MA30337B1 - Anticorps - Google Patents

Anticorps

Info

Publication number
MA30337B1
MA30337B1 MA31293A MA31293A MA30337B1 MA 30337 B1 MA30337 B1 MA 30337B1 MA 31293 A MA31293 A MA 31293A MA 31293 A MA31293 A MA 31293A MA 30337 B1 MA30337 B1 MA 30337B1
Authority
MA
Morocco
Prior art keywords
antibodies
amyloid
beta
methods
antibody
Prior art date
Application number
MA31293A
Other languages
English (en)
Inventor
Stephen Anthony Burbidge
Jonathan Henry Ellis
Susannah K Ford
Volker Germaschewski
Umesh Kumar
Karen Louise Philpott
Peter Ernest Soden
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA30337B1 publication Critical patent/MA30337B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des anticorps se liant au peptide (beta)-amyloïde, des méthodes destinées à traiter, au moyen de ces anticorps, des maladies ou des troubles caractérisés par des taux élevés de (beta)-amyloïde ou des dépôts de (beta)-amyloïde, des compositions pharmaceutiques comprenant lesdits anticorps ainsi que leurs procédés de fabrication.
MA31293A 2006-03-30 2008-10-15 Anticorps MA30337B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78758806P 2006-03-30 2006-03-30

Publications (1)

Publication Number Publication Date
MA30337B1 true MA30337B1 (fr) 2009-04-01

Family

ID=38284050

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31293A MA30337B1 (fr) 2006-03-30 2008-10-15 Anticorps

Country Status (32)

