MA28547B1 - Chlorhydrate de [4-(5-aminomethyl-2-fluoro-phenyl)- piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone en tant qu'inhibiteur de tryptase de mastocyte - Google Patents

Chlorhydrate de [4-(5-aminomethyl-2-fluoro-phenyl)- piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone en tant qu'inhibiteur de tryptase de mastocyte

Info

Publication number: MA28547B1
Authority: MA; Morocco
Prior art keywords: mastocyte; tryptase; thiophen; piperidin; aminomethyl
Prior art date: 2004-03-26

Application number

MA29405A

Other languages

English (en)

Inventor

Zhongli Gao

Larry Davis

Julian Levell

Mark Czekaj

Adam W Sledeski

El-Bdaoui Haddad

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-26

Filing date

2006-10-20

Publication date

2007-04-03

2006-10-20 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2007-04-03 Publication of MA28547B1 publication Critical patent/MA28547B1/fr

Links

102000001400 Tryptase Human genes 0.000 title 1
108060005989 Tryptase Proteins 0.000 title 1
XRGUAUFOUNIQRI-UHFFFAOYSA-N [4-[5-(aminomethyl)-2-fluorophenyl]piperidin-1-yl]-(4-bromo-3-methyl-5-propoxythiophen-2-yl)methanone;hydrochloride Chemical compound Cl.BrC1=C(OCCC)SC(C(=O)N2CCC(CC2)C=2C(=CC=C(CN)C=2)F)=C1C XRGUAUFOUNIQRI-UHFFFAOYSA-N 0.000 title 1
210000003630 histaminocyte Anatomy 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Immunology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

MA29405A 2004-03-26 2006-10-20 Chlorhydrate de [4-(5-aminomethyl-2-fluoro-phenyl)- piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone en tant qu'inhibiteur de tryptase de mastocyte MA28547B1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US55692704P	2004-03-26	2004-03-26

Publications (1)

Publication Number	Publication Date
MA28547B1 true MA28547B1 (fr)	2007-04-03

Family

ID=34964263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA29405A MA28547B1 (fr)	2004-03-26	2006-10-20	Chlorhydrate de [4-(5-aminomethyl-2-fluoro-phenyl)- piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone en tant qu'inhibiteur de tryptase de mastocyte

Country Status (25)

Country	Link
US (1)	US20070142435A1 (fr)
EP (1)	EP1737848A1 (fr)
JP (1)	JP2007530580A (fr)
KR (1)	KR20060130682A (fr)
CN (1)	CN1956978A (fr)
AR (1)	AR048336A1 (fr)
AU (1)	AU2005230934A1 (fr)
BR (1)	BRPI0509245A (fr)
CA (1)	CA2560649A1 (fr)
CR (1)	CR8603A (fr)
DO (1)	DOP2005000039A (fr)
EC (1)	ECSP066878A (fr)
IL (1)	IL178031A0 (fr)
MA (1)	MA28547B1 (fr)
MX (1)	MXPA06010610A (fr)
NO (1)	NO20064811L (fr)
PA (1)	PA8627601A1 (fr)
PE (1)	PE20060084A1 (fr)
RU (1)	RU2330034C1 (fr)
TN (1)	TNSN06278A1 (fr)
TW (1)	TW200602035A (fr)
UA (1)	UA83738C2 (fr)
UY (1)	UY28821A1 (fr)
WO (1)	WO2005097780A1 (fr)
ZA (1)	ZA200607752B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20071148A1 (es) *	2006-03-29	2007-12-10	Sanofi Aventis	Mejoras en la preparacion de intermedios que conducen a hidrocloruro de [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona
AR065616A1 (es) *	2007-03-07	2009-06-17	Sanofi Aventis	Sintesis regioselectiva de ullmann de acido 4- bromo-3- metil-5- propoxi- tiofeno-2- carboxilico
WO2008115912A1 (fr) *	2007-03-21	2008-09-25	Sanofi-Aventis	Synthèse régiospécifique de l'acide 4-bromo-3-méthyl-5-propoxy-thiophène-2-carboxylique
WO2008121666A1 (fr) *	2007-03-29	2008-10-09	Sanofi-Aventis	Utilisation de 2,5-dioxo-pyrrolidin-1-yl ester d'acide 4-bromo-3-méthyl-5-propoxythiophène-2-carboxylique pour la préparation d'un inhibiteur de tryptase [4-(5-aminométhyl-2-fluoro-phényl)-pipéridin-1-yl]-(4-bromo-3-méthyl-5-propoxy-thiophén-2-yl)-méthanone
AR065859A1 (es) *	2007-03-29	2009-07-08	Sanofi Aventis	Ester de 2,5-dioxo-pirrolidin-1-ilo de acido 4-bromo-3-metil-5-propoxitiofen-2- carboxilico ,su sintesis regioespecifica y un intermedio del mismo
ES2469824T3 (es)	2007-11-21	2014-06-20	Janssen Pharmaceutica N.V.	Espiropiperidinas para su uso como inhibidores de la triptasa
NZ587119A (en) *	2008-01-24	2013-01-25	Soligenix Inc	Use of beclomethasone dipropionate in the treatment of an interstitial lung disease
BRPI0916920A2 (pt) *	2008-08-22	2015-11-24	Sanofi Aventis	4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-[7-fluoro-1-(2-metóxi-etil)-4-trifluorometóxi-1h-indol-3-il]-metanona como inibidor de triptase de mastócito, seu uso e método de preparação, bem como forma cristalina
AR074776A1 (es)	2008-12-18	2011-02-09	Sanofi Aventis	Metodo para tratar la degeneracion macular; modulando el sistema inmunitario del paciente
FR2955324A1 (fr) *	2010-01-15	2011-07-22	Sanofi Aventis	[4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones disubstituees
MX2012003023A (es) *	2009-09-24	2012-04-10	Sanofi Aventis Us Llc	Sintesis del ester terc-butilico del acido (4-fluoro-3-piperidin-4 -il-bencil)-carbamico y sus productos intermedios.
KR20120107999A (ko) *	2009-12-23	2012-10-04	사노피	염증성 장 질환의 치료
AU2010333779A1 (en) *	2009-12-23	2012-07-12	Sanofi	Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors
EP2516428A1 (fr) *	2009-12-23	2012-10-31	Sanofi	Benzylamines de tropinone utilisés comme inhibiteurs de la bêta-tryptase
AR080255A1 (es) *	2010-02-24	2012-03-21	Sanofi Aventis	Tratamiento de afecciones alergicas dermatologicas. composicion farmaceutica
CA2851087C (fr)	2011-10-07	2019-09-24	Takeda Pharmaceutical Company Limited	Composes de 1-arylcarbonyl-4-oxypiperidine utiles pour le traitement de maladies neurodegeneratives
BR112019016595A2 (pt) *	2017-02-10	2020-03-31	Genentech, Inc.	Anticorpos isolados, métodos de produção do anticorpo e de tratamento de um distúrbio, ácido nucleico isolado, vetor ou conjunto de vetores, célula hospedeira, composições farmacêuticas e uso

