MA27764A1 - Acides carboxyliques alpha-substitués servant de modulateurs de PPAR - Google Patents

Acides carboxyliques alpha-substitués servant de modulateurs de PPAR

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Publication number
MA27764A1
MA27764A1 MA28552A MA28552A MA27764A1 MA 27764 A1 MA27764 A1 MA 27764A1 MA 28552 A MA28552 A MA 28552A MA 28552 A MA28552 A MA 28552A MA 27764 A1 MA27764 A1 MA 27764A1
Authority
MA
Morocco
Prior art keywords
alpha
carboxylic acids
substituted carboxylic
formula
ppar
Prior art date
Application number
MA28552A
Other languages
English (en)
Inventor
Simon Bailey
Paul Stuart Humphries
Donald James Skalitzky
Wei-Guo Su
Luke Raymond Zehnder
Original Assignee
Pfizer
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Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA27764A1 publication Critical patent/MA27764A1/fr

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07—ORGANIC CHEMISTRY
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    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Acides carboxyliques alpha-substitués servant de modulateurs de PPAR Des acides carboxyliques alpha-substitués de formule (I) dans laquelle R1 et R2 sont tels que définis dans le présent mémoire et R3 répond à A) la formule (II) ; B) la formule (III) ; C) la formule (IV) ; et D) la formule (V) ; dans lesquelles Y, Y", Ar1, Ar2, Ar3, Ar4, R4, R5, R6, R7, R8, R9, R9a, R11, R12, R17, le noyau A et p sont tels que définis dans le présent mémoire ; des compositions pharmaceutiques contenant des quantités efficaces desdits composés ou de leurs sels, sont utiles pour le traitement d'affections en rapport avec PPAR, spécifiquement de troubles en rapport avec PPAR (alpha)/(gamma), tels que le diabète, la dyslipidémie, l'obésité et des troubles inflammatoires.
MA28552A 2003-04-15 2005-10-14 Acides carboxyliques alpha-substitués servant de modulateurs de PPAR MA27764A1 (fr)

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US46321303P 2003-04-15 2003-04-15

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MA27764A1 true MA27764A1 (fr) 2006-02-01

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MA28552A MA27764A1 (fr) 2003-04-15 2005-10-14 Acides carboxyliques alpha-substitués servant de modulateurs de PPAR

Country Status (25)

Country Link
EP (1) EP1615899A1 (fr)
JP (1) JP2006523671A (fr)
KR (1) KR20060009846A (fr)
CN (1) CN1805943A (fr)
AP (1) AP2005003418A0 (fr)
AR (1) AR044514A1 (fr)
AU (1) AU2004230316A1 (fr)
BR (1) BRPI0409429A (fr)
CA (1) CA2521915A1 (fr)
CL (1) CL2004000800A1 (fr)
EA (1) EA200501462A1 (fr)
EC (1) ECSP056105A (fr)
IS (1) IS8033A (fr)
MA (1) MA27764A1 (fr)
MX (1) MXPA05010967A (fr)
NL (1) NL1025946C2 (fr)
NO (1) NO20055370L (fr)
OA (1) OA13157A (fr)
PA (1) PA8600201A1 (fr)
PE (1) PE20050415A1 (fr)
TN (1) TNSN05262A1 (fr)
TW (1) TW200510353A (fr)
UY (1) UY28266A1 (fr)
WO (1) WO2004092145A1 (fr)
ZA (1) ZA200508362B (fr)

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PT1088824E (pt) * 1999-09-30 2004-04-30 Pfizer Prod Inc Pirrolil-amidas biciclicas como inibidores de glicogenio-fosforilase
EP1372632A1 (fr) * 2001-02-15 2004-01-02 Pfizer Products Inc. Composes de recepteurs actives de la proliferation des peroxysomes (ppar)

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AP2005003418A0 (en) 2005-12-31
PA8600201A1 (es) 2005-02-04
NO20055370L (no) 2006-01-12
UY28266A1 (es) 2004-11-30
NL1025946A1 (nl) 2004-10-18
MXPA05010967A (es) 2005-11-28
AR044514A1 (es) 2005-09-14
CL2004000800A1 (es) 2005-03-04
NO20055370D0 (no) 2005-11-14
ZA200508362B (en) 2006-11-29
TW200510353A (en) 2005-03-16
NL1025946C2 (nl) 2005-02-01
EP1615899A1 (fr) 2006-01-18
CN1805943A (zh) 2006-07-19
AU2004230316A1 (en) 2004-10-28
WO2004092145A1 (fr) 2004-10-28
PE20050415A1 (es) 2005-06-13
JP2006523671A (ja) 2006-10-19
CA2521915A1 (fr) 2004-10-28
OA13157A (en) 2006-12-13
EA200501462A1 (ru) 2006-04-28
WO2004092145A8 (fr) 2005-05-12
BRPI0409429A (pt) 2006-04-18
KR20060009846A (ko) 2006-02-01
ECSP056105A (es) 2006-03-01
TNSN05262A1 (fr) 2007-07-10

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