MA29888B1 - Antagonistes du recepteur d'histamine h3 - Google Patents

Antagonistes du recepteur d'histamine h3

Info

Publication number
MA29888B1
MA29888B1 MA30879A MA30879A MA29888B1 MA 29888 B1 MA29888 B1 MA 29888B1 MA 30879 A MA30879 A MA 30879A MA 30879 A MA30879 A MA 30879A MA 29888 B1 MA29888 B1 MA 29888B1
Authority
MA
Morocco
Prior art keywords
compound
formula
disorders
disorder
disease
Prior art date
Application number
MA30879A
Other languages
English (en)
Inventor
Travis T Wager
Ramalakshmi Yegna Chandrasekaran
Todd William Butler
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA29888B1 publication Critical patent/MA29888B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

CETTE INVENTION CONCERNE UN COMPOSÉ DE FORMULE I TELLE QUE DÉFINIE ICI OU UN SEL ACCEPTABLE DU POINT DE VUE PHARMACEUTIQUE DE CELUI-CI ; UNE COMPOSITION PHARMACEUTIQUE CONTENANT UN COMPOSÉ DE FORMULE I, UN PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ DE FORMULE I, UN PROCÉDÉ DE TRAITEMENT D'UN TROUBLE OU D'UNE AFFECTION QUI PEUT ÊTRE TRAITÉ EN INHIBANT LES RÉCEPTEURS DE L'HISTAMINE H3, LEDIT PROCÉDÉ COMPRENANT D'ADMINISTRER À UN MAMMIFÈRE QUI A BESOIN D'UN TEL TRAITEMENT UN COMPOSÉ DE FORMULE I TEL QUE DÉCRIT CI-DESSUS, ET UN PROCÉDÉ DE TRAITEMENT D'UN TROUBLE OU D'UNE AFFECTION SÉLECTIONNÉ DANS LE GROUPE CONSTITUÉ DE LA DÉPRESSION, DE TROUBLES DE L'HUMEUR, DE LA SCHIZOPHRÉNIE, DE TROUBLES DE L'ANXIÉTÉ, DE LA MALADIE D'ALZHEIMER, DU TROUBLE DÉFICITAIRE DE L'ATTENTION AVEC HYPERACTIVITÉ (TDAH), DE TROUBLES PSYCHOTIQUES, DE TROUBLES COGNITIFS, DE TROUBLES DU SOMMEIL, DE L'OBÉSITÉ, DE VERTIGES, DE L'ÉPILEPSIE, DU MAL DES TRANSPORTS, DE MALADIES RESPIRATOIRES, DE L'ALLERGIE, DE RÉPONSES DES VOIES RESPIRATOIRES INDUITES PAR UNE ALLERGIE, DE LA RHINITE ALLERGIQUE, DE L'OBSTRUCTION NASALE, DE LA CONGESTION ALLERGIQUE, DE LA CONGESTION, DE L'HYPOTENSION, DE MALADIES CARDIOVASCULAIRES, DE MALADIES DU TRACTUS GASTRO-INTESTINAL, DE L'HYPERMOTILITÉ ET DE L'HYPOMOTILITÉ ET DE LA SÉCRÉTION ACIDE DU TRACTUS GASTRO-INTESTINAL, LEDIT PROCÉDÉ COMPRENANT D'ADMINISTRER À UN MAMMIFÈRE QUI A BESOIN D'UN TEL TRAITEMENT UN COMPOSÉ DE FORMULE I TEL QUE DÉCRIT CI-DESSUS.
MA30879A 2005-10-27 2008-04-25 Antagonistes du recepteur d'histamine h3 MA29888B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73099605P 2005-10-27 2005-10-27

Publications (1)

Publication Number Publication Date
MA29888B1 true MA29888B1 (fr) 2008-10-03

Family

ID=37776539

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30879A MA29888B1 (fr) 2005-10-27 2008-04-25 Antagonistes du recepteur d'histamine h3

Country Status (39)