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
OA12274A (en) *	2000-05-22	2006-05-09	Aventis Pharma Inc	Arylmethylamine derivatives for use as tryptase inhibitors.
GB0012362D0 (en) *	2000-05-22	2000-07-12	Aventis Pharma Ltd	Chemical compounds

2005
- 2005-03-21 DO DO2005000039A patent/DOP2005000039A/es unknown
- 2005-03-22 PE PE2005000325A patent/PE20060084A1/es not_active Application Discontinuation
- 2005-03-23 AR ARP050101170A patent/AR048336A1/es not_active Application Discontinuation
- 2005-03-23 UY UY28821A patent/UY28821A1/es unknown
- 2005-03-24 JP JP2007505191A patent/JP2007530580A/ja not_active Abandoned
- 2005-03-24 KR KR1020067019886A patent/KR20060130682A/ko not_active Withdrawn
- 2005-03-24 RU RU2006137717/04A patent/RU2330034C1/ru not_active IP Right Cessation
- 2005-03-24 EP EP05731154A patent/EP1737848A1/fr not_active Withdrawn
- 2005-03-24 UA UAA200611261A patent/UA83738C2/ru unknown
- 2005-03-24 CA CA002560649A patent/CA2560649A1/fr not_active Abandoned
- 2005-03-24 MX MXPA06010610A patent/MXPA06010610A/es not_active Application Discontinuation
- 2005-03-24 WO PCT/US2005/009899 patent/WO2005097780A1/fr not_active Ceased
- 2005-03-24 CN CNA2005800164250A patent/CN1956978A/zh active Pending
- 2005-03-24 AU AU2005230934A patent/AU2005230934A1/en not_active Abandoned
- 2005-03-24 BR BRPI0509245-0A patent/BRPI0509245A/pt not_active IP Right Cessation
- 2005-03-25 TW TW094109209A patent/TW200602035A/zh unknown
- 2005-03-28 PA PA20058627601A patent/PA8627601A1/es unknown
2006
- 2006-09-07 CR CR8603A patent/CR8603A/es not_active Application Discontinuation
- 2006-09-12 IL IL178031A patent/IL178031A0/en unknown
- 2006-09-12 TN TNP2006000278A patent/TNSN06278A1/en unknown
- 2006-09-14 US US11/520,998 patent/US20070142435A1/en active Granted
- 2006-09-15 ZA ZA200607752A patent/ZA200607752B/en unknown
- 2006-09-22 EC EC2006006878A patent/ECSP066878A/es unknown
- 2006-10-20 MA MA29405A patent/MA28547B1/fr unknown
- 2006-10-23 NO NO20064811A patent/NO20064811L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DOP2005000039A (es)	2005-10-31
EP1737848A1 (fr)	2007-01-03
US20070142435A1 (en)	2007-06-21
MXPA06010610A (es)	2006-12-15
RU2006137717A (ru)	2008-05-10
AR048336A1 (es)	2006-04-19
CA2560649A1 (fr)	2005-10-20
RU2330034C1 (ru)	2008-07-27
UA83738C2 (en)	2008-08-11
WO2005097780A1 (fr)	2005-10-20
CN1956978A (zh)	2007-05-02
CR8603A (es)	2007-06-08
TNSN06278A1 (en)	2007-12-03
AU2005230934A1 (en)	2005-10-20
JP2007530580A (ja)	2007-11-01
ECSP066878A (es)	2006-11-24
TW200602035A (en)	2006-01-16
KR20060130682A (ko)	2006-12-19
IL178031A0 (en)	2006-12-31
PA8627601A1 (es)	2006-01-23
NO20064811L (no)	2006-10-23
PE20060084A1 (es)	2006-03-09
UY28821A1 (es)	2005-10-31
ZA200607752B (en)	2008-05-28
BRPI0509245A (pt)	2007-09-11

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