MA33071B1 - Compose a noyau condenses et son utilisation - Google Patents

Compose a noyau condenses et son utilisation

Info

Publication number
MA33071B1
MA33071B1 MA34132A MA34132A MA33071B1 MA 33071 B1 MA33071 B1 MA 33071B1 MA 34132 A MA34132 A MA 34132A MA 34132 A MA34132 A MA 34132A MA 33071 B1 MA33071 B1 MA 33071B1
Authority
MA
Morocco
Prior art keywords
nucleus
intensive
composite
diseases
angiotensin
Prior art date
Application number
MA34132A
Other languages
Arabic (ar)
English (en)
Inventor
Tsuyoshi Maekawa
Hideyuki Igawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA33071B1 publication Critical patent/MA33071B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention porte sur un nouveau composé représenté par la formule suivante, dans laquelle chaque symbole est tel que défini dans la description, ou sur un sel de ce composé, qui a une activité antagoniste des récepteurs de l'angiotensine II et une activité agoniste du récepteur ³ activé par les proliférateurs des peroxysomes, et qui est utile en tant qu'agent pour la prophylaxie ou le traitement de maladies circulatoires, telles que l'hypertension et similaire, et/ou de maladies métaboliques, telles que le diabète et similaire, et similaires.
MA34132A 2009-01-30 2010-01-29 Compose a noyau condenses et son utilisation MA33071B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009020720 2009-01-30
PCT/JP2010/051651 WO2010087515A1 (fr) 2009-01-30 2010-01-29 Composé à noyaux condensés et son utilisation

Publications (1)

Publication Number Publication Date
MA33071B1 true MA33071B1 (fr) 2012-02-01

Family

ID=42026435

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34132A MA33071B1 (fr) 2009-01-30 2010-01-29 Compose a noyau condenses et son utilisation

Country Status (36)

Country Link
US (4) US8283353B2 (fr)
EP (1) EP2384327B1 (fr)
JP (2) JP4892649B1 (fr)
KR (1) KR20110113758A (fr)
CN (2) CN103788097B (fr)
AR (1) AR075344A1 (fr)
AU (1) AU2010208863A1 (fr)
CA (1) CA2750710C (fr)
CL (1) CL2011001848A1 (fr)
CO (1) CO6362011A2 (fr)
CR (1) CR20110463A (fr)
CY (1) CY1114530T1 (fr)
DK (1) DK2384327T3 (fr)
DO (1) DOP2011000249A (fr)
EA (1) EA019823B1 (fr)
EC (1) ECSP11011294A (fr)
ES (1) ES2433225T3 (fr)
GE (1) GEP20135961B (fr)
HR (1) HRP20131017T1 (fr)
IL (1) IL214283A0 (fr)
MA (1) MA33071B1 (fr)
ME (1) ME01621B (fr)
MX (1) MX2011008058A (fr)
MY (1) MY152946A (fr)
NZ (1) NZ594606A (fr)
PE (1) PE20120593A1 (fr)
PL (1) PL2384327T3 (fr)
PT (1) PT2384327E (fr)
RS (1) RS53012B (fr)
SG (1) SG173135A1 (fr)
SI (1) SI2384327T1 (fr)
TN (1) TN2011000368A1 (fr)
TW (2) TW201444848A (fr)
UY (1) UY32409A (fr)
WO (1) WO2010087515A1 (fr)
ZA (1) ZA201105867B (fr)

