MA30268B1 - Derive polycyclique de cinnamide - Google Patents

Derive polycyclique de cinnamide

Info

Publication number
MA30268B1
MA30268B1 MA31220A MA31220A MA30268B1 MA 30268 B1 MA30268 B1 MA 30268B1 MA 31220 A MA31220 A MA 31220A MA 31220 A MA31220 A MA 31220A MA 30268 B1 MA30268 B1 MA 30268B1
Authority
MA
Morocco
Prior art keywords
cinnamide
polycyclic derivative
novel pharmaceutical
polycyclic
derivative
Prior art date
Application number
MA31220A
Other languages
English (en)
Inventor
Teiji Kimura
Noritaka Kitazawa
Toshihiko Kaneko
Nobuaki Sato
Koki Kawano
Koichi Ito
Eriko Doi
Mamoru Takaishi
Takeo Sasaki
Takashi Doko
Takehiko Miyagawa
Hiroaki Hagiwara
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MA30268B1 publication Critical patent/MA30268B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

«Composition pharmaceutique nouvelle» Il est révélé des compositions pharmaceutiques nouvelles contenant de l'acide 3'-[(2Z)-[1-(3,4-diméthylphényl)-1,5-dihydro-3-méthyl-5-oxo-4H-pyrazole-4-ylidène]hydrazino]-2'-hydroxy-[1,1'-biphényl]-3-carboxylique bis-(monoéthanolamine) (eltrombopag olamine) et des procédés pour leur préparation.
MA31220A 2006-03-09 2008-09-08 Derive polycyclique de cinnamide MA30268B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78051706P 2006-03-09 2006-03-09
JP2006063562 2006-03-09
US86170206P 2006-11-30 2006-11-30
JP2006322728 2006-11-30

Publications (1)

Publication Number Publication Date
MA30268B1 true MA30268B1 (fr) 2009-03-02

Family

ID=38474999

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31220A MA30268B1 (fr) 2006-03-09 2008-09-08 Derive polycyclique de cinnamide

Country Status (15)

