MA27309A1 - Comprimes orodispersibles et processus pour les obtenir - Google Patents

Comprimes orodispersibles et processus pour les obtenir

Info

Publication number
MA27309A1
MA27309A1 MA27981A MA27981A MA27309A1 MA 27309 A1 MA27309 A1 MA 27309A1 MA 27981 A MA27981 A MA 27981A MA 27981 A MA27981 A MA 27981A MA 27309 A1 MA27309 A1 MA 27309A1
Authority
MA
Morocco
Prior art keywords
weight
particle size
mixing
active ingredient
tablets
Prior art date
Application number
MA27981A
Other languages
English (en)
Inventor
Ferran Javier Segado
Original Assignee
Vita Cientifica S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29724735&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA27309(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vita Cientifica S L filed Critical Vita Cientifica S L
Publication of MA27309A1 publication Critical patent/MA27309A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Les comprimés comprennent: au moins 59,5% de mannitol séché par atomisation; l'ingrédient actif inférieur ou égal à 10%, oé au moins 90% en poids de l'ingrédient actif a une dimension particulaire de moins de 100 Ám; de la cellulose microcristalline 10-18%, ayant une dimension particulaire moyenne de 50 Ám et oé au moins 99% en poids de la cellulose microcristalline ont une dimension particulaire au-dessous de 250 Ám; de la croscarmellose de sodium 1-4%; et un agent lubrifiant 0,5-2%; oé, sauf indication contraire, les pourcentages sont exprimés en poids du poids total du comprimé. Et aussi un processus comprenant: le tamisage et le mélange des composants à l'exception de l'agent lubrifiant; le mélange de tous les composants; et la compression directe du mélange final. Les comprimés de l'invention diminuent les temps de désagrégation, donnent une bonne perception sur la langue après la désagrégation, et surmontent le problème de la résistance mécanique insuffisante pour les opérations d'emballage et de transport.
MA27981A 2002-06-10 2004-12-06 Comprimes orodispersibles et processus pour les obtenir MA27309A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200201440A ES2199061B1 (es) 2002-06-10 2002-06-10 Comprimidos bucodispersables y procedimiento para su obtencion.

Publications (1)

Publication Number Publication Date
MA27309A1 true MA27309A1 (fr) 2005-05-02

Family

ID=29724735

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27981A MA27309A1 (fr) 2002-06-10 2004-12-06 Comprimes orodispersibles et processus pour les obtenir

Country Status (32)

