MA33064B1 - Systemes à base de conjugués pour administration contrôlée de médicaments - Google Patents

Systemes à base de conjugués pour administration contrôlée de médicaments

Info

Publication number
MA33064B1
MA33064B1 MA34121A MA34121A MA33064B1 MA 33064 B1 MA33064 B1 MA 33064B1 MA 34121 A MA34121 A MA 34121A MA 34121 A MA34121 A MA 34121A MA 33064 B1 MA33064 B1 MA 33064B1
Authority
MA
Morocco
Prior art keywords
management system
control management
concomitant drug
drug control
conjugates
Prior art date
Application number
MA34121A
Other languages
Arabic (ar)
English (en)
Inventor
Todd C Zion
Thomas M Lancaster
Original Assignee
Smartcells Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smartcells Inc filed Critical Smartcells Inc
Publication of MA33064B1 publication Critical patent/MA33064B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des conjugués qui comprennent un médicamentset un ligand qui comprend un premier saccharide. Le conjugué est caractérisé en ce que, lorsqu'il est administré à un mammifère, au moins une propriété pharmacocinétique ou pharmacodynamique de celui-ci est sensible à la concentration de sérum d'un second saccharide. Outre des procédés d'utilisation et de préparation de ces conjugués, l'invention concerne également des exemples de conjugués et des formulations à libération prolongée.
MA34121A 2009-01-28 2010-01-27 Systemes à base de conjugués pour administration contrôlée de médicaments MA33064B1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US14787809P 2009-01-28 2009-01-28
US15964309P 2009-03-12 2009-03-12
US16210709P 2009-03-20 2009-03-20
US16308409P 2009-03-25 2009-03-25
US21989709P 2009-06-24 2009-06-24
US22357209P 2009-07-07 2009-07-07
US25285709P 2009-10-19 2009-10-19
PCT/US2010/022268 WO2010088294A1 (fr) 2009-01-28 2010-01-27 Systèmes à base de conjugués pour administration contrôlée de médicaments

Publications (1)

Publication Number Publication Date
MA33064B1 true MA33064B1 (fr) 2012-02-01

Family

ID=42395986

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34121A MA33064B1 (fr) 2009-01-28 2010-01-27 Systemes à base de conjugués pour administration contrôlée de médicaments

Country Status (24)

Country Link
US (5) US9050370B2 (fr)
EP (1) EP2391218B1 (fr)
JP (3) JP5508438B2 (fr)
KR (2) KR101635689B1 (fr)
CN (2) CN105753965A (fr)
AU (2) AU2015202871B2 (fr)
BR (1) BRPI1007457A2 (fr)
CA (2) CA2932926C (fr)
CO (1) CO6400173A2 (fr)
CR (1) CR20110408A (fr)
DO (1) DOP2011000244A (fr)
EA (1) EA027757B1 (fr)
EC (1) ECSP11011240A (fr)
ES (1) ES2791683T3 (fr)
GT (1) GT201100208A (fr)
IL (1) IL214099A0 (fr)
MA (1) MA33064B1 (fr)
MX (1) MX2011007929A (fr)
NI (1) NI201100150A (fr)
NZ (1) NZ594248A (fr)
PE (1) PE20120583A1 (fr)
SG (3) SG173112A1 (fr)
TN (1) TN2011000354A1 (fr)
WO (1) WO2010088294A1 (fr)

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WO2010088268A1 (fr) 2009-01-28 2010-08-05 Smartcells, Inc. Matériaux à libération contrôlée déclenchée de façon exogène et leurs utilisations
WO2010088286A1 (fr) 2009-01-28 2010-08-05 Smartcells, Inc. Conjugués synthétiques et leurs utilisations
BRPI1007457A2 (pt) 2009-01-28 2015-08-25 Smartcells Inc Conjungado, formulação de liberação prolongada, e, sistema de distribuição de bomba.
US9095623B2 (en) 2009-03-20 2015-08-04 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
US8623345B2 (en) 2009-03-20 2014-01-07 Smartcells Terminally-functionalized conjugates and uses thereof
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JP2013535467A (ja) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
AU2011282983A1 (en) * 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
WO2012050822A1 (fr) * 2010-10-14 2012-04-19 Smartcells, Inc. Utilisations de récepteur du mannose des macrophages (mmr) pour cribler des composés et utilisations de ces composés
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US9725493B2 (en) * 2013-01-22 2017-08-08 Case Western Reserve University N-terminal truncated insulin analogues
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CN108610494B (zh) * 2018-03-20 2020-11-06 南京理工大学 聚醚砜/功能性含糖聚合物杂化膜的制备方法
CN110146605A (zh) * 2019-04-19 2019-08-20 南通联亚药业有限公司 一种测定格列吡嗪原料药及其缓释片中特定基因毒性杂质的分析方法
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CN113773400B (zh) * 2020-06-09 2023-08-18 宁波鲲鹏生物科技有限公司 一种门冬胰岛素衍生物及其应用
CN113773398B (zh) * 2020-06-10 2023-05-23 宁波鲲鹏生物科技有限公司 一种德谷胰岛素衍生物及其应用
CN112480184A (zh) * 2020-12-09 2021-03-12 上海应用技术大学 一种利用梯度点击化学合成含多种糖的树枝化糖胺的方法
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US10398781B2 (en) 2019-09-03
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US9265838B2 (en) 2016-02-23
BRPI1007457A2 (pt) 2015-08-25
AU2015202871B2 (en) 2017-08-17
KR20110104081A (ko) 2011-09-21
ECSP11011240A (es) 2011-11-30
SG2014006597A (en) 2014-04-28
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