Country Link
EP (1) EP1992618B1 (fr)
KR (1) KR101464651B1 (fr)
AR (1) AR059955A1 (fr)
AU (1) AU2007223158B2 (fr)
CA (1) CA2643796A1 (fr)
CY (1) CY1112767T1 (fr)
EA (1) EA016464B1 (fr)
GE (1) GEP20115139B (fr)
HN (1) HN2008001374A (fr)
HR (1) HRP20120174T1 (fr)
IL (1) IL193770A (fr)
MA (1) MA30268B1 (fr)
MX (1) MX2008011221A (fr)
PL (1) PL1992618T3 (fr)
WO (1) WO2007102580A1 (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2566094A1 (fr) 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. Compose de cinnamide
AU2005297966B2 (en) 2004-10-26 2010-12-23 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
BRPI0618814A2 (pt) 2005-11-24 2014-04-29 Eisai R&D Man Co Ltd Composto ou um sal farmacologicamente aceitável do mesmo, e, agente farmacêutico
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
US7737141B2 (en) 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
CA2677296A1 (fr) * 2007-02-08 2008-08-14 Merck & Co., Inc. Agents therapeutiques
CL2008000582A1 (es) 2007-02-28 2008-06-27 Eisai R&D Man Co Ltd Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis.
DE602008004769D1 (en) 2007-05-11 2011-03-10 Hoffmann La Roche Hetarylaniline als modulatoren für amyloid beta
EP2152695A2 (fr) * 2007-06-01 2010-02-17 Schering Corporation Modulateurs de sécrétase gamma
CA2694401C (fr) * 2007-08-31 2012-12-04 Eisai R&D Management Co., Ltd. Compose polycyclique
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
WO2009061699A1 (fr) * 2007-11-05 2009-05-14 Schering Corporation Modulateurs de gamma-secrétase
CA2708151A1 (fr) * 2007-12-11 2009-06-18 Schering Corporation Modulateurs de la gamma secretase
US8217064B2 (en) 2007-12-20 2012-07-10 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
WO2009080533A1 (fr) 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Dérivés hétéroaryles en tant qu'antagonistes du récepteur à orexine
WO2009087127A1 (fr) 2008-01-11 2009-07-16 F. Hoffmann-La Roche Ag Modulateurs pour l'amyloïde-bêta
KR101247840B1 (ko) 2008-02-22 2013-03-26 에프. 호프만-라 로슈 아게 아밀로이드 베타 조절제
JP2012501336A (ja) * 2008-08-27 2012-01-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物の製造法
JP5502089B2 (ja) 2008-10-09 2014-05-28 エフ．ホフマン−ラ ロシュ アーゲー アミロイドβのモジュレーター
WO2010054064A1 (fr) * 2008-11-06 2010-05-14 Schering Corporation Modulateurs de sécrétase gamma
WO2010054067A1 (fr) * 2008-11-06 2010-05-14 Schering Corporation Modulateurs de sécrétase gamma
WO2010052199A1 (fr) 2008-11-10 2010-05-14 F. Hoffmann-La Roche Ag Modulateurs de la gamma secrétase hétérocyclique
CA2742472A1 (fr) * 2008-11-13 2010-05-20 Schering Corporation Modulateurs de gamma secretase
JP2012513399A (ja) * 2008-12-22 2012-06-14 シェーリング コーポレイション γ−セクレターゼ調節剤
TW201030002A (en) * 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
JP2012051805A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd テトラヒドロトリアゾロピリジン誘導体の製造方法
AU2010218714A1 (en) 2009-02-26 2011-09-08 Eisai R&D Management Co., Ltd. Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
JP2012051807A (ja) * 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
JP2012121809A (ja) * 2009-02-26 2012-06-28 Eisai R & D Management Co Ltd 多環式化合物の製造法およびその中間体
KR20110118626A (ko) 2009-02-26 2011-10-31 에자이 알앤드디 매니지먼트 가부시키가이샤 테트라하이드로트리아졸로피리딘 유도체의 염과 이의 결정
JPWO2011007756A1 (ja) * 2009-07-13 2012-12-27 武田薬品工業株式会社 複素環化合物及びその用途
US8871760B2 (en) * 2009-09-21 2014-10-28 Roche Palo Alto Llc [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators
PE20121511A1 (es) 2010-01-15 2012-12-06 Janssen Pharmaceuticals Inc Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa
US8486967B2 (en) 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
CN103002742B (zh) 2010-03-05 2016-07-13 卡尔约药物治疗公司 核转运调节剂及其应用
WO2012029991A1 (fr) * 2010-09-02 2012-03-08 Takeda Pharmaceutical Company Limited Triazoles fusionnés pour le traitement ou la prophylaxie du trouble cognitif léger
JP2014012641A (ja) * 2010-10-29 2014-01-23 Dainippon Sumitomo Pharma Co Ltd 新規ピリジン誘導体
JP6106605B2 (ja) * 2011-01-17 2017-04-05 カリオファーム セラピューティクス，インコーポレイテッド オレフィン含有核輸送調節剤およびその使用
CA2842364A1 (fr) 2011-07-29 2013-02-07 Karyopharm Therapeutics, Inc. Modulateurs de transport nucleaire et leurs utilisations
ES2954991T3 (es) 2011-07-29 2023-11-28 Karyopharm Therapeutics Inc Moduladores del transporte nuclear que contienen hidrazida y usos de los mismos
WO2013055793A1 (fr) * 2011-10-12 2013-04-18 University Of Pittsburg-Of The Commonwealth System Of Higher Education Petites molécules ciblant la localisation et/ou le niveau nucléaire des récepteurs de l'androgène dans le cancer de la prostate
SMT202000347T1 (it) 2012-05-09 2020-07-08 Biogen Ma Inc Modulatori di trasporto nucleare e loro usi
JP6106745B2 (ja) 2012-05-16 2017-04-05 ヤンセン ファーマシューティカルズ，インコーポレーテッド （特に）アルツハイマー病の治療に有用な置換３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体
EP2687528A1 (fr) * 2012-07-17 2014-01-22 Ares Trading S.A. Dérivés de triazole fusionnés comme modulateurs de gamma-sécrétase
US10112943B2 (en) 2012-12-20 2018-10-30 Janssen Pharmaceutica Nv Substituted imidazoles as gamma secretase modulators
WO2014111457A1 (fr) 2013-01-17 2014-07-24 Janssen Pharmaceutica Nv Dérivés substitués de pyrido-pipérazinone d'un nouveau type en tant que modulateurs de la gamma-sécrétase
WO2014144772A1 (fr) 2013-03-15 2014-09-18 Karyopharm Therapeutics Inc. Procédés de promotion de la cicatrisation d'une plaie à l'aide d'inhibiteurs de crm1
PL3010892T3 (pl) 2013-06-21 2019-07-31 Karyopharm Therapeutics, Inc. 1,2,4-triazole jako modulatory transportu jądrowego i ich zastosowania
US20160257657A1 (en) 2013-09-20 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
CA2924527C (fr) 2013-09-20 2022-07-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Composes destines au traitement du cancer de la prostate
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
CN111484483B (zh) 2014-08-15 2023-05-26 卡尔约药物治疗公司 赛灵克斯的多晶型物
EP3397633A1 (fr) 2015-12-31 2018-11-07 Karyopharm Therapeutics, Inc. Modulateurs de transport nucléaire et leurs utilisations
EP3397634A1 (fr) 2015-12-31 2018-11-07 Karyopharm Therapeutics, Inc. Modulateurs de transport nucléaire et leurs utilisations
US10323042B2 (en) * 2016-02-23 2019-06-18 Pfizer Inc. 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
US10980806B2 (en) 2016-03-24 2021-04-20 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
US11602530B2 (en) 2016-11-28 2023-03-14 Biogen Ma Inc. CRM1 inhibitors for treating epilepsy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE288898T1 (de) * 2000-12-04 2005-02-15 Hoffmann La Roche Phenylethenyl- oder phenylethinylderivate als glutamatrezeptorantagonisten
CN1747936A (zh) * 2003-02-12 2006-03-15 特兰斯泰克制药公司 作为治疗试剂的取代吡咯衍生物
NZ548208A (en) * 2004-02-12 2010-09-30 Transtech Pharma Inc Substituted azole derivatives, compositions, and methods of use
CA2566094A1 (fr) * 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. Compose de cinnamide

