MA28429B1 - Dérivés de 1H-thiéno [2,3-c] pyrazole utiles comme inhibiteurs de kinases - Google Patents
Dérivés de 1H-thiéno [2,3-c] pyrazole utiles comme inhibiteurs de kinasesInfo
- Publication number
- MA28429B1 MA28429B1 MA29227A MA29227A MA28429B1 MA 28429 B1 MA28429 B1 MA 28429B1 MA 29227 A MA29227 A MA 29227A MA 29227 A MA29227 A MA 29227A MA 28429 B1 MA28429 B1 MA 28429B1
- Authority
- MA
- Morocco
- Prior art keywords
- thieno
- derivatives
- kinase inhibitors
- pyrazole
- useful
- Prior art date
Links
- FKWUPVHNVKGGSD-UHFFFAOYSA-N 1h-thieno[2,3-c]pyrazole Chemical class C1=NNC2=C1C=CS2 FKWUPVHNVKGGSD-UHFFFAOYSA-N 0.000 title abstract 3
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002074 deregulated effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Dérivés de 1H-thiéno[2,3-c]pyrazole utiles comme inhibiteurs de kinases Des dérivés de thiéno[2,3-c]pyrazole de formule (I) et leurs sels pharmaceutiquement acceptables, tels que définis dans le présent mémoire, des procédés pour leur préparation et des compositions pharmaceutiques les contenant sont décrits ; les composés de l'invention peuvent être utiles en thérapeutique, dans le traitement de maladies associées à une activité de protéine-kinase dérégulée, telles que le cancer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54145204P | 2004-02-03 | 2004-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA28429B1 true MA28429B1 (fr) | 2007-02-01 |
Family
ID=34837492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA29227A MA28429B1 (fr) | 2004-02-03 | 2006-08-03 | Dérivés de 1H-thiéno [2,3-c] pyrazole utiles comme inhibiteurs de kinases |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US8138217B2 (fr) |
| EP (1) | EP1711177B1 (fr) |
| JP (1) | JP4908233B2 (fr) |
| KR (1) | KR20060124734A (fr) |
| CN (1) | CN1946395B (fr) |
| AP (1) | AP2006003701A0 (fr) |
| AR (1) | AR047531A1 (fr) |
| AT (1) | ATE396724T1 (fr) |
| AU (1) | AU2005210114B2 (fr) |
| BR (1) | BRPI0507375A (fr) |
| CA (1) | CA2555262C (fr) |
| CR (1) | CR8546A (fr) |
| CY (1) | CY1108246T1 (fr) |
| DE (1) | DE602005007181D1 (fr) |
| DK (1) | DK1711177T3 (fr) |
| DO (1) | DOP2005000014A (fr) |
| EA (1) | EA011032B1 (fr) |
| EC (1) | ECSP066767A (fr) |
| ES (1) | ES2307144T3 (fr) |
| GE (1) | GEP20094633B (fr) |
| GT (1) | GT200500020A (fr) |
| IL (1) | IL177141A0 (fr) |
| MA (1) | MA28429B1 (fr) |
| MX (1) | MXPA06008787A (fr) |
| NO (1) | NO20063768L (fr) |
| NZ (1) | NZ548896A (fr) |
| PA (1) | PA8622801A1 (fr) |
| PE (1) | PE20051095A1 (fr) |
| PL (1) | PL1711177T3 (fr) |
| PT (1) | PT1711177E (fr) |
| SI (1) | SI1711177T1 (fr) |
| TN (1) | TNSN06244A1 (fr) |
| TW (1) | TW200526204A (fr) |
| UA (1) | UA86223C2 (fr) |
| UY (1) | UY28738A1 (fr) |
| WO (1) | WO2005074922A1 (fr) |
| ZA (1) | ZA200606179B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05000946A (es) * | 2002-07-25 | 2005-05-16 | Pharmacia Italia Spa | Derivados heterociclicos condensados de pirazol como inhibidores de cinasa. |
| JP5303271B2 (ja) | 2005-07-19 | 2013-10-02 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害剤として有用な１Ｈ−チエノ［２，３−ｃ］ピラゾール化合物 |
