MA33071B1 - Compose a noyau condenses et son utilisation - Google Patents
Compose a noyau condenses et son utilisationInfo
- Publication number
- MA33071B1 MA33071B1 MA34132A MA34132A MA33071B1 MA 33071 B1 MA33071 B1 MA 33071B1 MA 34132 A MA34132 A MA 34132A MA 34132 A MA34132 A MA 34132A MA 33071 B1 MA33071 B1 MA 33071B1
- Authority
- MA
- Morocco
- Prior art keywords
- nucleus
- intensive
- composite
- diseases
- angiotensin
- Prior art date
Links
- 239000002131 composite material Substances 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention porte sur un nouveau composé représenté par la formule suivante, dans laquelle chaque symbole est tel que défini dans la description, ou sur un sel de ce composé, qui a une activité antagoniste des récepteurs de l'angiotensine II et une activité agoniste du récepteur ³ activé par les proliférateurs des peroxysomes, et qui est utile en tant qu'agent pour la prophylaxie ou le traitement de maladies circulatoires, telles que l'hypertension et similaire, et/ou de maladies métaboliques, telles que le diabète et similaire, et similaires.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009020720 | 2009-01-30 | ||
| PCT/JP2010/051651 WO2010087515A1 (fr) | 2009-01-30 | 2010-01-29 | Composé à noyaux condensés et son utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA33071B1 true MA33071B1 (fr) | 2012-02-01 |
Family
ID=42026435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA34132A MA33071B1 (fr) | 2009-01-30 | 2010-01-29 | Compose a noyau condenses et son utilisation |
Country Status (36)
| Country | Link |
|---|---|
| US (4) | US8283353B2 (fr) |
| EP (1) | EP2384327B1 (fr) |
| JP (2) | JP4892649B1 (fr) |
| KR (1) | KR20110113758A (fr) |
| CN (2) | CN102369205B (fr) |
| AR (1) | AR075344A1 (fr) |
| AU (1) | AU2010208863A1 (fr) |
| CA (1) | CA2750710C (fr) |
| CL (1) | CL2011001848A1 (fr) |
| CO (1) | CO6362011A2 (fr) |
| CR (1) | CR20110463A (fr) |
| CY (1) | CY1114530T1 (fr) |
| DK (1) | DK2384327T3 (fr) |
| DO (1) | DOP2011000249A (fr) |
| EA (1) | EA019823B1 (fr) |
| EC (1) | ECSP11011294A (fr) |
| ES (1) | ES2433225T3 (fr) |
| GE (1) | GEP20135961B (fr) |
| HR (1) | HRP20131017T1 (fr) |
| IL (1) | IL214283A0 (fr) |
| MA (1) | MA33071B1 (fr) |
| ME (1) | ME01621B (fr) |
| MX (1) | MX2011008058A (fr) |
| MY (1) | MY152946A (fr) |
| NZ (1) | NZ594606A (fr) |
| PE (1) | PE20120593A1 (fr) |
| PL (1) | PL2384327T3 (fr) |
| PT (1) | PT2384327E (fr) |
| RS (1) | RS53012B (fr) |
| SG (1) | SG173135A1 (fr) |
| SI (1) | SI2384327T1 (fr) |
| TN (1) | TN2011000368A1 (fr) |
| TW (2) | TW201444848A (fr) |
| UY (1) | UY32409A (fr) |
| WO (1) | WO2010087515A1 (fr) |
| ZA (1) | ZA201105867B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA33071B1 (fr) | 2009-01-30 | 2012-02-01 | Takeda Pharmaceutical | Compose a noyau condenses et son utilisation |
| HUE024504T2 (en) | 2010-12-23 | 2016-01-28 | Sanofi Sa | Pyrimidine derivatives, a process for their preparation and their use in medicine |
| CZ304252B6 (cs) * | 2011-04-11 | 2014-01-29 | Zentiva, K. S. | Způsob výroby 2-ethoxy-1-((2´-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)bifenyl-4-yl)methyl)-1H-benzo[d]imidazol-7-karboxylátů a jejich převedení na azilsartan |
| EP3472168B1 (fr) | 2016-06-20 | 2024-01-10 | Novartis AG | Formes cristallines d'un composé de triazolopyrimidine |
| CA3077050A1 (fr) | 2017-09-26 | 2019-04-04 | Ecolab Usa Inc. | Compositions antimicrobiennes et virocides acides/anioniques et leurs utilisations |
