MA28739B1 - Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer - Google Patents

Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer

Info

Publication number: MA28739B1
Authority: MA; Morocco
Prior art keywords: dymethylpropyl; ksp; imidazol; fungal; inhibitors
Prior art date: 2004-06-18

Application number

MA29617A

Other languages

English (en)

Inventor

Weibo Wang

Paul A Barsanti

Yi Xi

Rustum S Boyce

Sabina Pecchi

Nathan Brammeier

Megan Phillips

Kris Mendenhall

Kelly Wayman

Liana Marie Lagniton

Ryan Constantine

Hong Yang

Elizabeth Mieuli

Savithri Ramurthy

Elisa Jazan

Anu Sharma

Jain Rama

Sharadha Sabramanian

Paul Renhowe

Kenneth Walter Bair

David Duhl

Annette Walter

Tinya Abrams

Kay Huh

Eric Martin

Mark Knapp

Vincent Le

Original Assignee

David Duhl

Annette Walter

Tinya Abrams

Kay Huh

Eric Martin

Mark Knapp

Vincent Le

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-18

Filing date

2007-01-17

Publication date

2007-07-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34980173&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA28739(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-01-17 Application filed by David Duhl, Annette Walter, Tinya Abrams, Kay Huh, Eric Martin, Mark Knapp, Vincent Le filed Critical David Duhl

2007-07-02 Publication of MA28739B1 publication Critical patent/MA28739B1/fr

Links

-1 1-BENZYL-4-PHENYL-1H-IMIDAZOL-2-YL Chemical class 0.000 title 1
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 1
102000010638 Kinesin Human genes 0.000 title 1
108010063296 Kinesin Proteins 0.000 title 1
206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
230000002538 fungal effect Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D498/10—Spiro-condensed systems

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
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General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

MA29617A 2004-06-18 2007-01-17 Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer MA28739B1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US58092704P	2004-06-18	2004-06-18

Publications (1)

Publication Number	Publication Date
MA28739B1 true MA28739B1 (fr)	2007-07-02

Family

ID=34980173

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA29617A MA28739B1 (fr)	2004-06-18	2007-01-17	Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer

Country Status (21)

Country	Link
US (3)	US7576221B2 (fr)
EP (1)	EP1765789B1 (fr)
JP (2)	JP4836280B2 (fr)
KR (1)	KR101170925B1 (fr)
CN (1)	CN1993331A (fr)
AU (1)	AU2005258135B2 (fr)
BR (1)	BRPI0510929A (fr)
CA (1)	CA2571002A1 (fr)
EC (1)	ECSP077183A (fr)
ES (1)	ES2409345T3 (fr)
IL (1)	IL180147A0 (fr)
MA (1)	MA28739B1 (fr)
MX (1)	MXPA06014909A (fr)
NO (1)	NO20070343L (fr)
NZ (1)	NZ552510A (fr)
RU (1)	RU2427572C2 (fr)
SG (1)	SG153851A1 (fr)
TN (1)	TNSN06419A1 (fr)
TW (1)	TW200612958A (fr)
WO (1)	WO2006002236A1 (fr)
ZA (1)	ZA200700481B (fr)