Country Link
US (1) US20060165781A1 (fr)
EP (1) EP1534237B1 (fr)
JP (1) JP2005533045A (fr)
KR (1) KR100826819B1 (fr)
CN (1) CN100428926C (fr)
AR (1) AR040183A1 (fr)
AT (1) ATE422154T1 (fr)
AU (1) AU2003232415B2 (fr)
BR (1) BR0311708A (fr)
CA (1) CA2487834C (fr)
CY (1) CY1108961T1 (fr)
DE (1) DE60326074D1 (fr)
DK (1) DK1534237T3 (fr)
EG (1) EG25919A (fr)
ES (2) ES2199061B1 (fr)
HR (1) HRP20041158B1 (fr)
IL (1) IL165523A (fr)
JO (1) JO2560B1 (fr)
MA (1) MA27309A1 (fr)
MX (1) MXPA04012464A (fr)
MY (1) MY139585A (fr)
NO (1) NO334159B1 (fr)
NZ (1) NZ536966A (fr)
PE (1) PE20040069A1 (fr)
PL (1) PL207009B1 (fr)
PT (1) PT1534237E (fr)
RU (1) RU2321389C2 (fr)
SA (1) SA03240275B1 (fr)
SI (1) SI1534237T1 (fr)
TW (1) TWI288002B (fr)
WO (1) WO2003103629A1 (fr)
ZA (1) ZA200409894B (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7815937B2 (en) 1998-10-27 2010-10-19 Biovail Laboratories International Srl Quick dissolve compositions and tablets based thereon
CA2348452A1 (fr) * 1998-10-27 2000-05-04 Biovail Technologies Ltd. Microparticules contenant du peg et/ou des esters glyceriliques de peg
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20050112196A1 (en) * 2003-10-07 2005-05-26 Jianbo Xie Rapidly disintegrating formulation
ES2238001B1 (es) 2004-01-21 2006-11-01 Vita Cientifica, S.L. Nuevas formas polimorficas de ondansetron, procedimientos para su preparacion, composiciones farmaceuticas que los contienen y su uso como aantiemeticos.
JP2005306770A (ja) * 2004-04-21 2005-11-04 Toa Eiyo Ltd 口腔内速崩壊型製剤及びその製造方法
IS7290A (is) * 2004-05-28 2005-11-29 Actavis Group Lyfjasamsetningar sem innihalda risperidone
DE102004034043A1 (de) * 2004-07-13 2006-02-09 Krka Tovarna Zdravil, D.D. Feste pharmazeutische Zusammensetzung, die Mirtazapin enthält
GB0423800D0 (en) * 2004-10-27 2004-12-01 Orexo Ab New pharmaceutical formulations
WO2006087629A2 (fr) * 2005-02-21 2006-08-24 Aurobindo Pharma Limited Composition de medicament antipsychotique a delitement rapide
TWI383809B (zh) * 2005-06-29 2013-02-01 Otsuka Pharma Co Ltd 含有西洛他唑（ｃｉｌｏｓｔａｚｏｌ）之口腔崩解粉末
US20070092586A1 (en) * 2005-10-26 2007-04-26 Alamo Pharmaceuticals Compositions and methods for the administration psychotropic drugs which modulate body weight
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US7811604B1 (en) 2005-11-14 2010-10-12 Barr Laboratories, Inc. Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same
CN100457100C (zh) * 2005-12-23 2009-02-04 北京科信必成医药科技发展有限公司 甲氧氯普胺口腔崩解片及其生产方法
CN100360128C (zh) * 2005-12-23 2008-01-09 北京科信必成医药科技发展有限公司 石杉碱甲口腔崩解片及其制备方法
EP1852108A1 (fr) * 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG Compositions d'inhibiteurs de la DPP IV
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
BRPI0711558A2 (pt) 2006-05-04 2011-11-08 Boeringer Ingelheim Internat Gmbh polimorfos
US20080254118A1 (en) * 2007-04-11 2008-10-16 Hans-Werner Wernersbach Process for preparing pramipexole dihydrochloride tablets
DE602007011792D1 (de) * 2006-10-27 2011-02-17 Fmc Corp Gemeinsam aufbereitete mikrokristalline cellulose und zuckeralkohol als hilfsstoff für tablettenformulierungen
US20080254117A1 (en) * 2007-04-10 2008-10-16 Noel Cotton Process for preparing pramipexole dihydrochloride tablets
TWI547282B (zh) * 2007-07-02 2016-09-01 愛戴爾製藥股份有限公司 樂命達之口服分解錠劑組合物
EP2572705B1 (fr) * 2007-10-01 2017-09-13 Laboratorios Lesvi, S.L. Comprimés orodispersibles
DK3354276T3 (da) 2007-11-13 2020-03-30 Meritage Pharma Inc Sammensætninger til behandlingen af gastrointestinal inflammation
EP2257177A4 (fr) * 2007-11-14 2012-07-11 Manuel Gidekel Nouveaux extraits de deschampsia antarctica desv. dotés d'une activité antinéoplasique
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
EP2299982B1 (fr) 2008-06-20 2018-04-04 Merck Patent GmbH Matrice pour comprimé directement compressible et à désintégration rapide
FR2933299B1 (fr) 2008-07-04 2012-02-03 Roquette Freres Mannitol orodispersible
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