| US20090306169A1 (en) * | 2005-10-06 | 2009-12-10 | Brandish Philip E | Use of Fused Pyrrole Carboxylic Acids for the Treatment of Neurodegenerative and Psychiatric Diseases and D-Amino Acid Oxidase Inhibitors |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| EP2007380B1 (fr) * | 2006-03-30 | 2011-09-14 | Nerviano Medical Sciences S.r.l. | Utilisation d'un inhibiteur de la kinase pour traiter des tumeurs résistantes spécifiques |
| DE602007008736D1 (de) * | 2006-05-31 | 2010-10-07 | Nerviano Medical Sciences Srl | 1h-furoä3,2-cü pyrazolverbindungen, die sich als kinaseinhibitoren eignen |
| FR2904626B1 (fr) * | 2006-08-03 | 2008-09-19 | Sanofi Aventis | Derives de pyrazolo[4,3]thiazole, leur preparation et leur application en therapeutique |
| SG158147A1 (en) | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
| KR100923540B1 (ko) | 2007-11-23 | 2009-10-27 | 한국과학기술연구원 | 5-아실하이드라진카르보닐-3,4-디치환 피라졸 유도체 및이의 제조방법 |
| CL2009001158A1 (es) * | 2008-05-15 | 2009-10-23 | Nerviano Medical Sciences Srl | Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer. |
| US8569512B2 (en) | 2009-03-23 | 2013-10-29 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| US9255072B2 (en) | 2011-03-04 | 2016-02-09 | National Health Rsearch Institutes | Pyrazole compounds and thiazole compounds as protein kinases inhibitors |
| EP2836494B1 (fr) * | 2012-04-05 | 2019-08-21 | Nerviano Medical Sciences S.r.l. | Nouveaux agents alkylants |
| CN110945002B (zh) * | 2017-08-01 | 2021-12-24 | 正大天晴药业集团股份有限公司 | 作为RORγ抑制剂的双环化合物 |
| MX2020005563A (es) * | 2017-11-30 | 2020-10-28 | Hanmi Pharm Ind Co Ltd | Compuesto de tieno[3,2-d]pirimidina que tiene actividad inhibidora para proteina cinasa. |
| CN113072562B (zh) * | 2021-04-06 | 2022-01-14 | 山东大学 | 一种GSK-3β抑制剂及其制备方法与应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0234622B1 (fr) | 1986-02-19 | 1990-06-27 | Duphar International Research B.V | Composés à fonction "thio", pourvus d'activité fongicide |
| GB9911053D0 (en) | 1999-05-12 | 1999-07-14 | Pharmacia & Upjohn Spa | 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents |
| US6387900B1 (en) | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
| WO2001012189A1 (fr) | 1999-08-12 | 2001-02-22 | Pharmacia Italia S.P.A. | Derives de 3(5)-amino-pyrazole, leur procede de fabrication et leur emploi comme agents anti-tumoraux |
| DK1320531T3 (da) * | 2000-08-10 | 2011-01-03 | Pfizer Italia Srl | Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse |
| AU2002215053A1 (en) | 2000-11-27 | 2002-06-24 | Pharmacia Italia S.P.A. | Phenylacetamido- pyrazole derivatives and their use as antitumor agents |
| MXPA03006478A (es) | 2001-01-26 | 2003-09-22 | Pharmacia Italia Spa | Derivados de cromano, procedimiento para su preparacion y su uso como agentes antitumorales. |
| BR0212841A (pt) | 2001-09-26 | 2004-08-03 | Pharmacia Italia Spa | Derivado ativo de aminoindazole como inibidores de cinase, processo para sua preparação e composições farmacêuticas que os contém |
| MXPA04011417A (es) * | 2002-05-17 | 2005-02-14 | Pharmacia Italia Spa | Derivados de aminoindazol activos como inhibidores de cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden. |
