MA27167A1 - ACIDES 3-(IMIDAZOLYL)-2-ALKOXYPROPANOiQUES SERVANT D'INHIBITEURS DE TAFIa. - Google Patents

ACIDES 3-(IMIDAZOLYL)-2-ALKOXYPROPANOiQUES SERVANT D'INHIBITEURS DE TAFIa.

Info

Publication number: MA27167A1
Authority: MA; Morocco
Prior art keywords: imidazolyl; january; optionally substituted; hydrogen atom; alkoxypropanoic
Prior art date: 2002-01-22

Application number

MA27786A

Other languages

English (en)

French (fr)

Inventor

Charlotte Moira Norfo Allerton

Mark Edward Bunnage

John Steele

David John Bull

Robert John Maguire

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-22

Filing date

2004-07-15

Publication date

2005-01-03

2002-01-22 Priority claimed from GB0201389A external-priority patent/GB0201389D0/en

2002-01-29 Priority claimed from GB0202027A external-priority patent/GB0202027D0/en

2004-07-15 Application filed by Pfizer filed Critical Pfizer

2005-01-03 Publication of MA27167A1 publication Critical patent/MA27167A1/fr

Links

239000002253 acid Substances 0.000 title abstract 2
150000007513 acids Chemical class 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
-1 IMIDAZOLYL Chemical class 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
102000009123 Fibrin Human genes 0.000 abstract 1
108010073385 Fibrin Proteins 0.000 abstract 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000008021 deposition Effects 0.000 abstract 1
229950003499 fibrin Drugs 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Surgery (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

MA27786A 2002-01-22 2004-07-15 ACIDES 3-(IMIDAZOLYL)-2-ALKOXYPROPANOiQUES SERVANT D'INHIBITEURS DE TAFIa. MA27167A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0201389A GB0201389D0 (en)	2002-01-22	2002-01-22	3-(imidazolyl)-2-alkoxypropanoic acids
GB0202027A GB0202027D0 (en)	2002-01-29	2002-01-29	3-(imidazolyl)-2-alkoxypropanoic acids

Publications (1)

Publication Number	Publication Date
MA27167A1 true MA27167A1 (fr)	2005-01-03

Family

ID=27614792

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA27786A MA27167A1 (fr)	2002-01-22	2004-07-15	ACIDES 3-(IMIDAZOLYL)-2-ALKOXYPROPANOiQUES SERVANT D'INHIBITEURS DE TAFIa.

Country Status (24)

Country	Link
EP (1)	EP1467731A1 (es)
JP (1)	JP2005520811A (es)
KR (1)	KR20040077775A (es)
CN (1)	CN1620291A (es)
AP (1)	AP2004003084A0 (es)
AR (1)	AR038197A1 (es)
BR (1)	BR0307016A (es)
CA (1)	CA2472238A1 (es)
EA (1)	EA200400716A1 (es)
EC (1)	ECSP045200A (es)
HR (1)	HRP20040659A2 (es)
IL (1)	IL162677A0 (es)
IS (1)	IS7310A (es)
MA (1)	MA27167A1 (es)
MX (1)	MXPA04006573A (es)
NO (1)	NO20043457L (es)
OA (1)	OA12756A (es)
PA (1)	PA8563501A1 (es)
PE (1)	PE20030929A1 (es)
PL (1)	PL371487A1 (es)
TN (1)	TNSN04121A1 (es)
TW (1)	TW200302094A (es)
UY (1)	UY27615A1 (es)
WO (1)	WO2003061652A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005051384A1 (en) *	2003-11-25	2005-06-09	Pfizer Limited	Stabilised pharmaceutical compositions
US20060234986A1 (en) *	2005-04-18	2006-10-19	Schering Aktiengesellschaft	Use of TAFI inhibitors for enhanced myocardial reperfusion and facilitated PCI
NZ592764A (en)	2008-10-29	2012-08-31	Taisho Pharmaceutical Co Ltd	Compound having tafia inhibitory activity
WO2010065717A1 (en) *	2008-12-05	2010-06-10	Mochida Pharmaceutical Co., Ltd.	Morpholinone compounds as factor ixa inhibitors
US8987242B2 (en)	2008-12-05	2015-03-24	Merck Sharp & Dohme Corp.	Morpholinone compounds as factor IXA inhibitors
CA2791505C (en)	2010-03-18	2016-06-07	Daiichi Sankyo Company, Limited	Cycloalkyl-substituted imidazole derivative
CN102884053B (zh) *	2010-03-18	2016-03-02	第一三共株式会社	环丙烷甲酸衍生物
JP6461113B2 (ja)	2013-06-10	2019-01-30	サノフイＳａｎｏｆｉ	ＴＡＦＩａの阻害剤としての大環状尿素誘導体、それらの製造および医薬としての使用
US20190117624A1 (en)	2016-03-29	2019-04-25	Daiichi Sankyo Company, Limited	Therapeutic agent for inflammatory bowel diseases
DK3682881T3 (da)	2017-09-14	2026-05-11	Daiichi Sankyo Co Limited	Forbindelse med cyklisk struktur