KR101033975B1 (ko) * 2008-10-10 2011-05-11 이희엽 직접압축법을 이용한 발사르탄 함유 고형 경구 제형의 제조방법 및 이에 따라 제조된 고형 경구 제형
EP2198857A1 (fr) 2008-12-19 2010-06-23 Ratiopharm GmbH Comprimé dispersible oral
DE102009016584A1 (de) * 2009-04-06 2010-10-07 Ratiopharm Gmbh Schmelztablette, enthaltend ein Sildenafil-Salz
CN101874790B (zh) * 2009-04-29 2012-06-06 齐鲁制药有限公司 雷沙吉兰或者其药用盐口腔崩解片及其制备方法
CN101904824B (zh) * 2009-06-04 2012-07-18 齐鲁制药有限公司 奥氮平口崩片制剂及其制备方法
EP2440210A4 (fr) 2009-06-12 2014-01-29 Meritage Pharma Inc Procédés de traitement de troubles gastro-intestinaux
US20110105441A1 (en) * 2009-10-30 2011-05-05 Fmc Corporation Stable Orally Disintegrating Tablets Having Low Superdisintegrant
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
WO2011087705A2 (fr) * 2009-12-22 2011-07-21 Fmc Corporation Croscarmellose à particules fines et utilisations associées
WO2011138797A2 (fr) 2010-05-04 2011-11-10 Cadila Healthcare Limited Composition pharmaceutique de lansoprazole à action différée se désintégrant par la voie buccale
MX341025B (es) 2010-05-05 2016-08-04 Boehringer Ingelheim Int Gmbh * Terapia de combinacion.
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
WO2013174767A1 (fr) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh Dérivé de xanthine en tant qu'inhibiteur de la dpp-4 à utiliser dans la modification de l'apport alimentaire et dans la régulation des préférences alimentaires
JP6084826B2 (ja) * 2012-11-27 2017-02-22 古河産機システムズ株式会社 造粒物検査装置および造粒物の検査方法
KR101545268B1 (ko) 2015-02-05 2015-08-20 보령제약 주식회사 정제 및 이의 제조방법
WO2016126012A1 (fr) * 2015-02-05 2016-08-11 Boryung Pharmaceutical Co., Ltd Comprimé et procédé de préparation associé
CN108136035A (zh) * 2015-09-04 2018-06-08 株式会社大赛璐 超速崩解片剂及其制备方法
CN107789328B (zh) * 2016-09-07 2021-02-26 成都康弘药业集团股份有限公司 一种含有盐酸多奈哌齐的口崩片及其制备方法
KR102290312B1 (ko) 2017-04-10 2021-08-17 주식회사 엘지생활건강 정제 조성물 및 이의 제조방법
WO2019004155A1 (fr) * 2017-06-27 2019-01-03 第一三共株式会社 Comprimé
AU2020407163A1 (en) * 2019-12-16 2022-07-21 Minute Molecular Diagnostics, Inc. Lyophilized reagents
CN113730365A (zh) * 2021-08-10 2021-12-03 杭州新诺华医药有限公司 一种奥氮平口腔崩解片及其制备方法
CN114224855B (zh) * 2021-12-01 2023-11-28 北京悦康科创医药科技股份有限公司 一种甲磺酸多沙唑嗪口含片及其制备方法
GB2627294A (en) * 2023-02-20 2024-08-21 Novumgen Ltd A fast-disintegrating tablet of bisoprolol or pharmaceutically acceptable salts thereof and its process of preparation
CN116251067B (zh) * 2023-04-23 2024-06-07 淄博市中心医院 一种氟康唑片、制备方法及用途
CN116919910A (zh) * 2023-07-30 2023-10-24 南京百思福医药科技有限公司 一种含β-烟酰胺单核苷酸的咀嚼片及其制备工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0830005B2 (ja) * 1985-09-25 1996-03-27 ゲルゲリイ、ゲルハルト 崩壊性錠剤とその製造方法
IT1238072B (it) * 1990-01-19 1993-07-03 Sclavo Spa Composizioni farmaceutiche e forme di dosaggio per la somministrazione orale di calcitonina
FR2710637B1 (fr) * 1993-09-28 1995-12-08 Roquette Freres Mannitol pulvérulent de friabilité modérée et son procédé de préparation.
FR2722408B1 (fr) * 1994-07-15 1996-10-04 Vacher Dominique Nouveau procede de realisation de formes pharmaceutiques seches a delitement quasiment instantane etles formes pharmaceutiques ainsi realisees
US5686107A (en) * 1995-01-30 1997-11-11 Fmc Corporation Chewable pharmaceutical tablets
US6024981A (en) * 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
JPH10298062A (ja) * 1997-04-24 1998-11-10 Pfizer Pharmaceut Co Ltd 口腔内速溶型錠剤
US5904937A (en) * 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
SE9803240D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
AU3574500A (en) * 1999-03-25 2000-10-16 Yuhan Corporation Rapidly disintegrable tablet for oral administration
JP2001058944A (ja) * 1999-06-18 2001-03-06 Takeda Chem Ind Ltd 速崩壊性固形製剤
CA2374760A1 (fr) * 1999-06-18 2000-12-28 Takeda Chemical Industries, Ltd. Preparations solides a desintegration rapide
TR200200313T2 (tr) * 1999-08-17 2002-04-22 Novartis Consumer Health S.A. Hızla çözünen dozaj formu ve bunun yapım prosesi.
CA2342121C (fr) * 2000-03-29 2010-05-25 Roquette Freres Mannitol pulverulent et son procede de preparation

