MA33128B1 - Derives de triazolopyridine utilises comme inhibiteurs de la p38 map kinase - Google Patents

Derives de triazolopyridine utilises comme inhibiteurs de la p38 map kinase

Info

Publication number
MA33128B1
MA33128B1 MA34175A MA34175A MA33128B1 MA 33128 B1 MA33128 B1 MA 33128B1 MA 34175 A MA34175 A MA 34175A MA 34175 A MA34175 A MA 34175A MA 33128 B1 MA33128 B1 MA 33128B1
Authority
MA
Morocco
Prior art keywords
radical
formula
cycle
represented
possibly substituted
Prior art date
Application number
MA34175A
Other languages
Arabic (ar)
English (en)
Inventor
Harry Finch
John Montana
Niel Monique Bodil Van
Chi-Kit Woo
Jamie Knight
Bohdan Waszkowycz
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42232647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33128(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0902651A external-priority patent/GB0902651D0/en
Priority claimed from GB0908069A external-priority patent/GB0908069D0/en
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of MA33128B1 publication Critical patent/MA33128B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSÉS REPRÉSENTÉS PAR LA FORMULE (I) QUI SONT DES INHIBITEURS DE LA P38 MAP UTILISÉS COMME AGENTS ANTI-INFLAMMATOIRES POUR TRAITER, INTER ALIA, LES MALADIES DES VOIES RESPIRATOIRES. DANS LA FORMULE (I), R1 REPRÉSENTE ALKYLE C1-C6, CYCLOALKYLE C3-C6, PHÉNYLE QUI EST ÉVENTUELLEMENT SUBSTITUÉ, HÉTÉROARYLE MONOCYCLIQUE À 5 OU 6 ÉLÉMENTS QUI EST ÉVENTUELLEMENT SUBSTITUÉ, OU UN RADICAL REPRÉSENTÉ PAR LA FORMULE (II) DANS LEQUEL N EST ÉGAL À 1 OU 2, ET R3 ET R4 REPRÉSENTENT INDÉPENDAMMENT H OU ALKYLE C1-C6, OU R3 ET R4 PRIS ENSEMBLE AVEC L'AZOTE À LAQUELLE ILS SONT LIÉS FORMENT UN CYCLE HÉTÉROCYCLIQUE À 6 ÉLÉMENTS CONTENANT ÉVENTUELLEMENT UN AUTRE HÉTÉROATOME SÉLECTIONNÉ PARMI N ET O; Y REPRÉSENTE -O- OU -S(O)P- DANS LEQUEL P EST ÉGAL À 0, 1 OU 2 ; A REPRÉSENTE ÉVENTUELLEMENT UN RADICAL ARYLÈNE DIVALENT ÉVENTUELLEMENT SUBSTITUÉ, OU UN RADICAL HÉTÉROARYLÈNE MONOCYCLIQUE OU BICYCLIQUE, OU UN RADICAL CYCLOALKYLÈNE DIVALENT C3-C6 COMPRENANT 5 OU 6 ATOMES DE CYCLE, OU UN RADICAL PIPÉRIDINYLÈNE DANS LEQUEL L'AZOTE DE CYCLE EST LIÉE À R2NHC(=O)W- ; W REPRÉSENTE UNE LIAISON, -NH- OU -C(RA)(RB), DANS LEQUEL RA ET RB REPRÉSENTENT INDÉPENDAMMENT H, MÉTHYLE, ÉTHYLE, AMINO, HYDROXYLE OU HALO ; ET R2 REPRÉSENTE UN RADICAL TEL QUE DÉFINI DANS LES REVENDICATIONS.
MA34175A 2009-02-17 2010-02-16 Derives de triazolopyridine utilises comme inhibiteurs de la p38 map kinase MA33128B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0902651A GB0902651D0 (en) 2009-02-17 2009-02-17 Pharmaceutical compounds and compositions
GB0908069A GB0908069D0 (en) 2009-05-11 2009-05-11 Pharmaceutical compounds and compositions
PCT/GB2010/050257 WO2010094956A1 (fr) 2009-02-17 2010-02-16 Dérivés de triazolopyridine utilisés comme inhibiteurs de la p38 map kinase

Publications (1)

Publication Number Publication Date
MA33128B1 true MA33128B1 (fr) 2012-03-01

Family

ID=42232647

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34175A MA33128B1 (fr) 2009-02-17 2010-02-16 Derives de triazolopyridine utilises comme inhibiteurs de la p38 map kinase

Country Status (19)