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9901572D0 (sv) *	1999-05-03	1999-05-03	Astra Ab	New compounds
SI1311488T1 (sl) *	2000-08-17	2010-01-29	Pfizer Ltd	Substituirani imidazoli kot inhibitorji TAFIA

2003
- 2003-01-10 HR HR20040659A patent/HRP20040659A2/hr not_active Application Discontinuation
- 2003-01-10 EA EA200400716A patent/EA200400716A1/ru unknown
- 2003-01-10 CA CA002472238A patent/CA2472238A1/en not_active Abandoned
- 2003-01-10 AP APAP/P/2004/003084A patent/AP2004003084A0/en unknown
- 2003-01-10 MX MXPA04006573A patent/MXPA04006573A/es unknown
- 2003-01-10 WO PCT/IB2003/000060 patent/WO2003061652A1/en not_active Ceased
- 2003-01-10 EP EP03700059A patent/EP1467731A1/en not_active Withdrawn
- 2003-01-10 CN CNA03802599XA patent/CN1620291A/zh active Pending
- 2003-01-10 IL IL16267703A patent/IL162677A0/xx unknown
- 2003-01-10 BR BR0307016-6A patent/BR0307016A/pt not_active IP Right Cessation
- 2003-01-10 PL PL03371487A patent/PL371487A1/xx unknown
- 2003-01-10 OA OA1200400190A patent/OA12756A/en unknown
- 2003-01-10 KR KR10-2004-7011370A patent/KR20040077775A/ko not_active Ceased
- 2003-01-10 JP JP2003561596A patent/JP2005520811A/ja active Pending
- 2003-01-16 TW TW092100889A patent/TW200302094A/zh unknown
- 2003-01-17 PE PE2003000058A patent/PE20030929A1/es not_active Application Discontinuation
- 2003-01-20 UY UY27615A patent/UY27615A1/es not_active Application Discontinuation
- 2003-01-21 AR ARP030100165A patent/AR038197A1/es unknown
- 2003-01-22 PA PA20038563501A patent/PA8563501A1/es unknown
2004
- 2004-06-14 IS IS7310A patent/IS7310A/is unknown
- 2004-06-30 TN TNP2004000121A patent/TNSN04121A1/en unknown
- 2004-07-15 MA MA27786A patent/MA27167A1/fr unknown
- 2004-07-22 EC EC2004005200A patent/ECSP045200A/es unknown
- 2004-08-19 NO NO20043457A patent/NO20043457L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
UY27615A1 (es)	2003-08-29
CA2472238A1 (en)	2003-07-31
KR20040077775A (ko)	2004-09-06
MXPA04006573A (es)	2004-10-04
OA12756A (en)	2006-07-03
HRP20040659A2 (en)	2004-10-31
BR0307016A (pt)	2004-11-03
PA8563501A1 (es)	2004-08-31
JP2005520811A (ja)	2005-07-14
NO20043457L (no)	2004-08-19
CN1620291A (zh)	2005-05-25
AR038197A1 (es)	2005-01-05
EA200400716A1 (ru)	2004-12-30
EP1467731A1 (en)	2004-10-20
TNSN04121A1 (en)	2006-06-01
WO2003061652A8 (en)	2004-09-10
TW200302094A (en)	2003-08-01
WO2003061652A1 (en)	2003-07-31
IS7310A (is)	2004-06-14
PL371487A1 (en)	2005-06-13
AP2004003084A0 (en)	2004-09-30
IL162677A0 (en)	2005-11-20
PE20030929A1 (es)	2003-11-05
ECSP045200A (es)	2004-08-27

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