiento o prevencion del crecimiento de patogenos fungicos en planta y para tratar o prevenir infecciones producidas por hongos.
SI3788040T1 (sl) *	2018-04-30	2023-07-31	Ribon Therapeutics Inc.	Piridazinoni kot zaviralci parp7
CN109053693B (zh)	2018-09-20	2021-02-05	顺毅股份有限公司	哒嗪胺类化合物的制备及其应用
US12371421B2 (en)	2019-04-29	2025-07-29	Ribon Therapeutics, Inc.	Solid forms of a PARP7 inhibitor
MX2022005216A (es)	2019-10-30	2022-06-02	Ribon Therapeutics Inc	Piridazinonas como inhibidores de poli(adp-ribosa) polimerasa 7 (parp7).
WO2022188889A1 (fr) *	2021-03-12	2022-09-15	杭州英创医药科技有限公司	Composé utile en tant qu'inhibiteur de parp7
CN115490671B (zh) *	2022-10-21	2024-05-14	水木未来(北京)科技有限公司	Parp7抑制剂及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH557820A (de) *	1970-11-12	1975-01-15	Sandoz Ag	Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
IE62890B1 (en) *	1988-12-06	1995-03-08	Hafslund Nycomed Pharma	New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
PL164079B1 (pl) *	1990-06-15	1994-06-30	Akad Medyczna	posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU209388B (en) *	1990-12-27	1994-05-30	Richter Gedeon Vegyeszet	Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
HU214320B (hu) *	1991-12-20	1998-03-02	EGIS Gyógyszergyár Rt.	Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
HU224067B1 (hu) *	1995-05-29	2005-05-30	Gyógyszerkutató Intézet Kft.	3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
JP2004500314A (ja) *	1998-06-05	2004-01-08	エギシュ　ヂョヂセルヂャール　エルテー	３（２ｈ）−ピリダジノン−４−置換アミノ−５−クロロ−誘導体の製法

2001
- 2001-09-27 HU HU0103912A patent/HU227237B1/hu not_active IP Right Cessation
2002
- 2002-09-26 EA EA200400470A patent/EA006942B1/ru not_active IP Right Cessation
- 2002-09-26 ES ES02767729T patent/ES2237696T3/es not_active Expired - Lifetime
- 2002-09-26 CN CNB028204425A patent/CN1325489C/zh not_active Expired - Fee Related
- 2002-09-26 DK DK02767729T patent/DK1430034T3/da active
- 2002-09-26 CZ CZ2004532A patent/CZ2004532A3/cs unknown
- 2002-09-26 NZ NZ532103A patent/NZ532103A/en unknown
- 2002-09-26 KR KR1020047004606A patent/KR100890667B1/ko not_active Expired - Fee Related
- 2002-09-26 JP JP2003530669A patent/JP2005508914A/ja active Pending
- 2002-09-26 CZ CZ2004528A patent/CZ2004528A3/cs unknown
- 2002-09-26 AT AT02762620T patent/ATE288910T1/de not_active IP Right Cessation
- 2002-09-26 AU AU2002330656A patent/AU2002330656B9/en not_active Ceased
- 2002-09-26 BR BR0212932-9A patent/BR0212932A/pt not_active IP Right Cessation
- 2002-09-26 EP EP02767729A patent/EP1430034B1/fr not_active Expired - Lifetime
- 2002-09-26 SK SK1902004A patent/SK1902004A3/sk unknown
- 2002-09-26 BR BR0212839-0A patent/BR0212839A/pt not_active IP Right Cessation
- 2002-09-26 PT PT02762620T patent/PT1430047E/pt unknown
- 2002-09-26 US US10/490,959 patent/US20050043314A1/en not_active Abandoned
- 2002-09-26 CN CNB028189752A patent/CN100368404C/zh not_active Expired - Fee Related
- 2002-09-26 DK DK02762620T patent/DK1430047T3/da active
- 2002-09-26 DE DE60202970T patent/DE60202970T2/de not_active Expired - Lifetime
- 2002-09-26 SI SI200230109T patent/SI1430047T1/xx unknown
- 2002-09-26 DE DE60202969T patent/DE60202969T2/de not_active Expired - Lifetime
