MA32967B1 - Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement érectile - Google Patents
Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement érectileInfo
- Publication number
- MA32967B1 MA32967B1 MA34016A MA34016A MA32967B1 MA 32967 B1 MA32967 B1 MA 32967B1 MA 34016 A MA34016 A MA 34016A MA 34016 A MA34016 A MA 34016A MA 32967 B1 MA32967 B1 MA 32967B1
- Authority
- MA
- Morocco
- Prior art keywords
- sgc
- treatment
- combination
- pde5 inhibitors
- erectile dysfunction
- Prior art date
Links
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 title abstract 3
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 title abstract 3
- 208000010228 Erectile Dysfunction Diseases 0.000 title abstract 2
- 201000001881 impotence Diseases 0.000 title abstract 2
- 239000000021 stimulant Substances 0.000 title 1
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 abstract 4
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 abstract 4
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 3
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 3
- 239000012190 activator Substances 0.000 abstract 2
- 229940127296 soluble guanylate cyclase stimulator Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La présente invention concerne la cyclase guanylate soluble (sGC) et des phosphodiestérases (PDE), ainsi que la pharmacologie des stimulateurs sGC, des activateurs sGC et des inhibiteurs PDE. Plus particulièrement, l'invention concerne l'utilisation de stimulateurs sGC et d'activateurs sGC en combinaison avec des inhibiteurs PDE5, dans la préparation de médicaments destinés au traitement du dysfonctionnement érectile masculin (MED), et en particulier au traitement du MED pour des patients difficiles à traiter et des patients ne réagissant pas, ou pas totalement, aux inhibiteurs de PDE5.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09000619 | 2009-01-17 | ||
| EP09002177 | 2009-02-17 | ||
| PCT/EP2010/000029 WO2010081647A2 (fr) | 2009-01-17 | 2010-01-07 | Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement érectile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA32967B1 true MA32967B1 (fr) | 2012-01-02 |
Family
ID=42153923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA34016A MA32967B1 (fr) | 2009-01-17 | 2010-01-07 | Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement érectile |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20120022028A1 (fr) |
| EP (1) | EP2387404B1 (fr) |
| JP (1) | JP5780430B2 (fr) |
| KR (1) | KR20110117655A (fr) |
| CN (1) | CN102316870A (fr) |
| AU (1) | AU2010205931A1 (fr) |
| BR (1) | BRPI1006869A2 (fr) |
| CA (1) | CA2749730C (fr) |
| CL (1) | CL2011001712A1 (fr) |
| EA (1) | EA201170942A1 (fr) |
| ES (1) | ES2493718T3 (fr) |
| IL (1) | IL213857A0 (fr) |
| MA (1) | MA32967B1 (fr) |
| MX (1) | MX2011007515A (fr) |
| SG (1) | SG172841A1 (fr) |
| SV (1) | SV2011003973A (fr) |
| TN (1) | TN2011000349A1 (fr) |
| TW (1) | TW201036971A (fr) |
| WO (1) | WO2010081647A2 (fr) |
| ZA (1) | ZA201105085B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011095553A1 (fr) * | 2010-02-05 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft | Stimulateurs de sgc ou activateurs de sgc en combinaison avec des inhibiteurs de pde5 pour le traitement du dysfonctionnement érectile |
| HRP20150987T1 (hr) | 2010-05-26 | 2015-10-23 | Adverio Pharma Gmbh | UPORABA sGC STIMULATORA, sGC AKTIVATORA, SAMOSTALNO I U KOMBINACIJAMA S INHIBITORIMA PDE5 ZA LIJEÄŚENJE SISTEMSKE SKLEROZE (SSc) |
| EP2687210A1 (fr) * | 2010-06-25 | 2014-01-22 | Bayer Intellectual Property GmbH | Stimulateurs et activateurs de la guanylate cyclase soluble pour leur utilisation dans le traitement de la drépanocytose et de la conservation des substituts sanguins |
| JP5715713B2 (ja) | 2011-03-10 | 2015-05-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性グアニル酸シクラーゼ活性化因子 |
| US8815857B2 (en) | 2011-08-12 | 2014-08-26 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclase activators |