| BR0312722A (pt) * | 2002-07-17 | 2005-05-10 | Pharmacia Italia Spa | Derivados de pirazol heterobicìclico como inibidores de qinase |
| MXPA05000946A (es) * | 2002-07-25 | 2005-05-16 | Pharmacia Italia Spa | Derivados heterociclicos condensados de pirazol como inhibidores de cinasa. |
| US20050026984A1 (en) * | 2003-07-29 | 2005-02-03 | Aventis Pharma S.A. | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products |
-
2005
- 2005-01-28 TW TW094102761A patent/TW200526204A/zh unknown
- 2005-02-02 AP AP2006003701A patent/AP2006003701A0/xx unknown
- 2005-02-02 NZ NZ548896A patent/NZ548896A/en unknown
- 2005-02-02 PE PE2005000121A patent/PE20051095A1/es not_active Application Discontinuation
- 2005-02-02 DO DO2005000014A patent/DOP2005000014A/es unknown
- 2005-02-02 WO PCT/EP2005/001021 patent/WO2005074922A1/fr not_active Ceased
- 2005-02-02 MX MXPA06008787A patent/MXPA06008787A/es active IP Right Grant
- 2005-02-02 AT AT05701307T patent/ATE396724T1/de active
- 2005-02-02 AU AU2005210114A patent/AU2005210114B2/en not_active Ceased
- 2005-02-02 GE GEAP20059600A patent/GEP20094633B/en unknown
- 2005-02-02 EA EA200601418A patent/EA011032B1/ru not_active IP Right Cessation
- 2005-02-02 CN CN200580005922.0A patent/CN1946395B/zh not_active Expired - Fee Related
- 2005-02-02 UA UAA200609515A patent/UA86223C2/uk unknown
- 2005-02-02 DE DE602005007181T patent/DE602005007181D1/de not_active Expired - Lifetime
- 2005-02-02 PL PL05701307T patent/PL1711177T3/pl unknown
- 2005-02-02 JP JP2006551790A patent/JP4908233B2/ja not_active Expired - Fee Related
- 2005-02-02 DK DK05701307T patent/DK1711177T3/da active
- 2005-02-02 KR KR1020067017754A patent/KR20060124734A/ko not_active Ceased
- 2005-02-02 ES ES05701307T patent/ES2307144T3/es not_active Expired - Lifetime
- 2005-02-02 SI SI200530297T patent/SI1711177T1/sl unknown
- 2005-02-02 PT PT05701307T patent/PT1711177E/pt unknown
- 2005-02-02 AR ARP050100399A patent/AR047531A1/es not_active Application Discontinuation
- 2005-02-02 CA CA2555262A patent/CA2555262C/fr not_active Expired - Fee Related
- 2005-02-02 BR BRPI0507375-8A patent/BRPI0507375A/pt not_active IP Right Cessation
- 2005-02-02 EP EP05701307A patent/EP1711177B1/fr not_active Expired - Lifetime
- 2005-02-03 UY UY28738A patent/UY28738A1/es not_active Application Discontinuation
- 2005-02-03 PA PA20058622801A patent/PA8622801A1/es unknown
- 2005-02-03 US US11/050,360 patent/US8138217B2/en not_active Expired - Fee Related
- 2005-02-03 GT GT200500020A patent/GT200500020A/es unknown
-
2006
- 2006-07-26 ZA ZA200606179A patent/ZA200606179B/xx unknown
- 2006-07-27 IL IL177141A patent/IL177141A0/en unknown
- 2006-08-03 TN TNP2006000244A patent/TNSN06244A1/fr unknown
- 2006-08-03 MA MA29227A patent/MA28429B1/fr unknown
- 2006-08-03 CR CR8546A patent/CR8546A/es not_active Application Discontinuation
- 2006-08-10 EC EC2006006767A patent/ECSP066767A/es unknown
- 2006-08-23 NO NO20063768A patent/NO20063768L/no not_active Application Discontinuation
-
2008
- 2008-08-07 CY CY20081100834T patent/CY1108246T1/el unknown
-
2012
- 2012-02-24 US US13/404,697 patent/US8481584B2/en not_active Expired - Fee Related
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