Country Link
US (3) US8227576B2 (fr)
EP (2) EP1996621B1 (fr)
JP (1) JP5103466B2 (fr)
KR (2) KR101263294B1 (fr)
CN (2) CN101415729B (fr)
AR (1) AR060332A1 (fr)
AT (1) ATE451392T1 (fr)
AU (1) AU2007233831B2 (fr)
BR (1) BRPI0709246A2 (fr)
CA (1) CA2647808C (fr)
CR (1) CR10347A (fr)
CY (1) CY1109877T1 (fr)
DE (1) DE602007003703D1 (fr)
DK (2) DK2177536T3 (fr)
EA (1) EA015654B9 (fr)
ES (2) ES2338179T3 (fr)
HR (2) HRP20100115T1 (fr)
IL (1) IL193695A (fr)
JO (1) JO2576B1 (fr)
MA (1) MA30337B1 (fr)
MX (1) MX2008012483A (fr)
MY (1) MY149630A (fr)
NO (1) NO20083793L (fr)
NZ (1) NZ571038A (fr)
PE (1) PE20080181A1 (fr)
PL (2) PL2177536T3 (fr)
PT (2) PT1996621E (fr)
SI (2) SI2177536T1 (fr)
TW (1) TWI385179B (fr)
UA (1) UA94734C2 (fr)
WO (1) WO2007113172A2 (fr)
ZA (1) ZA200807911B (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
CN1747747B (zh) 2003-01-06 2012-09-05 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
PE20061329A1 (es) 2004-12-15 2006-12-08 Neuralab Ltd Anticuerpos ab humanizados para mejorar la cognicion
CA2589860A1 (fr) 2005-01-24 2006-08-03 Amgen Inc. Anticorps anti-amyloide humanise
PT1976877E (pt) 2005-11-30 2014-04-29 Abbvie Inc Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações
BRPI0619249A2 (pt) 2005-11-30 2011-09-20 Abbott Lab anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
NZ574188A (en) 2006-07-14 2012-05-25 Ac Immune Sa Humanized antibody against amyloid beta
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
EP2124952A2 (fr) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Méthode de traitement d'amyloïdoses
US7931899B2 (en) 2007-05-14 2011-04-26 Medtronic, Inc Humanized anti-amyloid beta antibodies
US8323654B2 (en) 2007-05-14 2012-12-04 Medtronic, Inc. Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
SI2182983T1 (sl) * 2007-07-27 2014-09-30 Janssen Alzheimer Immunotherapy Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta
EP2185591B1 (fr) * 2007-08-20 2014-05-14 Glaxo Group Limited Procédé de production
GB0718737D0 (en) * 2007-09-25 2007-11-07 Glaxo Group Ltd Antibodies
EP2586795B1 (fr) 2007-10-05 2018-05-16 Genentech, Inc. Utilisation d'anticorps anti-beta amyloide aux maladies oculaires
EP2205631B1 (fr) * 2007-10-05 2016-11-23 Genentech, Inc. Anticorps humanisé
ES2695999T3 (es) 2007-10-12 2019-01-11 Hoffmann La Roche Expresión de proteínas a partir de múltiples ácidos nucleicos
JO3076B1 (ar) * 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
EP2222700A2 (fr) * 2007-11-27 2010-09-01 Medtronic, Inc. Anticorps anti-amyloïde bêta humanisés
EP2222705B1 (fr) * 2007-12-11 2014-10-22 Glaxo Group Limited Protéines de liaison à l'antigène
CA2709354C (fr) 2007-12-21 2014-06-17 Amgen Inc. Anticorps anti-amyloide et utilisations de ceux-ci
UY31807A (es) 2008-05-06 2009-12-14 Glaxo Group Ltd Encapsulación de agentes biológicamente activos
US8921314B2 (en) 2008-10-15 2014-12-30 Angiochem, Inc. Conjugates of GLP-1 agonists and uses thereof
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
MX2011005963A (es) 2008-12-05 2011-09-01 Angiochem Inc Conjugados de neurotensina o analogos de neurotensina y sus usos.
AU2010239069B2 (en) 2009-04-20 2015-05-14 Angiochem Inc Treatment of ovarian cancer using an anticancer agent conjugated to an Angiopep-2 analog
MX2012000016A (es) * 2009-07-02 2012-03-26 Angiochem Inc Conjugados de peptidos multimericos y sus usos.
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
EP2308897A1 (fr) * 2009-10-09 2011-04-13 Pierre Fabre Medicament Anticorps chimères spécifiques de CD151 et leurs utilisations pour le traitement du cancer
US8337845B2 (en) 2010-03-03 2012-12-25 Boehringer Ingelheim International Gmbh A-beta binding polypeptides
EP2558494B1 (fr) 2010-04-15 2018-05-23 AbbVie Inc. Protéines de liaison à la bêta amyloïde
WO2011149461A1 (fr) * 2010-05-27 2011-12-01 Medtronic, Inc. Anticorps anti-amyloïde bêta conjugués à des molécules contenant de l'acide sialique
AU2011282536B2 (en) 2010-07-30 2015-12-24 Ac Immune S.A. Safe and functional humanized anti beta-amyloid antibody
CN105348387B (zh) 2010-08-14 2020-08-25 Abbvie 公司 β淀粉样蛋白结合蛋白
