BRPI0917492A2 - Processos para preparação de metil éster de ácido 4-oxo-octa-hidro-indol-1-carboxílio e derivados dos mesmos - Google Patents
Processos para preparação de metil éster de ácido 4-oxo-octa-hidro-indol-1-carboxílio e derivados dos mesmosInfo
- Publication number
- BRPI0917492A2 BRPI0917492A2 BRPI0917492-3A BRPI0917492A BRPI0917492A2 BR PI0917492 A2 BRPI0917492 A2 BR PI0917492A2 BR PI0917492 A BRPI0917492 A BR PI0917492A BR PI0917492 A2 BRPI0917492 A2 BR PI0917492A2
- Authority
- BR
- Brazil
- Prior art keywords
- octahydro
- indol
- oxo
- derivatives
- preparing
- Prior art date
Links
- NZYYBAHLELETLF-UHFFFAOYSA-N methyl 4-oxo-3,3a,5,6,7,7a-hexahydro-2h-indole-1-carboxylate Chemical compound C1CCC(=O)C2C1N(C(=O)OC)CC2 NZYYBAHLELETLF-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
- C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8815608P | 2008-08-12 | 2008-08-12 | |
| PCT/EP2009/060351 WO2010018154A1 (en) | 2008-08-12 | 2009-08-10 | Processes for the preparation of 4-oxo-octahydro-indole-1-carbocylic acid methyl ester and derivatives thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0917492A2 true BRPI0917492A2 (pt) | 2015-08-04 |
| BRPI0917492A8 BRPI0917492A8 (pt) | 2016-07-05 |
Family
ID=41278189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0917492A BRPI0917492A8 (pt) | 2008-08-12 | 2009-08-10 | processos para preparação de metil éster de ácido 4-oxo-octa-hidro-indol-1-carboxílico e derivados dos mesmos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8084487B2 (pt) |
| EP (1) | EP2315748B1 (pt) |
| JP (1) | JP5468608B2 (pt) |
| KR (1) | KR101673634B1 (pt) |
| CN (1) | CN102119151A (pt) |
| AU (1) | AU2009281218B2 (pt) |
| BR (1) | BRPI0917492A8 (pt) |
| CA (1) | CA2732095C (pt) |
| CL (1) | CL2011000296A1 (pt) |
| CO (1) | CO6341608A2 (pt) |
| EC (1) | ECSP11010883A (pt) |
| ES (1) | ES2547269T3 (pt) |
| IL (1) | IL210835A (pt) |
| MA (1) | MA32618B1 (pt) |
| MX (1) | MX2011001664A (pt) |
| MY (1) | MY151183A (pt) |
| NZ (1) | NZ590753A (pt) |
| PE (1) | PE20110415A1 (pt) |
| RU (1) | RU2513856C2 (pt) |
| WO (1) | WO2010018154A1 (pt) |
| ZA (1) | ZA201100558B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130274294A1 (en) * | 2010-12-20 | 2013-10-17 | David Carcache | 4-(Hetero)Aryl-Ethynyl-Octahydro-Indole-1-Esters |
| EP2668159A1 (en) | 2011-01-24 | 2013-12-04 | Novartis AG | 4-tolyl-ethynyl-octahydro-indole-1-ester derivatives |
| EP2650284A1 (en) | 2012-04-10 | 2013-10-16 | Merz Pharma GmbH & Co. KGaA | Heterocyclic derivatives as metabotropic glutamate receptor modulators |
| GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
| AU2018310882C1 (en) | 2017-07-31 | 2021-12-09 | Novartis Ag | Use of mavoglurant in the reduction of alcohol use or in preventing relapse into alcohol use |
| KR20200035035A (ko) | 2017-07-31 | 2020-04-01 | 노파르티스 아게 | 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도 |
| KR20210120011A (ko) * | 2019-01-29 | 2021-10-06 | 노파르티스 아게 | 오피오이드 진통제 내약성을 치료하기 위한 mglur5 길항제의 용도 |
| JP7620694B2 (ja) | 2020-07-17 | 2025-01-23 | ノバルティス アーゲー | オピオイド使用の低減用医薬品及びオピオイド禁断の促進用医薬品 |
| WO2022123482A1 (en) | 2020-12-11 | 2022-06-16 | Novartis Ag | Use of mglur5 antagonists for treating amphetamine addiction |