- 2002-09-26 WO PCT/HU2002/000097 patent/WO2003027078A1/fr not_active Ceased
- 2002-09-26 EP EP02762620A patent/EP1430047B1/fr not_active Expired - Lifetime
- 2002-09-26 AT AT02767729T patent/ATE288899T1/de not_active IP Right Cessation
- 2002-09-26 AU AU2002328166A patent/AU2002328166B2/en not_active Ceased
- 2002-09-26 CA CA002461510A patent/CA2461510C/fr not_active Expired - Fee Related
- 2002-09-26 JP JP2003530685A patent/JP4472337B2/ja not_active Expired - Lifetime
- 2002-09-26 CA CA002461467A patent/CA2461467A1/fr not_active Abandoned
- 2002-09-26 CN CN200710104934XA patent/CN101099740B/zh not_active Expired - Fee Related
- 2002-09-26 ES ES02762620T patent/ES2237690T3/es not_active Expired - Lifetime
- 2002-09-26 PT PT02767729T patent/PT1430034E/pt unknown
- 2002-09-26 SK SK1892004A patent/SK1892004A3/sk unknown
- 2002-09-26 MX MXPA04002838A patent/MXPA04002838A/es active IP Right Grant
- 2002-09-26 SI SI200230107T patent/SI1430034T1/xx unknown
- 2002-09-26 KR KR1020047004607A patent/KR100911069B1/ko not_active Expired - Fee Related
- 2002-09-26 WO PCT/HU2002/000096 patent/WO2003027097A1/fr not_active Ceased
- 2002-09-26 MX MXPA04002836A patent/MXPA04002836A/es active IP Right Grant
- 2002-09-26 EA EA200400469A patent/EA006392B1/ru not_active IP Right Cessation
- 2002-09-26 PL PL02369107A patent/PL369107A1/xx not_active IP Right Cessation
- 2002-09-26 NZ NZ532104A patent/NZ532104A/en unknown
- 2002-09-26 US US10/491,151 patent/US6930110B2/en not_active Expired - Fee Related
- 2002-09-26 PL PL02369256A patent/PL369256A1/xx unknown
2004
- 2004-03-24 MA MA27589A patent/MA27068A1/fr unknown
- 2004-03-24 MA MA27588A patent/MA27137A1/fr unknown
- 2004-03-31 ZA ZA200402545A patent/ZA200402545B/en unknown
- 2004-03-31 ZA ZA200402544A patent/ZA200402544B/en unknown
- 2004-04-16 NO NO20041551A patent/NO326370B1/no not_active IP Right Cessation
- 2004-04-26 NO NO20041704A patent/NO325080B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR0212839A (pt)	2004-10-13
DK1430034T3 (da)	2005-05-30
ATE288910T1 (de)	2005-02-15
MA27068A1 (fr)	2004-12-20
HUP0103912A2 (hu)	2003-07-28
PT1430047E (pt)	2005-06-30
HUP0103912A3 (en)	2004-03-01
MXPA04002838A (es)	2004-07-05
EP1430047B1 (fr)	2005-02-09
SI1430034T1 (en)	2005-08-31
ZA200402545B (en)	2005-04-26
EP1430047A1 (fr)	2004-06-23
ES2237690T3 (es)	2005-08-01
CN101099740B (zh)	2010-09-08
CA2461510A1 (fr)	2003-04-03
NO20041704L (no)	2004-04-26
DE60202969T2 (de)	2006-01-19
WO2003027097A1 (fr)	2003-04-03
KR100911069B1 (ko)	2009-08-06
AU2002328166B2 (en)	2008-04-17
AU2002330656B2 (en)	2009-04-09
KR20040039445A (ko)	2004-05-10
PT1430034E (pt)	2005-06-30
JP2005508914A (ja)	2005-04-07
CN1571783A (zh)	2005-01-26
SI1430047T1 (en)	2005-08-31
HU0103912D0 (en)	2001-12-28
JP4472337B2 (ja)	2010-06-02
CA2461510C (fr)	2009-07-07
CN100368404C (zh)	2008-02-13
PL369107A1 (en)	2005-04-18
AU2002328166A2 (en)	2003-04-07
CN1558904A (zh)	2004-12-29
HK1069816A1 (en)	2005-06-03
NO326370B1 (no)	2008-11-17
AU2002330656B9 (en)	2009-09-03
CN101099740A (zh)	2008-01-09
DE60202970T2 (de)	2006-02-16
ES2237696T3 (es)	2005-08-01
ATE288899T1 (de)	2005-02-15
NZ532103A (en)	2005-08-26
