MA28117A1 - Procédé pour la préparation de composés hétérocycliques à substitution N-amino - Google Patents
Procédé pour la préparation de composés hétérocycliques à substitution N-aminoInfo
- Publication number
- MA28117A1 MA28117A1 MA28977A MA28977A MA28117A1 MA 28117 A1 MA28117 A1 MA 28117A1 MA 28977 A MA28977 A MA 28977A MA 28977 A MA28977 A MA 28977A MA 28117 A1 MA28117 A1 MA 28117A1
- Authority
- MA
- Morocco
- Prior art keywords
- propylidene
- amine
- indol
- hydrogen
- integer
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- NZVNTPKKKIVEOY-UHFFFAOYSA-N n-(1h-carbazol-1-yl)propan-1-imine Chemical compound C1=CC=C2C3=CC=CC(N=CCC)C3=NC2=C1 NZVNTPKKKIVEOY-UHFFFAOYSA-N 0.000 abstract 1
- HAPDTGGOWRVVKA-UHFFFAOYSA-N n-(3-methylindol-1-yl)propan-1-imine Chemical compound C1=CC=C2N(N=CCC)C=C(C)C2=C1 HAPDTGGOWRVVKA-UHFFFAOYSA-N 0.000 abstract 1
- PIEUYICYHSQDHD-UHFFFAOYSA-N n-(5-methoxyindol-1-yl)propan-1-imine Chemical compound COC1=CC=C2N(N=CCC)C=CC2=C1 PIEUYICYHSQDHD-UHFFFAOYSA-N 0.000 abstract 1
- WHWBGXUEVLJPSC-UHFFFAOYSA-N n-(5-phenylmethoxyindol-1-yl)propan-1-imine Chemical compound C=1C=C2N(N=CCC)C=CC2=CC=1OCC1=CC=CC=C1 WHWBGXUEVLJPSC-UHFFFAOYSA-N 0.000 abstract 1
- BHUWZHNCPCFHCU-UHFFFAOYSA-N n-indol-1-ylpropan-1-imine Chemical compound C1=CC=C2N(N=CCC)C=CC2=C1 BHUWZHNCPCFHCU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Ceramic Engineering (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
fluoroalkyle ou un fluoroalcoxy de formule CnHxFy ou OCnHxFy où n est un nombre entier de 1 à 4, x est un nombre entier de 0 à 8, y est un nombre entier de 1 à 9 et la somme de x et y vaut 2n+l ; ou R1 et R2 pris ensemble avec les atomes de carbone auxquels ils sont attachés forment un noyau cyclique en Cs-Cg; R3 et R4 sont identiques ou différents et sont chacun indépendamment sélectionnés parmi un hydrogène ou un alkyle en C1-C4; et m vaut 1 ou 2; ou un énantiomère, un stéréoisomère ou un mélange de ceux-ci, un tautomère de celui-ci ou un sel pharmaceutiquement acceptable, un solvate ou un dérivé de celui-ci; à condition que lorsque R et R3 sont un hydrogène, R4 ne soit pas un hydrogène ou un methyle. 54. Composé suivant la revendication 53, dans lequel R, Ri et R3 sont un hydrogène et R2 est un méthyle. 55. Composé suivant la revendication 53, qui est sélectionné parmi le groupe comprenant : la 3 méthyl-N-(propylidène)-lH-indol-l-amine; la N-(propylidène)-l H-indol-1-amine; la 5-benzyloxy-N-(propylidène)-l H-indol-1-amine; 2 5 la 5 -méthoxy-N-(propylidène)-1 H-indol-1-amine; et la N-(propylidène)-1 H-carbazol-1-amine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50833503P | 2003-10-03 | 2003-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA28117A1 true MA28117A1 (fr) | 2006-08-01 |
Family
ID=34434904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA28977A MA28117A1 (fr) | 2003-10-03 | 2006-04-28 | Procédé pour la préparation de composés hétérocycliques à substitution N-amino |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7112682B2 (fr) |
| EP (1) | EP1678135B1 (fr) |
| JP (1) | JP2007507518A (fr) |
| KR (1) | KR20060120028A (fr) |
| CN (2) | CN101391976A (fr) |
| AR (1) | AR046041A1 (fr) |
| AT (1) | ATE431339T1 (fr) |
| AU (1) | AU2004279808B2 (fr) |
| BR (1) | BRPI0415002A (fr) |
| CA (1) | CA2540867A1 (fr) |
| DE (1) | DE602004021126D1 (fr) |
| DK (1) | DK1678135T3 (fr) |
| ES (1) | ES2327417T3 (fr) |
| HR (2) | HRP20060124A2 (fr) |
| IL (1) | IL174238A0 (fr) |
| MA (1) | MA28117A1 (fr) |
| ME (1) | MEP19508A (fr) |
| MX (1) | MXPA06003446A (fr) |
| NO (1) | NO20061929L (fr) |
| NZ (1) | NZ545838A (fr) |
| PL (1) | PL1678135T3 (fr) |
| PT (1) | PT1678135E (fr) |
| RS (1) | RS20060225A (fr) |
| RU (1) | RU2364588C2 (fr) |
| SI (1) | SI1678135T1 (fr) |
| TW (1) | TW200519086A (fr) |
| WO (1) | WO2005035496A1 (fr) |
| ZA (1) | ZA200602694B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039476A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | Proceso para preparar derivados de 6-alquiliden penem |