WO2012075037A1 (fr) 2010-11-30 2012-06-07 Genentech, Inc. Anticorps anti-récepteur de la barrière hémato-encéphalique à faible affinité et leurs utilisations
US8703137B2 (en) 2011-01-31 2014-04-22 Intellect Neurosciences Inc. Treatment of tauopathies
SG194510A1 (en) 2011-04-22 2013-12-30 Emergent Product Dev Seattle Prostate-specific membrane antigen binding proteins and related compositionsand methods
GB201113570D0 (en) * 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
MX374424B (es) 2012-05-21 2025-03-06 Genentech Inc Metodos para mejorar la seguridad del transporte de la barrera hematoencefalica.
RU2509155C1 (ru) * 2012-10-25 2014-03-10 Федеральное государственное бюджетное учреждение науки Институт биохимии им. А.Н. Баха Российской академии наук Способ детекции белков в амилоидном состоянии и набор для детекции белков в амилоидном состоянии
JP2016529482A (ja) 2013-06-19 2016-09-23 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ 新規アッセイ
CN104558172A (zh) * 2015-01-04 2015-04-29 东南大学 一种针对β淀粉样蛋白的单域重链纳米抗体及其应用
US10980892B2 (en) 2015-06-15 2021-04-20 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
KR102784293B1 (ko) 2015-09-21 2025-03-20 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Cd3 결합 폴리펩타이드
WO2017072090A1 (fr) * 2015-10-27 2017-05-04 Glaxosmithkline Intellectual Property Development Limited Polythérapie
MX2019015914A (es) * 2017-06-29 2020-08-06 Univ Columbia Anticuerpos quiméricos para el tratamiento de enfermedades por deposición de amiloide.
US11382974B2 (en) 2017-08-01 2022-07-12 The Trustees Of Columbia University In The City Of New York Methods and compositions for treatment of amyloid deposition diseases
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
US12018069B2 (en) 2018-06-28 2024-06-25 The Trustees Of Columbia University In The City Of New York Methods and compositions for imaging amyloid deposits
CA3106116A1 (fr) 2018-07-17 2020-01-23 Jiangsu Hengrui Medicine Co., Ltd. Anticorps anti-abeta, fragment de liaison a l'antigene de celui-ci et son application
CA3135170A1 (fr) 2019-04-05 2020-10-08 Tauc3 Biologics Limited Anticorps anti-tauc3 et leurs utilisations
WO2022020680A1 (fr) 2020-07-23 2022-01-27 Othair Prothena Limited Anticorps anti-abêta
TW202300517A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗類澱粉β抗體及其用途
WO2022251048A1 (fr) 2021-05-24 2022-12-01 Eli Lilly And Company Anticorps anti-amyloïde bêta et leurs utilisations
CN114591918B (zh) * 2022-05-07 2022-07-26 北京第一生物化学药业有限公司 产生抗β-淀粉样蛋白抗体的杂交瘤细胞及其用途
CN114591917B (zh) * 2022-05-07 2022-09-02 北京第一生物化学药业有限公司 产生结合β-淀粉样蛋白的抗体的杂交瘤细胞及其用途
KR102530956B1 (ko) * 2022-09-08 2023-05-11 주식회사 알츠코리아 아밀로이드 베타 유래 에피토프를 유효성분으로 포함하는 알츠하이머성 치매 백신 조성물 및 이의 용도
CN118638219B (zh) * 2024-08-19 2024-11-22 成都迈科康生物科技有限公司 一种抗轮状病毒vp8蛋白的抗体或其抗原结合片段、抗体偶联物、核酸、载体、细胞及其应用
WO2026082154A1 (fr) * 2024-10-18 2026-04-23 Lepu Biopharma Co., Ltd. Anticorps anti-bêta-amyloïdes et leurs utilisations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773218A (en) * 1992-01-27 1998-06-30 Icos Corporation Method to identify compounds which modulate ICAM-related protein interactions
WO1998044955A1 (fr) * 1997-04-09 1998-10-15 Mindset Ltd. Anticorps recombines specifiques contre les terminaisons beta-amyloide, codage par molecule d'adn, et leurs procedes d'utilisation
US7179892B2 (en) * 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
US6428950B1 (en) * 1998-11-25 2002-08-06 Scios Inc. Assay to identify compounds that alter apolipoprotein E expression
IL151378A0 (en) * 2000-02-24 2003-04-10 Univ Washington Humanized antibodies that sequester amyloid beta peptide
JP4399160B2 (ja) * 2000-11-03 2010-01-13 ザ ジェイ． デビッド グラッドストーン インスティテューツ ａｐｏＥに関連する疾患を治療する方法
WO2004029629A1 (fr) * 2002-09-27 2004-04-08 Janssen Pharmaceutica N.V. Anticorps monoclonaux beta-amyloide n-11 tronques, compositions, methodes et utilisations
ITTO20020867A1 (it) * 2002-10-08 2004-04-09 Pro Cord Spa Schienale di sedia.
EP1633786A4 (fr) * 2002-10-09 2007-07-25 Rinat Neuroscience Corp Methodes de traitement de la maladie d'alzheimer au moyen d'anticorps diriges contre le peptide g(b)-amyloide et compositions les comprenant

