MA28358A1 - Inhibiteurs de l'integrase du vih - Google Patents

Inhibiteurs de l'integrase du vih

Info

Publication number
MA28358A1
MA28358A1 MA29263A MA29263A MA28358A1 MA 28358 A1 MA28358 A1 MA 28358A1 MA 29263 A MA29263 A MA 29263A MA 29263 A MA29263 A MA 29263A MA 28358 A1 MA28358 A1 MA 28358A1
Authority
MA
Morocco
Prior art keywords
inhibitors
hiv integrase
integrase
hiv
Prior art date
Application number
MA29263A
Other languages
English (en)
Inventor
Brian Alvin Johns
Eric Eugene Boros
Takashi Kawasuji
Cecilia S Koble
Noriyuki Kurose
Hitoshi Murai
Ronald George Sherrill
Jason Gordon Weatherhead
Original Assignee
Smithkline Beecham Corp
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Shionogi & Co filed Critical Smithkline Beecham Corp
Publication of MA28358A1 publication Critical patent/MA28358A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA29263A 2004-02-11 2006-08-11 Inhibiteurs de l'integrase du vih MA28358A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54367004P 2004-02-11 2004-02-11

Publications (1)

Publication Number Publication Date
MA28358A1 true MA28358A1 (fr) 2006-12-01

Family

ID=34860447

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29263A MA28358A1 (fr) 2004-02-11 2006-08-11 Inhibiteurs de l'integrase du vih

Country Status (15)