| DK3804716T3 (da) | 2018-05-31 | 2025-03-03 | Hua Medicine Shanghai Ltd | Farmaceutisk kombination, sammensætning og kombinationspræparat omfattende glucokinase-aktivator og sglt-2-inhibitor og fremgangsmåder til fremstilling og anvendelser deraf |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| US11472791B2 (en) | 2019-03-05 | 2022-10-18 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors |
| WO2020205560A1 (fr) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Composés sulfonylamides utilisés comme inhibiteurs de la cdk2 |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| MX2022001940A (es) | 2019-08-14 | 2022-05-10 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2. |
| CN119930610A (zh) | 2019-10-11 | 2025-05-06 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
| CN112745319B (zh) * | 2019-10-30 | 2022-06-17 | 中国科学院上海药物研究所 | 一类取代三环结构的化合物、其制备方法及用途 |
| CN114901072B (zh) | 2019-12-16 | 2024-12-17 | 埃科莱布美国股份有限公司 | 阴离子表面活性剂对杀病毒功效的影响 |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2672892B1 (fr) * | 1991-02-20 | 1994-01-14 | Synthelabo | Derives de 4-pyrimidinones, leur preparation et leur application en therapeutique. |
| US5472967A (en) | 1991-02-20 | 1995-12-05 | Synthelabo | 4-pyrimidinone derivatives their preparation and their application in therapy |
| TW251288B (fr) * | 1991-06-27 | 1995-07-11 | Takeda Dharm Industry Co Ltd | |
| IL102183A (en) | 1991-06-27 | 1999-11-30 | Takeda Chemical Industries Ltd | Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them |
| IT1250749B (it) | 1991-08-02 | 1995-04-21 | Luso Farmaco Inst | Composti eterociclici ad attivita' a ii antagonista |
| US5389632A (en) | 1992-02-24 | 1995-02-14 | Laboratoires Upsa | Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists |
| FR2687677B1 (fr) * | 1992-02-24 | 1996-10-11 | Union Pharma Scient Appl | Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| US5387747A (en) | 1992-02-24 | 1995-02-07 | Laboratoires Upsa | Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present |
| IT1263804B (it) | 1993-01-22 | 1996-09-03 | Luso Farmaco Inst | Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista |
| GB9406573D0 (en) | 1994-03-31 | 1994-05-25 | Merck Sharp & Dohme | Medicaments |
| WO1996040256A1 (fr) | 1995-06-07 | 1996-12-19 | G.D. Searle & Co. | Procede de traitement de la cardiofibrose avec une combinaison de spironolactone et d'un antagoniste de l'angiotensive ii |
| IL122246A (en) | 1995-06-07 | 2004-06-01 | Searle & Co | Combination of spironolactone and angiotensin II antagonist for the treatment of heart failure |
| KR100618466B1 (ko) | 1995-06-07 | 2006-12-13 | 지.디. 썰 엘엘씨 | 울혈성심마비의치료를위한에폭시-스테로이드계알도스테론길항제및앤지오탠신ii길항제복합요법 |
| WO1996040255A2 (fr) | 1995-06-07 | 1996-12-19 | G.D. Searle & Co. | Procede de traitement de la fibrose cardiaque par une combinaison therapeutique d'un antagoniste de l'angiotensine ii et d'un antagoniste de l'aldosterone epoxy-steroide |
| FR2812876B1 (fr) | 2000-08-08 | 2002-09-27 | Galderma Res & Dev | Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques |
| SE0101579D0 (sv) | 2001-05-04 | 2001-05-04 | Astrazeneca Ab | New compounds |
| US7232828B2 (en) | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| TW200418835A (en) | 2003-01-24 | 2004-10-01 | Tanabe Seiyaku Co | A pyrazolopyrimidine compound and a process for preparing the same |
| US20050065184A1 (en) | 2003-08-29 | 2005-03-24 | Aaipharma Inc. | Method of reducing the risk of oxidative stress |
| JP2007520559A (ja) * | 2004-02-03 | 2007-07-26 | アボット・ラボラトリーズ | 治療薬としてのアミノベンゾオキサゾール類 |
| MEP8409A (en) | 2004-06-02 | 2011-12-20 | Fused heterocyclic compound | |