Also Published As

Publication number Publication date
US20060165781A1 (en) 2006-07-27
EP1534237B1 (fr) 2009-02-04
ES2320753T3 (es) 2009-05-28
PL374197A1 (en) 2005-10-03
CN1658838A (zh) 2005-08-24
MY139585A (en) 2009-10-30
CN100428926C (zh) 2008-10-29
DE60326074D1 (de) 2009-03-19
DK1534237T3 (da) 2009-05-04
ES2199061A1 (es) 2004-02-01
TW200403080A (en) 2004-03-01
NZ536966A (en) 2006-08-31
HK1076252A1 (zh) 2006-01-13
NO334159B1 (no) 2013-12-23
WO2003103629A1 (fr) 2003-12-18
ZA200409894B (en) 2006-05-31
EG25919A (en) 2012-10-15
HRP20041158B1 (en) 2012-11-30
CA2487834A1 (fr) 2003-12-18
AU2003232415A1 (en) 2003-12-22
HRP20041158A2 (en) 2005-04-30
AR040183A1 (es) 2005-03-16
NO20045577L (no) 2004-12-21
IL165523A0 (en) 2006-01-15
MXPA04012464A (es) 2005-06-08
RU2321389C2 (ru) 2008-04-10
AU2003232415B2 (en) 2008-05-15
SI1534237T1 (sl) 2009-06-30
TWI288002B (en) 2007-10-11
PT1534237E (pt) 2009-05-05
ATE422154T1 (de) 2009-02-15
BR0311708A (pt) 2005-03-15
KR20050062467A (ko) 2005-06-23
ES2199061B1 (es) 2005-02-16
IL165523A (en) 2011-07-31
KR100826819B1 (ko) 2008-05-02
CA2487834C (fr) 2009-07-14
SA03240275B1 (ar) 2008-11-19
PL207009B1 (pl) 2010-10-29
JO2560B1 (en) 2010-09-05
CY1108961T1 (el) 2014-07-02
EP1534237A1 (fr) 2005-06-01
JP2005533045A (ja) 2005-11-04
PE20040069A1 (es) 2004-03-25
RU2004135377A (ru) 2005-09-10

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