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| US20040132708A1 (en) * | 2002-05-01 | 2004-07-08 | Wyeth | Process for preparing 6-alkylidene penem derivatives |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| US7538227B2 (en) * | 2004-01-13 | 2009-05-26 | Sanofi-Aventis Deutschland Gmbh | Process for stabilizing 4-halopyridines |
| WO2006115456A1 (fr) * | 2005-04-26 | 2006-11-02 | Cambrex Karlskoga Ab | Synthese de la 1-aminopiperidine |
| MX2008001083A (es) * | 2005-07-27 | 2008-03-19 | Wyeth Corp | Inhibidores de 6-alquiliden-penem b-lactamasa triciclicos y combinacion de antibioticos de beta-lactama: un antibiotico de amplio espectro. |
| PE20070403A1 (es) * | 2005-07-27 | 2007-05-15 | Wyeth Corp | COMPOSICION FARMACEUTICA QUE COMPRENDE CEFEPIME Y DERIVADOS DE 6-ALQUILIDEN-PENEM BICICLICOS COMO INHIBIDORES DE ß-LACTAMASA |
| GT200600380A (es) * | 2005-08-24 | 2007-03-29 | Proceso para la preparacion de inhibidores de beta-lactamasa | |
| FR2897614B1 (fr) * | 2006-02-20 | 2008-05-23 | Urogene | Forme cristalline du chlorhydrate de la besipirdine, procedes de preparation et utilisations |
| EP2493305B1 (fr) * | 2009-10-30 | 2015-03-25 | Genzyme Corporation | Composés 2-aminoindoles et méthodes de traitement de la malaria |
| CN105753838A (zh) * | 2016-02-11 | 2016-07-13 | 安阳师范学院 | 喹啉衍生物高区域选择性胺化新方法 |
| TWI780152B (zh) | 2017-05-12 | 2022-10-11 | 日商中外製藥股份有限公司 | 環狀有機化合物的製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0629273B2 (ja) * | 1986-06-13 | 1994-04-20 | 宇部興産株式会社 | Ｎ−アミノヘキサメチレンイミンの製造法 |
| JPH01157922A (ja) * | 1987-12-15 | 1989-06-21 | Citizen Watch Co Ltd | ニトリル化合物の製造方法 |
| US5459274A (en) * | 1994-05-13 | 1995-10-17 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines |
-
2004
- 2004-09-30 AR ARP040103557A patent/AR046041A1/es not_active Application Discontinuation
- 2004-10-01 HR HR20060124A patent/HRP20060124A2/xx not_active Application Discontinuation
- 2004-10-01 AT AT04785294T patent/ATE431339T1/de not_active IP Right Cessation
- 2004-10-01 TW TW093129738A patent/TW200519086A/zh unknown
- 2004-10-01 ES ES04785294T patent/ES2327417T3/es not_active Expired - Lifetime
- 2004-10-01 BR BRPI0415002-3A patent/BRPI0415002A/pt not_active IP Right Cessation
- 2004-10-01 NZ NZ545838A patent/NZ545838A/en unknown
- 2004-10-01 ME MEP-195/08A patent/MEP19508A/xx unknown
- 2004-10-01 MX MXPA06003446A patent/MXPA06003446A/es active IP Right Grant
- 2004-10-01 AU AU2004279808A patent/AU2004279808B2/en not_active Ceased
- 2004-10-01 CN CNA2008101707936A patent/CN101391976A/zh active Pending
- 2004-10-01 SI SI200431204T patent/SI1678135T1/sl unknown
- 2004-10-01 PL PL04785294T patent/PL1678135T3/pl unknown
- 2004-10-01 DK DK04785294T patent/DK1678135T3/da active
- 2004-10-01 JP JP2006534079A patent/JP2007507518A/ja not_active Abandoned
- 2004-10-01 KR KR1020067006835A patent/KR20060120028A/ko not_active Ceased
- 2004-10-01 CA CA002540867A patent/CA2540867A1/fr not_active Abandoned
- 2004-10-01 HR HR20090441T patent/HRP20090441T1/xx unknown
- 2004-10-01 DE DE602004021126T patent/DE602004021126D1/de not_active Expired - Lifetime
- 2004-10-01 WO PCT/US2004/032086 patent/WO2005035496A1/fr not_active Ceased
- 2004-10-01 RS RSP-2006/0225A patent/RS20060225A/sr unknown
- 2004-10-01 PT PT04785294T patent/PT1678135E/pt unknown
- 2004-10-01 CN CN200480035790A patent/CN100579963C/zh not_active Expired - Fee Related
- 2004-10-01 EP EP04785294A patent/EP1678135B1/fr not_active Expired - Lifetime
- 2004-10-01 RU RU2006114667/04A patent/RU2364588C2/ru not_active IP Right Cessation
- 2004-10-01 US US10/957,124 patent/US7112682B2/en not_active Expired - Lifetime
-
2006
- 2006-03-09 IL IL174238A patent/IL174238A0/en unknown
- 2006-03-31 ZA ZA200602694A patent/ZA200602694B/en unknown
- 2006-04-28 NO NO20061929A patent/NO20061929L/no not_active Application Discontinuation
- 2006-04-28 MA MA28977A patent/MA28117A1/fr unknown
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