Also Published As

Publication number Publication date
US9193784B2 (en) 2015-11-24
SI1996621T1 (sl) 2010-04-30
DE602007003703D1 (de) 2010-01-21
JP2009531380A (ja) 2009-09-03
AR060332A1 (es) 2008-06-11
PT2177536E (pt) 2014-08-22
EA015654B1 (ru) 2011-10-31
BRPI0709246A2 (pt) 2011-07-12
US8227576B2 (en) 2012-07-24
HRP20140618T1 (hr) 2014-08-15
DK2177536T3 (da) 2014-07-14
TW200815466A (en) 2008-04-01
KR20120093400A (ko) 2012-08-22
MY149630A (en) 2013-09-13
HK1138015A1 (en) 2010-08-13
KR20080113273A (ko) 2008-12-29
DK1996621T3 (da) 2010-04-19
EP1996621A2 (fr) 2008-12-03
MX2008012483A (es) 2008-10-10
KR101263294B1 (ko) 2013-06-04
EP2177536B1 (fr) 2014-06-04
AU2007233831B2 (en) 2013-02-14
EP2177536A1 (fr) 2010-04-21
WO2007113172A2 (fr) 2007-10-11
CN101415729B (zh) 2013-09-04
PL2177536T3 (pl) 2014-11-28
CN101415729A (zh) 2009-04-22
CA2647808C (fr) 2015-11-17
EP1996621B1 (fr) 2009-12-09
ZA200807911B (en) 2009-11-25
WO2007113172A3 (fr) 2007-11-29
AU2007233831A1 (en) 2007-10-11
TWI385179B (zh) 2013-02-11
IL193695A (en) 2012-05-31
CN103539857A (zh) 2014-01-29
EA015654B9 (ru) 2012-01-30
US20160024197A1 (en) 2016-01-28
PT1996621E (pt) 2010-03-08
US20110142824A1 (en) 2011-06-16
ES2484967T3 (es) 2014-08-12
ATE451392T1 (de) 2009-12-15
PE20080181A1 (es) 2008-03-16
PL1996621T3 (pl) 2010-05-31
CA2647808A1 (fr) 2007-10-11
JO2576B1 (en) 2011-02-27
NO20083793L (no) 2008-10-13
IL193695A0 (en) 2011-08-01
SI2177536T1 (sl) 2014-09-30
UA94734C2 (ru) 2011-06-10
JP5103466B2 (ja) 2012-12-19
EA200801842A1 (ru) 2009-02-27
US20140050719A1 (en) 2014-02-20
HK1122311A1 (en) 2009-05-15
ES2338179T3 (es) 2010-05-04
CY1109877T1 (el) 2014-09-10
CR10347A (es) 2008-10-29
HRP20100115T1 (hr) 2010-04-30
NZ571038A (en) 2011-03-31

Similar Documents

Publication Publication Date Title
MA46665B1 (fr) Composés de tyrosine tyrosine de peptide cyclique couplés à un anticorps en tant que modulateurs des récepteurs du neuropeptide y
MA31999B1 (fr) Proteines de liaison a l'antigene
TNSN07398A1 (fr) Anticorps contre la p-cadherine
BRPI0619357A8 (pt) Anticorpos monoclonais, composição farmacêutica, vacina, uso dos mesmos para tratamento ou prevenção de doença de alzheimer, métodos in vitro para diagnosticar e para identificar compostos apropriados para imunização de doença de alzheimer e kits
LUC00053I2 (fr) Anticorps diriges contre cd38 pour le traitement du myelome multiple
MA30353B1 (fr) Anticorps se liant à la protéine tyrosine phosphatase bêta humaine (hptpbêta) et utilisations correspondantes.
MA40041B1 (fr) Anticorps anti-gitr et leurs procédés d'utilisation
MA67288A1 (fr) Tubulysines et conjugués tubulysines-protéines
MA31437B1 (fr) Polypeptides, domaines variables d'anticorps et antagonistes
TW200642694A (en) Anti-M-CSF antibody compositions
MA47392B1 (fr) Bis-octahydrophénanthrène carboxamides et leurs conjugués protéiques
MA31502B1 (fr) Anticorps anti-notch 1 specifiques a nrr et ses procedes d'utilisation
MA32928B1 (fr) Anticorps anti-cxcr4 et leur utilisation pour le traitement du cancer
MA32907B1 (fr) Régime posologique d'un agoniste du récepteur s1p
BRPI0513959A (pt) anticorpos dirigidos contra o peptìdeo beta-amilóide, suas composições farmacêuticas, kit e métodos de fabricação dos mesmos
TNSN07305A1 (fr) Agonistes de pyy et leurs utilisations
MA33402B1 (fr) Compositions et procédés de ciblage de la proteine c3b de complément par des anticorps
MA58646A1 (fr) Tubulysines et conjugués tubulysines-protéines
MA31899B1 (fr) Anticorps monoclonaux qui se lient au hgm-csf et compositions medicales les comprenant
EA200801842A1 (ru) Антитела против бета-амилоидного пептида
MA29427B1 (fr) Antagonistes et leurs methodes d'utilisation
MA31231B1 (fr) Anticorps anti-robo4 et utilisations de ceux-ci
MA30557B1 (fr) Composés de pyrrolopyrimidine et leurs utilisations.
MA34286B1 (fr) Compositions pharmaceutiques et procédés pour les fabriquer
MA37761A1 (fr) Protéines de liaison à un antigène antagoniste d'un double récepteur et leurs utilisations