MA27137A1 - Derives substitues d'alkylaminopyridazinone, procedes de preparation et composition pharmaceutique les contenant - Google Patents

Derives substitues d'alkylaminopyridazinone, procedes de preparation et composition pharmaceutique les contenant

Info

Publication number
MA27137A1
MA27137A1 MA27588A MA27588A MA27137A1 MA 27137 A1 MA27137 A1 MA 27137A1 MA 27588 A MA27588 A MA 27588A MA 27588 A MA27588 A MA 27588A MA 27137 A1 MA27137 A1 MA 27137A1
Authority
MA
Morocco
Prior art keywords
sub
hydrogen
stands
alkyl
carbon atoms
Prior art date
Application number
MA27588A
Other languages
English (en)
Inventor
Jozsef Barkoczy
Gyula Simig
Nagy Peter Kotay
Gyorgy Levay
Istvan Gacsalyi
Marko Bernadett Martonne
Eva Schmidt
Andras Egyed
Hajnalka Kompagne
Csilla Leveleki
Kovacs Aniko Miklosne
Gabor Szenasi
Janos Wellmann
Laszlo Gabor Harsing
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of MA27137A1 publication Critical patent/MA27137A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA27588A 2001-09-27 2004-03-24 Derives substitues d'alkylaminopyridazinone, procedes de preparation et composition pharmaceutique les contenant MA27137A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0103912A HU227237B1 (en) 2001-09-27 2001-09-27 Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
MA27137A1 true MA27137A1 (fr) 2005-01-03

Family

ID=89979721

Family Applications (2)

Application Number Title Priority Date Filing Date
MA27589A MA27068A1 (fr) 2001-09-27 2004-03-24 Derives d'alkylaminopyridazinone substitues, leur procede de preparation et composition pharmaceutique les contenant.
MA27588A MA27137A1 (fr) 2001-09-27 2004-03-24 Derives substitues d'alkylaminopyridazinone, procedes de preparation et composition pharmaceutique les contenant

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA27589A MA27068A1 (fr) 2001-09-27 2004-03-24 Derives d'alkylaminopyridazinone substitues, leur procede de preparation et composition pharmaceutique les contenant.

Country Status (25)

Country Link
US (2) US20050043314A1 (fr)
EP (2) EP1430034B1 (fr)
JP (2) JP2005508914A (fr)
KR (2) KR100890667B1 (fr)
CN (3) CN101099740B (fr)
AT (2) ATE288910T1 (fr)
AU (2) AU2002328166B2 (fr)
BR (2) BR0212932A (fr)
CA (2) CA2461510C (fr)
CZ (2) CZ2004532A3 (fr)
DE (2) DE60202969T2 (fr)
DK (2) DK1430034T3 (fr)
EA (2) EA006942B1 (fr)
ES (2) ES2237690T3 (fr)
HU (1) HU227237B1 (fr)
MA (2) MA27068A1 (fr)
MX (2) MXPA04002838A (fr)
NO (2) NO326370B1 (fr)
NZ (2) NZ532103A (fr)
PL (2) PL369107A1 (fr)
PT (2) PT1430034E (fr)
SI (2) SI1430034T1 (fr)
SK (2) SK1892004A3 (fr)
WO (2) WO2003027078A1 (fr)
ZA (2) ZA200402545B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
EP2137179B1 (fr) * 2007-03-15 2015-09-02 Merck Sharp & Dohme Corp. Dérivés de pyridazinone utiles en tant qu'inhibiteurs de synthase de glucane
EP3788040B1 (fr) * 2018-04-30 2023-04-12 Ribon Therapeutics Inc. Pyridazinones utilisés en tant qu'inhibiteurs de parp7
CN109053693B (zh) 2018-09-20 2021-02-05 顺毅股份有限公司 哒嗪胺类化合物的制备及其应用
US12371421B2 (en) 2019-04-29 2025-07-29 Ribon Therapeutics, Inc. Solid forms of a PARP7 inhibitor
WO2022188889A1 (fr) * 2021-03-12 2022-09-15 杭州英创医药科技有限公司 Composé utile en tant qu'inhibiteur de parp7
CN115490671B (zh) * 2022-10-21 2024-05-14 水木未来(北京)科技有限公司 Parp7抑制剂及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH557820A (de) * 1970-11-12 1975-01-15 Sandoz Ag Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
PL164079B1 (pl) * 1990-06-15 1994-06-30 Akad Medyczna posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU209388B (en) * 1990-12-27 1994-05-30 Richter Gedeon Vegyeszet Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
HU224067B1 (hu) 1995-05-29 2005-05-30 Gyógyszerkutató Intézet Kft. 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
AU752967B2 (en) 1998-06-05 2002-10-03 Egis Gyogyszergyar Rt. Process for the preparation of a 3(2H)-pyridazinone- 4-substituted amino- 5-chloro- derivative