Country Link
US (1) US8557797B2 (fr)
EP (1) EP2398798A1 (fr)
JP (1) JP2012517992A (fr)
KR (1) KR20110116030A (fr)
CN (2) CN103483338A (fr)
AU (1) AU2010215261A1 (fr)
BR (1) BRPI1005327A2 (fr)
CA (1) CA2752693A1 (fr)
CL (1) CL2011001977A1 (fr)
CO (1) CO6420344A2 (fr)
EA (1) EA201190119A1 (fr)
IL (1) IL214658A0 (fr)
MA (1) MA33128B1 (fr)
MX (1) MX2011008496A (fr)
PE (1) PE20120655A1 (fr)
SG (1) SG174134A1 (fr)
TN (1) TN2011000380A1 (fr)
WO (1) WO2010094956A1 (fr)
ZA (1) ZA201105993B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100072266A (ko) * 2007-10-24 2010-06-30 머크 샤프 앤드 돔 코포레이션 헤테로사이클 페닐 아미드 ｔ-형 칼슘 채널 길항제
GB201009731D0 (en) 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
WO2013013816A1 (fr) 2011-07-26 2013-01-31 Grünenthal GmbH Dérivés de carboxamide et d'urée aromatiques bicycliques substitués en tant que ligands de récepteur de vanilloïde
SG11201402985VA (en) * 2011-12-09 2014-08-28 Chiesi Farma Spa Kinase inhibitors
BR112014013178A2 (pt) 2011-12-09 2017-06-13 Chiesi Farm Spa composto, composição farmacêutica e uso de um composto
MY167216A (en) * 2011-12-09 2018-08-14 Chiesi Farm Spa Kinase inhibitors
EP2875014B1 (fr) * 2012-07-17 2017-11-29 Washington University Médicaments anti-mucus et leurs utilisations
RU2015151886A (ru) 2013-06-06 2017-06-08 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Ингибиторы киназ
KR20160015221A (ko) * 2013-06-06 2016-02-12 키에시 파르마슈티시 엣스. 피. 에이. 키나아제 억제제
EP3004087B1 (fr) * 2013-06-06 2017-08-09 CHIESI FARMACEUTICI S.p.A. Derives de [1,2,4]triazolo[4,3-a]pyridine en tant qu'inhibituers de la p38-map kinase
GB201321742D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
EA201790806A1 (ru) 2014-11-05 2017-11-30 Флексус Байосайенсиз, Инк. Иммунорегулирующие средства
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
ES2927715T3 (es) 2017-10-05 2022-11-10 Fulcrum Therapeutics Inc Inhibidores de la quinasa p38 reducen la expresión de dux4 y de los genes que le siguen para el tratamiento de la FSHD

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
JPH11508583A (ja) 1995-07-06 1999-07-27 ゼネカ・リミテッド ペプチド系のフィブロネクチン阻害薬
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
GB0028383D0 (en) 2000-11-21 2001-01-03 Novartis Ag Organic compounds
EP1241176A1 (fr) 2001-03-16 2002-09-18 Pfizer Products Inc. Dérivés de purine pour le traitement de l'ischémie
AU2002361992A1 (en) 2001-12-20 2003-07-09 Bayer Aktiengesellschaft 1,4-dihydro-1,4-diphenylpyridine derivatives
EP1601672B1 (fr) 2003-02-14 2006-07-26 Pfizer Products Inc. Triazolo-pyridines utilisees comme composes anti-inflammatoires
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
US7838524B2 (en) 2004-04-30 2010-11-23 Bayer Healthcare Llc Substituted pyrazolyl urea derivatives useful in the treatment of cancer
SI1761520T1 (sl) 2004-06-23 2008-10-31 Lilly Co Eli Inhibitorji kinaze
EP1609789A1 (fr) 2004-06-23 2005-12-28 Eli Lilly And Company Derives de ureido-pyrazole et leur utilisation comme inhibiteurs de kinase
AU2005273612B2 (en) 2004-08-12 2010-10-14 Pfizer Inc. Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors
GB0418015D0 (en) * 2004-08-12 2004-09-15 Pfizer Ltd New compounds
JP2008509985A (ja) 2004-08-18 2008-04-03 ファルマシア アンド アップジョン カンパニー リミテッド ライアビリティ カンパニー 炎症治療用の新規トリアゾロピリジン化合物
GB0502258D0 (en) 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
EP1984363A1 (fr) 2006-02-09 2008-10-29 Pfizer Limited Composes triazolopyridine
ES2396715T3 (es) 2006-08-21 2013-02-25 Array Biopharma, Inc. Derivados de ácido fenoxifenilacético 4-sustituido
GB0902648D0 (en) 2009-02-17 2009-04-01 Argenta Discovery Ltd Pharmaceutical compounds and compositions

Also Published As

Publication number Publication date
MX2011008496A (es) 2011-11-18
SG174134A1 (en) 2011-10-28
CA2752693A1 (fr) 2010-08-26
CL2011001977A1 (es) 2011-11-18
ZA201105993B (en) 2012-10-31
EP2398798A1 (fr) 2011-12-28
US20120088763A1 (en) 2012-04-12
WO2010094956A1 (fr) 2010-08-26
EA201190119A1 (ru) 2012-05-30
BRPI1005327A2 (pt) 2019-09-24
AU2010215261A1 (en) 2011-09-08
IL214658A0 (en) 2011-09-27
CN103483338A (zh) 2014-01-01
PE20120655A1 (es) 2012-06-07
CN102395586A (zh) 2012-03-28
JP2012517992A (ja) 2012-08-09
TN2011000380A1 (en) 2013-03-27
US8557797B2 (en) 2013-10-15
KR20110116030A (ko) 2011-10-24
CO6420344A2 (es) 2012-04-16

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