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WO2016020791A1 (fr)	2014-08-05	2016-02-11	Novartis Ag	Conjugués anticorps ckit-médicament
JP6743015B2 (ja)	2014-12-15	2020-08-19	バイエルファーマアクチエンゲゼルシャフト	Ｋｓｐ阻害剤の脱グリコシル化抗ｔｗｅａｋｒ抗体との抗体薬物複合体（ａｄｃ類）
IS2977B (is)	2015-02-23	2017-07-15	Actavis Group Ptc Ehf.	Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni
SG11201710639YA (en) *	2015-06-22	2018-01-30	Bayer Pharma AG	Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups
WO2016207104A1 (fr)	2015-06-23	2016-12-29	Bayer Pharma Aktiengesellschaft	Conjugués anticorps-principe actif (adc) d'inhibiteurs de ksp avec des anticorps anti-b7h3
MX2017017138A (es)	2015-06-23	2018-04-30	Bayer Pharma AG	Conjugados homogeneos especificos de sitio con inhibidores de ksp.
CA2990394A1 (fr)	2015-06-23	2016-12-29	Bayer Pharma Aktiengesellschaft	Conjugues anticorps-principe actif (adc) d'inhibiteurs de ksp avec des anticorps anti-tweakr
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CA3103327A1 (fr)	2018-06-18	2019-12-26	Bayer Aktiengesellschaft	Conjugues d'agent liant-principe actif inhibant cxcr5 comprenant des elements de liaison pouvant etre fragmentes de maniere enzymatique et presentant un profil d'action ameliore
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2005
- 2005-06-20 MX MXPA06014909A patent/MXPA06014909A/es active IP Right Grant
- 2005-06-20 NZ NZ552510A patent/NZ552510A/en not_active IP Right Cessation
- 2005-06-20 SG SG200904294-6A patent/SG153851A1/en unknown
- 2005-06-20 ES ES05760871T patent/ES2409345T3/es not_active Expired - Lifetime
- 2005-06-20 KR KR1020077000979A patent/KR101170925B1/ko not_active Expired - Fee Related
- 2005-06-20 WO PCT/US2005/022062 patent/WO2006002236A1/fr not_active Ceased
- 2005-06-20 BR BRPI0510929-9A patent/BRPI0510929A/pt not_active IP Right Cessation
- 2005-06-20 US US11/158,574 patent/US7576221B2/en not_active Expired - Fee Related
- 2005-06-20 AU AU2005258135A patent/AU2005258135B2/en not_active Ceased
- 2005-06-20 CA CA002571002A patent/CA2571002A1/fr not_active Abandoned
- 2005-06-20 RU RU2007101612/04A patent/RU2427572C2/ru not_active IP Right Cessation
- 2005-06-20 EP EP05760871A patent/EP1765789B1/fr not_active Expired - Lifetime
- 2005-06-20 CN CNA2005800262037A patent/CN1993331A/zh active Pending
- 2005-06-20 JP JP2007516842A patent/JP4836280B2/ja not_active Expired - Fee Related
- 2005-06-20 TW TW094120475A patent/TW200612958A/zh unknown
2006
- 2006-12-18 IL IL180147A patent/IL180147A0/en unknown
- 2006-12-18 TN TNP2006000419A patent/TNSN06419A1/en unknown
2007
- 2007-01-16 ZA ZA200700481A patent/ZA200700481B/xx unknown
- 2007-01-17 MA MA29617A patent/MA28739B1/fr unknown
- 2007-01-18 EC EC2007007183A patent/ECSP077183A/es unknown
- 2007-01-18 NO NO20070343A patent/NO20070343L/no not_active Application Discontinuation
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- 2009-06-05 US US12/455,798 patent/US8318791B2/en not_active Expired - Fee Related
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- 2011-08-18 JP JP2011179247A patent/JP2011256197A/ja not_active Withdrawn
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Also Published As

Publication number	Publication date
NO20070343L (no)	2007-03-05
EP1765789B1 (fr)	2013-02-27
IL180147A0 (en)	2007-06-03
US8318791B2 (en)	2012-11-27
US20090258016A1 (en)	2009-10-15
AU2005258135B2 (en)	2011-09-22
MXPA06014909A (es)	2007-02-28
KR20070106961A (ko)	2007-11-06
JP2008503501A (ja)	2008-02-07
KR101170925B1 (ko)	2012-08-07
AU2005258135A1 (en)	2006-01-05
RU2007101612A (ru)	2008-08-10
TW200612958A (en)	2006-05-01
BRPI0510929A (pt)	2007-07-17
US8735599B2 (en)	2014-05-27
RU2427572C2 (ru)	2011-08-27
US20060009472A1 (en)	2006-01-12
US20130017196A1 (en)	2013-01-17
WO2006002236A1 (fr)	2006-01-05
US7576221B2 (en)	2009-08-18
ECSP077183A (es)	2007-02-28
CA2571002A1 (fr)	2006-01-05
NZ552510A (en)	2010-12-24
EP1765789A1 (fr)	2007-03-28
CN1993331A (zh)	2007-07-04
JP4836280B2 (ja)	2011-12-14
SG153851A1 (en)	2009-07-29
ES2409345T3 (es)	2013-06-26
JP2011256197A (ja)	2011-12-22
ZA200700481B (en)	2008-10-29
TNSN06419A1 (en)	2008-02-22

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