Country Link
US (2) US8158673B2 (fr)
EP (1) EP1951660B1 (fr)
JP (2) JP4319245B2 (fr)
KR (1) KR101025358B1 (fr)
CN (1) CN101296898B (fr)
AP (1) AP2403A (fr)
AR (1) AR056879A1 (fr)
AU (1) AU2006307645B2 (fr)
BR (1) BRPI0617797A2 (fr)
CA (1) CA2621323C (fr)
CR (1) CR9910A (fr)
CU (1) CU23806B7 (fr)
DK (1) DK1951660T3 (fr)
DO (1) DOP2006000239A (fr)
EA (1) EA013602B1 (fr)
EC (1) ECSP088373A (fr)
ES (1) ES2444370T3 (fr)
GE (1) GEP20104937B (fr)
GT (1) GT200600471A (fr)
HN (1) HN2006036385A (fr)
HR (1) HRP20140061T1 (fr)
IL (1) IL189866A (fr)
MA (1) MA29888B1 (fr)
MY (1) MY145001A (fr)
NI (1) NI200800132A (fr)
NL (1) NL1032713C2 (fr)
NO (1) NO20082264L (fr)
NZ (1) NZ566488A (fr)
PE (1) PE20070720A1 (fr)
PL (1) PL1951660T3 (fr)
PT (1) PT1951660E (fr)
RS (2) RS20080173A (fr)
SI (1) SI1951660T1 (fr)
TN (1) TNSN08150A1 (fr)
TW (1) TWI318206B (fr)
UA (1) UA88719C2 (fr)
UY (1) UY29882A1 (fr)
WO (1) WO2007049123A1 (fr)
ZA (1) ZA200803130B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8158673B2 (en) * 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
JP4585610B2 (ja) 2007-01-22 2010-11-24 ファイザー・プロダクツ・インク 治療用化合物のトシル酸塩およびその医薬組成物
EP2123644B1 (fr) 2007-03-07 2014-12-17 Takeda Pharmaceutical Company Limited Dérivés de benzodiazépine et utilisation de ces derniers
HRP20140047T1 (en) 2007-08-22 2014-02-14 Astrazeneca Ab Cycloptopyl amide derivatives
WO2009071988A1 (fr) * 2007-12-07 2009-06-11 Pfizer Inc. Sel de tosylate de trans-n-isobutyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylméthyl)phényl]cyclobutanecarboxamide
EP2300422B1 (fr) 2008-05-08 2014-11-05 Evotec AG Azétidines comme antagonistes des récepteurs h3 de l histamine
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
BR112012020629A2 (pt) 2010-02-18 2018-06-19 Astrazeneca Ab forma cristalina, e, método para a terapia de um distúrbio
JP5767393B2 (ja) 2011-03-31 2015-08-19 ファイザー・インク 新規二環式ピリジノン
WO2012172449A1 (fr) 2011-06-13 2012-12-20 Pfizer Inc. Lactames convenant comme inhibiteurs des bêta-sécrétases
WO2013030713A1 (fr) 2011-08-31 2013-03-07 Pfizer Inc. Hexahydropyrano[3,4-d][1,3]thiazine-2-amines
WO2013151982A1 (fr) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Méthodes et composés utiles pour traiter le prurit, et procédés d'identification desdits composés
JP6110937B2 (ja) 2012-05-04 2017-04-05 ファイザー・インク ＡＰＰ、ＢＡＣＥ１、およびＢＡＣＥ２の阻害剤としての複素環式置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
CN105732639A (zh) 2012-06-29 2016-07-06 辉瑞大药厂 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类
CA2882389A1 (fr) 2012-09-20 2014-03-27 Pfizer Inc. Composes d'hexahydropyrano[3,4-d][1,3]thiazine-2-amine alkyl-substitues
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
JP2016502978A (ja) 2012-12-11 2016-02-01 ファイザー・インク ＢＡＣＥ１の阻害剤としてのヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
CA2893333C (fr) 2012-12-19 2017-10-24 Pfizer Inc. Composes hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitues carbocycliques et heterocycliques
CA2897678A1 (fr) 2013-02-13 2014-08-21 Pfizer Inc. Composes hexahydropyrano [3,4-d][1,3] thiazin-2-amine substitues par un heteroaryle
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CA2900302C (fr) 2013-02-19 2018-07-03 Pfizer Inc. Composes d'azabenzimidazole en tant qu'inhibiteurs d'isozymes pde4 pour le traitement de troubles du snc et d'autres affections
JP6425717B2 (ja) 2013-10-04 2018-11-21 ファイザー・インク ガンマセクレターゼモジュレーターとしての新規二環式ピリジノン
EP3083618B1 (fr) 2013-12-17 2018-02-21 Pfizer Inc Nouvelles 1h-pyrrolo[2,3- b]pyridines 3,4-disubstituées et 7h-pyrrolo[2,3-c]pyridazines 4,5-disubstituées en tant qu'inhibiteurs de la lrrk2
EP3126361B1 (fr) 2014-04-01 2019-11-06 Pfizer Inc Chromène et 1,1a,2,7b-tétrahydrocyclopropa[c]chromène pyridopyrazinediones comme modulateurs de gamma-sécrétase
