MA27677A1 - Azoles, procedes pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation - Google Patents
Azoles, procedes pour leur preparation, compositions pharmaceutiques les contenant et leur utilisationInfo
- Publication number
- MA27677A1 MA27677A1 MA25480A MA25480A MA27677A1 MA 27677 A1 MA27677 A1 MA 27677A1 MA 25480 A MA25480 A MA 25480A MA 25480 A MA25480 A MA 25480A MA 27677 A1 MA27677 A1 MA 27677A1
- Authority
- MA
- Morocco
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- formula
- compositions containing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003851 azoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 150000007980 azole derivatives Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Azoles, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur utilisation L'invention décrit des dérivés de type azole de formule I dans laquelle R14 et R15 représentent chacun indépendamment un atome d'hydrogène ou de fluor, T est un groupe de formule ou formules dans lesquelles R9 est un groupe pyrrolidinyle ou A-NH-B- ; A est un atome d'hydrogène ou un groupe alkyle en C1-C5 à chaîne droite ou ramifiée; B est un groupe alkylène en C1-C4 à chaîne droite ou ramifiée, -CH2-CONH-CH2 ou -CH2CH2CH2-CH(NH2); et X- est un anion pharmaceutiquement acceptable ; et les sels pharmaceutiquement acceptables de tels composés et les hydrates et produits de solvatation des composés de formule I et de leurs sels, des procédés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation dans la fabrication de médicaments destinés au traitement d'infections fongiques et de mycoses.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98104036 | 1998-03-06 | ||
| EP98123310 | 1998-12-08 | ||
| EP99101360 | 1999-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27677A1 true MA27677A1 (fr) | 2006-01-02 |
Family
ID=27239027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA25480A MA27677A1 (fr) | 1998-03-06 | 1999-03-02 | Azoles, procedes pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6300353B1 (fr) |
| AR (1) | AR018303A1 (fr) |
| AU (1) | AU2931399A (fr) |
| MA (1) | MA27677A1 (fr) |
| PE (1) | PE20000328A1 (fr) |
| WO (1) | WO1999045008A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1185230C (zh) * | 1999-11-02 | 2005-01-19 | 巴斯利尔药物股份公司 | N－取代的氨基甲酰氧基烷基－吡咯鎓衍生物 |
| US6812238B1 (en) | 1999-11-02 | 2004-11-02 | Basilea Pharmaceutica Ag | N-substituted carbamoyloxyalkyl-azolium derivatives |
| HUP0303249A3 (en) | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
| CA2822457C (fr) | 2001-12-14 | 2016-03-08 | The University Of Wyoming | Methodes et compositions de liberation controlee de medicaments |
| US7582781B2 (en) | 2003-07-18 | 2009-09-01 | Kaneka Corporation | Optically active halohydrin derivative and process for producing optically active epoxy alcohol derivative from the same |
| JP4404611B2 (ja) * | 2003-11-27 | 2010-01-27 | 住友化学株式会社 | エポキシトリアゾール化合物の製造方法及びその中間体 |
| DE102004059725A1 (de) | 2004-12-11 | 2006-06-22 | Bayer Cropscience Ag | 2-Alkyl-cycloalk(en)yl-carboxamide |
| SI1954264T1 (sl) * | 2005-12-01 | 2010-01-29 | Basilea Pharmaceutica Ag | Postopek priprave intermediatov epoksibutanola |
| JP5576279B2 (ja) | 2007-08-21 | 2014-08-20 | バジリア ファルマスーチカ アーゲー | 抗真菌組成物 |
| US8207352B2 (en) * | 2009-10-08 | 2012-06-26 | Drug Process Licensing Associates LLC | Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole |
| CA2878361C (fr) | 2012-08-07 | 2020-09-22 | Basilea Pharmaceutica Ag | Procede pour la fabrication d'isavuconazole ou ravuconazole |
| WO2015150947A1 (fr) * | 2014-03-29 | 2015-10-08 | Wockhardt Limited | Procédé de préparation de l'isavuconazole et de ses intermédiaires |
| WO2016055918A1 (fr) | 2014-10-08 | 2016-04-14 | Wockhardt Limited | Nouveaux polymorphes stables d'isavuconazole ou de son sel |
| CN106565699B (zh) * | 2015-10-10 | 2019-07-26 | 江苏正大丰海制药有限公司 | 一种艾沙康唑硫酸盐晶体及其制备方法 |
| CN105367528A (zh) * | 2015-11-10 | 2016-03-02 | 南通诺泰生物医药技术有限公司 | 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法 |
| CN105777740B (zh) * | 2016-02-24 | 2018-03-27 | 苏州金点生物科技有限公司 | 一种艾沙康唑的制备方法 |
| WO2018149359A1 (fr) * | 2017-02-17 | 2018-08-23 | 武汉朗来科技发展有限公司 | Dérivé antibactérien de triazole, composition pharmaceutique et utilisation associées |
| CN108558846B (zh) * | 2018-05-17 | 2020-07-07 | 天津莱茵泰克生物科技有限公司 | 艾莎康唑中间体的合成方法及其应用 |
| CN110498774A (zh) * | 2018-05-18 | 2019-11-26 | 上海医药工业研究院 | 一种艾沙康唑中间体的制备方法 |
| WO2021245590A1 (fr) * | 2020-06-04 | 2021-12-09 | Metrochem Api Private Limited | Procédé amélioré pour la préparation de dérivés de triazole |
| CN115215850B (zh) * | 2021-04-19 | 2024-08-16 | 同济大学 | 一种四氮唑醇类化合物、制备方法以及一种抗真菌药物 |
| JP7454905B2 (ja) * | 2021-09-28 | 2024-03-25 | 旭化成ファーマ株式会社 | 有効成分であるイサブコナゾール又はそのプロドラッグを含有する真菌症治療及び／又は予防剤 |
| TW202541814A (zh) | 2023-11-30 | 2025-11-01 | 瑞士商巴塞利亞阿爾斯維爾藥業國際股份有限公司 | 用於治療真菌感染的藥物組合 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861879A (en) | 1983-02-28 | 1989-08-29 | Janssen Pharmaceutica N.V. | [[4-[4-Phenyl-1-piperazinyl)phenoxymethyl]-1-3-dioxolan-2-yl]-methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| GB9107055D0 (en) * | 1991-04-04 | 1991-05-22 | Pfizer Ltd | Triazole antifungal agents |
| NZ270418A (en) * | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
| NZ328607A (en) | 1996-09-09 | 1999-08-30 | Hoffmann La Roche | Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions |
| AU726495B2 (en) * | 1996-09-09 | 2000-11-09 | F. Hoffmann-La Roche Ag | N-benzylazolium derivatives |
-
1999
- 1999-03-01 AU AU29313/99A patent/AU2931399A/en not_active Abandoned
- 1999-03-01 WO PCT/EP1999/001327 patent/WO1999045008A1/fr not_active Ceased
- 1999-03-02 MA MA25480A patent/MA27677A1/fr unknown
- 1999-03-02 PE PE1999000171A patent/PE20000328A1/es not_active Application Discontinuation
- 1999-03-04 AR ARP990100912A patent/AR018303A1/es active IP Right Grant
- 1999-03-05 US US09/263,027 patent/US6300353B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2931399A (en) | 1999-09-20 |
| PE20000328A1 (es) | 2000-05-08 |
| US6300353B1 (en) | 2001-10-09 |
| WO1999045008A1 (fr) | 1999-09-10 |
| AR018303A1 (es) | 2001-11-14 |
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