Also Published As

Publication number Publication date
CY1112767T1 (el) 2016-02-10
WO2007102580A1 (fr) 2007-09-13
IL193770A (en) 2012-10-31
AR059955A1 (es) 2008-05-14
HK1128085A1 (en) 2009-10-16
EP1992618A4 (fr) 2010-11-10
PL1992618T3 (pl) 2012-06-29
GEP20115139B (en) 2011-01-10
EP1992618B1 (fr) 2012-01-18
HRP20120174T1 (hr) 2012-03-31
MX2008011221A (es) 2008-09-11
AU2007223158A1 (en) 2007-09-13
CA2643796A1 (fr) 2007-09-13
HK1122027A1 (en) 2009-05-08
EA016464B1 (ru) 2012-05-30
IL193770A0 (en) 2009-05-04
KR20080108481A (ko) 2008-12-15
EA200870336A1 (ru) 2009-02-27
AU2007223158B2 (en) 2012-04-12
KR101464651B1 (ko) 2014-11-24
HN2008001374A (es) 2011-03-15
EP1992618A1 (fr) 2008-11-19

Similar Documents

Publication Publication Date Title
MA30268B1 (fr) Derive polycyclique de cinnamide
ECSP077628A (es) Nueva composición farmacéutica
MA67365B1 (fr) Dérivés de benzisoxazole sulfonamide
MA34013B1 (fr) Inhibiteurs du virus de l'hépatite c
MA27389A1 (fr) Derives de benzimidazole nouveaux utiles comme agents antiproliferatifs.
CR9314A (es) Derivado de espirocetal y uso del mismo como medicina para la diabetes
MA29746B1 (fr) Nouveaux inhibiteurs macrocycliques de la multiplication du virus de l'hepatite c
MA45223A (fr) Nouveaux dérivés de pipéridinyle subsitués par (hétéro)aryle, leur procédé de préparation et compositions pharmaceutiques les contenant
TNSN08139A1 (fr) Composes therapeutiques
MA30526B1 (fr) Inhibiteurs de prolyle hydroxylase
MA45782B1 (fr) Modulateurs du récepteur de cxcr7 pipéridine
TN2010000026A1 (fr) Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
TN2009000138A1 (fr) Biaryl-ether-urees
NO20050741L (no) Ny fremgangsmate for syntesen og ny krystallinsk form av agomelatin og farmasoytiske sammensetninger inneholdende den
MA33836B1 (fr) Compositions pharmaceutiques contenant des ligands des récepteurs sigma
MA56883B1 (fr) Dérivés de 2-hydroxycycloalcane-1-carbamoyle
TN2009000033A1 (fr) Derives de pyrazole servant d'inhibiteurs du cytochrome p450
MA31761B1 (fr) Nouveaux inhibiteurs de seh et leur utilisation
MA30609B1 (fr) Imidazolidine-2,4-diones arylaminoaryl-alkyl-substituees, leur procede de synthese, les medicaments comprenant ces composes, et leurs applications.
MA30487B1 (fr) Nouveaux composes heterocycliques
MA30916B1 (fr) Nouveaux derives de benzamide en tant qu'antagonistes de bradykinine
MA34308B1 (fr) Triazolopyridines substituées
MA31142B1 (fr) Derives heteroaryles de pyrrolidinyl et piperdinyl cetones.
TNSN07366A1 (fr) Tetrahydro-pyridoazepine -8- ones et composes apparentes, pour le traitement de la schizophrenie
DE60122555D1 (de) Spiroverbindungen und diese als wirkstoff enthaltende adhäsionsmolekülinhibitoren