| WO2013085276A1 (fr) * | 2011-12-08 | 2013-06-13 | 에스케이케미칼 주식회사 | Film pour administration orale contenant du mirodénafil ou l'un de ses sels pharmaceutiquement acceptables |
| HRP20191755T1 (hr) * | 2012-09-07 | 2019-12-27 | Boehringer Ingelheim International Gmbh | Alkoksipirazoli kao aktivatori topljive gvanilat ciklaze |
| EP3024455A1 (fr) | 2013-07-25 | 2016-06-01 | Bayer Pharma Aktiengesellschaft | Stimulateurs de sgc ou activateurs de sgc et inhibiteurs de pde5 en combinaison avec un autre traitement pour la thérapie de la fibrose kystique |
| US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| PL3172202T3 (pl) | 2014-07-22 | 2020-07-13 | Boehringer Ingelheim International Gmbh | Heterocykliczne kwasy karboksylowe jako aktywatory rozpuszczalnej cyklazy guanylanowej |
| SMT202200190T1 (it) | 2015-11-16 | 2022-07-21 | Topadur Pharma Ag | Derivati del 2-fenil-3,4-diidropirrolo[2,1-f] [1,2,4]triazinone come inibitori della fosfodesterasi e loro usi |
| MX2019013626A (es) | 2017-05-22 | 2020-01-13 | Topadur Pharma Ag | Modo de accion dual novedoso de activadores de guanilato ciclasa solubles e inhibidores de fosfodiesterasa y usos de los mismos. |
| BR112021009958A2 (pt) | 2018-11-28 | 2021-08-17 | Topadur Pharma Ag | modo duplo de ação de ativadores de guanilato ciclase solúveis e inibidores de fosfodiesterase e seus usos |
| CN110305837A (zh) * | 2019-06-05 | 2019-10-08 | 西北师范大学 | 磷酸二酯酶5活性抑制剂作为诱导斑马鱼卵母细胞成熟的催熟剂的应用 |
| WO2021245192A1 (fr) | 2020-06-04 | 2021-12-09 | Topadur Pharma Ag | Nouveaux activateurs de la guanylate cyclase soluble à double mode d'action et inhibiteurs de phosphodiestérase et leurs utilisations |
| CN117462685A (zh) * | 2023-04-14 | 2024-01-30 | 北京悦康科创医药科技股份有限公司 | Pde5抑制剂或其组合物在制备用于治疗泌尿系统疾病药物中的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB371800A (en) | 1929-10-21 | 1932-04-28 | Willem Zaadnoordijk | A process of filtering gases and fogs |
| GB369003A (en) | 1931-03-25 | 1932-03-17 | Richard Henry Sansome | Improvements in fire extinguishing fluids |
| CZ302691B6 (cs) * | 1998-07-08 | 2011-09-07 | Sanofi - Aventis Deutschland GmbH | N-Arylamidová sloucenina, zpusob její prípravy, farmaceutický prostredek tuto slouceninu obsahující, tato sloucenina pro použití jako aktivátor a pro použití k terapii nebo profylaxi |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19943635A1 (de) * | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| DE10220570A1 (de) * | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| US20100144864A1 (en) * | 2007-04-05 | 2010-06-10 | Ironwood Pharmaceuticals, Inc. | Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders |
| AU2008250643A1 (en) * | 2007-05-12 | 2008-11-20 | Bayer Schering Pharma Aktiengesellschaft | sGC stimulators, sGC activators and combinations for the treatment of urological disorders |
-
2010
- 2010-01-07 JP JP2011545666A patent/JP5780430B2/ja not_active Expired - Fee Related
- 2010-01-07 WO PCT/EP2010/000029 patent/WO2010081647A2/fr not_active Ceased
- 2010-01-07 MX MX2011007515A patent/MX2011007515A/es not_active Application Discontinuation
- 2010-01-07 EA EA201170942A patent/EA201170942A1/ru unknown
- 2010-01-07 CA CA2749730A patent/CA2749730C/fr not_active Expired - Fee Related
- 2010-01-07 BR BRPI1006869A patent/BRPI1006869A2/pt not_active Application Discontinuation
- 2010-01-07 ES ES10700938.3T patent/ES2493718T3/es active Active
- 2010-01-07 MA MA34016A patent/MA32967B1/fr unknown
- 2010-01-07 SG SG2011048840A patent/SG172841A1/en unknown
- 2010-01-07 CN CN2010800047775A patent/CN102316870A/zh active Pending
- 2010-01-07 AU AU2010205931A patent/AU2010205931A1/en not_active Abandoned
- 2010-01-07 KR KR1020117016559A patent/KR20110117655A/ko not_active Withdrawn
- 2010-01-07 EP EP10700938.3A patent/EP2387404B1/fr active Active
- 2010-01-07 US US13/144,929 patent/US20120022028A1/en not_active Abandoned
