MA37946A1 - Traitement de la polyarthrite rhumatoïde - Google Patents

Traitement de la polyarthrite rhumatoïde

Info

Publication number
MA37946A1
MA37946A1 MA37946A MA37946A MA37946A1 MA 37946 A1 MA37946 A1 MA 37946A1 MA 37946 A MA37946 A MA 37946A MA 37946 A MA37946 A MA 37946A MA 37946 A1 MA37946 A1 MA 37946A1
Authority
MA
Morocco
Prior art keywords
rheumatoid arthritis
treatment
relates
csf antibodies
mor103
Prior art date
Application number
MA37946A
Other languages
English (en)
Other versions
MA37946B1 (fr
Inventor
Stefan Haertle
Stephane Leclair
Amgad Shebl
Stefan Steidl
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Publication of MA37946A1 publication Critical patent/MA37946A1/fr
Publication of MA37946B1 publication Critical patent/MA37946B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des anticorps anti-gm-csf destinés à être utilisés dans le traitement de la polyarthrite rhumatoïde. L'invention concerne des anticorps anti-gm-csf, en particulier mor103, qui sont administrés à des patients souffrant de la polyarthrite rhumatoïde à des dosages qui sont avantageux dans des conditions cliniques.
MA37946A 2012-09-20 2013-09-19 Utilisation d’un anticorps anti-gm-csf pour le traitement de la polyarthrite rhumatoïde MA37946B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12185235 2012-09-20
PCT/EP2013/069501 WO2014044768A1 (fr) 2012-09-20 2013-09-19 Traitement de la polyarthrite rhumatoïde

Publications (2)

Publication Number Publication Date
MA37946A1 true MA37946A1 (fr) 2018-01-31
MA37946B1 MA37946B1 (fr) 2018-09-28

Family

ID=46963526

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37946A MA37946B1 (fr) 2012-09-20 2013-09-19 Utilisation d’un anticorps anti-gm-csf pour le traitement de la polyarthrite rhumatoïde

Country Status (22)

Country Link
US (4) US20150246969A1 (fr)
EP (3) EP3345923A1 (fr)
JP (4) JP2015533806A (fr)
KR (4) KR20230041086A (fr)
CN (2) CN104995210A (fr)
AU (2) AU2013320261A1 (fr)
BR (1) BR112015006189B1 (fr)
CL (2) CL2015000696A1 (fr)
CR (1) CR20150153A (fr)
DO (1) DOP2015000070A (fr)
EA (1) EA031489B1 (fr)
HK (1) HK1208231A1 (fr)
IL (1) IL237554B (fr)
IN (1) IN2015KN00657A (fr)
MA (1) MA37946B1 (fr)
MX (2) MX382937B (fr)
MY (1) MY175388A (fr)
PE (1) PE20151079A1 (fr)
PH (1) PH12015500591A1 (fr)
SG (2) SG10201803778PA (fr)
UA (1) UA117228C2 (fr)
WO (1) WO2014044768A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1208231A1 (en) * 2012-09-20 2016-02-26 Morphosys Ag Treatment for rheumatoid arthritis
WO2014068029A1 (fr) 2012-10-31 2014-05-08 Takeda Gmbh Formulation lyophilisée comprenant un composé neutralisant gm-csf
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res Munich Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
CN105705518A (zh) * 2013-08-30 2016-06-22 塔科达有限责任公司 用于治疗类风湿性关节炎或作为镇痛药的中和gm-csf的抗体
WO2015138638A1 (fr) * 2014-03-11 2015-09-17 Theraly Pharmaceuticals, Inc. Agonistes de récepteur de protéine trail à action prolongée pour le traitement de maladies auto-immunes
AU2015257798C1 (en) * 2014-05-07 2020-10-22 Takeda Pharmaceutical Company Limited Liquid formulation comprising GM-CSF neutralizing compound
GB201519331D0 (en) * 2015-11-02 2015-12-16 Glaxosmithkline Ip Dev Ltd Treatment paradigm
JP6797203B2 (ja) 2015-12-17 2020-12-09 ザ・ジョンズ・ホプキンス・ユニバーシティー デスレセプターアゴニストによる全身性硬化症の改善
KR102508650B1 (ko) 2016-04-07 2023-03-13 더 존스 홉킨스 유니버시티 사멸 수용체 작용제로써 췌장암 및 통증을 치료하기 위한 조성물 및 방법
KR101953706B1 (ko) * 2016-09-19 2019-03-05 아이-맵 항-gm-csf 항체 및 이것의 사용
US11655293B2 (en) * 2018-02-22 2023-05-23 Universitat Zurich Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT
EP3623382A1 (fr) 2018-09-14 2020-03-18 Universität Zürich Ligands vers gm-csf ou un récepteur gm-csf destinés à être utilisés dans une leucémie chez un patient ayant subi une allo-hct
WO2021204649A1 (fr) 2020-04-06 2021-10-14 Glaxosmithkline Intellectual Property Development Limited Antagonistes du gm-csf destinés à être utilisés dans le traitement de la covid-19 pulmonaire sévère, du syndrome de libération de cytokine et/ou du syndrome de détresse respiratoire aiguë
WO2025218746A1 (fr) * 2024-04-17 2025-10-23 Sinomab Bioscience Limited Méthodes de traitement de la polyarthrite rhumatoïde