Country Link
US (3) US8691991B2 (fr)
EP (1) EP1720856B1 (fr)
JP (1) JP4859676B2 (fr)
KR (1) KR20070002006A (fr)
CN (1) CN1976915A (fr)
AU (1) AU2005211733A1 (fr)
BR (1) BRPI0507628A (fr)
CA (1) CA2555176A1 (fr)
ES (1) ES2433477T3 (fr)
IL (1) IL177189A0 (fr)
MA (1) MA28358A1 (fr)
MX (1) MXPA06009132A (fr)
NO (1) NO20063958L (fr)
RU (1) RU2006128848A (fr)
WO (1) WO2005077050A2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1720856B1 (fr) 2004-02-11 2013-08-14 GlaxoSmithKline LLC Inhibiteurs de l'integrase du vih
PT1874117E (pt) 2005-04-28 2013-10-17 Shionogi & Co Derivado policíclico de carbamoílpiridona possuindo actividade inibidora de hiv-integrasse
EP1910363A4 (fr) * 2005-08-04 2010-05-26 Glaxosmithkline Llc Inhibiteurs de l'integrase du vih
WO2007019130A2 (fr) * 2005-08-04 2007-02-15 Smithkline Beecham Corporation Inhibiteurs d'integrase du vih
JP2009503083A (ja) * 2005-08-04 2009-01-29 スミスクライン ビーチャム コーポレーション Ｈｉｖインテグラーゼ阻害薬
US20080194523A1 (en) * 2005-08-04 2008-08-14 Smithkline Beecham Corporation Hiv Integrase Inhibitors
AR059733A1 (es) * 2006-03-07 2008-04-23 Smithkline Beecham Corp Compuesto derivado de glicina n- sustituida con heteroaromaticos bicicicos, composicion farmaceutica que lo comprende, uso para preparar un medicamento para tratar la anemia y proceso para su preparacion
MX2008014908A (es) 2006-05-26 2009-05-13 Toyama Chemical Co Ltd Compuesto heterociclico nuevo o sal del mismo e intermedio del mismo.
EP1956016A1 (fr) * 2006-12-15 2008-08-13 Bayer Schering Pharma Aktiengesellschaft Acyltryptophanols
EP2111399A2 (fr) 2006-12-18 2009-10-28 Amgen Inc. Composés de naphtalénone présentant une activité inhibititrice de prolyle hydroxylase, compositions et utilisations de ceux-ci
ES2393326T3 (es) 2006-12-18 2012-12-20 Amgen, Inc Compuestos basados en azaquinolona que presentan actividad inhibidora de prolil hidroxilasas, composiciones y usos de los mismos
ES2446418T3 (es) 2007-04-18 2014-03-07 Amgen, Inc Derivados de indanona que inhiben la prolil hidroxilasa
EP2142509B1 (fr) 2007-04-18 2013-12-04 Amgen, Inc Quinolones et azaquinolones inhibant la prolyl hydroxylase
AU2008241503A1 (en) * 2007-04-18 2008-10-30 Merck Sharp & Dohme Corp. Novel 1,8-naphthyridine compounds
WO2008137084A2 (fr) 2007-05-04 2008-11-13 Amgen Inc. Diazaquinolones inhibant l'activité de la prolyl hydroxylase
US8030346B2 (en) 2007-05-04 2011-10-04 Amgen Inc. Heterocyclic quinolone derivatives that inhibit prolyl hydroxylase activity
WO2010011818A1 (fr) * 2008-07-25 2010-01-28 Smithkline Beecham Corporation Composés chimiques
WO2010011819A1 (fr) * 2008-07-25 2010-01-28 Smithkline Beecham Corporation Composés chimiques
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
UA105556C2 (uk) * 2010-01-27 2014-05-26 Віів Гелскер Компані Комбінація сполук, що містить інгібітори віл інтегрази з іншими терапевтичними агентами
US20110223131A1 (en) * 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
NZ603332A (en) 2010-04-02 2014-11-28 Senomyx Inc Sweet flavor modifier
KR20130065728A (ko) 2010-10-14 2013-06-19 임뮤나르 에이비 Ahr 활성화제로서의 1,2-디히드로-4-히드록시-2-옥소-퀴놀린-3-카르복사닐리드
CA2819889C (fr) 2010-12-06 2020-12-15 Confluence Life Sciences, Inc. Composes pyridinone-pyridinyle substitues
US9359300B2 (en) 2010-12-06 2016-06-07 Confluence Life Sciences, Inc. Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
WO2012147763A1 (fr) 2011-04-26 2012-11-01 塩野義製薬株式会社 Dérivé d'oxazine et inhibiteur de bace 1 le contenant
EP2742026B1 (fr) 2011-08-12 2016-10-05 Senomyx, Inc. Agent modificateur de la saveur sucrée
CA2893843C (fr) 2012-12-21 2018-09-04 Gilead Sciences, Inc. Composes de carbamoylpyridone polycycliques et leur utilisation pharmaceutique
CA2917344C (fr) 2013-06-07 2021-09-07 Confluence Life Sciences, Inc. Composes de pyridinone-pyridinyle substitues avec methyle/fluoro-pyridinyle-methoxy et des composes de pyridinone-pyridinyle substitues avec fluoro-pyrimidinyl-methoxy
US11339128B2 (en) 2014-11-07 2022-05-24 Firmenich Incorporated Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
CN105348282B (zh) * 2015-12-02 2018-06-29 北京工业大学 一种hiv-1整合酶抑制剂化合物及其制备方法和应用
BR112022019349A2 (pt) 2020-03-27 2022-11-16 Aclaris Therapeutics Inc Forma cristalina, composição farmacêutica, comprimido e método para isolar um composto
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1532802A (en) 2000-10-12 2002-04-22 Merck & Co Inc Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
DE60124577T2 (de) 2000-10-12 2007-09-27 Merck & Co., Inc. Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
WO2002036734A2 (fr) 2000-10-12 2002-05-10 Merck & Co., Inc. Aza- et polyaza-naphtalenyl cetones utiles en tant qu'inhibiteurs de l'integrase du vih
ATE430745T1 (de) 2000-10-12 2009-05-15 Merck & Co Inc Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase
IL157638A0 (en) 2001-03-01 2004-03-28 Shionogi & Co Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity
ES2291642T3 (es) * 2002-01-17 2008-03-01 MERCK & CO., INC. Hidroxinaftiridinoncarboxamidas utiles como inhibidores de la integrasa de vih.
DE60322920D1 (de) 2002-08-13 2008-09-25 Shionogi & Co Heterocyclische verbindungen mit hiv-integrase-hemmender wirkung
EP1545538A2 (fr) 2002-08-29 2005-06-29 Merck & Co., Inc. Derives n-biarylmethyl aminocycloalcanecarboxamide
TW200505902A (en) * 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
WO2005023189A2 (fr) 2003-09-03 2005-03-17 Pharmacia Corporation Procede de prevention ou de traitement de la douleur, de l'inflammation, et de troubles lies a l'inflammation avec un inhibiteur selectif de cox-2 en combinaison avec un agent donneur de monoxyde d'azote et compositions en contenant
WO2005028478A1 (fr) 2003-09-19 2005-03-31 Gilead Sciences, Inc. Composes d'aza-quinolinol phosphonate inhibiteurs de l'integrase
EP1720856B1 (fr) 2004-02-11 2013-08-14 GlaxoSmithKline LLC Inhibiteurs de l'integrase du vih

Also Published As

Publication number Publication date
WO2005077050A3 (fr) 2006-11-23
EP1720856A4 (fr) 2009-11-11
JP2007523086A (ja) 2007-08-16
JP4859676B2 (ja) 2012-01-25
AU2005211733A1 (en) 2005-08-25
KR20070002006A (ko) 2007-01-04
NO20063958L (no) 2006-09-22
EP1720856B1 (fr) 2013-08-14
ES2433477T3 (es) 2013-12-11
BRPI0507628A (pt) 2007-07-03
US20140256713A1 (en) 2014-09-11
CN1976915A (zh) 2007-06-06
CA2555176A1 (fr) 2005-08-25
US20150225399A1 (en) 2015-08-13
EP1720856A2 (fr) 2006-11-15
WO2005077050A2 (fr) 2005-08-25
US8691991B2 (en) 2014-04-08
IL177189A0 (en) 2006-12-10
US20070124152A1 (en) 2007-05-31
RU2006128848A (ru) 2008-03-20
MXPA06009132A (es) 2007-03-26

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