Also Published As

Publication number Publication date
KR20040039446A (ko) 2004-05-10
HUP0103912A2 (hu) 2003-07-28
BR0212932A (pt) 2004-10-13
DK1430034T3 (da) 2005-05-30
NO325080B1 (no) 2008-01-28
ATE288910T1 (de) 2005-02-15
DE60202969D1 (de) 2005-03-17
AU2002330656B2 (en) 2009-04-09
HU0103912D0 (en) 2001-12-28
PT1430047E (pt) 2005-06-30
DE60202970T2 (de) 2006-02-16
NO20041704L (no) 2004-04-26
HK1069816A1 (en) 2005-06-03
KR100890667B1 (ko) 2009-03-26
SI1430034T1 (en) 2005-08-31
NO326370B1 (no) 2008-11-17
NZ532104A (en) 2005-10-28
NZ532103A (en) 2005-08-26
DK1430047T3 (da) 2005-06-06
JP4472337B2 (ja) 2010-06-02
ZA200402545B (en) 2005-04-26
HU227237B1 (en) 2010-12-28
SK1902004A3 (en) 2004-10-05
HUP0103912A3 (en) 2004-03-01
CA2461510A1 (fr) 2003-04-03
EA200400470A1 (ru) 2004-08-26
AU2002328166B2 (en) 2008-04-17
AU2002330656A2 (en) 2003-04-07
EA006392B1 (ru) 2005-12-29
CN1558904A (zh) 2004-12-29
CN101099740B (zh) 2010-09-08
EA006942B1 (ru) 2006-06-30
NO20041551L (no) 2004-06-10
US20050043314A1 (en) 2005-02-24
WO2003027097A1 (fr) 2003-04-03
DE60202969T2 (de) 2006-01-19
CA2461467A1 (fr) 2003-04-03
SK1892004A3 (en) 2004-10-05
ATE288899T1 (de) 2005-02-15
CA2461510C (fr) 2009-07-07
KR20040039445A (ko) 2004-05-10
AU2002330656B9 (en) 2009-09-03
CN100368404C (zh) 2008-02-13
PL369256A1 (en) 2005-04-18
EP1430047B1 (fr) 2005-02-09
KR100911069B1 (ko) 2009-08-06
US6930110B2 (en) 2005-08-16
EP1430034A1 (fr) 2004-06-23
JP2005503437A (ja) 2005-02-03
SI1430047T1 (en) 2005-08-31
AU2002328166A2 (en) 2003-04-07
MXPA04002838A (es) 2004-07-05
EP1430034B1 (fr) 2005-02-09
WO2003027078A1 (fr) 2003-04-03
CZ2004528A3 (cs) 2004-08-18
MA27068A1 (fr) 2004-12-20
ZA200402544B (en) 2005-04-26
CN1325489C (zh) 2007-07-11
PT1430034E (pt) 2005-06-30
ES2237690T3 (es) 2005-08-01
US20040242873A1 (en) 2004-12-02
EP1430047A1 (fr) 2004-06-23
EA200400469A1 (ru) 2004-08-26
HK1069817A1 (en) 2005-06-03
PL369107A1 (en) 2005-04-18
MXPA04002836A (es) 2004-07-05
CN1571783A (zh) 2005-01-26
JP2005508914A (ja) 2005-04-07
CZ2004532A3 (cs) 2004-08-18
DE60202970D1 (de) 2005-03-17
BR0212839A (pt) 2004-10-13
ES2237696T3 (es) 2005-08-01
HK1115728A1 (en) 2008-12-05
CN101099740A (zh) 2008-01-09

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