KR20040039446A (ko)	2004-05-10
US6930110B2 (en)	2005-08-16
DE60202969D1 (de)	2005-03-17
NO20041551L (no)	2004-06-10
PL369256A1 (en)	2005-04-18
JP2005503437A (ja)	2005-02-03
EP1430034A1 (fr)	2004-06-23
CZ2004532A3 (cs)	2004-08-18
CN1325489C (zh)	2007-07-11
HU227237B1 (en)	2010-12-28
DE60202970D1 (de)	2005-03-17
CA2461467A1 (fr)	2003-04-03
EA200400469A1 (ru)	2004-08-26
MXPA04002836A (es)	2004-07-05
DK1430047T3 (da)	2005-06-06
NO325080B1 (no)	2008-01-28
HK1115728A1 (en)	2008-12-05
ZA200402544B (en)	2005-04-26
EA006392B1 (ru)	2005-12-29
EP1430034B1 (fr)	2005-02-09
NZ532104A (en)	2005-10-28
AU2002330656A2 (en)	2003-04-07
HK1069817A1 (en)	2005-06-03
US20040242873A1 (en)	2004-12-02
BR0212932A (pt)	2004-10-13
SK1902004A3 (en)	2004-10-05
EA006942B1 (ru)	2006-06-30
WO2003027078A1 (fr)	2003-04-03
KR100890667B1 (ko)	2009-03-26
SK1892004A3 (en)	2004-10-05
CZ2004528A3 (cs)	2004-08-18
EA200400470A1 (ru)	2004-08-26
US20050043314A1 (en)	2005-02-24

Publication	Publication Date	Title
HUP0100615A2 (hu)	2001-10-28	Szubsztituált 2-(2,6-dioxo-3-fluoro-piperidin-3-il)-izoindolinok és ezek alkalmazása TNFalfa-szint csökkentésére
UA37178C2 (uk)	2001-05-15	Терапевтичні гетероциклічні сполуки, спосіб їх одержання, спосіб профілактики та лікування, лікарський засіб та спосіб його одержання
ATE169008T1 (de)	1998-08-15	3,5-dioxo-(2h,4h)-1,2,4-triazinderivate ihre herstellung und verwendung als medikament
HUP0002112A2 (hu)	2000-09-28	Helyettesített 3-ciano-kinolinok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
CO5271675A1 (es)	2003-04-30	Derivados de decahidro-isoquinolinas, proceso para su preparacion, composicion y compuestos farmaceuticos que los contienen
HUP0204354A2 (hu)	2003-04-28	Új heterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
MA27068A1 (fr)	2004-12-20	Derives d'alkylaminopyridazinone substitues, leur procede de preparation et composition pharmaceutique les contenant.
HUP0301553A2 (hu)	2003-08-28	Gyógyászati készítmények és alkalmazásuk neurológiai rendellenességek kezelésére
ATE149494T1 (de)	1997-03-15	Benzopyranderivate und verfahren zu deren herstellung
PL371520A1 (en)	2005-06-27	New piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds
HUP9800889A1 (hu)	2000-11-28	Új naftil-piperazin-származékok
ES2006165A6 (es)	1989-04-16	Procedimiento para la preparacion de derivados de 1,4-dihidropiridina y sus sales de adicion farmaceuticamente aceptables
HUP0302901A2 (hu)	2004-03-01	Cianoaril-(vagy cianoheteroaril)-karbonil-piperazinil-pirimidinek új származékai, előállításuk, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
FR2823749B1 (fr)	2004-02-20	Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
ATE67197T1 (de)	1991-09-15	Thiadiazinon-derivate.
SE9700803L (sv)	1998-09-07	Farmaceutisk komposition för behandling av s k restless legs
NO308304B1 (no)	2000-08-28	Nye 5H-thiazol[3,2-a]pyrimidin-5-on derivater, anvendelse derav for fremstilling av farmasøytiske sammensetninger, farmasøytiske sammensetninger inneholdende derivatene, samt et preparat til behandling av psykose, schizofreni og angst
HUP0303691A2 (hu)	2004-03-01	Uretánszármazékok, eljárás az előállításukra és alkalmazásuk gyógyszerkészítmények előállítására