| CA3204360A1 (en) | 2020-12-14 | 2022-06-23 | Novartis Ag | Use of mglur5 antagonists for treating gambling disorder |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0128996D0 (en) * | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| GB0514296D0 (en) * | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
| EP2272509A1 (en) * | 2006-09-11 | 2011-01-12 | Novartis AG | New Uses of metabotropic glutamate receptors |
| MX2010003913A (es) * | 2007-10-12 | 2010-04-27 | Novartis Ag | Moduladores de los receptores de glutamato metabotropicos para el tratamiento de enfermedades de parkinson. |
| WO2010000763A2 (en) * | 2008-06-30 | 2010-01-07 | Novartis Ag | Combination products |
-
2009
- 2009-08-10 NZ NZ590753A patent/NZ590753A/en not_active IP Right Cessation
- 2009-08-10 WO PCT/EP2009/060351 patent/WO2010018154A1/en not_active Ceased
- 2009-08-10 JP JP2011522496A patent/JP5468608B2/ja active Active
- 2009-08-10 KR KR1020117005727A patent/KR101673634B1/ko not_active Expired - Fee Related
- 2009-08-10 RU RU2011108663/04A patent/RU2513856C2/ru not_active IP Right Cessation
- 2009-08-10 CA CA2732095A patent/CA2732095C/en not_active Expired - Fee Related
- 2009-08-10 US US13/058,608 patent/US8084487B2/en active Active
- 2009-08-10 PE PE2011000147A patent/PE20110415A1/es not_active Application Discontinuation
- 2009-08-10 CN CN2009801306666A patent/CN102119151A/zh active Pending
- 2009-08-10 BR BRPI0917492A patent/BRPI0917492A8/pt not_active IP Right Cessation
- 2009-08-10 MY MYPI20110380 patent/MY151183A/en unknown
- 2009-08-10 MX MX2011001664A patent/MX2011001664A/es active IP Right Grant
- 2009-08-10 ES ES09781678.9T patent/ES2547269T3/es active Active
- 2009-08-10 EP EP09781678.9A patent/EP2315748B1/en active Active
- 2009-08-10 AU AU2009281218A patent/AU2009281218B2/en not_active Ceased
-
2011
- 2011-01-21 ZA ZA2011/00558A patent/ZA201100558B/en unknown
- 2011-01-24 IL IL210835A patent/IL210835A/en not_active IP Right Cessation
- 2011-02-11 CL CL2011000296A patent/CL2011000296A1/es unknown
- 2011-03-07 MA MA33679A patent/MA32618B1/fr unknown
- 2011-03-11 CO CO11030452A patent/CO6341608A2/es active IP Right Grant
- 2011-03-11 EC EC2011010883A patent/ECSP11010883A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009281218B2 (en) | 2013-05-16 |
| EP2315748B1 (en) | 2015-06-24 |
| RU2011108663A (ru) | 2012-09-20 |
| US8084487B2 (en) | 2011-12-27 |
| IL210835A (en) | 2016-05-31 |
| HK1155733A1 (en) | 2012-05-25 |
| ECSP11010883A (es) | 2011-04-29 |
| NZ590753A (en) | 2012-06-29 |
| ZA201100558B (en) | 2011-10-26 |
| WO2010018154A1 (en) | 2010-02-18 |
| JP5468608B2 (ja) | 2014-04-09 |
| US20110144352A1 (en) | 2011-06-16 |
| CO6341608A2 (es) | 2011-11-21 |
| AU2009281218A1 (en) | 2010-02-18 |
| KR101673634B1 (ko) | 2016-11-07 |
| CA2732095A1 (en) | 2010-02-18 |
| CN102119151A (zh) | 2011-07-06 |
| EP2315748A1 (en) | 2011-05-04 |
| ES2547269T3 (es) | 2015-10-05 |
| CA2732095C (en) | 2017-04-25 |
| PE20110415A1 (es) | 2011-07-04 |
| MX2011001664A (es) | 2011-03-25 |
| MY151183A (en) | 2014-04-30 |
| IL210835A0 (en) | 2011-04-28 |
| MA32618B1 (fr) | 2011-09-01 |
| CL2011000296A1 (es) | 2011-11-04 |
| BRPI0917492A8 (pt) | 2016-07-05 |
| JP2011530566A (ja) | 2011-12-22 |
| KR20110042222A (ko) | 2011-04-25 |
| RU2513856C2 (ru) | 2014-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2474 DE 05-06-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |