MA32009B1 - Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux - Google Patents

Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux

Info

Publication number
MA32009B1
MA32009B1 MA33007A MA33007A MA32009B1 MA 32009 B1 MA32009 B1 MA 32009B1 MA 33007 A MA33007 A MA 33007A MA 33007 A MA33007 A MA 33007A MA 32009 B1 MA32009 B1 MA 32009B1
Authority
MA
Morocco
Prior art keywords
pyrazolo
pyrimidine
anticancer agents
novel derivatives
human
Prior art date
Application number
MA33007A
Other languages
Arabic (ar)
English (en)
Inventor
Durga Prasad Konakanchi
Subba Rao Pula
Lakshmi Ananthaneni
Ramakrishna Pilli
Reddy Muddasani Pulla
Kali Satya Bhujanga Rao Adibhatla
Chowdary Nannapaneni Venkaiah
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of MA32009B1 publication Critical patent/MA32009B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des dérivés substitutes de pyrazolo [3,4-d] pyrimidine de formule (i), ou leurs sels pharmaceutiquement acceptables, qui possèdent une activité anti-proliférante telle qu'une activité anticancéreuse et sont donc utiles dans des procédés de traitement de l'organisme humain ou animal. L'invention concerne également des procédés de fabrication de dérivés substitués de pyrazolo [3,4-d] pyrimidine, des compositions pharmaceutiques contenant le composé et son utilisation dans la fabrication de médicaments pour la production d'un effet anti-proliférant dans un animal à sang chaud tel qu'un humain.
MA33007A 2008-01-11 2010-07-09 Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux MA32009B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN109CH2008 2008-01-11
PCT/IN2009/000037 WO2009098715A2 (fr) 2008-01-11 2009-01-12 Nouveaux dérivés de pyrazolo [3, 4 -d] pyrimidine en tant qu’agents anticancéreux

Publications (1)

Publication Number Publication Date
MA32009B1 true MA32009B1 (fr) 2011-01-03

Family

ID=40933862

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33007A MA32009B1 (fr) 2008-01-11 2010-07-09 Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux

Country Status (18)

Country Link
US (1) US8349847B2 (fr)
EP (1) EP2247596A2 (fr)
JP (1) JP2011509290A (fr)
KR (1) KR20100116607A (fr)
CN (1) CN101965350A (fr)
AP (1) AP2010005347A0 (fr)
AU (1) AU2009211004C1 (fr)
BR (1) BRPI0906475A2 (fr)
CA (1) CA2711777A1 (fr)
CO (1) CO6382174A2 (fr)
EA (1) EA201070841A1 (fr)
GE (1) GEP20135780B (fr)
IL (1) IL206811A0 (fr)
MA (1) MA32009B1 (fr)
MX (1) MX2010007523A (fr)
NZ (1) NZ586642A (fr)
WO (1) WO2009098715A2 (fr)
ZA (1) ZA201004823B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2448938B9 (fr) 2009-06-29 2015-06-10 Incyte Corporation Pyrimidinones comme inhibiteurs de pi3k
AR079529A1 (es) * 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
WO2011075643A1 (fr) 2009-12-18 2011-06-23 Incyte Corporation Dérivés condensés d'hétéroaryles substitués à titre d'inhibiteurs de pi3k
EP2558463A1 (fr) 2010-04-14 2013-02-20 Incyte Corporation Dérivés condensés en tant qu'inhibiteurs de i3
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
TW201249844A (en) 2010-12-20 2012-12-16 Incyte Corp N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
WO2012125629A1 (fr) 2011-03-14 2012-09-20 Incyte Corporation Dérivés diamino-pyrimidines et diamino-pyridines substituées en tant qu'inhibiteurs de pi3k
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
KR102030609B1 (ko) 2011-09-02 2019-10-11 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
CN102746309B (zh) * 2012-07-09 2013-06-05 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN102746307B (zh) * 2012-07-09 2013-07-31 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN103965202B (zh) * 2014-05-21 2016-01-20 邹宏丽 二环稠合杂环化合物、其制备方法及用途
WO2015191677A1 (fr) 2014-06-11 2015-12-17 Incyte Corporation Dérivés d'hétéroarylaminoalkylphényle bicycliques à titre d'inhibiteurs de pi3k
DK3831833T3 (da) 2015-02-27 2022-11-14 Incyte Holdings Corp Fremgangsmåder til fremstillingen af en pi3k-inhibitor
WO2016183063A1 (fr) 2015-05-11 2016-11-17 Incyte Corporation Formes cristallines d'un inhibiteur de pi3k
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
CN106008527B (zh) * 2016-06-29 2018-05-15 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN107698596A (zh) * 2017-11-15 2018-02-16 双鹤药业（商丘）有限责任公司 一种别嘌醇的合成方法
CN119258070A (zh) 2018-06-01 2025-01-07 因赛特公司 治疗pi3k相关病症的给药方案
AU2020412779A1 (en) * 2019-12-23 2022-06-23 Sanford Burnham Prebys Medical Discovery Institute Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) modulators and uses thereof
CN115304607B (zh) * 2022-07-06 2023-06-27 华南农业大学 吡唑并嘧啶衍生物的制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3000688A (en) 1961-09-19 Process for vatting of vat dyestuffs
US3551428A (en) 1956-02-10 1970-12-29 Ciba Geigy Corp New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
JPS5439096A (en) 1977-08-27 1979-03-24 Lion Dentifrice Co Ltd 11phenyll1hhpyrazolo*3*44d*pyrimidinee44 carbonitrile
US5958930A (en) 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
US5877178A (en) 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
ATE212993T1 (de) 1995-07-06 2002-02-15 Novartis Erfind Verwalt Gmbh Pyrolopyrimidine und verfahren zu ihrer herstellung
US6140317A (en) 1996-01-23 2000-10-31 Novartis Ag Pyrrolopyrimidines and processes for their preparation
CH690773A5 (de) 1996-02-01 2001-01-15 Novartis Ag Pyrrolo(2,3-d)pyrimide und ihre Verwendung.
US6537999B2 (en) 1996-06-06 2003-03-25 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
DE69738468T2 (de) 1996-08-23 2009-01-08 Novartis Ag Substituierte pyrrolopyrimidine und verfahren zu ihrer herstellung
DE19709488A1 (de) 1997-03-07 1998-09-10 Basf Ag Verfahren zur N-Alkylierung von Aminen
US6187778B1 (en) 1997-08-05 2001-02-13 Pfizer Inc. 4-aminopyrrole (3, 2-D) pyrimidines as neuropeptide Y receptor antagonists
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6423871B1 (en) 1999-02-26 2002-07-23 University Of South Florida Efficient synthesis of secondary amines by selective alkylation of primary amines
ES2258459T3 (es) 1999-05-21 2006-09-01 Bristol-Myers Squibb Company Pirrolotriazinas inhibidoras de quinasas.
ITMI992711A1 (it) 1999-12-27 2001-06-27 Novartis Ag Composti organici
AU2000240570A1 (en) 2000-03-29 2001-10-08 Knoll Gesellschaft Mit Beschraenkter Haftung Pyrrolopyrimidines as tyrosine kinase inhibitors
EP1347980A4 (fr) 2000-12-01 2005-02-09 Osi Pharm Inc Composes specifiques aux recepteurs de l'adenosine-a1,-a2a, et - a3 et leurs utilisations
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
DE10060388A1 (de) 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen
TWI238824B (en) 2001-05-14 2005-09-01 Novartis Ag 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives
EP1463742A4 (fr) 2001-06-21 2006-05-10 Ariad Pharma Inc Nouvelles pyrazolo-pyrimidines et pyrrolo-pyrimidines et leur utilisation
GB0115393D0 (en) 2001-06-23 2001-08-15 Aventis Pharma Ltd Chemical compounds
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
DE60304718T2 (de) 2002-08-06 2007-04-26 Astrazeneca Ab Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität
US20040138238A1 (en) 2002-08-08 2004-07-15 Dhanoa Dale S. Substituted aminopyrimidine compounds as neurokinin antagonists

Also Published As

Publication number Publication date
NZ586642A (en) 2012-04-27
IL206811A0 (en) 2010-12-30
JP2011509290A (ja) 2011-03-24
WO2009098715A2 (fr) 2009-08-13
GEP20135780B (en) 2013-03-11
WO2009098715A3 (fr) 2009-10-15
ZA201004823B (en) 2011-09-28
CN101965350A (zh) 2011-02-02
AU2009211004C1 (en) 2013-08-01
AU2009211004A2 (en) 2011-01-27
EA201070841A1 (ru) 2011-02-28
AP2010005347A0 (en) 2010-08-31
US8349847B2 (en) 2013-01-08
EP2247596A2 (fr) 2010-11-10
KR20100116607A (ko) 2010-11-01
BRPI0906475A2 (pt) 2015-07-14
CA2711777A1 (fr) 2009-08-13
AU2009211004B2 (en) 2011-09-01
MX2010007523A (es) 2010-08-18
US20100298351A1 (en) 2010-11-25
WO2009098715A4 (fr) 2009-12-10
AU2009211004A1 (en) 2009-08-13
CO6382174A2 (es) 2012-02-15

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