AU2015245260A1 (en) 2014-04-10 2016-10-06 Pfizer Inc. 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
WO2016012896A1 (fr) 2014-07-24 2016-01-28 Pfizer Inc. Composés de pyrazolopyrimidine
CR20170035A (es) 2014-08-06 2017-04-28 Pfizer Compuestos de imidazopiridazina
JP6628805B2 (ja) 2015-02-03 2020-01-15 ファイザー・インク 新規シクロプロパベンゾフラニルピリドピラジンジオン
BR112017026191B1 (pt) 2015-06-17 2023-10-10 Pfizer Inc Compostos tricíclicos inibidores de fosfodiesterase, sua composição farmacêutica e uso dos mesmos
CN108137586B (zh) 2015-09-14 2021-04-13 辉瑞大药厂 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物
AU2016325665A1 (en) 2015-09-24 2018-03-08 Pfizer Inc. N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3] thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl] amides
WO2017051294A1 (fr) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-diméthyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides utiles comme inhibiteurs de bace
JP2018531924A (ja) 2015-09-24 2018-11-01 ファイザー・インク テトラヒドロピラノ［３，４−ｄ］［１，３］オキサジン誘導体、およびｂａｃｅ阻害剤としてのその使用
US10323042B2 (en) 2016-02-23 2019-06-18 Pfizer Inc. 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
MX386258B (es) 2016-07-01 2025-03-18 Pfizer Derivados de 5,7-dihidro-pirrolo-piridina para tratar enfermedades neurologicas y neurodegenerativas
IL269215B (en) 2017-03-10 2022-09-01 Pfizer Disubstituted imidazole[4,5-c]quinoline derivatives
KR102582626B1 (ko) 2017-03-10 2023-09-22 화이자 인코포레이티드 Lrrk2 억제제로서의 신규 이미다조[4,5-c]퀴놀린 유도체
EP3634978A1 (fr) 2017-06-07 2020-04-15 Adrx, Inc. Inhibiteur d'agrégation de tau
PL3642202T3 (pl) 2017-06-22 2023-03-13 Pfizer Inc. Pochodne dihydropirolopirydyny
EP3668886A2 (fr) 2017-08-18 2020-06-24 Adrx, Inc. Inhibiteurs peptidiques d'agrégation de tau
CA3094366A1 (fr) 2018-03-23 2019-09-26 Pfizer Inc. Derives azaspiro de piperazine
WO2022182658A1 (fr) 2021-02-23 2022-09-01 Hoth Therapeutics, Inc. Utilisation d'aprépitant pour le traitement de la maladie d'alzheimer
CN116514645A (zh) * 2023-04-08 2023-08-01 绍兴上虞华伦化工有限公司 二氟-4溴苯甲醛及其制备工艺
WO2025145091A1 (fr) 2023-12-29 2025-07-03 Pfizer Inc. Formes cristallines d'un modulateur muscarinique m4 du récepteur et méthodes de traitement de maladies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6559140B2 (en) 2000-03-09 2003-05-06 Abbott Laboratories Cyclic and bicyclic diamino histamine-3 receptor antagonists
CA2441080A1 (fr) 2001-03-23 2002-10-03 Eli Lilly And Company Composes d'aryl alkylamines non imidazole comme antagonistes des recepteurs h3 de l'histamine, preparation et applications therapeutiques
US7671047B2 (en) 2002-06-19 2010-03-02 Sanofi-Aventis Deutschland Gmbh Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
JP2004131497A (ja) * 2002-09-18 2004-04-30 Satoshi Shuto シスシクロプロパン誘導体
AU2004259263B2 (en) * 2003-07-29 2010-12-16 High Point Pharmaceuticals, Llc Pyridazinyl- piperazines and their use as histamine H3 receptor ligands
WO2005028438A1 (fr) * 2003-09-22 2005-03-31 Banyu Pharmaceutical Co., Ltd. Nouveau derive de piperidine
WO2005080361A1 (fr) 2004-02-02 2005-09-01 Pfizer Products Inc. Modulateurs du recepteur de l'histamine-3
JP4777974B2 (ja) * 2004-04-01 2011-09-21 イーライ リリー アンド カンパニー ヒスタミンｈ３受容体作用物質、製剤および治療的使用
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
EP1595881A1 (fr) 2004-05-12 2005-11-16 Pfizer Limited Dérivés de tetrahydronaphthyridine en tant que ligands de récepteur H3 d'histamine
DE602006018301D1 (de) 2005-06-22 2010-12-30 Pfizer Prod Inc Histamin-3-rezeptorantagonisten
US8158673B2 (en) * 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
JP4585610B2 (ja) * 2007-01-22 2010-11-24 ファイザー・プロダクツ・インク 治療用化合物のトシル酸塩およびその医薬組成物

