MA32618B1 - Procedes de preparation d'ester methylique d'acide 4-oxo-octahydro-indole-1-carbocylique et de ses derives - Google Patents

Procedes de preparation d'ester methylique d'acide 4-oxo-octahydro-indole-1-carbocylique et de ses derives

Info

Publication number
MA32618B1
MA32618B1 MA33679A MA33679A MA32618B1 MA 32618 B1 MA32618 B1 MA 32618B1 MA 33679 A MA33679 A MA 33679A MA 33679 A MA33679 A MA 33679A MA 32618 B1 MA32618 B1 MA 32618B1
Authority
MA
Morocco
Prior art keywords
octahydro
indole
methyl ester
acid methyl
oxo
Prior art date
Application number
MA33679A
Other languages
Arabic (ar)
English (en)
Inventor
Ernst Kuesters
Murat Acemoglu
Philipp Lustenberger
Gottfried Sedelmeier
Beat Schmidt
Gerhard Penn
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41278189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32618(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA32618B1 publication Critical patent/MA32618B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention porte sur un procédé de production d'ester méthylique d'acide (3ar, 4s,7ar)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylique (i), d'énantiomères d'ester (2-chloroéthyl) (3-oxocyclohexyl)-alkylique de l'acide carbamique (ii)et d'énantiomères de 1-carbalcoxy-4-cétoperhydroindole (iii).
MA33679A 2008-08-12 2011-03-07 Procedes de preparation d'ester methylique d'acide 4-oxo-octahydro-indole-1-carbocylique et de ses derives MA32618B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8815608P 2008-08-12 2008-08-12
PCT/EP2009/060351 WO2010018154A1 (fr) 2008-08-12 2009-08-10 Procédés de préparation d'ester méthylique d'acide 4-oxo-octahydro-indole-1-carbocylique et de ses dérivés

Publications (1)

Publication Number Publication Date
MA32618B1 true MA32618B1 (fr) 2011-09-01

Family

ID=41278189

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33679A MA32618B1 (fr) 2008-08-12 2011-03-07 Procedes de preparation d'ester methylique d'acide 4-oxo-octahydro-indole-1-carbocylique et de ses derives

Country Status (21)

Country Link
US (1) US8084487B2 (fr)
EP (1) EP2315748B1 (fr)
JP (1) JP5468608B2 (fr)
KR (1) KR101673634B1 (fr)
CN (1) CN102119151A (fr)
AU (1) AU2009281218B2 (fr)
BR (1) BRPI0917492A8 (fr)
CA (1) CA2732095C (fr)
CL (1) CL2011000296A1 (fr)
CO (1) CO6341608A2 (fr)
EC (1) ECSP11010883A (fr)
ES (1) ES2547269T3 (fr)
IL (1) IL210835A (fr)
MA (1) MA32618B1 (fr)
MX (1) MX2011001664A (fr)
MY (1) MY151183A (fr)
NZ (1) NZ590753A (fr)
PE (1) PE20110415A1 (fr)
RU (1) RU2513856C2 (fr)
WO (1) WO2010018154A1 (fr)
ZA (1) ZA201100558B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130274294A1 (en) * 2010-12-20 2013-10-17 David Carcache 4-(Hetero)Aryl-Ethynyl-Octahydro-Indole-1-Esters
EP2668159A1 (fr) 2011-01-24 2013-12-04 Novartis AG Dérivés de 4-tolyl-éthynyl-octahydro-indole-1-ester
EP2650284A1 (fr) 2012-04-10 2013-10-16 Merz Pharma GmbH & Co. KGaA Dérivés hétérocycliques comme modulateurs de récepteurs du glutamate métabotropique
GB201312800D0 (en) 2013-07-17 2013-08-28 Heptares Therapeutics Ltd mGlu5 modulators
AU2018310882C1 (en) 2017-07-31 2021-12-09 Novartis Ag Use of mavoglurant in the reduction of alcohol use or in preventing relapse into alcohol use
KR20200035035A (ko) 2017-07-31 2020-04-01 노파르티스 아게 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도
KR20210120011A (ko) * 2019-01-29 2021-10-06 노파르티스 아게 오피오이드 진통제 내약성을 치료하기 위한 mglur5 길항제의 용도
JP7620694B2 (ja) 2020-07-17 2025-01-23 ノバルティス アーゲー オピオイド使用の低減用医薬品及びオピオイド禁断の促進用医薬品
WO2022123482A1 (fr) 2020-12-11 2022-06-16 Novartis Ag Utilisation d'antagonistes de mglur5 pour le traitement de la dépendance à l'amphétamine
CA3204360A1 (fr) 2020-12-14 2022-06-23 Novartis Ag Utilisation d'antagonistes de mglur5 pour traiter un trouble lie aux jeux d'argent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128996D0 (en) * 2001-12-04 2002-01-23 Novartis Ag Organic compounds
GB0514296D0 (en) * 2005-07-12 2005-08-17 Novartis Ag Organic compounds
EP2272509A1 (fr) * 2006-09-11 2011-01-12 Novartis AG Nouvelles utilisations des récepteurs du glutamate métabotropique
MX2010003913A (es) * 2007-10-12 2010-04-27 Novartis Ag Moduladores de los receptores de glutamato metabotropicos para el tratamiento de enfermedades de parkinson.
WO2010000763A2 (fr) * 2008-06-30 2010-01-07 Novartis Ag Produits de combinaison

