MA27305A1 - Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales - Google Patents

Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales

Info

Publication number: MA27305A1
Authority: MA; Morocco
Prior art keywords: diazabicyclo; derivatives; ene; hypertension; cardiovascular
Prior art date: 2002-04-29

Application number

MA27914A

Other languages

English (en)

Inventor

Olivier Bezencon

Daniel Bur

Walter Fischli

Lubos Remen

Sylvia Richard-Bildstein

Hans-Peter Weber

Thomas Weller

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-29

Filing date

2004-10-22

Publication date

2005-05-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29286070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA27305(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-10-22 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2005-05-02 Publication of MA27305A1 publication Critical patent/MA27305A1/fr

Links

206010020772 Hypertension Diseases 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000002526 effect on cardiovascular system Effects 0.000 title 1
YCBSHDKATAPNIA-UHFFFAOYSA-N non-3-ene Chemical compound CCCCCC=CCC YCBSHDKATAPNIA-UHFFFAOYSA-N 0.000 title 1
239000002461 renin inhibitor Substances 0.000 title 1
229940086526 renin-inhibitors Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 2
YJTZZSKGEPHUTF-UHFFFAOYSA-N 3,9-diazabicyclo[3.3.1]non-4-ene Chemical class C1NC=C2CCCC1N2 YJTZZSKGEPHUTF-UHFFFAOYSA-N 0.000 abstract 1
102100028255 Renin Human genes 0.000 abstract 1
108090000783 Renin Proteins 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

MA27914A 2002-04-29 2004-10-22 Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales MA27305A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP0204705		2002-04-29

Publications (1)

Publication Number	Publication Date
MA27305A1 true MA27305A1 (fr)	2005-05-02

Family

ID=29286070

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA27914A MA27305A1 (fr)	2002-04-29	2004-10-22	Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales

Country Status (26)

