MA33290B1 - Pipéridines substituées - Google Patents

Pipéridines substituées

Info

Publication number
MA33290B1
MA33290B1 MA34375A MA34375A MA33290B1 MA 33290 B1 MA33290 B1 MA 33290B1 MA 34375 A MA34375 A MA 34375A MA 34375 A MA34375 A MA 34375A MA 33290 B1 MA33290 B1 MA 33290B1
Authority
MA
Morocco
Prior art keywords
diseases
substituted piperidines
treating
preventing
piperidines
Prior art date
Application number
MA34375A
Other languages
English (en)
Inventor
Dirk Heimbach
Susanne Roehrig
Grande Yolanda Cancho
Eckhard Bender
Katja Zimmermann
Anja Buchmueller
Christoph Gerdes
Mark Jean Gnoth
Kersten Matthias Gericke
Mario Jeske
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MA33290B1 publication Critical patent/MA33290B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Non-Alcoholic Beverages (AREA)

Abstract

L'invention concerne de nouvelles pipéridines substituées, des procédés pour les produire, leur utilisation pour traiter et/ou prévenir des maladies, ainsi que leur utilisation pour produire des médicaments pour traiter et/ou prévenir des maladies, en particulier des maladies cardiovasculaires et des maladies tumorales.
MA34375A 2009-05-27 2010-05-19 Pipéridines substituées MA33290B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009022896A DE102009022896A1 (de) 2009-05-27 2009-05-27 Substituierte Piperidine
PCT/EP2010/003059 WO2010136144A1 (fr) 2009-05-27 2010-05-19 Pipéridines substituées

Publications (1)

Publication Number Publication Date
MA33290B1 true MA33290B1 (fr) 2012-05-02

Family

ID=42543057

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34375A MA33290B1 (fr) 2009-05-27 2010-05-19 Pipéridines substituées

Country Status (28)

Country Link
US (2) US20120220563A1 (fr)
EP (1) EP2435427A1 (fr)
JP (1) JP5718320B2 (fr)
KR (1) KR20120044289A (fr)
CN (2) CN104744452A (fr)
AR (1) AR076692A1 (fr)
AU (1) AU2010252345A1 (fr)
BR (1) BRPI1012055A2 (fr)
CA (1) CA2763400A1 (fr)
CL (1) CL2011002965A1 (fr)
CO (1) CO6470823A2 (fr)
CR (1) CR20110628A (fr)
CU (1) CU20110215A7 (fr)
DE (1) DE102009022896A1 (fr)
DO (1) DOP2011000364A (fr)
EA (1) EA201190312A1 (fr)
EC (2) ECSP11011482A (fr)
GT (1) GT201100300A (fr)
IL (1) IL215901A0 (fr)
MA (1) MA33290B1 (fr)
MX (1) MX2011012505A (fr)
PE (1) PE20120934A1 (fr)
SG (1) SG175753A1 (fr)
TN (1) TN2011000595A1 (fr)
TW (1) TW201109326A (fr)
UY (2) UY32638A (fr)
WO (1) WO2010136144A1 (fr)
ZA (1) ZA201108565B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009014484A1 (de) 2009-03-23 2010-09-30 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022896A1 (de) 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022892A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022894A1 (de) 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
US8648079B2 (en) 2011-10-07 2014-02-11 Takeda Pharmaceutical Company Limited Heterocyclic compounds
EP3445762B1 (fr) 2016-04-20 2023-09-13 Bristol-Myers Squibb Company Composes heterocycliques bicyliques substitues
CN110139862B (zh) 2016-11-03 2024-01-16 百时美施贵宝公司 可用作romk通道抑制剂的经取代的二环杂环衍生物
EP3929194B1 (fr) 2017-06-01 2024-04-17 Bristol-Myers Squibb Company Composés contenant de l'azote substitué
WO2023044364A1 (fr) 2021-09-15 2023-03-23 Enko Chem, Inc. Inhibiteurs de protoporphyrinogène oxydase

