MA30757B1 - Inhibiteurs de l'akt (proteine kinase b) - Google Patents

Inhibiteurs de l'akt (proteine kinase b)

Info

Publication number
MA30757B1
MA30757B1 MA31573A MA31573A MA30757B1 MA 30757 B1 MA30757 B1 MA 30757B1 MA 31573 A MA31573 A MA 31573A MA 31573 A MA31573 A MA 31573A MA 30757 B1 MA30757 B1 MA 30757B1
Authority
MA
Morocco
Prior art keywords
akt
inhibitors
protein kinase
compound
salt
Prior art date
Application number
MA31573A
Other languages
English (en)
Inventor
Sajan Joseph
Renhua Li
Michael Ray Myers
Aktham Aburub
Jenny Pingqi Dai
Christopher Randall Schmid
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA30757B1 publication Critical patent/MA30757B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE UN 4-[5-(2-AMINO-ÉTHANESULFONYL)-ISOQUINOLÉIN-7-YL]-PHÉNOL OU UN SEL DE QUALITÉ PHARMACEUTIQUE DUDIT COMPOSÉ OU UN HYDRATE DU COMPOSÉ OU DE SON SEL EN TANT QU'INHIBITEURS DE AKT ET AGENTS ANTINÉOPLASIQUES ET/OU ANTIVIRAUX, DE MÊME QUE DES COMPOSITIONS COMPRENANT CES COMPOSÉS ET DES MÉTHODES D'EMPLOI DE CES COMPOSÉS.
MA31573A 2006-06-20 2009-01-19 Inhibiteurs de l'akt (proteine kinase b) MA30757B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80526006P 2006-06-20 2006-06-20
US88576507P 2007-01-19 2007-01-19

Publications (1)

Publication Number Publication Date
MA30757B1 true MA30757B1 (fr) 2009-10-01

Family

ID=38834248

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31573A MA30757B1 (fr) 2006-06-20 2009-01-19 Inhibiteurs de l'akt (proteine kinase b)

Country Status (28)

Country Link
US (1) US7998977B2 (fr)
EP (1) EP2035385B1 (fr)
JP (1) JP2009541335A (fr)
KR (1) KR101067551B1 (fr)
AR (1) AR061240A1 (fr)
AT (1) ATE455102T1 (fr)
AU (1) AU2007261120A1 (fr)
BR (1) BRPI0713136A2 (fr)
CA (1) CA2652612A1 (fr)
CL (1) CL2007001752A1 (fr)
DE (1) DE602007004333D1 (fr)
DK (1) DK2035385T3 (fr)
DO (1) DOP2008000053A (fr)
EA (1) EA015712B1 (fr)
EC (1) ECSP088992A (fr)
ES (1) ES2336630T3 (fr)
HR (1) HRP20100147T1 (fr)
IL (1) IL195005A0 (fr)
MA (1) MA30757B1 (fr)
MX (1) MX2008015904A (fr)
NO (1) NO20090289L (fr)
PE (1) PE20080338A1 (fr)
PL (1) PL2035385T3 (fr)
PT (1) PT2035385E (fr)
SI (1) SI2035385T1 (fr)
TN (1) TNSN08529A1 (fr)
TW (1) TW200812970A (fr)
WO (1) WO2007149730A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
EP2613786A4 (fr) 2010-09-07 2013-10-23 Dmi Acquisition Corp Traitement de maladies
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
EA028343B1 (ru) 2011-10-10 2017-11-30 Ампио Фармасьютикалз, Инк. Лечение дегенеративного заболевания сустава
EP2771007B1 (fr) 2011-10-28 2018-04-04 Ampio Pharmaceuticals, Inc. Traitement de la rhinite
BR112015020469A2 (pt) 2013-03-15 2020-01-28 Ampio Pharmaceuticals Inc Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo
CN112472699A (zh) 2013-07-26 2021-03-12 种族肿瘤学公司 改善比生群及衍生物的治疗益处的组合方法
RU2736513C2 (ru) 2014-08-18 2020-11-17 Ампио Фармасьютикалз, Инк. Лечение патологических состояний суставов
US10123997B2 (en) * 2015-06-15 2018-11-13 Yong Liao Target for treating hepatitis B virus
EP3310375A4 (fr) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. Utilisation de fractions d'albumine de sérum humain de bas poids moléculaire pour traiter les maladies
WO2017156350A1 (fr) 2016-03-09 2017-09-14 K-Gen, Inc. Méthodes de traitement du cancer
WO2022017448A1 (fr) * 2020-07-22 2022-01-27 南京正大天晴制药有限公司 Sel et forme cristalline de dérivé de dihydropyrido[2,3-d]pyrimidine
US20230321108A1 (en) * 2020-07-22 2023-10-12 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. Unit dosage composition of akt inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136458A0 (en) 2000-05-30 2001-06-14 Peptor Ltd Protein kinase inhibitors
WO2004094386A1 (fr) * 2003-03-28 2004-11-04 Eli Lilly And Company Utilisation d'amides d'acide isoquinoline-5-sulfonique comme inhibiteurs de l'akt (proteine kinase b)
GB0317315D0 (en) 2003-07-24 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
US7449477B2 (en) * 2003-11-25 2008-11-11 Eli Lilly And Company 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B)

Also Published As

Publication number Publication date
WO2007149730A2 (fr) 2007-12-27
TNSN08529A1 (en) 2010-04-14
ECSP088992A (es) 2009-01-30
CA2652612A1 (fr) 2007-12-27
EP2035385B1 (fr) 2010-01-13
AU2007261120A1 (en) 2007-12-27
TW200812970A (en) 2008-03-16
HRP20100147T1 (hr) 2010-04-30
SI2035385T1 (sl) 2010-05-31
DOP2008000053A (es) 2009-01-15
MX2008015904A (es) 2009-01-12
EA015712B1 (ru) 2011-10-31
BRPI0713136A2 (pt) 2012-04-17
AR061240A1 (es) 2008-08-13
IL195005A0 (en) 2009-08-03
ATE455102T1 (de) 2010-01-15
JP2009541335A (ja) 2009-11-26
ES2336630T3 (es) 2010-04-14
WO2007149730A3 (fr) 2008-04-24
US20090221633A1 (en) 2009-09-03
PE20080338A1 (es) 2008-04-25
PT2035385E (pt) 2010-03-01
DK2035385T3 (da) 2010-03-22
CL2007001752A1 (es) 2008-01-18
US7998977B2 (en) 2011-08-16
PL2035385T3 (pl) 2010-06-30
DE602007004333D1 (de) 2010-03-04
KR20090015978A (ko) 2009-02-12
KR101067551B1 (ko) 2011-09-27
EP2035385A2 (fr) 2009-03-18
EA200970041A1 (ru) 2009-06-30
NO20090289L (no) 2009-01-19

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