| RU2384346C2 (ru) | 2004-06-23 | 2010-03-20 | Зольвай Фармасьютиклз Гмбх | Фармацевтические композиции, содержащие nep-ингибиторы, ингибиторы эндогенной эндотелинпродуцирующей системы и антагонисты at1-рецептора |
| US20050288272A1 (en) | 2004-06-23 | 2005-12-29 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists |
| AU2006273622A1 (en) | 2005-07-27 | 2007-02-01 | Mor Research Applications Ltd. | Inhibition of the renin-angiotensin system for the treatment of renal, vascular and cartilage pathology |
| WO2007053406A1 (fr) | 2005-10-28 | 2007-05-10 | Novartis Ag | Combinaison de composes organiques hypotenseurs et hypocholesterolemiant |
| WO2007051007A2 (fr) | 2005-10-28 | 2007-05-03 | Novartis Ag | Combinaison de composes organiques |
| US20080064871A1 (en) | 2006-05-26 | 2008-03-13 | Japan Tobacco Inc. | Production Method of Nitrogen-Containing Fused Ring Compounds |
| US20080132474A1 (en) | 2006-11-09 | 2008-06-05 | Gene Logic Inc. | Breast cancer screening and treatment methods |
| US20090012052A1 (en) | 2006-11-09 | 2009-01-08 | Ore Pharmaceuticals Inc. | Method for treating er+ breast cancer |
| MX2009005449A (es) * | 2006-11-24 | 2009-06-02 | Takeda Pharmaceutical | Compuesto heteromonociclico y uso del mismo. |
| JPWO2008143262A1 (ja) | 2007-05-21 | 2010-08-12 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| CN101888776B (zh) | 2007-09-20 | 2015-03-11 | 罗切斯特大学 | 治疗或预防炎性病症的方法和组合物 |
| KR101673621B1 (ko) | 2008-03-24 | 2016-11-07 | 노파르티스 아게 | 아릴술폰아미드-계 매트릭스 메탈로프로테아제 억제제 |
| EP2279009A4 (fr) | 2008-05-05 | 2011-09-21 | Univ Rochester | Procédés et compositions pour le traitement ou la prévention d'une remodélisation cardiaque pathologique et d'une insuffisance cardiaque |
| MA33071B1 (fr) * | 2009-01-30 | 2012-02-01 | Takeda Pharmaceutical | Compose a noyau condenses et son utilisation |
-
2010
- 2010-01-29 MA MA34132A patent/MA33071B1/fr unknown
- 2010-01-29 UY UY0001032409A patent/UY32409A/es not_active Application Discontinuation
- 2010-01-29 DK DK10703532.1T patent/DK2384327T3/da active
- 2010-01-29 GE GEAP201012358A patent/GEP20135961B/en unknown
- 2010-01-29 HR HRP20131017AT patent/HRP20131017T1/hr unknown
- 2010-01-29 TW TW103125956A patent/TW201444848A/zh unknown
- 2010-01-29 ES ES10703532T patent/ES2433225T3/es active Active
- 2010-01-29 CA CA2750710A patent/CA2750710C/fr not_active Expired - Fee Related
- 2010-01-29 PL PL10703532T patent/PL2384327T3/pl unknown
- 2010-01-29 US US12/696,147 patent/US8283353B2/en not_active Expired - Fee Related
- 2010-01-29 JP JP2011525329A patent/JP4892649B1/ja not_active Expired - Fee Related
- 2010-01-29 MX MX2011008058A patent/MX2011008058A/es active IP Right Grant
- 2010-01-29 RS RS20130472A patent/RS53012B/sr unknown
- 2010-01-29 ME MEP-2013-131A patent/ME01621B/me unknown
- 2010-01-29 EA EA201101138A patent/EA019823B1/ru not_active IP Right Cessation
- 2010-01-29 AR ARP100100240A patent/AR075344A1/es unknown
- 2010-01-29 PT PT107035321T patent/PT2384327E/pt unknown
- 2010-01-29 CN CN201080014441.7A patent/CN102369205B/zh not_active Expired - Fee Related
- 2010-01-29 US US13/146,989 patent/US8592431B2/en not_active Expired - Fee Related
- 2010-01-29 MY MYPI2011003554 patent/MY152946A/en unknown
- 2010-01-29 PE PE2011001418A patent/PE20120593A1/es not_active Application Discontinuation
- 2010-01-29 AU AU2010208863A patent/AU2010208863A1/en not_active Abandoned
- 2010-01-29 SI SI201030403T patent/SI2384327T1/sl unknown
- 2010-01-29 TW TW99102537A patent/TWI468410B/zh not_active IP Right Cessation
- 2010-01-29 KR KR1020117020049A patent/KR20110113758A/ko not_active Withdrawn
