MA33281B1 - Résistance à de multiples virus dans des plantes - Google Patents
Résistance à de multiples virus dans des plantesInfo
- Publication number
- MA33281B1 MA33281B1 MA34359A MA34359A MA33281B1 MA 33281 B1 MA33281 B1 MA 33281B1 MA 34359 A MA34359 A MA 34359A MA 34359 A MA34359 A MA 34359A MA 33281 B1 MA33281 B1 MA 33281B1
- Authority
- MA
- Morocco
- Prior art keywords
- plant
- viruses
- resistance
- expression
- coding sequences
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 241000712894 Orthotospovirus Species 0.000 abstract 1
- 241000710007 Potexvirus Species 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 238000013459 approach Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 abstract 1
- 230000004034 genetic regulation Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003071 parasitic effect Effects 0.000 abstract 1
- 230000001124 posttranscriptional effect Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8283—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for virus resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention porte sur des cibles géniques, des produits de construction et des procédés pour la régulation génétique de maladies végétales causées par de multiples virus de plantes. La présente invention porte sur la réalisation d'un effet protecteur de plante par l'identification de séquences codantes cibles et l'utilisation de technologies d'ADN recombinant pour la répression post-transcriptionnelle ou l'inhibition de l'expression des séquences codantes cibles de virus parasites de plante. Des approches basées sur une expression de protéines peuvent également être utilisées pour augmenter la résistance phénotypique. Ainsi, la transcription d'un évènement transgénique unique comprenant une ou plusieurs cassettes d'expression végétale peut permettre une résistance à large spectre d'une plante contre de multiples souches virales de plante et des espèces parmi les virus Gemini, tospovirus et potexvirus.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17102109P | 2009-04-20 | 2009-04-20 | |
| PCT/US2010/031757 WO2010123904A1 (fr) | 2009-04-20 | 2010-04-20 | Résistance à de multiples virus dans des plantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA33281B1 true MA33281B1 (fr) | 2012-05-02 |
Family
ID=42272567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA34359A MA33281B1 (fr) | 2009-04-20 | 2010-04-20 | Résistance à de multiples virus dans des plantes |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8455716B2 (fr) |
| EP (2) | EP2421977B1 (fr) |
| JP (1) | JP2012523850A (fr) |
| KR (1) | KR20140014374A (fr) |
| CN (1) | CN102428187A (fr) |
| AU (1) | AU2010239381B2 (fr) |
| BR (1) | BRPI1013833A2 (fr) |
| CA (1) | CA2759291C (fr) |
| ES (1) | ES2651909T3 (fr) |
| IL (1) | IL215853A (fr) |
| MA (1) | MA33281B1 (fr) |
| MX (1) | MX2011011076A (fr) |
| WO (1) | WO2010123904A1 (fr) |
| ZA (1) | ZA201107675B (fr) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA33281B1 (fr) | 2009-04-20 | 2012-05-02 | Monsanto Technology Llc | Résistance à de multiples virus dans des plantes |
| KR102095850B1 (ko) | 2011-11-02 | 2020-04-02 | 리즈크 즈완 자드틸트 엔 자드한델 비.브이. | 페피노 모자이크 바이러스 저항성 토마토 식물 |
| AU2013282356B2 (en) | 2012-06-30 | 2017-02-02 | Boston Scientific Neuromodulation Corporation | System for compounding low-frequency sources for high-frequency neuromodulation |
| US9002459B2 (en) | 2012-09-19 | 2015-04-07 | Boston Scientific Neuromodulation Corporation | Method for selectively modulating neural elements in the dorsal horn |
| HK1214295A1 (zh) * | 2012-10-16 | 2016-07-22 | Monsanto Technology Llc | 防治植物病毒感染的方法和组合物 |
