MA30420B1 - Derives de terphenyle pour le traitment de la maladie d'alzheimer - Google Patents

Derives de terphenyle pour le traitment de la maladie d'alzheimer

Info

Publication number
MA30420B1
MA30420B1 MA31394A MA31394A MA30420B1 MA 30420 B1 MA30420 B1 MA 30420B1 MA 31394 A MA31394 A MA 31394A MA 31394 A MA31394 A MA 31394A MA 30420 B1 MA30420 B1 MA 30420B1
Authority
MA
Morocco
Prior art keywords
alzheimer
disease
treatment
terphenyl derivatives
compounds
Prior art date
Application number
MA31394A
Other languages
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard John Harrison
Mihiro Sunose
Remedios Hernadez-Perni
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Jess Taylor
Adeline Leformal
Andrew Cansfield
Svenja Burckhardt
Yan Zhang
Chih Yung Ho
Original Assignee
Ortho Mcneil Pharm Inc
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30420(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ortho Mcneil Pharm Inc, Cellzome Ltd filed Critical Ortho Mcneil Pharm Inc
Publication of MA30420B1 publication Critical patent/MA30420B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'INVENTION CONCERNE LES COMPOSÉS DE FORMULE GÉNÉRALE (I), DANS LAQUELLE X, Y, R1, R2, R3, R4, R9, R10 SONT TELS QUE DÉFINIS CI-DESSOUS, AINSI QUE LES SOLVATES, HYDRATES, ESTERS ET SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CEUX-CI. DE PLUS, L'INVENTION CONCERNE L'UTILISATION DESDITS COMPOSÉS DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER AINSI QUE DANS LA MODULATION DE L'ACTIVITÉ DE LA &GGR;-SÉCRÉTASE.
MA31394A 2006-04-21 2008-11-20 Derives de terphenyle pour le traitment de la maladie d'alzheimer MA30420B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112934A EP1847524B1 (fr) 2006-04-21 2006-04-21 Derives de terphényle pour le traitement de l' Alzheimer

Publications (1)

Publication Number Publication Date
MA30420B1 true MA30420B1 (fr) 2009-05-04

Family

ID=36293499

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31394A MA30420B1 (fr) 2006-04-21 2008-11-20 Derives de terphenyle pour le traitment de la maladie d'alzheimer

Country Status (34)

Country Link
US (1) US8106236B2 (fr)
EP (2) EP1847524B1 (fr)
JP (1) JP5422827B2 (fr)
KR (1) KR101494906B1 (fr)
CN (1) CN101484410B (fr)
AR (1) AR060621A1 (fr)
AT (1) ATE445586T1 (fr)
AU (1) AU2007240382B2 (fr)
BR (1) BRPI0710632A2 (fr)
CA (1) CA2649845C (fr)
CR (2) CR10376A (fr)
CY (1) CY1109729T1 (fr)
DE (1) DE602006009764D1 (fr)
DK (1) DK1847524T3 (fr)
EA (1) EA016908B1 (fr)
ES (2) ES2333539T3 (fr)
GE (1) GEP20115211B (fr)
IL (2) IL194853A0 (fr)
MA (1) MA30420B1 (fr)
MX (1) MX2008013447A (fr)
MY (1) MY148988A (fr)
NO (1) NO20084516L (fr)
NZ (1) NZ572999A (fr)
PE (1) PE20080267A1 (fr)
PL (1) PL1847524T3 (fr)
PT (1) PT1847524E (fr)
SI (1) SI1847524T1 (fr)
SM (1) SMP200800062B (fr)
TN (1) TNSN08414A1 (fr)
TW (1) TWI435720B (fr)
UA (1) UA95766C2 (fr)
UY (1) UY30300A1 (fr)
WO (1) WO2007124351A1 (fr)
ZA (1) ZA200809857B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1847524B1 (fr) 2006-04-21 2009-10-14 Cellzome Limited Derives de terphényle pour le traitement de l' Alzheimer
EP2212277B1 (fr) 2007-10-19 2016-08-31 Janssen Pharmaceutica, N.V. Modulateurs de la g-secrétase liés à une amine
US8692017B2 (en) 2007-10-19 2014-04-08 Janssen Pharmaceutica, N.V. Carbon linked modulators of gamma-secretase
EA201070497A1 (ru) * 2007-10-19 2010-12-30 Янссен Фармацевтика, Н.В. Промежуточные продукты мгс
ATE543799T1 (de) 2007-10-19 2012-02-15 Janssen Pharmaceutica Nv Piperidinyl- und piperazinylmodulatoren von g- sekretase
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
JP2011506445A (ja) * 2007-12-13 2011-03-03 アムジエン・インコーポレーテツド γ−セクレターゼ調節剤
WO2009086277A1 (fr) 2007-12-20 2009-07-09 Envivo Pharmaceuticals, Inc. Benzènes tétrasubstitués
CA2718241A1 (fr) * 2008-03-11 2009-09-17 Neurosearch A/S Nouveaux derives de triaryle utiles en tant que modulateurs de recepteurs d'acetylcholine nicotiniques
US7968725B2 (en) * 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
EP2681208B1 (fr) * 2011-03-03 2016-05-18 Denovamed Inc. Composés antimicrobiens/d'adjuvants
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (fr) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Morpholino-pyrimidines fusionnées et leurs procédés d'utilisation
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
BR112021022659A2 (pt) * 2019-05-15 2022-03-29 Chemocentryx Inc Compostos triarílicos para o tratamento de doenças pd-l1
EP4253396A4 (fr) * 2020-11-27 2024-09-11 Mirailab Bioscience Inc. Mononucléotide beta-nicotinamide de grande pureté (nmn) et son procédé de production