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
WO1998014476A1 (fr) 1996-10-04 1998-04-09 Amgen Inc. Compositions pharmaceutiques contenant un ligand mpl
US7455836B2 (en) 2000-05-08 2008-11-25 The University Of Melbourne Method of treatment and agents useful for same
PT1888643E (pt) * 2005-05-18 2015-01-14 Morphosys Ag Anticorpos anti-fec-gm e as respectivas utilizações
AU2006295340B2 (en) 2005-08-05 2010-11-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
WO2007120656A2 (fr) * 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Utilisations et compositions pour le traitement de la polyarthrite rhumatoïde
WO2008042261A2 (fr) * 2006-09-28 2008-04-10 Elusys Therapeutics, Inc. Anticorps anti-charbon, ses formulations, et procédés d'utilisation
CN101605547A (zh) * 2006-11-21 2009-12-16 卡罗拜奥斯制药公司 使用gm-csf拮抗剂治疗慢性炎症疾病的方法
AU2008232903B9 (en) * 2007-03-30 2013-09-05 Medimmune Llc Antibodies with decreased deamidation profiles
CL2008000948A1 (es) * 2007-04-02 2008-10-10 Genentech Inc Uso de un antagonista de celulas b para tratar la artritis reumatoide a condicion que se observe la presencia de polimorfismo de nucleotido simple, epitope compartido o ambos en una muestra genetica del paciente.
JP5349452B2 (ja) 2007-04-05 2013-11-20 サンド アクチエンゲゼルシャフト 安定な水性ｇ‐ｃｓｆ製剤
WO2008157282A1 (fr) * 2007-06-18 2008-12-24 Genentech, Inc. Marqueurs biologiques prédictifs d'une réponse d'arthrite rhumatoïde à des antagonistes de cellule b
TW200918553A (en) * 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
PL2215119T3 (pl) * 2007-11-13 2013-06-28 Evec Inc Przeciwciała monoklonalne, które wiążą się z hGM-CSF i kompozycje lecznicze je zawierające
EP2196476A1 (fr) * 2008-12-10 2010-06-16 Novartis Ag Formulation d'anticorps
KR101799264B1 (ko) 2008-12-22 2017-11-20 더 유니버시티 오브 멜버른 골관절염 치료
JP5674677B2 (ja) 2008-12-22 2015-02-25 ザ ユニバーシティー オブ メルボルンＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｍｅｌｂｏｕｒｎｅ 疼痛治療
JP2010241718A (ja) 2009-04-03 2010-10-28 Kyowa Hakko Kirin Co Ltd 安定な抗体の水溶液製剤
JP2012530047A (ja) * 2009-05-05 2012-11-29 モルフォシス・アー・ゲー 多発性硬化症のための治療
PT2341061E (pt) 2009-12-31 2013-11-05 Arven Ilac Sanayi Ve Ticaret As Um processo novo para a preparação de g-csf (fator de estimulação de colónias de granulócitos)
BR112012022223B1 (pt) * 2010-03-01 2022-08-09 Cytodyn Inc Formulação de proteína concentrada, uso e método de preparação da mesma
EP2729498A1 (fr) 2011-07-06 2014-05-14 MorphoSys AG Associations thérapeutiques d'anticorps anti-cd20 et anti-gm-csf, et leurs utilisations
HK1208231A1 (en) * 2012-09-20 2016-02-26 Morphosys Ag Treatment for rheumatoid arthritis

Also Published As

Publication number Publication date
AU2016250388B2 (en) 2018-07-19
WO2014044768A1 (fr) 2014-03-27
KR20150056846A (ko) 2015-05-27
AU2016250388A1 (en) 2016-11-17
MX382937B (es) 2025-03-13
MX2021006111A (es) 2021-07-07
EP2897977A1 (fr) 2015-07-29
CR20150153A (es) 2015-09-14
MA37946B1 (fr) 2018-09-28
CA2884124A1 (fr) 2014-03-27
EP3916013A1 (fr) 2021-12-01
BR112015006189A2 (pt) 2019-11-26
EA031489B1 (ru) 2019-01-31
CN104995210A (zh) 2015-10-21
CL2018000933A1 (es) 2018-07-20
MY175388A (en) 2020-06-23
SG11201501595YA (en) 2015-05-28
KR20220028177A (ko) 2022-03-08
US20240417455A1 (en) 2024-12-19
MX2015003644A (es) 2015-09-25
US20180230208A1 (en) 2018-08-16
EP3345923A1 (fr) 2018-07-11
PE20151079A1 (es) 2015-08-07
SG10201803778PA (en) 2018-06-28
IL237554B (en) 2019-12-31
HK1208231A1 (en) 2016-02-26
CL2015000696A1 (es) 2015-10-23
AU2013320261A1 (en) 2015-04-09
US20210130451A1 (en) 2021-05-06
IL237554A0 (en) 2015-04-30
PH12015500591B1 (en) 2015-05-11
JP2022169709A (ja) 2022-11-09
US10913792B2 (en) 2021-02-09
US20150246969A1 (en) 2015-09-03
BR112015006189B1 (pt) 2022-04-05
JP2018138551A (ja) 2018-09-06
UA117228C2 (uk) 2018-07-10
JP2024156992A (ja) 2024-11-06
CN109999195A (zh) 2019-07-12
DOP2015000070A (es) 2015-08-16
PH12015500591A1 (en) 2015-05-11
KR20240091288A (ko) 2024-06-21
JP2015533806A (ja) 2015-11-26
EA201590359A1 (ru) 2015-08-31
KR20230041086A (ko) 2023-03-23
IN2015KN00657A (fr) 2015-07-17

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