Country	Link
US (2)	US7427613B2 (fr)
EP (1)	EP1501830B1 (fr)
JP (1)	JP4041123B2 (fr)
KR (1)	KR100783863B1 (fr)
CN (1)	CN1649870A (fr)
AT (1)	ATE527261T1 (fr)
AU (1)	AU2003233963B2 (fr)
BR (1)	BR0309498A (fr)
CA (1)	CA2483241C (fr)
CL (1)	CL2003002042A1 (fr)
CO (1)	CO5631443A2 (fr)
EC (1)	ECSP045378A (fr)
ES (1)	ES2372931T3 (fr)
HR (1)	HRP20041132A2 (fr)
IL (1)	IL164767A0 (fr)
IS (1)	IS7545A (fr)
MA (1)	MA27305A1 (fr)
MX (1)	MXPA04010608A (fr)
NO (1)	NO20045042L (fr)
NZ (1)	NZ536750A (fr)
PL (1)	PL372141A1 (fr)
RU (1)	RU2343153C2 (fr)
TW (1)	TW200514786A (fr)
UA (1)	UA80821C2 (fr)
WO (1)	WO2003093267A1 (fr)
ZA (1)	ZA200408283B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060217371A1 (en) *	2003-04-28	2006-09-28	Olivier Bezencon	Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors
US20060205768A1 (en) *	2003-04-30	2006-09-14	Olivier Bezencon	Tropane derivatives and their use as ace inhibitors
BRPI0409818A (pt) *	2003-04-30	2006-05-09	Actelion Pharmaceuticals Ltd	compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos
CN1780663A (zh) *	2003-04-30	2006-05-31	埃科特莱茵药品有限公司	作为肾素抑制剂的新型3－位具有杂原子的9－氮杂双环壬烯衍生物
MXPA05011711A (es) *	2003-05-02	2006-01-23	Actelion Pharmaceuticals Ltd	Derivados de diazabiciclononeno.
WO2004105762A1 (fr) *	2003-05-30	2004-12-09	Actelion Pharmaceuticals Ltd	Utilisation medicale de derives de diazabicyclononene utilises comme inhibiteurs des proteases aspartiques parasites
CN1863773A (zh) *	2003-10-09	2006-11-15	埃科特莱茵药品有限公司	四氢吡啶衍生物
WO2005040165A1 (fr) *	2003-10-13	2005-05-06	Actelion Pharmaceuticals Ltd	Derives de diazabicyclononene et leur utilisation en tant qu'inhibiteurs de la renine
US20070135405A1 (en) *	2003-10-23	2007-06-14	Olivier Bezencon	Novel diazabicyclononene and tetrahydropyridine derivatives with a new polar side-chain
CA2547547A1 (fr) *	2003-12-05	2005-06-16	Actelion Pharmaceuticals Ltd	Derives de diazabicyclononene et leur utilisation en tant qu'inhibiteurs de la renine
JP2007513107A (ja) *	2003-12-05	2007-05-24	アクテリオン　ファマシューティカルズ　リミテッド	ジアザビシクロノネンおよび新側鎖を有するテトラヒドロピリジン誘導体
WO2006021401A2 (fr) *	2004-08-25	2006-03-02	Actelion Pharmaceuticals Ltd	Derives de bicyclononene
WO2006021399A2 (fr) *	2004-08-25	2006-03-02	Actelion Pharmaceuticals Ltd	Derives de bicyclononene
WO2006021403A1 (fr) *	2004-08-25	2006-03-02	Actelion Pharmaceuticals Ltd	Dérivés du bicyclononène
AU2005276624B2 (en) *	2004-08-25	2011-09-29	Actelion Pharmaceuticals Ltd.	Bicyclononene derivatives as renin inhibitors
AR052263A1 (es) *	2004-12-08	2007-03-07	Actelion Pharmaceuticals Ltd	Derivado de diazabiciclononeno
WO2006063610A1 (fr) *	2004-12-17	2006-06-22	Actelion Pharmaceuticals Ltd	Dérivés de diazabicyclononène substitués par des groupements hétéroaryle
GB0428526D0 (en)	2004-12-30	2005-02-09	Novartis Ag	Organic compounds
CA2595986A1 (fr) *	2005-01-28	2006-08-03	Actelion Pharmaceuticals Ltd	Acide 7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.31]non-6-ene-6-carboxylique cyclopropyl-(2,3-dimethylbenzyl)amide utilises comme inhibiteurs de la renine pour le traitement de l'hypertension
US7799805B2 (en)	2005-05-27	2010-09-21	Actelion Pharmaceuticals Ltd.	Piperidine carboxylic acid amide derivatives
GB0514203D0 (en)	2005-07-11	2005-08-17	Novartis Ag	Organic compounds
NZ569135A (en)	2005-12-30	2011-08-26	Novartis Ag	3,5-Substituted piperidine compounds as renin inhibitors
KR20080091273A (ko) *	2006-02-02	2008-10-09	액테리온 파마슈티칼 리미티드	레닌 저해제로서의 2차 아민
CL2007000595A1 (es) *	2006-03-08	2008-01-04	Actelion Pharmaceuticals Ltd	Compuestos derivados de piperidina; composicion farmaceutica y uso para el tratamiento y/o profilaxis de enfermedades seleccionadas entre hipertension, insuficiencia cardiaca congestiva e insuficiencia renal entre otras.
CA2688057A1 (fr)	2007-05-24	2008-11-27	Merck Frosst Canada Ltd.	Nouveaux inhibiteurs de rhenine
WO2009000811A1 (fr)	2007-06-25	2008-12-31	Novartis Ag	Composés organiques
EP2190811B1 (fr)	2007-08-20	2013-08-07	Merck Canada Inc.	Inhibiteurs de la rénine
NZ589019A (en)	2008-05-05	2012-10-26	Merck Frosst Canada Ltd	3, 4 - substituted piperidine derivatives as renin inhibitors
CN109721613B (zh) *	2017-10-27	2021-07-30	四川科伦博泰生物医药股份有限公司	含季铵离子的大环酰胺化合物及其药物组合物和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3509161A (en)	1967-07-10	1970-04-28	Boehringer & Soehne Gmbh	3-phenyl-granatene-(2)-derivatives
GB9020927D0 (en)	1990-09-26	1990-11-07	Beecham Group Plc	Pharmaceuticals
US5268361A (en) *	1991-06-07	1993-12-07	Sri International	Hydroxyazido derivatives and related compounds as renin inhibitors
US5374719A (en) *	1993-06-04	1994-12-20	Eli Lilly And Company	Process for converting loracarbef dihydrate to loracarbef monohydrate
PL193686B1 (pl)	1995-09-07	2007-03-30	Hoffmann La Roche	Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych
EP0966464B1 (fr)	1997-03-03	2003-05-28	Basilea Pharmaceutica AG	2,4,-diaminopyrimidines substitues
US20060223795A1 (en) *	2003-05-02	2006-10-05	Oliver Bezencon	Novel diazabicyclononene derivatives
CA2547547A1 (fr) *	2003-12-05	2005-06-16	Actelion Pharmaceuticals Ltd	Derives de diazabicyclononene et leur utilisation en tant qu'inhibiteurs de la renine

