MA27482A1 - Piperazines, (1,4) diazepines, et 2,5-diazabicyclo (2.2.1) heptanes substitues en tant qu'antagonistes de l'histamine h1 et/ou h3 ou antagonistes inverses de l'histamine h3 - Google Patents

Piperazines, (1,4) diazepines, et 2,5-diazabicyclo (2.2.1) heptanes substitues en tant qu'antagonistes de l'histamine h1 et/ou h3 ou antagonistes inverses de l'histamine h3

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Publication number
MA27482A1
MA27482A1 MA28246A MA28246A MA27482A1 MA 27482 A1 MA27482 A1 MA 27482A1 MA 28246 A MA28246 A MA 28246A MA 28246 A MA28246 A MA 28246A MA 27482 A1 MA27482 A1 MA 27482A1
Authority
MA
Morocco
Prior art keywords
antagonists
histamine
diazepines
heptanes
piperazines
Prior art date
Application number
MA28246A
Other languages
English (en)
Inventor
Ancliff Rachael
Colin David Eldred
Yvonne C Fogden
Ashley Paul Hancock
Thomas Daniel Heightman
Heather Hobbs
Simon Teanby Hodgson
Matthew J Lindon
David Matthew Wilson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA27482A1 publication Critical patent/MA27482A1/fr

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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Abstract

La présente invention a trait à de nouveaux dérivés de pipérazine et d'azépine présentant une activité pharmacologique, leurs procédés de préparation, des compositions les contenant et leur utilisation dans le traitement de troubles neurodégénératifs y compris la maladie d'Alzheimer.
MA28246A 2002-10-16 2005-04-29 Piperazines, (1,4) diazepines, et 2,5-diazabicyclo (2.2.1) heptanes substitues en tant qu'antagonistes de l'histamine h1 et/ou h3 ou antagonistes inverses de l'histamine h3 MA27482A1 (fr)

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GBGB0224084.4A GB0224084D0 (en) 2002-10-16 2002-10-16 Novel compounds

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MA28246A MA27482A1 (fr) 2002-10-16 2005-04-29 Piperazines, (1,4) diazepines, et 2,5-diazabicyclo (2.2.1) heptanes substitues en tant qu'antagonistes de l'histamine h1 et/ou h3 ou antagonistes inverses de l'histamine h3

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CN (2) CN100400523C (fr)
AU (1) AU2003280380A1 (fr)
BR (1) BR0315283A (fr)
CA (1) CA2502249A1 (fr)
GB (1) GB0224084D0 (fr)
IS (1) IS7782A (fr)
MA (1) MA27482A1 (fr)
MX (1) MXPA05004078A (fr)
NO (1) NO20051689L (fr)
NZ (2) NZ539446A (fr)
PL (1) PL376477A1 (fr)
RU (1) RU2328494C2 (fr)
WO (1) WO2004035556A1 (fr)
ZA (2) ZA200502873B (fr)

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AU2003280380A1 (en) 2004-05-04
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RU2005110061A (ru) 2006-01-20
JP2007016041A (ja) 2007-01-25
GB0224084D0 (en) 2002-11-27
IS7782A (is) 2005-03-31
PL376477A1 (en) 2005-12-27
NZ539446A (en) 2006-11-30
JP2006508935A (ja) 2006-03-16
EP1567511A1 (fr) 2005-08-31
US7615550B2 (en) 2009-11-10
WO2004035556A1 (fr) 2004-04-29
MXPA05004078A (es) 2005-06-08
RU2328494C2 (ru) 2008-07-10
NO20051689L (no) 2005-07-07
KR20050049553A (ko) 2005-05-25
US20100075953A1 (en) 2010-03-25
NZ549963A (en) 2008-03-28
CN101070309A (zh) 2007-11-14
BR0315283A (pt) 2005-08-30
CA2502249A1 (fr) 2004-04-29
US20060025404A1 (en) 2006-02-02
NO20051689D0 (no) 2005-04-05
ZA200603604B (en) 2007-04-25
CN100400523C (zh) 2008-07-09

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