| WO2014130865A2 (fr) | 2013-02-22 | 2014-08-28 | Boston Scientific Neuromodulation Corporation | Système de neurostimulation doté d'une flexibilité augmentée permettant de créer des trains d'impulsions complexes |
| US9174053B2 (en) | 2013-03-08 | 2015-11-03 | Boston Scientific Neuromodulation Corporation | Neuromodulation using modulated pulse train |
| EP3583979B1 (fr) | 2013-03-15 | 2021-04-28 | Boston Scientific Neuromodulation Corporation | Systèmes d'administration de thérapie déficitaire à un patient |
| US9180297B2 (en) | 2013-05-16 | 2015-11-10 | Boston Scientific Neuromodulation Corporation | System and method for spinal cord modulation to treat motor disorder without paresthesia |
| WO2014197596A1 (fr) | 2013-06-06 | 2014-12-11 | Doan Que T | Système d'administration d'un traitement modulé en dessous du seuil |
| US9950173B2 (en) | 2013-06-06 | 2018-04-24 | Boston Scientific Neuromodulation Corporation | System and method for delivering sub-threshold and super-threshold therapy to a patient |
| AU2014302297B2 (en) | 2013-06-28 | 2017-04-13 | Boston Scientific Neuromodulation Corporation | Electrode selection for sub-threshold modulation therapy |
| CN105407964B (zh) | 2013-07-26 | 2018-05-04 | 波士顿科学神经调制公司 | 提供调制治疗而无感知的系统 |
| AU2014342534B9 (en) | 2013-10-30 | 2018-01-25 | Boston Scientific Neuromodulation Corporation | Fractional control to avoid dorsal root stimulation |
| CN105682734B (zh) | 2013-10-31 | 2018-08-17 | 波士顿科学神经调制公司 | 用于并入来自图像的引线信息的系统 |
| EP3062869B1 (fr) | 2013-11-01 | 2018-03-21 | Boston Scientific Neuromodulation Corporation | Système pour délivrer une thérapie infra-seuil au niveau d'une ligne médiane |
| CN103667322B (zh) * | 2013-11-21 | 2015-11-11 | 上海市农业科学院 | 一种抗番茄黄化曲叶病毒的多基因嵌合体avctc及其制备方法和应用 |
| US10010715B2 (en) | 2013-12-04 | 2018-07-03 | Boston Scientific Neuromodulation Corporation | Systems and methods for delivering therapy to the dorsal horn of a patient |
| WO2015089411A2 (fr) | 2013-12-12 | 2015-06-18 | Boston Scientific Neuromodulation Corporation | Systèmes et procédés de programmation d'un système de neuromodulation |
| AU2015214607B2 (en) | 2014-02-05 | 2017-05-18 | Boston Scientific Neuromodulation Corporation | System and method for delivering modulated sub-threshold therapy to a patient |
| EP3102283B1 (fr) | 2014-02-05 | 2018-02-28 | Boston Scientific Neuromodulation Corporation | Système d'administration de thérapie infraliminaire modulé à un patient |
| CA2953578C (fr) | 2014-07-03 | 2019-01-08 | Boston Scientific Neuromodulation Corporation | Systeme de neurostimulation a modelisation et formes d'onde flexibles |
| US9662495B2 (en) | 2014-07-24 | 2017-05-30 | Boston Scientific Neuromodulation Corporation | Enhanced dorsal horn stimulation using multiple electrical fields |
| CN106687173A (zh) | 2014-09-15 | 2017-05-17 | 波士顿科学神经调制公司 | 用于对神经刺激脉冲模式进行编程的图形用户界面 |
| CN106714900A (zh) | 2014-09-23 | 2017-05-24 | 波士顿科学神经调制公司 | 对患者输入的亚感知调制响应 |
| JP6437638B2 (ja) | 2014-09-23 | 2018-12-12 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 後角刺激を較正するためのシステム |
| JP6580678B2 (ja) | 2014-09-23 | 2019-09-25 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | バースト刺激を用いた神経変調 |
| CN107073265B (zh) | 2014-09-23 | 2020-11-10 | 波士顿科学神经调制公司 | 短脉冲宽度刺激 |
| CN106687174B (zh) | 2014-09-23 | 2019-12-03 | 波士顿科学神经调制公司 | 专用于针对目标组织的调制场的目标函数的神经调制 |
| EP3197551A1 (fr) | 2014-09-23 | 2017-08-02 | Boston Scientific Neuromodulation Corporation | Étalonnage d'une perception de tissus nerveux à l'aide d'un parcours de champ |