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767144A (en) * 1994-08-19 1998-06-16 Abbott Laboratories Endothelin antagonists
AU2722297A (en) 1996-04-03 1997-10-22 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
US6403612B2 (en) * 2000-01-31 2002-06-11 Merck & Co., Inc. Thrombin receptor antagonists
CA2462374C (fr) 2001-10-15 2011-01-18 Janssen Pharmaceutica N.V. Derives de 4-phenyl-4-(1h-imidazol-2-yl)-piperidine substituee utiles pour reduire les lesions ischemiques
JP4383177B2 (ja) * 2002-03-01 2009-12-16 スミスクライン ビーチャム コーポレーション ｈＰＰＡＲ活性化剤
MXPA06014572A (es) 2004-06-24 2007-03-12 Incyte Corp Compuestos amido y su uso como farmaceuticos.
WO2006012226A2 (fr) 2004-06-24 2006-02-02 Incyte Corporation Piperidines a substitution n et utilisation de ces dernieres en tant que substances pharmaceutiques
US20060009491A1 (en) 2004-06-24 2006-01-12 Incyte Corporation Amido compounds and their use as pharmaceuticals
CN1993128A (zh) * 2004-06-24 2007-07-04 因塞特公司 N－取代的哌啶及它们作为药物的用途
EA200700251A1 (ru) 2004-08-10 2007-08-31 Инсайт Корпорейшн Амидосоединения и их применение в качестве фармацевтических средств
JP2007008913A (ja) * 2004-09-17 2007-01-18 Tanabe Seiyaku Co Ltd ピペリジン化合物およびその製法
DE102004045796A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
DE102004061750A1 (de) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Heteroaryl-substituierte Pyrazoline
CA2621255A1 (fr) 2005-09-21 2007-04-05 Incyte Corporation Utilisation pharmaceutique de composes amido
BRPI0707408A2 (pt) 2006-01-31 2011-05-03 Incyte Corp compostos de amido e seu uso como produtos farmacêuticos
WO2007101270A1 (fr) 2006-03-02 2007-09-07 Incyte Corporation MODULATEURS DE LA 11β-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1, COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT ET PROCEDE D'UTILISATION DESDITS MODULATEURS
JP2009535420A (ja) 2006-05-01 2009-10-01 インサイト・コーポレイション １１−βヒドロキシルステロイドデヒドロゲナーゼタイプ１のモジュレーターとしてのテトラ置換ウレア
JP5450435B2 (ja) * 2007-11-30 2014-03-26 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ヘテロアリールで置換されたピペリジン類
DE102009014484A1 (de) * 2009-03-23 2010-09-30 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022896A1 (de) 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022894A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022897A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine

Also Published As

Publication number Publication date
EP2435427A1 (fr) 2012-04-04
EA201190312A1 (ru) 2012-05-30
DE102009022896A1 (de) 2010-12-02
CN102596944A (zh) 2012-07-18
JP2012528090A (ja) 2012-11-12
SG175753A1 (en) 2011-12-29
MX2011012505A (es) 2011-12-14
CU20110215A7 (es) 2012-03-15
CR20110628A (es) 2012-03-22
US20110021489A1 (en) 2011-01-27
ECSP11011482A (es) 2011-12-30
BRPI1012055A2 (pt) 2016-05-17
PE20120934A1 (es) 2012-08-01
GT201100300A (es) 2013-08-21
CA2763400A1 (fr) 2010-12-02
AR076692A1 (es) 2011-06-29
UY32638A (es) 2010-10-29
CL2011002965A1 (es) 2012-07-06
IL215901A0 (en) 2012-01-31
UY32636A (es) 2010-12-31
US20120220563A1 (en) 2012-08-30
CN104744452A (zh) 2015-07-01
US8084469B2 (en) 2011-12-27
WO2010136144A1 (fr) 2010-12-02
CN102596944B (zh) 2015-08-26
TW201109326A (en) 2011-03-16
AU2010252345A1 (en) 2011-12-08
DOP2011000364A (es) 2012-02-29
TN2011000595A1 (en) 2013-05-24
ZA201108565B (en) 2013-01-30
ECSP11011483A (es) 2011-12-30
KR20120044289A (ko) 2012-05-07
CO6470823A2 (es) 2012-06-29
JP5718320B2 (ja) 2015-05-13

Similar Documents

Publication Publication Date Title
MA31245B1 (fr) Amides de 4-aryl-1,4-dihydro-1,6-naphthyridine substitués et utilisation de ceux-ci
MY172372A (en) Compositions and methods for lowering triglycerides
MX2011009539A (es) 2-acetamido-5-aril-1,2,4-triazolonas sustituidas y su uso.
PH12013502192A1 (en) Antibodies against human angiopoietin 2
MY159375A (en) Combinatorial therapy
MX337933B (es) Nuevas composiciones para prevenir y/o tratar trastornos de almacenamiento lisosomal.
MY151191A (en) Novel antibodies
MA33291B1 (fr) Pipéridines substituées
MA34248B1 (fr) 5-fluoro-1h-pyrazolopyridines substituées et leur utilisation
IN2012DN02737A (fr)
EA201001639A1 (ru) Композиции и способы их получения и применения
MY178926A (en) Bispecific anti-vegf/anti-ang-2 antibodies
DE502005006149D1 (de) Hetaryloxy-substituierte phenylaminopyrimidine als rho-kinasehemmer
JO2931B1 (en) Double-substituted phthalazin compounds as antagonists of the cell-specific factor pathway
MA38060A1 (fr) Imidazo[1,2-a]pyridincarboxamides amino-substitués et leur utilisation
MA32349B1 (fr) Antagonistes de la voie hedgehog a base de phtalazines disubstituees
CA2755394C (fr) Procedes et compositions pour des troubles lies a la proliferation cellulaire
MX2007002470A (es) Fenilaminotiazoles sustituidos y su uso.
MX2011012505A (es) Piperidinas sustituidas.
WO2009115252A3 (fr) Pyrazolamides substitués et leur utilisation
MX2012000572A (es) Moduladores del receptor 5-hidroxi triptamina 3 (5-ht3), metodos para su realización y uso de los mismos.
MY164998A (en) Isoquinolinone derivatives as nk3 antagonists
TW200517144A (en) Flavouring-containing pharmaceutical formulations with improved pharmaceutical properties
MA37700B1 (fr) N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicaments
TW200745132A (en) Novel, acyclically substituted furopyrimidine derivatives and use thereof