Also Published As

Publication number Publication date
AU2009281218B2 (en) 2013-05-16
EP2315748B1 (fr) 2015-06-24
RU2011108663A (ru) 2012-09-20
US8084487B2 (en) 2011-12-27
IL210835A (en) 2016-05-31
BRPI0917492A2 (pt) 2015-08-04
HK1155733A1 (en) 2012-05-25
ECSP11010883A (es) 2011-04-29
NZ590753A (en) 2012-06-29
ZA201100558B (en) 2011-10-26
WO2010018154A1 (fr) 2010-02-18
JP5468608B2 (ja) 2014-04-09
US20110144352A1 (en) 2011-06-16
CO6341608A2 (es) 2011-11-21
AU2009281218A1 (en) 2010-02-18
KR101673634B1 (ko) 2016-11-07
CA2732095A1 (fr) 2010-02-18
CN102119151A (zh) 2011-07-06
EP2315748A1 (fr) 2011-05-04
ES2547269T3 (es) 2015-10-05
CA2732095C (fr) 2017-04-25
PE20110415A1 (es) 2011-07-04
MX2011001664A (es) 2011-03-25
MY151183A (en) 2014-04-30
IL210835A0 (en) 2011-04-28
CL2011000296A1 (es) 2011-11-04
BRPI0917492A8 (pt) 2016-07-05
JP2011530566A (ja) 2011-12-22
KR20110042222A (ko) 2011-04-25
RU2513856C2 (ru) 2014-04-20

Similar Documents

Publication Publication Date Title
MY151183A (en) Processes for the preparation of 4-oxo-octahydro-indole-1-carbocyclic acid methyl ester and derivatives thereof
EP2100957A4 (fr) Procédé de production d'un acide aminé l
ATE502001T1 (de) Herstellung von essigsäure
EP1947190A4 (fr) Procédé de production d'acide succinique
EP1790665A4 (fr) Processus de production de la modification de l'acide hyaluronique hydrosoluble
FR2884818B1 (fr) Procede de preparation d'acide acrylique a partir de glycerol
EA201070700A1 (ru) Способы получения циклоалкилкарбоксамидопиридинбензойных кислот
EP2123636A4 (fr) Procédé de préparation d'un dérivé d'aminoacétylpyrrolidinecarbonitrile
EP2080808A4 (fr) Procédé de fabrication d'un l-amino acide
FR2897059B1 (fr) Procede de preparation d'acide acrylique
MA32255B1 (fr) Procede pour la preparation de triamides a partir d'ammmoniac et d'amidodichlorures
EP2070684A4 (fr) Procédé de production d'un film d'acide polylactique
FR2909999B1 (fr) Procede de preparation d'acide acrylique a partir de glycerol
EP1995308A4 (fr) Bactérie productrice d'acide organique et procédé de production d'acide organique
ITMI20081164A1 (it) Processo per la produzione di esteri dell'acido levulinico da biomasse
MA29464B1 (fr) Methode de preparation d'acides 1,6-dihydro-6-oxo-4-pyrimidinecarboxyliques eventuellement 2-substitues
EP2093210A4 (fr) Procédé de production de l'acide térephtalique
CL2012000560A1 (es) Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08).
MA32297B1 (fr) Procede de preparation de derives d'acide 1-(2-halobiphenyl-4-yl)-cyclopropane carboxylique
DE602004008183D1 (de) Verfahren zur Herstellung von L-Cystein unter Verwendung eines zur Gattung Escherichia gehörenden Bakteriums
EP2046709A4 (fr) Procédé de production d'acide succinique
EP2006274A4 (fr) Procédé de production de chlorure d'acide 3,3,3-trifluoropropionique
EP2060578A4 (fr) Procédé de fabrication d'un acide aminophosphinylbutanoïque optiquement actif
MA33596B1 (fr) Procédé photochimique pour la production d'artémisinine
EA201300440A1 (ru) Способ получения (3s,3s') 4,4'-дисульфандиилбис(3-аминобутан-1-сульфокислоты)