MA30663B1 - Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actif - Google Patents

Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actif

Info

Publication number
MA30663B1
MA30663B1 MA31663A MA31663A MA30663B1 MA 30663 B1 MA30663 B1 MA 30663B1 MA 31663 A MA31663 A MA 31663A MA 31663 A MA31663 A MA 31663A MA 30663 B1 MA30663 B1 MA 30663B1
Authority
MA
Morocco
Prior art keywords
derivative
active ingredient
acid ester
receptor modulator
ester derivatives
Prior art date
Application number
MA31663A
Other languages
English (en)
Inventor
Yasushi Kohno
Kiyoshi Fujii
Tatsuhiro Saito
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of MA30663B1 publication Critical patent/MA30663B1/fr

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    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
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Abstract

Fournir un dérivé aminophosphorique ayant une excellente activité modulatoire dU récepteur de sphingosine-1-phosphate (S1P). Suite aux recherches intensives continues pour créer un composé fortement sûr qui a une activité modulatoire sur le récepteur de S1P, il a été découvert que le dérivé aminophosphorique représenté par la formule générale (1) suivante, a une forte action activité modulatoire sur le récepteur de S1P.
MA31663A 2006-08-08 2009-02-26 Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actif MA30663B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006215280 2006-08-08

Publications (1)

Publication Number Publication Date
MA30663B1 true MA30663B1 (fr) 2009-08-03

Family

ID=39032957

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31663A MA30663B1 (fr) 2006-08-08 2009-02-26 Derives d'ester de l'acide aminophosphorique et modulateur du recepteur s1p contenant ledit derive en tant que principe actif

Country Status (26)

Country Link
US (1) US8232319B2 (fr)
EP (1) EP2058317B1 (fr)
JP (1) JP5188972B2 (fr)
KR (1) KR101339976B1 (fr)
CN (1) CN101501049B (fr)
CA (1) CA2659598A1 (fr)
CY (1) CY1114681T1 (fr)
DK (1) DK2058317T3 (fr)
ES (1) ES2438265T3 (fr)
HR (1) HRP20131172T1 (fr)
IL (1) IL196275A (fr)
MA (1) MA30663B1 (fr)
ME (1) ME02095B (fr)
MX (1) MX2009001456A (fr)
MY (1) MY152176A (fr)
NO (1) NO20090606L (fr)
NZ (1) NZ574011A (fr)
PL (1) PL2058317T3 (fr)
PT (1) PT2058317E (fr)
RS (1) RS53080B (fr)
RU (1) RU2430925C2 (fr)
SG (1) SG174028A1 (fr)
SI (1) SI2058317T1 (fr)
TN (1) TNSN08545A1 (fr)
WO (1) WO2008018427A1 (fr)
ZA (1) ZA200900206B (fr)

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CN102863345A (zh) * 2011-07-06 2013-01-09 中国医学科学院药物研究所 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途
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PL3310760T3 (pl) 2015-06-22 2023-03-06 Arena Pharmaceuticals, Inc. Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
HUE060485T2 (hu) 2016-06-07 2023-03-28 Tesla Inc Villanymotor hûtési rendszer
JP2020507610A (ja) 2017-02-16 2020-03-12 アリーナ ファーマシューティカルズ， インコーポレイテッド 腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法
KR20190116416A (ko) 2017-02-16 2019-10-14 아레나 파마슈티칼스, 인크. 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
US10967702B2 (en) 2017-09-07 2021-04-06 Tesla, Inc. Optimal source electric vehicle heat pump with extreme temperature heating capability and efficient thermal preconditioning
AU2019280822A1 (en) 2018-06-06 2021-01-07 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
EP3847158A1 (fr) 2018-09-06 2021-07-14 Arena Pharmaceuticals, Inc. Composés utiles dans le traitement de troubles auto-immuns et inflammatoires
JP7535532B2 (ja) 2019-02-26 2024-08-16 バイエル・アクチエンゲゼルシヤフト 有害生物防除剤としての縮合二環式複素環式誘導体
EP4240350A4 (fr) * 2020-11-09 2024-09-18 Arena Pharmaceuticals, Inc. <sup2/>? <sub2/>?1?procédés de traitement d'états liés au récepteur s1p
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JP5188972B2 (ja) 2013-04-24
PT2058317E (pt) 2013-12-11
HK1131154A1 (en) 2010-01-15
KR20090046929A (ko) 2009-05-11
WO2008018427A1 (fr) 2008-02-14
MY152176A (en) 2014-08-15
ES2438265T3 (es) 2014-01-16
US8232319B2 (en) 2012-07-31
RU2009106934A (ru) 2010-09-20
MX2009001456A (es) 2009-02-19
SG174028A1 (en) 2011-09-29
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DK2058317T3 (da) 2014-01-06
CN101501049B (zh) 2013-04-24
PL2058317T3 (pl) 2014-03-31
US20090325907A1 (en) 2009-12-31
CY1114681T1 (el) 2016-10-05
EP2058317A4 (fr) 2011-06-29
AU2007282536A1 (en) 2008-02-14
CA2659598A1 (fr) 2008-02-14
SI2058317T1 (sl) 2014-01-31
NO20090606L (no) 2009-03-03
EP2058317A1 (fr) 2009-05-13
IL196275A0 (en) 2009-09-22
TNSN08545A1 (en) 2010-04-14
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HRP20131172T1 (hr) 2014-01-17
RS53080B (sr) 2014-06-30
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ME02095B (fr) 2014-06-30
IL196275A (en) 2013-10-31
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ZA200900206B (en) 2009-12-30
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