MA29757B1 - Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc - Google Patents

Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc

Info

Publication number
MA29757B1
MA29757B1 MA30689A MA30689A MA29757B1 MA 29757 B1 MA29757 B1 MA 29757B1 MA 30689 A MA30689 A MA 30689A MA 30689 A MA30689 A MA 30689A MA 29757 B1 MA29757 B1 MA 29757B1
Authority
MA
Morocco
Prior art keywords
hcv
protease
inhibitors
macrocyclic peptides
macrocyclic
Prior art date
Application number
MA30689A
Other languages
English (en)
Inventor
Katharine M Holloway
Nigel J Liverton
John A Mccauley
Michael T Rudd
Joseph P Vacca
Steven W Ludmerer
David B Olsen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MA29757B1 publication Critical patent/MA29757B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

ABREGE DE LA DESCRIPTION La présente invention concerne des composés macrocycliques de formule (I) qui sont utiles comme inhibiteurs de la protéase NS3 du virus de l'hépatite C (VHC), leur synthèse, et leur usage pour le traitement ou la prévention des infections par le VHC.
MA30689A 2005-08-01 2008-02-25 Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc MA29757B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70425605P 2005-08-01 2005-08-01
US72450905P 2005-10-07 2005-10-07

Publications (1)

Publication Number Publication Date
MA29757B1 true MA29757B1 (fr) 2008-09-01

Family

ID=37404447

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30689A MA29757B1 (fr) 2005-08-01 2008-02-25 Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc

Country Status (16)

Country Link
US (1) US8278322B2 (fr)
EP (1) EP1913016B1 (fr)
JP (1) JP4705984B2 (fr)
KR (1) KR20080036598A (fr)
AU (1) AU2006275605B2 (fr)
BR (1) BRPI0614205A2 (fr)
CA (1) CA2615896C (fr)
CR (1) CR9731A (fr)
EC (1) ECSP088157A (fr)
IL (1) IL189166A0 (fr)
MA (1) MA29757B1 (fr)
MX (1) MX2008001588A (fr)
NO (1) NO20081086L (fr)
NZ (1) NZ565269A (fr)
RU (1) RU2008107972A (fr)
WO (1) WO2007016441A1 (fr)

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KR20080036598A (ko) 2008-04-28
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CR9731A (es) 2008-04-10
US20110028494A1 (en) 2011-02-03
JP2009503080A (ja) 2009-01-29
WO2007016441A1 (fr) 2007-02-08
BRPI0614205A2 (pt) 2016-11-22
EP1913016B1 (fr) 2013-01-16
CA2615896A1 (fr) 2007-02-08
ECSP088157A (es) 2008-02-20
AU2006275605B2 (en) 2011-01-06
NO20081086L (no) 2008-04-30
RU2008107972A (ru) 2009-09-10
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IL189166A0 (en) 2008-08-07
CA2615896C (fr) 2012-11-13

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