- 2010-01-15 TW TW099101001A patent/TW201036971A/zh unknown
-
2011
- 2011-06-30 IL IL213857A patent/IL213857A0/en unknown
- 2011-07-11 ZA ZA2011/05085A patent/ZA201105085B/en unknown
- 2011-07-14 CL CL2011001712A patent/CL2011001712A1/es unknown
- 2011-07-14 TN TN2011000349A patent/TN2011000349A1/fr unknown
- 2011-07-14 SV SV2011003973A patent/SV2011003973A/es unknown
-
2014
- 2014-03-18 US US14/217,664 patent/US20140288079A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010081647A2 (fr) | 2010-07-22 |
| CL2011001712A1 (es) | 2012-04-09 |
| CA2749730A1 (fr) | 2010-07-22 |
| EP2387404B1 (fr) | 2014-06-25 |
| US20140288079A1 (en) | 2014-09-25 |
| SV2011003973A (es) | 2011-12-06 |
| BRPI1006869A2 (pt) | 2016-03-15 |
| ZA201105085B (en) | 2012-09-26 |
| EA201170942A1 (ru) | 2012-02-28 |
| TN2011000349A1 (en) | 2013-03-27 |
| EP2387404A2 (fr) | 2011-11-23 |
| ES2493718T3 (es) | 2014-09-12 |
| JP2012515176A (ja) | 2012-07-05 |
| US20120022028A1 (en) | 2012-01-26 |
| IL213857A0 (en) | 2011-07-31 |
| SG172841A1 (en) | 2011-08-29 |
| AU2010205931A1 (en) | 2011-07-28 |
| TW201036971A (en) | 2010-10-16 |
| MX2011007515A (es) | 2011-08-12 |
| JP5780430B2 (ja) | 2015-09-16 |
| CA2749730C (fr) | 2017-02-14 |
| WO2010081647A3 (fr) | 2010-10-21 |
| CN102316870A (zh) | 2012-01-11 |
| KR20110117655A (ko) | 2011-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA32967B1 (fr) | Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement érectile | |
| MA34655B1 (fr) | Dérivés de 2,3- dihydroimidazo[1,2-c]quinazoléine substitués par un aminoalcool utiles pour traiter des troubles hyperprolifératifs et des maladies associées à l'angiogenèse | |
| EA201290702A1 (ru) | СТИМУЛЯТОРЫ sGC ИЛИ АКТИВАТОРЫ sGC, ПРИМЕНЯЕМЫЕ ДЛЯ ЛЕЧЕНИЯ КИСТОЗНОГО ФИБРОЗА ОТДЕЛЬНО ИЛИ В КОМБИНАЦИИ С ИНГИБИТОРАМИ PDE5 | |
| EP4275752A3 (fr) | Traitement d'addiction et de troubles de contrôle des impulsions au moyen d'inhibiteurs de la pde7 | |
| MA34002B1 (fr) | Thérapie antivirale | |
| MA29378B1 (fr) | Composition pharmaceutique comprenant une diphenyluree substituee par un omega-carboxyaryle pour le traitement du cancer | |
| RU2009120992A (ru) | Применение 3-андростандиола, необязательно в сочетании с агонистом 5-ht1а для лечения сексуальной дисфункции | |
| TNSN08283A1 (en) | Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use | |
| MA32903B1 (fr) | Inhibiteurs de proteine-kinases | |
| PT2222669E (pt) | Derivados de oxadiazole ativos em esfingosina-1-fosfato (s1p) | |
| SG170828A1 (en) | Deazapurines useful as inhibitors of janus kinases | |
| MA39211B1 (fr) | Composés tricycliques comme agents anti-cancers | |
| MA29615B1 (fr) | Preparations et methodes pour le diagnostic et le traitement d'une tumeur | |
| MX2010004281A (es) | Composiciones y metodos para el tratamiento de la retinopatia diabetica. | |
| BRPI0611705A2 (pt) | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de composto | |
| ATE502633T1 (de) | Cyclosporins zur behandlung und vorbeugung von augenerkrankungen | |
| MA45598B1 (fr) | Stéroles 24-hydroxylés substitués en position 11 pour le traitement des maladies liées au récepteur nmda | |
| MA31335B1 (fr) | Procédés de traitement impliquant l'inhibition de pi3k-alpha au moyen d'inhibiteurs de type quinaxoline | |
| MA47356B1 (fr) | Dérivés d'isochromène utiles en tant qu'inhibiteurs des phosphoinositide 3-kinases | |
| MY144773A (en) | 6-(heterocycle-susbtituted benzyl) -4-oxoquinoline compound and use of the same as hiv integrase inhibitor | |
| WO2018089330A8 (fr) | Stimulateurs de sgc | |
| MX2007002689A (es) | 7-azaindoles y su uso como agonistas de ppar. | |
| TW200621236A (en) | Use of inhibitors of jun n-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases | |
| MA34489B1 (fr) | Agonistes du récepteur a1 à l'adénosine destinés au traitement du glaucome et de l'hypertension oculaire | |
| MA34291B1 (fr) | Compositions et méthodes de diagnostic et de traitement d'une tumeur |