MA32095B1 - Inhibiteurs d'aldh-2 dans le traitement d'une accoutumance - Google Patents

Inhibiteurs d'aldh-2 dans le traitement d'une accoutumance

Info

Publication number
MA32095B1
MA32095B1 MA33106A MA33106A MA32095B1 MA 32095 B1 MA32095 B1 MA 32095B1 MA 33106 A MA33106 A MA 33106A MA 33106 A MA33106 A MA 33106A MA 32095 B1 MA32095 B1 MA 32095B1
Authority
MA
Morocco
Prior art keywords
aldh
addiction
inhibitors
treatment
amphetamines
Prior art date
Application number
MA33106A
Other languages
Arabic (ar)
English (en)
Inventor
Yaroslav Bilokin
Elfatih Elzein
Jeff Zablocki
Michael Organ
Thao Perry
Tetsuya Kobayashi
Matthew Abelman
Rao Kalla
Peidong Fan
Ivan Diamond
Robert Jiang
Maria Pia Arolfo
Xiaofen Li
Lina Yao
Zhan Jiang
Wing Ming Keung
Guoxin Tao
Original Assignee
Endowment For Res In Human Biology Inc
Gilead Palo Alto Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endowment For Res In Human Biology Inc, Gilead Palo Alto Inc filed Critical Endowment For Res In Human Biology Inc
Publication of MA32095B1 publication Critical patent/MA32095B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

La présente invention concerne de nouveaux dérivés d'isoflavone, dont la structure est représentée par la formule (i), qui se révèlent utiles en tant qu'inhibiteurs d'aldh-2 pour traiter des mammifères qui dépendent de substances créant un effet d'accoutumance, par exemple l'accoutumance à un agent produisant de la dopamine tel que la cocaïne, la morphine, les amphétamines, la nicotine et l'alcool.
MA33106A 2008-01-24 2010-08-23 Inhibiteurs d'aldh-2 dans le traitement d'une accoutumance MA32095B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/051862 WO2009094028A1 (fr) 2008-01-24 2008-01-24 Inhibiteurs d'aldh-2 dans le traitement d'une accoutumance

Publications (1)

Publication Number Publication Date
MA32095B1 true MA32095B1 (fr) 2011-02-01

Family

ID=39731733

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33106A MA32095B1 (fr) 2008-01-24 2010-08-23 Inhibiteurs d'aldh-2 dans le traitement d'une accoutumance

Country Status (13)

Country Link
EP (1) EP2254878A1 (fr)
JP (1) JP2011510072A (fr)
KR (1) KR20100130589A (fr)
CN (1) CN101925590A (fr)
AU (1) AU2008348372A1 (fr)
BR (1) BRPI0822129A2 (fr)
CA (1) CA2712750A1 (fr)
EC (1) ECSP10010417A (fr)
IL (1) IL207127A0 (fr)
MA (1) MA32095B1 (fr)
MX (1) MX2010008111A (fr)
WO (1) WO2009094028A1 (fr)
ZA (1) ZA201004671B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102161648A (zh) * 2011-02-18 2011-08-24 中国药科大学 具有选择性雌激素受体调节活性的异黄酮类化合物的制备方法及其用途
TWI567061B (zh) 2011-07-01 2017-01-21 吉李德科學股份有限公司 用於治療成癮之化合物
AR087700A1 (es) * 2011-08-30 2014-04-09 Gilead Sciences Inc Inhibidores de aldh-2 en el tratamiento de adicciones
WO2019079209A1 (fr) * 2017-10-16 2019-04-25 Amygdala Neurosciences, Inc. Polythérapie pour la prévention d'une addiction
CN108276374B (zh) * 2018-03-29 2020-01-31 天津科技大学 黄酮类芳香化酶抑制剂及其制备方法与应用
CN110922394B (zh) * 2019-11-21 2021-04-06 中国科学院宁波材料技术与工程研究所 一种基于天然黄酮类化合物的生物基本征阻燃环氧树脂前驱体及其制备方法和应用
EP4532016A2 (fr) * 2022-05-31 2025-04-09 University of Maryland, Baltimore Inhibiteurs d'aldh2 et leurs procédés d'utilisation
CA3259203A1 (fr) 2022-06-14 2023-12-21 Amygdala Neurosciences, Inc. Composés inhibiteurs d'aldh-2 et procédés d'utilisation
WO2023244574A1 (fr) 2022-06-14 2023-12-21 Amygdala Neurosciences, Inc. Composés inhibiteurs d'aldh-2 et procédés d'utilisation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU162377B (fr) * 1970-05-27 1973-02-28
US4166862A (en) * 1971-05-25 1979-09-04 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Animal feed containing anabolic isoflavones
GB8626344D0 (en) * 1986-11-04 1986-12-03 Zyma Sa Bicyclic compounds
US5204369A (en) * 1991-07-01 1993-04-20 The Endowment For Research In Human Biology Method for the inhibition of aldh-i useful in the treatment of alcohol dependence or alcohol abuse
US6121010A (en) * 1998-05-12 2000-09-19 The Endowment For Research In Human Biology Methods and assays useful in the treatment of alcohol dependence or alcohol abuse
CA2445515A1 (fr) * 2001-05-04 2002-11-04 Paratek Pharmaceuticals, Inc. Composes modulant le facteur de transcription et methodes pour les utiliser
AUPR957001A0 (en) * 2001-12-19 2002-01-24 Novogen Research Pty Ltd Isoflavone conjugates, derivatives thereof and therapeutic methods involving same
KR20060011785A (ko) * 2002-06-27 2006-02-03 디 인다우먼트 포 리써치 인 휴먼 바이올로지, 인크. Ａｌｄｈ 억제에 유용한 화합물
WO2006002422A2 (fr) * 2004-06-24 2006-01-05 Novartis Vaccines And Diagnostics Inc. Composes utilises pour l'immunopotentialisation
PL377180A1 (pl) * 2005-09-21 2007-04-02 Instytut Farmaceutyczny Zastosowanie izoflawonów i ich pochodnych w leczeniu mukopolisacharydoz
EP2046769A2 (fr) * 2006-07-27 2009-04-15 Cv Therapeutics, Inc. Inhibiteurs d'aldh-2 utilisés pour le traitement d'une accoutumance
AU2008323953A1 (en) * 2007-11-06 2009-05-14 Gilead Palo Alto, Inc. ALDH-2 inhibitors in the treatment of psychiatric disorders

Also Published As

Publication number Publication date
WO2009094028A1 (fr) 2009-07-30
JP2011510072A (ja) 2011-03-31
CA2712750A1 (fr) 2009-07-30
MX2010008111A (es) 2010-11-30
ZA201004671B (en) 2011-03-30
AU2008348372A1 (en) 2009-07-30
BRPI0822129A2 (pt) 2015-06-23
EP2254878A1 (fr) 2010-12-01
KR20100130589A (ko) 2010-12-13
ECSP10010417A (es) 2010-11-30
IL207127A0 (en) 2010-12-30
CN101925590A (zh) 2010-12-22

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