MA28613B1 - Macrocycles d'amide antibacteriens - Google Patents

Macrocycles d'amide antibacteriens

Info

Publication number
MA28613B1
MA28613B1 MA28006A MA28006A MA28613B1 MA 28613 B1 MA28613 B1 MA 28613B1 MA 28006 A MA28006 A MA 28006A MA 28006 A MA28006 A MA 28006A MA 28613 B1 MA28613 B1 MA 28613B1
Authority
MA
Morocco
Prior art keywords
antibacterial amide
amide macrocycles
macrocycles
antibacterial
prophylaxis
Prior art date
Application number
MA28006A
Other languages
English (en)
Inventor
Thomas Lampe
Isabelle Adelt
Dieter Beyer
Nina Brunner
Rainer Endermann
Kerstin Ehlert
Hein-Peter Kroll
Nussbaum Franz Von
Siegfried Raddatz
Joachin Rudolph
Guido Schiffer
Andreas Schumacher
Yolanda Cancho-Grande
Martin Michels
Stefan Weigand
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of MA28613B1 publication Critical patent/MA28613B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA28006A 2002-06-17 2004-12-15 Macrocycles d'amide antibacteriens MA28613B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10226921A DE10226921A1 (de) 2002-06-17 2002-06-17 Antibakterielle Amid-Makrozyklen

Publications (1)

Publication Number Publication Date
MA28613B1 true MA28613B1 (fr) 2007-06-01

Family

ID=29594575

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28006A MA28613B1 (fr) 2002-06-17 2004-12-15 Macrocycles d'amide antibacteriens

Country Status (21)

Country Link
US (1) US20070129288A1 (fr)
EP (1) EP1515983B1 (fr)
JP (1) JP4437078B2 (fr)
KR (1) KR20050010060A (fr)
CN (1) CN1326870C (fr)
AT (1) ATE354585T1 (fr)
AU (1) AU2003245928B2 (fr)
BR (1) BR0311948A (fr)
CA (1) CA2489454A1 (fr)
DE (2) DE10226921A1 (fr)
EC (1) ECSP045499A (fr)
ES (1) ES2282643T3 (fr)
HR (1) HRP20050043A2 (fr)
MA (1) MA28613B1 (fr)
MX (1) MXPA04012438A (fr)
NO (1) NO20050210L (fr)
PL (1) PL374554A1 (fr)
PT (1) PT1515983E (fr)
RU (1) RU2005100954A (fr)
WO (1) WO2003106480A1 (fr)
ZA (1) ZA200410006B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2528375C (fr) 2003-06-18 2013-11-19 Tranzyme Pharma, Inc. Antagonistes macrocycliques du recepteur de motiline
JP2008502583A (ja) * 2003-10-01 2008-01-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗細菌性アミド大員環
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102004018405A1 (de) * 2004-04-16 2005-11-03 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen II
DE102004025731A1 (de) * 2004-05-26 2005-12-15 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen III
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005014245A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
EA019879B1 (ru) 2005-12-29 2014-07-30 Лексикон Фармасьютикалз, Инк. Полициклические производные аминокислот, содержащая их фармацевтическая композиция и способ лечения, использующий эти производные
CA2745364A1 (fr) * 2008-12-04 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Derives radio-marques de la lysine et de l'ornithine, utilisation et procedes de preparation associes
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
JP6437443B2 (ja) * 2012-11-21 2018-12-12 アールキューエックス ファーマシューティカルズ，インク． 大環状広域抗生物質
JP5437525B1 (ja) * 2012-12-28 2014-03-12 株式会社ナード研究所 チロシン誘導体およびチロシン誘導体の製造方法
US10392422B2 (en) 2014-05-20 2019-08-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
WO2016057931A1 (fr) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluorométhoxylation d'arènes via une migration intramoléculaire du groupe trifluorométhoxy
HRP20201273T1 (hr) 2015-10-27 2020-11-13 F. Hoffmann - La Roche Ag Peptidni makrocikli protiv bakterije acinetobacter baumannii
RU2761476C2 (ru) 2015-11-20 2021-12-08 АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. Макроциклические антибиотики широкого спектра действия
EP3388444A1 (fr) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Macrocycles peptidiques antibactériens et utilisation associée
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
PT3968983T (pt) 2019-05-28 2023-10-04 Hoffmann La Roche Antibióticos macrocíclicos de largo espectro