- 2010-01-29 SG SG2011053741A patent/SG173135A1/en unknown
- 2010-01-29 EP EP10703532.1A patent/EP2384327B1/fr active Active
- 2010-01-29 WO PCT/JP2010/051651 patent/WO2010087515A1/fr not_active Ceased
- 2010-01-29 NZ NZ594606A patent/NZ594606A/xx not_active IP Right Cessation
- 2010-01-29 CN CN201310750040.3A patent/CN103788097B/zh not_active Expired - Fee Related
-
2011
- 2011-06-30 JP JP2011146858A patent/JP5676379B2/ja not_active Expired - Fee Related
- 2011-07-25 IL IL214283A patent/IL214283A0/en unknown
- 2011-07-27 TN TN2011000368A patent/TN2011000368A1/fr unknown
- 2011-07-29 CL CL2011001848A patent/CL2011001848A1/es unknown
- 2011-07-29 DO DO2011000249A patent/DOP2011000249A/es unknown
- 2011-08-09 US US13/205,967 patent/US8921379B2/en not_active Expired - Fee Related
- 2011-08-11 ZA ZA2011/05867A patent/ZA201105867B/en unknown
- 2011-08-26 CR CR20110463A patent/CR20110463A/es unknown
- 2011-08-29 CO CO11109923A patent/CO6362011A2/es active IP Right Grant
- 2011-08-30 EC EC2011011294A patent/ECSP11011294A/es unknown
-
2013
- 2013-10-22 US US14/059,868 patent/US9115136B2/en not_active Expired - Fee Related
- 2013-10-25 CY CY20131100941T patent/CY1114530T1/el unknown
Also Published As
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|---|---|---|
| MA33071B1 (fr) | Compose a noyau condenses et son utilisation | |
| MA31084B1 (fr) | Derives de piperidine agonistes de gpcr | |
| MA30528B1 (fr) | Antagoniste du recepteur il-8. | |
| MA32614B1 (fr) | Compositions therapeutiques contenant du macitentan | |
| MA31189B1 (fr) | Composés à cycles fusionnés utiles en tant qu'agonistes partiels de ppar-gamma | |
| MA46286B1 (fr) | Dérivé de pyrazolopyridine ayant un effet agoniste du récepteur glp-1 | |
| EA200701705A1 (ru) | Антагонисты рецепторы глюкагона, получение и терапевтическое применение | |
| MA37866B1 (fr) | Dérivés de type aza-indazole ou diaza-indazole pour le traitement de la douleur | |
| MA33840B1 (fr) | Nouveau composé de spiropipéridine | |
| MA32903B1 (fr) | Inhibiteurs de proteine-kinases | |
| MX2011011156A (es) | COMPUESTOS DIAMIDA QUE TIENE ACTIVIDAD COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS Y COMO AGONISTAS DE LOS RECEPTORES ANDRENERGICOS ß2. | |
| EP2324029A4 (fr) | Inhibiteurs hétérocyliques des récepteurs de l'histamine destinés au traitement d'une maladie | |
| BRPI0714315B8 (pt) | arilamidas substituídas com tetrazol, seu uso e composição farmacêutica que as compreende | |
| MA33178B1 (fr) | Pipéridines substituées comme antagonistes de ccr3 | |
| TN2014000243A1 (fr) | Benzopyrannes nouveaux, compositions les contenant et leurs utilisations | |
| ATE464304T1 (de) | Carboxamid-spirolactam-cgrp-rezeptor-antagonist n | |
| MA34545B1 (fr) | Co-cristaux et sels d'inhibiteurs de ccr3 | |
| EA201070535A1 (ru) | Новые агонисты глюкокортикоидных рецепторов | |
| MA30556B1 (fr) | COMPOSES A BASE DE DIALKYLPHENYLE AYANT UNE ACTIVITE AGONISTE DU RECEPTEUR ADRENERGIQUE ß2 ET ANTAGONISTE DU RECEPTEUR MUSCARINIQUE. | |
| CY1110922T1 (el) | Ανταγωνιστες υποδοχεα γλυκαγονης, παρασκευη και θεραπευτικες χρησεις | |
| DK1735278T3 (da) | Histamin H3-receptormidler, fremstilling og terapeutiske anvendelser | |
| TNSN08337A1 (fr) | Piperidinoylpyrrolidines agonistes du recepteur de melanocortine de type 4 | |
| DK2081572T3 (da) | Benzimidazol-cannabinoid-agonister med en substitueret heterocyklisk gruppe | |
| MA33836B1 (fr) | Compositions pharmaceutiques contenant des ligands des récepteurs sigma | |
| ATE552246T1 (de) | Substituierte aryloxy-n- bicyclomethylacetamidverbindungen als vr1- antagonisten |