MA31075B1 - Dérivés d'isoquinolone substitués par une cycloalkylamine. - Google Patents

Dérivés d'isoquinolone substitués par une cycloalkylamine.

Info

Publication number
MA31075B1
MA31075B1 MA32036A MA32036A MA31075B1 MA 31075 B1 MA31075 B1 MA 31075B1 MA 32036 A MA32036 A MA 32036A MA 32036 A MA32036 A MA 32036A MA 31075 B1 MA31075 B1 MA 31075B1
Authority
MA
Morocco
Prior art keywords
cycloalkylamine
derivatives substituted
isoquinolone derivatives
rho
kinase
Prior art date
Application number
MA32036A
Other languages
Arabic (ar)
English (en)
Inventor
Oliver Plettenburg
Armin Hofmeister
Katrin Lorenz
Joachim Brendel
Matthias Löhn
John Weston
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38565513&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31075(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA31075B1 publication Critical patent/MA31075B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)

Abstract

L'invention concerne des dérivés d'isoquinolone 6-substitués représentés par la formule (i), utilisés dans le traitement et/ou la prévention de maladies associées à la rho-kinase et/ou à la phosphorylation médiée par la rho-kinase de la phosphatase de la chaîne légère de la myosine, et des compositions contenant lesdits composés.
MA32036A 2006-12-27 2009-06-24 Dérivés d'isoquinolone substitués par une cycloalkylamine. MA31075B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06026899 2006-12-27
PCT/EP2007/011164 WO2008077551A1 (fr) 2006-12-27 2007-12-19 Dérivés d'isoquinolone substitués par une cycloalkylamine

Publications (1)

Publication Number Publication Date
MA31075B1 true MA31075B1 (fr) 2010-01-04

Family

ID=38565513

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32036A MA31075B1 (fr) 2006-12-27 2009-06-24 Dérivés d'isoquinolone substitués par une cycloalkylamine.

Country Status (30)

Country Link
US (1) US8742116B2 (fr)
EP (1) EP2125745B1 (fr)
JP (1) JP5405314B2 (fr)
KR (1) KR101474228B1 (fr)
CN (1) CN101595094B (fr)
AR (1) AR064492A1 (fr)
AU (1) AU2007338407B2 (fr)
BR (1) BRPI0722064A2 (fr)
CA (1) CA2673917C (fr)
CL (1) CL2007003821A1 (fr)
CO (1) CO6210726A2 (fr)
CR (1) CR10813A (fr)
DO (1) DOP2009000164A (fr)
EC (1) ECSP099467A (fr)
ES (1) ES2625266T3 (fr)
GT (1) GT200900179A (fr)
IL (1) IL199540A (fr)
MA (1) MA31075B1 (fr)
MX (1) MX2009005966A (fr)
MY (1) MY155009A (fr)
NI (1) NI200900108A (fr)
NO (1) NO20092422L (fr)
NZ (1) NZ577980A (fr)
RU (1) RU2457203C2 (fr)
SV (1) SV2009003318A (fr)
TN (1) TN2009000269A1 (fr)
TW (1) TWI434689B (fr)
UY (1) UY30843A1 (fr)
WO (1) WO2008077551A1 (fr)
ZA (1) ZA200903551B (fr)

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TW201834020A (zh) 2003-10-28 2018-09-16 日商尼康股份有限公司 照明光學裝置、曝光裝置、曝光方法以及元件製造方法
TWI612338B (zh) 2003-11-20 2018-01-21 尼康股份有限公司 光學照明裝置、曝光裝置、曝光方法、以及元件製造方法
TWI511182B (zh) 2004-02-06 2015-12-01 尼康股份有限公司 光學照明裝置、曝光裝置、曝光方法以及元件製造方法
EP1910297B1 (fr) 2005-07-11 2016-05-25 Aerie Pharmaceuticals, Inc. Composes isoquinoliniques
CA2664335C (fr) 2006-09-20 2014-12-02 Boehringer Ingelheim International Gmbh Inhibiteurs de la rho-kinase
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
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DK2303845T3 (da) * 2008-06-24 2013-12-16 Sanofi Sa Bi- og polycyklisk substitueret isoquinolin og bi- og polycykliske substituerede isoquinolinderivater som rho-kinasehæmmere
JP5714485B2 (ja) * 2008-06-24 2015-05-07 サノフイ ６−置換イソキノリン類及びイソキノリノン類
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
ES2834451T3 (es) 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Inhibidores de mecanismo doble para el tratamiento de enfermedades
ES2942898T3 (es) 2013-03-15 2023-06-07 Aerie Pharmaceuticals Inc Compuesto para uso en el tratamiento de trastornos oculares
PE20161065A1 (es) 2013-10-18 2016-11-19 Celgene Quanticel Res Inc Inhibidores de bromodominio
US9902702B2 (en) * 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
US9399194B2 (en) * 2014-07-16 2016-07-26 Battelle Energy Alliance, Llc Methods for treating a liquid using draw solutions
EP3237397B1 (fr) 2014-12-24 2018-11-21 Gilead Sciences, Inc. Composés isoindoline pour le traitement du vih
ES2735087T3 (es) 2014-12-24 2019-12-16 Gilead Sciences Inc Compuestos de pirimidina fusionados para el tratamiento de VIH
TWI699355B (zh) 2014-12-24 2020-07-21 美商基利科學股份有限公司 喹唑啉化合物
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
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CN108601355B (zh) 2015-11-17 2021-03-30 爱瑞制药公司 制备激酶抑制剂及其中间体的方法
TWI730032B (zh) 2016-01-13 2021-06-11 美商必治妥美雅史谷比公司 作為ｒｏｃｋ抑制劑之螺庚烷水楊酸醯胺及相關化合物
TWI719138B (zh) 2016-02-12 2021-02-21 日商安斯泰來製藥股份有限公司 四氫異喹啉衍生物
EP3445750A4 (fr) 2016-04-18 2019-11-27 Celgene Quanticel Research, Inc. Composés thérapeutiques
US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
EP3481826B1 (fr) 2016-07-08 2021-11-03 Rigel Pharmaceuticals, Inc. Inhibiteurs de la tyrosine kinase
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UY30843A1 (es) 2008-07-31
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CN101595094A (zh) 2009-12-02
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