Also Published As

Publication number Publication date
TWI318206B (en) 2009-12-11
HN2006036385A (es) 2009-10-30
CR9910A (es) 2008-05-16
IL189866A (en) 2012-06-28
US20080096955A1 (en) 2008-04-24
TW200800886A (en) 2008-01-01
CA2621323A1 (fr) 2007-05-03
UA88719C2 (ru) 2009-11-10
KR20080054413A (ko) 2008-06-17
PL1951660T3 (pl) 2014-04-30
AU2006307645B2 (en) 2012-02-16
AR056879A1 (es) 2007-10-31
NL1032713C2 (nl) 2007-10-09
JP4319245B2 (ja) 2009-08-26
US8389743B2 (en) 2013-03-05
DOP2006000239A (es) 2007-04-30
WO2007049123A1 (fr) 2007-05-03
US8158673B2 (en) 2012-04-17
RS53153B (sr) 2014-06-30
CN101296898B (zh) 2013-07-24
TNSN08150A1 (fr) 2009-10-30
NL1032713A1 (nl) 2007-05-01
PT1951660E (pt) 2014-02-10
BRPI0617797A2 (pt) 2011-08-09
AP2403A (en) 2012-05-04
RS20080173A (sr) 2009-07-15
GT200600471A (es) 2007-06-08
GEP20104937B (en) 2010-03-25
EA013602B1 (ru) 2010-06-30
KR101025358B1 (ko) 2011-03-28
JP2009161554A (ja) 2009-07-23
AP2008004401A0 (en) 2008-04-30
DK1951660T3 (da) 2014-01-27
ECSP088373A (es) 2008-05-30
CN101296898A (zh) 2008-10-29
CA2621323C (fr) 2010-08-24
CU20080069A7 (es) 2009-12-17
PE20070720A1 (es) 2007-08-11
NO20082264L (no) 2008-07-22
HRP20140061T1 (hr) 2014-02-14
ES2444370T3 (es) 2014-02-24
ZA200803130B (en) 2009-01-28
IL189866A0 (en) 2008-11-03
EA200800946A1 (ru) 2008-10-30
MY145001A (en) 2011-12-15
EP1951660B1 (fr) 2013-12-11
EP1951660A1 (fr) 2008-08-06
AU2006307645A1 (en) 2007-05-03
SI1951660T1 (sl) 2014-02-28
JP2009513619A (ja) 2009-04-02
US20120220568A1 (en) 2012-08-30
HK1124831A1 (en) 2009-07-24
JP5064427B2 (ja) 2012-10-31
NZ566488A (en) 2011-07-29
NI200800132A (es) 2010-02-15
UY29882A1 (es) 2007-05-31
CU23806B7 (es) 2012-04-15

Similar Documents

Publication Publication Date Title
MA29888B1 (fr) Antagonistes du recepteur d'histamine h3
ATE488496T1 (de) Histamin-3-rezeptorantagonisten
WO2007105053A3 (fr) Tétralines en tant qu'antagonistes du récepteur h-3
WO2007088450A3 (fr) Chromane antagoniste du récepteur h-3
WO2007063385A3 (fr) Antagonistes des recepteurs de l'histamine 3 pour des amines spirocycliques
WO2007138431A3 (fr) Antagonistes de l'éther histamine-3 azabicyclique
MA27847A1 (fr) Derives d'azetidine substituee avec 3-alkyle et 3-alcenyle.
JP2007505111A (ja) 非沈静ａ−２アゴニスト１−（２，３−ジメチル−フェニル）−エチル−１、３−ジヒドロ−イミダゾール−２−チオン
BRPI0507374A (pt) moduladores do receptor de histamina-3
EA018064B1 (ru) Способ лечения депрессии
MA35194B1 (fr) Derives de benzamide substitues
US11173147B2 (en) Prophylactic or therapeutic agent for delirium
HRP940960A2 (en) N-substituted azabicycloheptane derivatives, the preparation and use thereof
US11547707B2 (en) Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
JP2022031814A (ja) 不安障害を治療するための（２Ｓ）－１－［４－（３，４－ジクロロフェニル）ピペリジン－１－イル］－３－［２－（５－メチル－１，３，４－オキサジアゾール－２－イル）ベンゾ［ｂ］フラン－４－イルオキシ］プロパン－２－オールまたはその代謝産物
AU2020271363B2 (en) Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
MX2007003587A (es) Antagonistas de los receptores de histamina-3.
WO2006024955A8 (fr) Antagonistes des recepteurs d'amine histamine-3 azabicycliques
BRPI0512567A (pt) compostos antagonistas de receptor de histamina-3 diazabicìclico e respectivas composições farmacêuticas
WO2018117063A1 (fr) Agent thérapeutique contre l'agitation
Jiang et al. 4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists
AR037711A1 (es) Sal de acido citrico de un compuesto terapeutico y composiciones farmaceuticas que la contienen
HK40067131B (en) Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
HK40067131A (en) Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
OA20885A (en) Carbamoyl cyclohexane derivatives for treating autism spectrum disorder.