MA29226B1 - Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations - Google Patents

Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations

Info

Publication number
MA29226B1
MA29226B1 MA30048A MA30048A MA29226B1 MA 29226 B1 MA29226 B1 MA 29226B1 MA 30048 A MA30048 A MA 30048A MA 30048 A MA30048 A MA 30048A MA 29226 B1 MA29226 B1 MA 29226B1
Authority
MA
Morocco
Prior art keywords
receptor
heavy chain
alpha
antibodies against
variable
Prior art date
Application number
MA30048A
Other languages
English (en)
Inventor
Josef Endl
Maria Fuentes
Yvo Graus
Adelbert Grossmann
Sebastian Neumann
Paul Parren
Frank Rebers
Joerg Regula
Ralf Schumacher
Stefan Seeber
Jan Stracke
Kay-Gunnar Stubenrauch
De Winkel Jan Van
Vugt Martine Van
Sandra Vereecken-Verploegen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA29226B1 publication Critical patent/MA29226B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRÉSENTE INVENTION DÉCRIT UN ANTICORPS SE LIANT AU RÉCEPTEUR $G(A)1 DE L'IL-13, INHIBANT LA BIO-ACTIVITÉ DE L'IL-13 ET COMPRENANT UNE CHAÎNE LOURDE VARIABLE ET UNE CHAÎNE LÉGÈRE VARIABLE, CARACTÉRISÉ EN CE QUE LA SÉQUENCE CDR3 D'ACIDES AMINÉS DE LA CHAÎNE LOURDE VARIABLE DUDIT ANTICORPS EST CHOISIE DANS LE GROUPE SE COMPOSANT DES SÉQUENCES CDR3 DE LA CHAÎNE LOURDE TELLES QUE SEQ ID N°: 1, 3, 5, 7 OU 9 ET EST UTILE DANS LE TRAITEMENT DE L'ASTHME ET DE MALADIES ALLERGIQUES.
MA30048A 2005-01-03 2007-07-06 Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations MA29226B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05000003 2005-01-03
EP05002229 2005-02-03

Publications (1)

Publication Number Publication Date
MA29226B1 true MA29226B1 (fr) 2008-02-01

Family

ID=36199730

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30048A MA29226B1 (fr) 2005-01-03 2007-07-06 Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations

Country Status (19)

Country Link
US (2) US7807158B2 (fr)
EP (1) EP1836226B1 (fr)
JP (1) JP5086098B2 (fr)
KR (1) KR100934894B1 (fr)
AR (1) AR051888A1 (fr)
AT (1) ATE513855T1 (fr)
AU (1) AU2006204480B2 (fr)
BR (1) BRPI0606368A2 (fr)
CA (1) CA2592614C (fr)
CR (1) CR9209A (fr)
IL (1) IL184205A0 (fr)
MA (1) MA29226B1 (fr)
MX (1) MX2007008128A (fr)
NO (1) NO20073655L (fr)
NZ (1) NZ556126A (fr)
RU (1) RU2413736C2 (fr)
SG (1) SG172504A1 (fr)
TW (2) TWI306862B (fr)
WO (1) WO2006072564A1 (fr)

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Also Published As

Publication number Publication date
KR20070091180A (ko) 2007-09-07
MX2007008128A (es) 2007-07-20
TW200902555A (en) 2009-01-16
RU2007129676A (ru) 2009-02-10
CA2592614C (fr) 2015-04-14
AU2006204480A1 (en) 2006-07-13
EP1836226B1 (fr) 2011-06-22
ATE513855T1 (de) 2011-07-15
TWI306862B (en) 2009-03-01
EP1836226A1 (fr) 2007-09-26
TW200635945A (en) 2006-10-16
RU2413736C2 (ru) 2011-03-10
US20060263356A1 (en) 2006-11-23
NZ556126A (en) 2008-09-26
SG172504A1 (en) 2011-07-28
KR100934894B1 (ko) 2010-01-07
WO2006072564A1 (fr) 2006-07-13
NO20073655L (no) 2007-08-02
JP5086098B2 (ja) 2012-11-28
BRPI0606368A2 (pt) 2009-06-23
IL184205A0 (en) 2007-10-31
AU2006204480B2 (en) 2011-06-09
AR051888A1 (es) 2007-02-14
US7807158B2 (en) 2010-10-05
US20110086026A1 (en) 2011-04-14
CR9209A (es) 2007-08-28
HK1112006A1 (en) 2008-08-22
CA2592614A1 (fr) 2006-07-13
JP2008526187A (ja) 2008-07-24

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