2003
- 2003-04-08 CA CA2483241A patent/CA2483241C/fr not_active Expired - Fee Related
- 2003-04-08 WO PCT/EP2003/003721 patent/WO2003093267A1/fr not_active Ceased
- 2003-04-08 AU AU2003233963A patent/AU2003233963B2/en not_active Ceased
- 2003-04-08 EP EP03727287A patent/EP1501830B1/fr not_active Expired - Lifetime
- 2003-04-08 US US10/513,103 patent/US7427613B2/en not_active Expired - Fee Related
- 2003-04-08 BR BR0309498-7A patent/BR0309498A/pt not_active IP Right Cessation
- 2003-04-08 PL PL03372141A patent/PL372141A1/xx not_active Application Discontinuation
- 2003-04-08 HR HR20041132A patent/HRP20041132A2/xx not_active Application Discontinuation
- 2003-04-08 AT AT03727287T patent/ATE527261T1/de not_active IP Right Cessation
- 2003-04-08 RU RU2004134320/04A patent/RU2343153C2/ru not_active IP Right Cessation
- 2003-04-08 JP JP2004501406A patent/JP4041123B2/ja not_active Expired - Fee Related
- 2003-04-08 ES ES03727287T patent/ES2372931T3/es not_active Expired - Lifetime
- 2003-04-08 IL IL16476703A patent/IL164767A0/xx unknown
- 2003-04-08 CN CNA038097664A patent/CN1649870A/zh active Pending
- 2003-04-08 KR KR1020047016845A patent/KR100783863B1/ko not_active Expired - Fee Related
- 2003-04-08 MX MXPA04010608A patent/MXPA04010608A/es not_active Application Discontinuation
- 2003-04-08 NZ NZ536750A patent/NZ536750A/xx unknown
- 2003-08-04 UA UA20041109469A patent/UA80821C2/uk unknown
- 2003-10-10 CL CL200302042A patent/CL2003002042A1/es unknown
- 2003-10-23 TW TW092129421A patent/TW200514786A/zh unknown
2004
- 2004-10-13 ZA ZA200408283A patent/ZA200408283B/xx unknown
- 2004-10-22 CO CO04106347A patent/CO5631443A2/es not_active Application Discontinuation
- 2004-10-22 EC EC2004005378A patent/ECSP045378A/es unknown
- 2004-10-22 MA MA27914A patent/MA27305A1/fr unknown
- 2004-11-19 NO NO20045042A patent/NO20045042L/no not_active Application Discontinuation
- 2004-11-22 IS IS7545A patent/IS7545A/is unknown
2008
- 2008-07-07 US US12/168,666 patent/US20080312242A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2003233963B2 (en)	2008-09-11
EP1501830A1 (fr)	2005-02-02
ATE527261T1 (de)	2011-10-15
JP2005527602A (ja)	2005-09-15
CA2483241A1 (fr)	2003-11-13
ECSP045378A (es)	2004-11-26
RU2343153C2 (ru)	2009-01-10
UA80821C2 (en)	2007-11-12
IL164767A0 (en)	2005-12-18
WO2003093267A1 (fr)	2003-11-13
CO5631443A2 (es)	2006-04-28
ZA200408283B (en)	2006-05-31
NZ536750A (en)	2007-02-23
TW200514786A (en)	2005-05-01
US20050176700A1 (en)	2005-08-11
MXPA04010608A (es)	2004-12-13
CN1649870A (zh)	2005-08-03
US20080312242A1 (en)	2008-12-18
NO20045042L (no)	2004-11-19
AU2003233963A1 (en)	2003-11-17
EP1501830B1 (fr)	2011-10-05
ES2372931T3 (es)	2012-01-27
KR100783863B1 (ko)	2007-12-10
IS7545A (is)	2004-11-22
PL372141A1 (en)	2005-07-11
CA2483241C (fr)	2011-05-31
BR0309498A (pt)	2005-02-15
HRP20041132A2 (en)	2006-07-31
JP4041123B2 (ja)	2008-01-30
RU2004134320A (ru)	2005-08-27
US7427613B2 (en)	2008-09-23
KR20040101546A (ko)	2004-12-02
CL2003002042A1 (es)	2005-02-04