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CZ304252B6 (cs) * 2011-04-11 2014-01-29 Zentiva, K. S. Způsob výroby 2-ethoxy-1-((2´-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)bifenyl-4-yl)methyl)-1H-benzo[d]imidazol-7-karboxylátů a jejich převedení na azilsartan
JP7042812B2 (ja) 2016-06-20 2022-03-28 ノバルティス アーゲー トリアゾロピリミジン化合物の結晶形態
WO2018165108A1 (fr) 2017-03-08 2018-09-13 Hope Medical Enterprises, Inc. Dba Hope Pharmaceuticals Utilisation intradialytique de thiosulfate de sodium
WO2019067560A1 (fr) 2017-09-26 2019-04-04 Ecolab Usa Inc. Compositions antimicrobiennes et virocides acides/anioniques et leurs utilisations
BR112020024269A2 (pt) 2018-05-31 2021-02-23 Hua Medicine (Shanghai) Ltd. combinação farmacêutica, composição e formulação de combinação contendo ativador de glucoquinase e ativador de receptor ppar e métodos de preparação e usos dos mesmos
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (fr) 2019-02-15 2020-08-20 Incyte Corporation Composés de pyrrolo[2,3-d]pyrimidinone en tant qu'inhibiteurs de cdk2
TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
WO2020223558A1 (fr) 2019-05-01 2020-11-05 Incyte Corporation Composés aminés tricycliques en tant qu'inhibiteurs de cdk2
WO2020223469A1 (fr) 2019-05-01 2020-11-05 Incyte Corporation Dérivés de n-(1-(méthylsulfonyl)pipéridin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine et composés apparentés utilisés en tant qu'inhibiteurs de kinase 2 dépendante des cyclines (cdk2) pour le traitement du cancer
WO2021030537A1 (fr) 2019-08-14 2021-02-18 Incyte Corporation Composés imidazolyl-pyrimidinylamines utilisés comme inhibiteurs de la cdk2
CR20220170A (es) 2019-10-11 2022-10-10 Incyte Corp Aminas bicíclicas como inhibidoras de la cdk2
CN112745319B (zh) * 2019-10-30 2022-06-17 中国科学院上海药物研究所 一类取代三环结构的化合物、其制备方法及用途
AU2020408331B2 (en) 2019-12-16 2023-12-14 Ecolab Usa Inc. Anionic surfactant impact on virucidal efficacy
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
EP4384167A1 (fr) * 2021-08-13 2024-06-19 Mpc Therapeutics Sa [1,2,4] triazolo [4,3-a] pyrimidin -7 (8h)-one en tant qu'inhibiteurs de transporteur de pyruvate mitochondrial pour une utilisation dans le traitement du cancer
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

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Also Published As

Publication number Publication date
CA2750710C (fr) 2018-09-04
DOP2011000249A (es) 2011-09-15
JP4892649B1 (ja) 2012-03-07
HRP20131017T1 (hr) 2013-12-06
AU2010208863A1 (en) 2011-09-08
ZA201105867B (en) 2012-10-31
ECSP11011294A (es) 2011-09-30
US20140046056A1 (en) 2014-02-13
CR20110463A (es) 2011-12-01
SI2384327T1 (sl) 2013-12-31
JP2011251970A (ja) 2011-12-15
JP2012513952A (ja) 2012-06-21
DK2384327T3 (da) 2013-10-28
US9115136B2 (en) 2015-08-25
KR20110113758A (ko) 2011-10-18
EP2384327B1 (fr) 2013-07-31
MY152946A (en) 2014-12-15
CA2750710A1 (fr) 2010-08-05
CY1114530T1 (el) 2017-01-25
PL2384327T3 (pl) 2013-12-31
ES2433225T3 (es) 2013-12-10
EP2384327A1 (fr) 2011-11-09
NZ594606A (en) 2013-06-28
EA201101138A1 (ru) 2012-04-30
PE20120593A1 (es) 2012-05-21
CO6362011A2 (es) 2012-01-20
US8283353B2 (en) 2012-10-09
CN102369205A (zh) 2012-03-07
US20110294832A1 (en) 2011-12-01
RS53012B (sr) 2014-04-30
CN103788097A (zh) 2014-05-14
US8592431B2 (en) 2013-11-26
UY32409A (es) 2010-08-31
IL214283A0 (en) 2011-09-27
TN2011000368A1 (en) 2013-03-27
TW201031669A (en) 2010-09-01
WO2010087515A1 (fr) 2010-08-05
US20110288087A1 (en) 2011-11-24
TW201444848A (zh) 2014-12-01
US8921379B2 (en) 2014-12-30
SG173135A1 (en) 2011-08-29
US20100197683A1 (en) 2010-08-05
JP5676379B2 (ja) 2015-02-25
MX2011008058A (es) 2011-09-01
AR075344A1 (es) 2011-03-23
EA019823B1 (ru) 2014-06-30
GEP20135961B (en) 2013-11-11
CN103788097B (zh) 2016-03-30
PT2384327E (pt) 2013-11-07
HK1162505A1 (en) 2012-08-31
ME01621B (me) 2014-09-20
TWI468410B (zh) 2015-01-11
CL2011001848A1 (es) 2012-02-03
CN102369205B (zh) 2014-10-29

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