MA33724B1 - Anticorps neutralisants anti-ngf humain en tant qu'inhibiteurs selectifs de la voie du ngf - Google Patents

Anticorps neutralisants anti-ngf humain en tant qu'inhibiteurs selectifs de la voie du ngf

Info

Publication number
MA33724B1
MA33724B1 MA34834A MA34834A MA33724B1 MA 33724 B1 MA33724 B1 MA 33724B1 MA 34834 A MA34834 A MA 34834A MA 34834 A MA34834 A MA 34834A MA 33724 B1 MA33724 B1 MA 33724B1
Authority
MA
Morocco
Prior art keywords
ngf
antibodies
antibodies against
against human
selective inhibitors
Prior art date
Application number
MA34834A
Other languages
Arabic (ar)
English (en)
Inventor
Kenneth D Wild
James J S Treanor
Haichun Huang
Heather Inoue
Tie J Zhang
Frank Martin
Original Assignee
Amgen Inc
Medarex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43466840&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33724(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc, Medarex Inc filed Critical Amgen Inc
Publication of MA33724B1 publication Critical patent/MA33724B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
    • G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
    • G03F7/004—Photosensitive materials
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Genetics & Genomics (AREA)
  • Virology (AREA)
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  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)

Abstract

La présente invention concerne des anticorps qui interagissent avec ou se lient au facteur de croissance nerveux (ngf) humain et neutralisent ainsi la fonction du ngf. La présente invention concerne également des compositions pharmaceutiques desdits anticorps et des procédés de neutralisation de la fonction du ngf, et particulièrement de traitement des troubles liés au ngf (par exemple, la douleur chronique) par administration d'une quantité pharmaceutiquement efficace d'anticorps anti-ngf. La présente invention concerne en outre des procédés de détection de la quantité de ngf dans un échantillon en utilisant des anticorps anti-ngf.
MA34834A 2009-10-09 2012-05-04 Anticorps neutralisants anti-ngf humain en tant qu'inhibiteurs selectifs de la voie du ngf MA33724B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/576,522 US9260514B2 (en) 2003-07-15 2009-10-09 Methods of treating conditions caused by increased expression of nerve growth factor (NGF) or increased sensitivity to NGF using anti-NGF neutralizing antibodies as selective NGF pathway inhibitors
PCT/US2010/051960 WO2011049758A1 (fr) 2009-10-09 2010-10-08 Anticorps neutralisants anti-ngf humain en tant qu'inhibiteurs sélectifs de la voie du ngf

Publications (1)

Publication Number Publication Date
MA33724B1 true MA33724B1 (fr) 2012-11-01

Family

ID=43466840

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34834A MA33724B1 (fr) 2009-10-09 2012-05-04 Anticorps neutralisants anti-ngf humain en tant qu'inhibiteurs selectifs de la voie du ngf

Country Status (28)

Country Link
US (1) US9260514B2 (fr)
EP (2) EP3028717A1 (fr)
JP (3) JP2013507385A (fr)
KR (1) KR101528393B1 (fr)
CN (1) CN102762228A (fr)
AR (1) AR078569A1 (fr)
AU (2) AU2010308418A1 (fr)
BR (1) BR112012008282A2 (fr)
CA (1) CA2775924A1 (fr)
CL (1) CL2012000881A1 (fr)
CO (1) CO6541558A2 (fr)
CR (1) CR20120198A (fr)
EA (1) EA201290189A1 (fr)
IL (1) IL218885A0 (fr)
MA (1) MA33724B1 (fr)
ME (1) ME00226B (fr)
MT (1) MTP4289B (fr)
MX (1) MX343748B (fr)
MY (1) MY172283A (fr)
NZ (2) NZ625391A (fr)
PE (1) PE20121028A1 (fr)
PH (1) PH12012500668A1 (fr)
SG (1) SG10201603945RA (fr)
TN (1) TN2012000136A1 (fr)
TW (1) TW201125581A (fr)
UA (1) UA102775C2 (fr)
WO (1) WO2011049758A1 (fr)
ZA (1) ZA201203135B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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ITRM20030601A1 (it) * 2003-12-24 2005-06-25 Lay Line Genomics Spa Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
ITRM20050290A1 (it) * 2005-06-07 2006-12-08 Lay Line Genomics Spa Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
SG175436A1 (en) 2009-05-04 2011-12-29 Abbott Res Bv Antibodies against nerve growth factor (ngf) with enhanced in vivo stability
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
EP2646468B1 (fr) 2010-12-01 2018-07-25 AlderBio Holdings LLC Compositions anti-ngf et leur utilisation
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
CA2875783C (fr) 2012-06-06 2018-12-11 Zoetis Llc Anticorps anti-ngf caninises et procedes associes
US9603775B2 (en) 2013-04-24 2017-03-28 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
CN111402950B (zh) * 2013-11-29 2024-03-19 豪夫迈·罗氏有限公司 抗体选择装置和方法
JP2018516112A (ja) 2015-04-17 2018-06-21 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 異方性をもつ生物学的組織の検出
IL266640B (en) 2016-11-29 2022-09-01 Regeneron Pharma A pharmaceutical composition for averting opioid addiction
EP3765516A2 (fr) * 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Molécules multifonctionnelles et utilisations associées
KR20210043624A (ko) * 2018-08-10 2021-04-21 리제너론 파아마슈티컬스, 인크. 무릎 및/또는 고관절 통증의 안전하고 효과적인 치료를 위한 약제학적 조성물
IT201800009384A1 (it) 2018-10-11 2020-04-11 Cosmo Srl Peptide for cosmetic application
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EP2485760A1 (fr) 2012-08-15
KR20120117007A (ko) 2012-10-23
CO6541558A2 (es) 2012-10-16
MX343748B (es) 2016-11-22
JP2017014286A (ja) 2017-01-19
CA2775924A1 (fr) 2011-04-28
CR20120198A (es) 2012-07-30
AU2010308418A1 (en) 2012-05-10
MX2012004035A (es) 2012-05-08
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TN2012000136A1 (en) 2013-09-19
JP2013507385A (ja) 2013-03-04
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