| WO2016048968A2 (fr) | 2014-09-23 | 2016-03-31 | Boston Scientific Neuromodulation Corporation | Systèmes et procédés pour recevoir la sélection des listes d'électrodes fournie par l'utilisateur |
| WO2016064347A1 (fr) | 2014-10-22 | 2016-04-28 | Temasek Life Sciences Laboratory Limited | Terpènes synthases obtenues à partir d'ylang-ylang (cananga odorata var. fruticosa) |
| JP6452836B2 (ja) | 2014-11-04 | 2019-01-16 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 複合神経刺激パターンをプログラムする方法及び装置 |
| CN107405484B (zh) | 2015-02-09 | 2021-09-24 | 波士顿科学神经调制公司 | 用于确定硬膜外引线的神经位置的系统 |
| CN107921261B (zh) | 2015-05-28 | 2022-01-14 | 波士顿科学神经调制公司 | 使用随机调节的刺激参数的神经调节 |
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| CN106609277B (zh) * | 2015-10-22 | 2021-02-12 | 中国种子集团有限公司 | 重组核酸片段RecCR020142及其检测方法 |
| BR112018011174A2 (pt) | 2015-11-30 | 2018-11-21 | Du Pont | polinucleotídeo recombinante, construto de dna, célula heteróloga, planta transgênica ou célula de planta, semente da planta transgênica, método para expressar um polinucleotídeo em uma planta e método para aprimorar a transcrição de um polinucleotídeo em uma célula hospedeira |
| WO2017135895A1 (fr) | 2016-02-05 | 2017-08-10 | Temasek Life Sciences Laboratory Limited | Promoteurs contenant des introns et leurs utilisations |
| EP3238533A1 (fr) * | 2016-04-28 | 2017-11-01 | Semillas Fito, S. A. | Plants de melons résistants au begomovirus |
| NZ749964A (en) * | 2016-07-12 | 2025-11-28 | Nunhems Bv | Tolcndv resistant melon plants |
| MX393239B (es) | 2016-07-12 | 2025-03-24 | Nunhems Bv | Plantas de melon resistentes a tolcndv. |
| US11591611B2 (en) | 2016-07-12 | 2023-02-28 | Nunhems B.V. | TolCNDV resistant melon plants |
| WO2018039117A1 (fr) | 2016-08-22 | 2018-03-01 | Boston Scientific Neuromodulation Corporation | Système de neuromodulation permettant d'obtenir une paresthésie et une analgésie, et système à sondes et électrodes |
| CA3045784A1 (fr) | 2016-10-11 | 2018-05-17 | Dow Agrosciences Llc | Modulation de l'expression de transgenes dans des plantes |
| CN107918017A (zh) * | 2016-12-26 | 2018-04-17 | 云南农业大学 | 一种快速检测辣椒褪绿病毒的血清学方法 |
| WO2019173721A1 (fr) * | 2018-03-09 | 2019-09-12 | Monsanto Technology Llc | Procédés et compositions pour lutter contre une infection virale végétale |
| CN109234221B (zh) * | 2018-11-19 | 2021-12-21 | 东北农业大学 | 一种马铃薯x病毒弱毒疫苗及其制备方法与应用 |
| EP3931321A1 (fr) * | 2019-03-01 | 2022-01-05 | Syngenta Crop Protection AG | Suppression de l'expression génique cible par édition génomique de micro-arn natifs |
| CN110999694A (zh) * | 2020-02-27 | 2020-04-14 | 天津市植物保护研究所 | 绿色防控番茄苗期烟粉虱及tylcv的方法 |
| WO2021234101A1 (fr) | 2020-05-20 | 2021-11-25 | KWS SAAT SE & Co. KGaA | Résistance à plusieurs virus |
| CN111778274A (zh) * | 2020-06-09 | 2020-10-16 | 新疆生产建设兵团第六师农业科学研究所 | 一种通过基因编辑提高番茄耐贮藏性的方法 |
| CN112625141A (zh) * | 2020-12-28 | 2021-04-09 | 昆明海关技术中心 | 一种番茄斑萎属病毒的蛋白标准物质及其应用 |
| EP4328311A4 (fr) * | 2021-04-21 | 2025-04-30 | Zhejiang University | Vecteur viral d'arn à brin négatif et procédé d'édition de génome de plante sans transformation |
| CN112980847B (zh) * | 2021-04-21 | 2023-05-02 | 中国热带农业科学院橡胶研究所 | 一种橡胶树泛素基因启动子proHbUBI3及其克隆与应用 |
| ES2931248A1 (es) * | 2021-06-18 | 2022-12-27 | Abiopep S L | Plantas resistentes a la infección por el virus del mosaico del pepino dulce |
| US20250002542A1 (en) * | 2021-10-19 | 2025-01-02 | University Of Florida Research Foundation, Inc. | Insect Toxin Delivery Mediated by a Begomovirus Coat Protein |
| EP4426842A1 (fr) | 2021-11-01 | 2024-09-11 | Flagship Pioneering Innovations VII, LLC | Polynucléotides pour modifier des organismes |
