MA27472A1 - Acetyle 2-hydroxy-1, 3 diaminoalcanes - Google Patents

Acetyle 2-hydroxy-1, 3 diaminoalcanes

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Publication number
MA27472A1
MA27472A1 MA28202A MA28202A MA27472A1 MA 27472 A1 MA27472 A1 MA 27472A1 MA 28202 A MA28202 A MA 28202A MA 28202 A MA28202 A MA 28202A MA 27472 A1 MA27472 A1 MA 27472A1
Authority
MA
Morocco
Prior art keywords
diaminoalcanes
acetyle
hydroxy
beta
compounds
Prior art date
Application number
MA28202A
Other languages
English (en)
Inventor
Michel Maillard
Eric T Baldwin
James T Beck
Robert Hughes
Varghese John
Shon R Pulley
Ruth Tenbrink
Original Assignee
Elan Pharm Inc
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, Pharmacia & Upjohn Co Llc filed Critical Elan Pharm Inc
Publication of MA27472A1 publication Critical patent/MA27472A1/fr

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    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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Abstract

Sont divulgués les composés de formule: oé les variables Z, X, R15, R2, R3 et Rc sont définies dans la présente. Les composés divulgués dans la présente sont des inhibiteurs de l'enzyme de bêta-sécrétase et sont, par conséquent, utiles pour le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par un dépôt de peptide bêta-amyloïde chez un mammifère
MA28202A 2002-09-10 2005-04-06 Acetyle 2-hydroxy-1, 3 diaminoalcanes MA27472A1 (fr)

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AR043679A1 (es) 2005-08-10
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US7645780B2 (en) 2010-01-12
PL376511A1 (pl) 2006-01-09
AU2003267132A1 (en) 2004-04-30
JP2006504793A (ja) 2006-02-09
UY27967A1 (es) 2004-05-31
MXPA05002695A (es) 2005-09-08
KR20060057520A (ko) 2006-05-26
TWI336320B (en) 2011-01-21
US20100145056A1 (en) 2010-06-10
GEP20074166B (en) 2007-07-25
EA200500472A1 (ru) 2005-10-27
US7244725B2 (en) 2007-07-17
TW200417534A (en) 2004-09-16
EP1565443A2 (fr) 2005-08-24
PE20041079A1 (es) 2005-02-05
IS7732A (is) 2005-03-09
ECSP055696A (es) 2005-07-06
US20040180939A1 (en) 2004-09-16
EP1565443A4 (fr) 2007-07-18
OA12919A (en) 2006-10-13
EA009196B1 (ru) 2007-12-28
WO2004024081A2 (fr) 2004-03-25
JP2011084568A (ja) 2011-04-28
US20070293483A1 (en) 2007-12-20
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