Publication	Publication Date	Title
HRP20041132A2 (en)	2006-07-31	7-aryl-3, 9-diazabicyclo (3.3.1) non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
MA27556A1 (fr)	2005-10-03	Derives de phenylalanine comme inhibiteurs de la dipeptidyl peptidase pour le traitement ou la prevention du diabete
EA200300713A1 (ru)	2004-02-26	Производные бензимидазола и пиридилимидазола в качестве лигандов рецепторов гамма-аминомасляной кислоты
EP1784188A4 (fr)	2009-06-24	Derives de triazole accoles inhibiteurs de la dipeptidyl peptidase-iv utilises dans le traitement ou la prevention du diabete
NO20053645L (no)	2002-10-22	(4R)- og (4S)-diastereoisomerer av (2S)-2-[ 2-oksy-4-propylpyrrolidinyl]butanamid og farmasoytisk preparat inneholdende disse
ATE286500T1 (de)	2005-01-15	1,2,3,4-tetrahydroisochinolin-derivate
MY140488A (en)	2009-12-31	Substituted oxazolidinones and their use in the field of blood coagulation
NO20051102L (no)	2005-05-04	Sulfonylamino-eddiksyre-derivater
TW200514772A (en)	2005-05-01	Novel tetrahydropyridine derivatives
MA30333B1 (fr)	2009-04-01	Aminotetrahydropyranes utiles en tant qu'inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete.
EP1490335A4 (fr)	2006-02-08	Inhibiteurs de la dipeptidyl peptidase beta-amino heterocycliques pour le traitement ou la prevention du diabete
WO2005032471A3 (fr)	2005-07-07	Inhibiteurs de type benzylether et benzylamino de beta-secretase pour le traitement de la maladie d'alzheimer
EP1721609A3 (fr)	2007-01-31	Dérivés de pyridylpyrimidine utilisés comme composés actifs contre des infections et des maladies à prions
BRPI0406801B8 (pt)	2021-05-25	derivados de tieno-pirimidinodiona e uso dos mesmos na modulação de doenças autoimunes
EP1689713A4 (fr)	2009-02-18	Inhibiteurs de benzylether et benzylamino de beta-secretase pour traiter la maladie d'alzheimer
MA30313B1 (fr)	2009-04-01	Amines secondaires en tant qu'inhibiteurs de la renine
MXPA05011496A (es)	2005-12-15	Derivados de azabiciclononeno.
WO2005030209A8 (fr)	2006-05-11	Derives de pyridine et leur utilisation comme antagonistes de l'urotensine ii
MA30292B1 (fr)	2009-03-02	Amines primaires comme inhibiteurs de la renine
MXPA05011497A (es)	2005-12-15	Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace).
MXPA04001773A (es)	2004-05-31	Derivados de 6,7-dihidroxitetrahidroisquinolinas 3-sustituidas parta uso como agentes antibacterianos.
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