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452136A (en) * 1968-04-17 1969-06-24 American Cyanamid Co Antibiotic af283 and production thereof
FR2720066B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Peptides antagonistes de la neurotensine.
DE10234422A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
JP2008502583A (ja) * 2003-10-01 2008-01-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗細菌性アミド大員環
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV

Also Published As

Publication number Publication date
EP1515983A1 (fr) 2005-03-23
ATE354585T1 (de) 2007-03-15
WO2003106480A1 (fr) 2003-12-24
KR20050010060A (ko) 2005-01-26
CN1326870C (zh) 2007-07-18
ES2282643T3 (es) 2007-10-16
RU2005100954A (ru) 2005-07-10
DE10226921A1 (de) 2003-12-24
JP4437078B2 (ja) 2010-03-24
ZA200410006B (en) 2006-02-22
AU2003245928A1 (en) 2003-12-31
AU2003245928B2 (en) 2009-03-05
EP1515983B1 (fr) 2007-02-21
JP2006511446A (ja) 2006-04-06
CA2489454A1 (fr) 2004-12-14
HK1083511A1 (zh) 2006-07-07
MXPA04012438A (es) 2005-04-19
HRP20050043A2 (hr) 2006-04-30
ECSP045499A (es) 2005-03-10
NO20050210L (no) 2005-03-01
BR0311948A (pt) 2005-03-29
US20070129288A1 (en) 2007-06-07
PT1515983E (pt) 2007-03-30
CN1675236A (zh) 2005-09-28
PL374554A1 (en) 2005-10-31
DE50306587D1 (de) 2007-04-05

Similar Documents

Publication Publication Date Title
ATE354585T1 (de) Antibakterielle amid-makrozyklen
YU91603A (sh) Kristalni oblici azitromicina
WO2003077828A3 (fr) Antibiotiques de type florfenicol
AU2003291227A8 (en) Antibacterial agents
TW200507841A (en) Antibacterial agents
DE60113851D1 (de) Bakteriophage mit breitem wirtspektrum
ATE430154T1 (de) Amino-substituierte cyclohexan derivate zur behandlung bakterieller infektionen
DE60307860D1 (de) Aminocyclohexenchinoline und ihre azaisosterischen analoga mit antibakterieller wirkung
SE0102315D0 (sv) Compounds
NO20052362D0 (no) Fremgangsmater for administrering av dalbavancin for behandling av bakterielle infeksjoner
EP1560821B8 (fr) Agents antibacteriens
WO2003099217A3 (fr) Methodes de traitement d'infections bacteriennes et de maladies associees
ATE353894T1 (de) Acyloxymethylcarbamat-prodrugs von oxazolidinonen
YU102503A (sh) Kondenzovani pirimidinski dhfr inhibitori kao antibakterijska sredstva
ATE510845T1 (de) Antibakterielle makrozyklen mit substituiertem biphenyl
DE50305587D1 (en) 2-heteroarylcarbonsäureamide
UY28542A1 (es) Amidas macrocíclicas antibacterianas
AU2003294565A8 (en) Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
WO2006081289A3 (fr) Agents antibacteriens
NO20043445L (no) Kombinasjonsterapi for behandling av bakterielle infeksjoner
ATE495186T1 (de) Antibakterielle amid-makrozyklen iv
WO2005118613A3 (fr) Macrocycles d'amide antibacteriens
WO2003024996A3 (fr) Macrocycles antibacteriens
WO2005011611A3 (fr) Composes bicycliques et compositions utilisees comme inhibiteurs pdf
WO2005121160A3 (fr) Agents antibacteriens macrolides de thiocarbamate cyclique 11,12