MA29374B1 - Anticorps anti-ccr5 et leurs utilisations - Google Patents

Anticorps anti-ccr5 et leurs utilisations

Info

Publication number
MA29374B1
MA29374B1 MA30257A MA30257A MA29374B1 MA 29374 B1 MA29374 B1 MA 29374B1 MA 30257 A MA30257 A MA 30257A MA 30257 A MA30257 A MA 30257A MA 29374 B1 MA29374 B1 MA 29374B1
Authority
MA
Morocco
Prior art keywords
seq
constituted
cdr1
cdr2
group
Prior art date
Application number
MA30257A
Other languages
English (en)
Inventor
Michael Brandt
Suryanarayana Sankuratri
Ralf Schumacher
Stefan Seeber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA29374B1 publication Critical patent/MA29374B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'INVENTION CONCERNE UN ANTICORPS SE LIANT AU CCR5 HUMAIN, COMPRENANT UNE CHAÎNE LOURDE VARIABLE ET UNE CHAÎNE LÉGÈRE VARIABLE, SE CARACTÉRISANT EN CE QUE LA CHAÎNE LOURDE VARIABLE COMPREND DES SÉQUENCES CDR, CDR1, CDR2 ET CDR3, CDR1 ÉTANT SÉLECTIONNÉE DANS LE GROUPE CONSTITUÉ PAR SEQ ID NO: 9, 10, 11, 12, CDR2 ÉTANT SÉLECTIONNÉE DANS LE GROUPE CONSTITUÉ PAR SEQ ID NO: 13, 14, 15, CDR3 ÉTANT SÉLECTIONNÉE DANS LE GROUPE CONSTITUÉ PAR SEQ ID NO: 16, 17, LESDITES CDR ÉTANT SÉLECTIONNÉES INDÉPENDAMMENT LES UNES DES AUTRES, OU EST UN VARIANT HUMANISÉ CHIMÉRIQUE OU UN FRAGMENT DUDIT ANTICORPS. L'ANTICORPS SELON L'INVENTION PRÉSENTE DES PROPRIÉTÉS AVANTAGEUSES DANS LE TRAITEMENT DES MALADIES IMMUNOSUPPRESSIVES.
MA30257A 2005-04-01 2007-09-27 Anticorps anti-ccr5 et leurs utilisations MA29374B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05007138 2005-04-01

Publications (1)

Publication Number Publication Date
MA29374B1 true MA29374B1 (fr) 2008-04-01

Family

ID=34934663

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30257A MA29374B1 (fr) 2005-04-01 2007-09-27 Anticorps anti-ccr5 et leurs utilisations

Country Status (19)

Country Link
US (1) US7615216B2 (fr)
EP (2) EP2336183A3 (fr)
JP (2) JP4733736B2 (fr)
KR (1) KR20070116136A (fr)
CN (1) CN101175771A (fr)
AR (1) AR052959A1 (fr)
AU (1) AU2006228663A1 (fr)
BR (1) BRPI0609792A2 (fr)
CA (1) CA2603692A1 (fr)
CR (1) CR9393A (fr)
IL (1) IL186071A0 (fr)
MA (1) MA29374B1 (fr)
MX (1) MX2007011842A (fr)
NO (1) NO20074867L (fr)
RU (1) RU2007139953A (fr)
SG (1) SG151284A1 (fr)
TW (1) TW200720289A (fr)
WO (1) WO2006103100A2 (fr)
ZA (1) ZA200708332B (fr)

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US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
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CA2710912A1 (fr) * 2008-01-15 2009-07-23 F. Hoffmann-La Roche Ag Anticorps afucosyles contre ccr5 et leurs utilisations
WO2010028798A1 (fr) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Anticorps multivalents
WO2010028796A1 (fr) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Anticorps hexavalents trispécifiques
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BRPI1014089A2 (pt) 2009-04-02 2016-04-19 Roche Glycart Ag anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples
PT2417156E (pt) 2009-04-07 2015-04-29 Roche Glycart Ag Anticorpos trivalentes, biespecíficos
SG176219A1 (en) 2009-05-27 2011-12-29 Hoffmann La Roche Tri- or tetraspecific antibodies
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TWI412375B (zh) 2009-08-28 2013-10-21 Roche Glycart Ag 人類化抗ｃｄｃｐ１抗體
TW201113037A (en) 2009-08-28 2011-04-16 Hoffmann La Roche Antibodies against CDCP1 for the treatment of cancer
BR112012002249A2 (pt) 2009-09-07 2016-06-14 Hoffmann La Roche método para determinação da glicosilação de uma imunoglobulina e uso de um método
CN102712696A (zh) 2009-09-16 2012-10-03 弗·哈夫曼-拉罗切有限公司 包含卷曲螺旋和/或系链的蛋白质复合体及其用途
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TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
WO2012010582A1 (fr) 2010-07-21 2012-01-26 Roche Glycart Ag Anticorps anti-cxcr5 et leurs méthodes d'utilisation
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KR20150030744A (ko) 2012-06-27 2015-03-20 에프. 호프만-라 로슈 아게 표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Ｆｃ－영역 접합체의 제조 방법 및 그의 용도
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Also Published As

Publication number Publication date
TW200720289A (en) 2007-06-01
CR9393A (es) 2008-02-20
JP4733736B2 (ja) 2011-07-27
CN101175771A (zh) 2008-05-07
JP2008533998A (ja) 2008-08-28
EP1869087A2 (fr) 2007-12-26
US20070036796A1 (en) 2007-02-15
WO2006103100A3 (fr) 2006-12-28
KR20070116136A (ko) 2007-12-06
JP2011079836A (ja) 2011-04-21
EP2336183A3 (fr) 2011-10-12
US7615216B2 (en) 2009-11-10
IL186071A0 (en) 2008-01-20
AU2006228663A1 (en) 2006-10-05
EP2336183A2 (fr) 2011-06-22
ZA200708332B (en) 2009-04-29
RU2007139953A (ru) 2009-05-10
NO20074867L (no) 2007-12-07
MX2007011842A (es) 2007-10-11
AR052959A1 (es) 2007-04-11
WO2006103100A2 (fr) 2006-10-05
SG151284A1 (en) 2009-04-30
CA2603692A1 (fr) 2006-10-05
BRPI0609792A2 (pt) 2010-04-27

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