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325182A (ja) * 1995-05-31 1996-12-10 Fuji Yakuhin Kogyo Kk 置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
WO2000069823A1 (fr) 1999-05-12 2000-11-23 Neurosearch A/S Agents de modulation de canal ionique
AU5702201A (en) 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
AU2001254555A1 (en) * 2000-04-24 2001-11-07 Merck Frosst Canada & Co Method of treatment using phenyl and biaryl derivatives as prostaglandin E inhibitors and compounds useful therefore
CA2438745C (fr) * 2001-02-20 2010-11-30 Isis Innovation Limited Dendrimeres contenant du metal
FR2838439B1 (fr) * 2002-04-11 2005-05-20 Sanofi Synthelabo Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
US20060122184A1 (en) * 2002-12-05 2006-06-08 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en) 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
CA2523336A1 (fr) * 2003-04-30 2004-11-11 Merck Frosst Canada Ltd. 8-(3-biaryl)phenylquinoleines comme inhibiteurs de la phosphodiesterase de type 4
WO2005110963A1 (fr) 2004-05-19 2005-11-24 Cellzome Ag Acides (biphenyl-3-yl)-carboxyliques et derives de ceux-ci ainsi que leur utilisation en therapie
GB0416508D0 (en) 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
MX2008002014A (es) * 2005-08-15 2008-03-27 Hoffmann La Roche Derivados de piperidina y piperazina como antagonistas de p2x3.
EP1937632A1 (fr) 2005-10-06 2008-07-02 Astra Zeneca AB Nouveaux composes
EP1847524B1 (fr) 2006-04-21 2009-10-14 Cellzome Limited Derives de terphényle pour le traitement de l' Alzheimer

Also Published As

Publication number Publication date
SMAP200800062A (it) 2008-11-19
NZ572999A (en) 2012-06-29
JP5422827B2 (ja) 2014-02-19
TW200810746A (en) 2008-03-01
ES2392352T3 (es) 2012-12-10
UY30300A1 (es) 2007-08-31
ATE445586T1 (de) 2009-10-15
KR20090024678A (ko) 2009-03-09
BRPI0710632A2 (pt) 2011-08-23
EP1847524B1 (fr) 2009-10-14
EP2016039A1 (fr) 2009-01-21
HK1134923A1 (en) 2010-05-20
SI1847524T1 (sl) 2010-01-29
MY148988A (en) 2013-06-28
MX2008013447A (es) 2009-03-10
ZA200809857B (en) 2009-08-26
AR060621A1 (es) 2008-07-02
SMP200800062B (it) 2009-07-14
PL1847524T3 (pl) 2010-03-31
AU2007240382B2 (en) 2013-05-02
TWI435720B (zh) 2014-05-01
CY1109729T1 (el) 2014-09-10
US20070254957A1 (en) 2007-11-01
CA2649845C (fr) 2014-09-16
WO2007124351A1 (fr) 2007-11-01
CN101484410B (zh) 2013-08-21
IL194853A0 (en) 2009-08-03
NO20084516L (no) 2009-01-13
CA2649845A1 (fr) 2007-11-01
TNSN08414A1 (en) 2010-04-14
ES2333539T3 (es) 2010-02-23
IL194789A0 (en) 2009-08-03
JP2009538275A (ja) 2009-11-05
DK1847524T3 (da) 2010-01-11
KR101494906B1 (ko) 2015-02-24
PE20080267A1 (es) 2008-05-16
CR10452A (es) 2009-02-23
US8106236B2 (en) 2012-01-31
CR10376A (es) 2009-02-26
EP2016039B1 (fr) 2012-08-01
AU2007240382A1 (en) 2007-11-01
PT1847524E (pt) 2009-12-18
EA200802173A1 (ru) 2009-06-30
UA95766C2 (ru) 2011-08-25
DE602006009764D1 (de) 2009-11-26
GEP20115211B (en) 2011-04-26
EA016908B1 (ru) 2012-08-30
CN101484410A (zh) 2009-07-15
EP1847524A1 (fr) 2007-10-24

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