| CN114015718B (zh) * | 2021-11-24 | 2023-07-18 | 中国农业科学院植物保护研究所 | 大豆黄曲叶病毒侵染性克隆载体及其构建方法和应用 |
| MX2024009021A (es) | 2022-01-20 | 2024-08-06 | Flagship Pioneering Innovations Vii Llc | Polinucleotidos para modificar organismos. |
| US20250361522A1 (en) * | 2022-03-21 | 2025-11-27 | Donald Danforth Plant Science Center | Geminivirus resistant plants |
| CN116426567B (zh) * | 2023-03-29 | 2023-11-03 | 潍坊科技学院 | 一种n基因及其蛋白在抗番茄黄化曲叶病毒中的应用 |
| EP4705477A1 (fr) | 2023-05-03 | 2026-03-11 | Flagship Pioneering Innovations VII, LLC | Systèmes d'amplification d'arn satellite endornaviral pour plantes |
| CN121666452A (zh) | 2023-05-03 | 2026-03-13 | 旗舰创业创新第七有限责任公司 | 人工马特利病毒目卫星rna |
| WO2024229395A1 (fr) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Systèmes d'amplification d'arn satellite de partitivirus pour plantes |
| CN121666453A (zh) | 2023-05-03 | 2026-03-13 | 旗舰创业创新第七有限责任公司 | 人工南方菜豆花叶病病毒科卫星rna |
| WO2024229385A1 (fr) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Arn satellite a base de ghabrivirales artificielles |
| WO2024229351A1 (fr) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Arn satellite de secoviridae artificiels |
| AR132588A1 (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de tymovirales artificiales |
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-
2010
- 2010-04-20 MA MA34359A patent/MA33281B1/fr unknown
- 2010-04-20 CN CN2010800220529A patent/CN102428187A/zh active Pending
- 2010-04-20 KR KR1020117027476A patent/KR20140014374A/ko not_active Withdrawn
- 2010-04-20 JP JP2012507317A patent/JP2012523850A/ja not_active Withdrawn
- 2010-04-20 AU AU2010239381A patent/AU2010239381B2/en not_active Ceased
- 2010-04-20 EP EP10718360.0A patent/EP2421977B1/fr not_active Not-in-force
- 2010-04-20 BR BRPI1013833-1A patent/BRPI1013833A2/pt not_active IP Right Cessation
- 2010-04-20 MX MX2011011076A patent/MX2011011076A/es active IP Right Grant
- 2010-04-20 EP EP17182503.7A patent/EP3260545B1/fr not_active Not-in-force
- 2010-04-20 US US12/763,790 patent/US8455716B2/en not_active Expired - Fee Related
- 2010-04-20 CA CA2759291A patent/CA2759291C/fr not_active Expired - Fee Related
- 2010-04-20 WO PCT/US2010/031757 patent/WO2010123904A1/fr not_active Ceased
- 2010-04-20 ES ES10718360.0T patent/ES2651909T3/es active Active
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2011
- 2011-10-19 ZA ZA2011/07675A patent/ZA201107675B/en unknown
- 2011-10-23 IL IL215853A patent/IL215853A/en active IP Right Grant
-
2013
- 2013-01-25 US US13/750,971 patent/US9670502B2/en not_active Expired - Fee Related
-
2017
- 2017-05-17 US US15/598,095 patent/US20170356004A1/en not_active Abandoned
-
2019
- 2019-02-19 US US16/279,798 patent/US20190249189A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL215853A (en) | 2017-07-31 |
| KR20140014374A (ko) | 2014-02-06 |
| US8455716B2 (en) | 2013-06-04 |
| US20170356004A1 (en) | 2017-12-14 |
| US9670502B2 (en) | 2017-06-06 |
| WO2010123904A1 (fr) | 2010-10-28 |
| ES2651909T3 (es) | 2018-01-30 |
| US20130198902A1 (en) | 2013-08-01 |
| CN102428187A (zh) | 2012-04-25 |
| JP2012523850A (ja) | 2012-10-11 |
| MX2011011076A (es) | 2011-11-18 |
| US20190249189A1 (en) | 2019-08-15 |
| ZA201107675B (en) | 2012-06-27 |
| US20100269224A1 (en) | 2010-10-21 |
| BRPI1013833A2 (pt) | 2019-04-09 |
| IL215853A0 (en) | 2012-01-31 |
| AU2010239381B2 (en) | 2015-01-15 |
| AU2010239381A1 (en) | 2011-11-10 |
| CA2759291A1 (fr) | 2010-10-28 |
| EP2421977B1 (fr) | 2017-09-13 |
| EP3260545B1 (fr) | 2020-07-01 |
| EP3260545A1 (fr) | 2017-12-27 |
| CA2759291C (fr) | 2020-09-15 |
| EP2421977A1 (fr) | 2012-02-29 |
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